-
1
-
-
54349097757
-
Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition
-
Abramowski, D., Wiederhold, K. H., Furrer, U., Jaton, A. L., Neuenschwander, A., Runser, M. J., Danner, S., Reichwald, J., Ammaturo, D., Staab, D., Stoeckli, M., Rueeger, H., Neumann, U., and Staufenbiel, M. (2008). Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition. J Pharmacol Exp Ther 327, 411-424.
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 411-424
-
-
Abramowski, D.1
Wiederhold, K.H.2
Furrer, U.3
Jaton, A.L.4
Neuenschwander, A.5
Runser, M.J.6
Danner, S.7
Reichwald, J.8
Ammaturo, D.9
Staab, D.10
Stoeckli, M.11
Rueeger, H.12
Neumann, U.13
Staufenbiel, M.14
-
2
-
-
84920686030
-
Human apolipoprotein E varepsilon4 expression impairs cerebral vascularization and blood-brain barrier function in mice
-
Alata, W., Ye, Y., St-Amour, I., Vandal, M., and Calon, F. (2015). Human apolipoprotein E varepsilon4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J Cereb Blood Flow Metab 35, 86-94.
-
(2015)
J Cereb Blood Flow Metab
, vol.35
, pp. 86-94
-
-
Alata, W.1
Ye, Y.2
St-Amour, I.3
Vandal, M.4
Calon, F.5
-
3
-
-
1842734659
-
The source of cerebral insulin
-
Banks, W. A. (2004). The source of cerebral insulin. Eur J Pharmacol 490, 5-12.
-
(2004)
Eur J Pharmacol
, vol.490
, pp. 5-12
-
-
Banks, W.A.1
-
4
-
-
0030664286
-
Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin
-
Banks, W. A., Jaspan, J. B., Huang, W., and Kastin, A. J. (1997a). Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin. Peptides 18, 1423-1429.
-
(1997)
Peptides
, vol.18
, pp. 1423-1429
-
-
Banks, W.A.1
Jaspan, J.B.2
Huang, W.3
Kastin, A.J.4
-
5
-
-
0031456345
-
Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays
-
Banks, W. A., Jaspan, J. B., and Kastin, A. J. (1997b). Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific radioimmunoassays. Peptides 18, 1257-1262.
-
(1997)
Peptides
, vol.18
, pp. 1257-1262
-
-
Banks, W.A.1
Jaspan, J.B.2
Kastin, A.J.3
-
6
-
-
0031837461
-
Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin
-
Banks, W. A., and Kastin, A. J. (1998). Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin. Peptides 19, 883-889.
-
(1998)
Peptides
, vol.19
, pp. 883-889
-
-
Banks, W.A.1
Kastin, A.J.2
-
7
-
-
0032853213
-
Uptake and degradation of blood-borne insulin by the olfactory bulb
-
Banks, W. A., Kastin, A. J., and Pan, W. (1999). Uptake and degradation of blood-borne insulin by the olfactory bulb. Peptides 20, 373-378.
-
(1999)
Peptides
, vol.20
, pp. 373-378
-
-
Banks, W.A.1
Kastin, A.J.2
Pan, W.3
-
8
-
-
84865575373
-
Insulin in the brain: there and back again
-
Banks, W. A., Owen, J. B., and Erickson, M. A. (2012). Insulin in the brain: there and back again. Pharmacol Ther 136, 82-93.
-
(2012)
Pharmacol Ther
, vol.136
, pp. 82-93
-
-
Banks, W.A.1
Owen, J.B.2
Erickson, M.A.3
-
9
-
-
84886611064
-
Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease
-
Barron, A. M., Rosario, E. R., Elteriefi, R., and Pike, C. J. (2013). Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease. PLoS One 8, e78554.
-
(2013)
PLoS One
, vol.8
-
-
Barron, A.M.1
Rosario, E.R.2
Elteriefi, R.3
Pike, C.J.4
-
10
-
-
19944430290
-
Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor
-
Barten, D. M., Guss, V. L., Corsa, J. A., Loo, A., Hansel, S. B., Zheng, M., Munoz, B., Srinivasan, K., Wang, B., Robertson, B. J., Polson, C. T., Wang, J., Roberts, S. B., Hendrick, J. P., Anderson, J. J., Loy, J. K., Denton, R., Verdoorn, T. A., Smith, D. W., and Felsenstein, K. M. (2005). Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor. J Pharmacol Exp Ther 312, 635-643.
-
(2005)
J Pharmacol Exp Ther
, vol.312
, pp. 635-643
-
-
Barten, D.M.1
Guss, V.L.2
Corsa, J.A.3
Loo, A.4
Hansel, S.B.5
Zheng, M.6
Munoz, B.7
Srinivasan, K.8
Wang, B.9
Robertson, B.J.10
Polson, C.T.11
Wang, J.12
Roberts, S.B.13
Hendrick, J.P.14
Anderson, J.J.15
Loy, J.K.16
Denton, R.17
Verdoorn, T.A.18
Smith, D.W.19
Felsenstein, K.M.20
more..
-
11
-
-
84862225603
-
Measurement of apolipoprotein E and amyloid beta clearance rates in the mouse brain using bolus stable isotope labeling
-
Basak, J. M., Kim, J., Pyatkivskyy, Y., Wildsmith, K. R., Jiang, H., Parsadanian, M., Patterson, B. W., Bateman, R. J., and Holtzman, D. M. (2012). Measurement of apolipoprotein E and amyloid beta clearance rates in the mouse brain using bolus stable isotope labeling. Mol Neurodegener 7, 14.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 14
-
-
Basak, J.M.1
Kim, J.2
Pyatkivskyy, Y.3
Wildsmith, K.R.4
Jiang, H.5
Parsadanian, M.6
Patterson, B.W.7
Bateman, R.J.8
Holtzman, D.M.9
-
12
-
-
33745920161
-
Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
-
Bateman, R. J., Munsell, L. Y., Morris, J. C., Swarm, R., Yarasheski, K. E., and Holtzman, D. M. (2006). Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med 12, 856-861.
-
(2006)
Nat Med
, vol.12
, pp. 856-861
-
-
Bateman, R.J.1
Munsell, L.Y.2
Morris, J.C.3
Swarm, R.4
Yarasheski, K.E.5
Holtzman, D.M.6
-
13
-
-
0027361094
-
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain
-
Baura, G. D., Foster, D. M., Porte, D. J., Kahn, S. E., Bergman, R. N., Cobelli, C., and Schwartz, M. W. (1993). Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest 92, 1824-1830.
-
(1993)
J Clin Invest
, vol.92
, pp. 1824-1830
-
-
Baura, G.D.1
Foster, D.M.2
Porte, D.J.3
Kahn, S.E.4
Bergman, R.N.5
Cobelli, C.6
Schwartz, M.W.7
-
14
-
-
84861418194
-
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
-
Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., Berk, B. C., and Zlokovic, B. V. (2012). Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516.
-
(2012)
Nature
, vol.485
, pp. 512-516
-
-
Bell, R.D.1
Winkler, E.A.2
Singh, I.3
Sagare, A.P.4
Deane, R.5
Wu, Z.6
Holtzman, D.M.7
Betsholtz, C.8
Armulik, A.9
Sallstrom, J.10
Berk, B.C.11
Zlokovic, B.V.12
-
15
-
-
84860577150
-
A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control
-
Bhaskar, V., Goldfine, I. D., Bedinger, D. H., Lau, A., Kuan, H. F., Gross, L. M., Handa, M., Maddux, B. A., Watson, S. R., Zhu, S., Narasimha, A. J., Levy, R., Webster, L., Wijesuriya, S. D., Liu, N., Wu, X., Chemla-Vogel, D., Tran, C., Lee, S. R., Wong, S., Wilcock, D., White, M.L., and Corbin, J. A. (2012). A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control. Diabetes 61, 1263-1271.
-
(2012)
Diabetes
, vol.61
, pp. 1263-1271
-
-
Bhaskar, V.1
Goldfine, I.D.2
Bedinger, D.H.3
Lau, A.4
Kuan, H.F.5
Gross, L.M.6
Handa, M.7
Maddux, B.A.8
Watson, S.R.9
Zhu, S.10
Narasimha, A.J.11
Levy, R.12
Webster, L.13
Wijesuriya, S.D.14
Liu, N.15
Wu, X.16
Chemla-Vogel, D.17
Tran, C.18
Lee, S.R.19
Wong, S.20
Wilcock, D.21
White, M.L.22
Corbin, J.A.23
more..
-
16
-
-
27744453362
-
Understanding RAGE, the receptor for advanced glycation end products
-
Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., and Nawroth, P. P. (2005). Understanding RAGE, the receptor for advanced glycation end products. J Mol Med (Berl) 83, 876-886.
-
(2005)
J Mol Med (Berl)
, vol.83
, pp. 876-886
-
-
Bierhaus, A.1
Humpert, P.M.2
Morcos, M.3
Wendt, T.4
Chavakis, T.5
Arnold, B.6
Stern, D.M.7
Nawroth, P.P.8
-
17
-
-
14544286348
-
Genetic factors in Alzheimer's disease
-
Bird, T. D. (2005). Genetic factors in Alzheimer's disease. N Engl J Med 352, 862-864.
-
(2005)
N Engl J Med
, vol.352
, pp. 862-864
-
-
Bird, T.D.1
-
18
-
-
0014313861
-
The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
-
Blessed, G., Tomlinson, B. E., and Roth, M. (1968). The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 114, 797-811.
-
(1968)
Br J Psychiatry
, vol.114
, pp. 797-811
-
-
Blessed, G.1
Tomlinson, B.E.2
Roth, M.3
-
19
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C. M., Kim, G., Seekins, S., Yager, D., Slunt, H. H., Wang, R., Seeger, M., Levey, A. I., Gandy, S. E., Copeland, N. G., Jenkins, N. A., Price, D. L., Younkin, S. G., and Sisodia, S. S. (1996). Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
20
-
-
85047698627
-
Sniffing neuropeptides: a transnasal approach to the human brain
-
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., and Fehm, H. L. (2002). Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 5, 514-516.
-
(2002)
Nat Neurosci
, vol.5
, pp. 514-516
-
-
Born, J.1
Lange, T.2
Kern, W.3
McGregor, G.P.4
Bickel, U.5
Fehm, H.L.6
-
21
-
-
60349096101
-
Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease
-
Bourasset, F., Ouellet, M., Tremblay, C., Julien, C., Do, T. M., Oddo, S., LaFerla, F., and Calon, F. (2009). Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease. Neuropharmacology 56, 808-813.
-
(2009)
Neuropharmacology
, vol.56
, pp. 808-813
-
-
Bourasset, F.1
Ouellet, M.2
Tremblay, C.3
Julien, C.4
Do, T.M.5
Oddo, S.6
LaFerla, F.7
Calon, F.8
-
22
-
-
0027490614
-
Staging of Alzheimer-related cortical destruction
-
Braak, H., Braak, E., and Bohl, J. (1993). Staging of Alzheimer-related cortical destruction. Eur Neurol 33, 403-408.
-
(1993)
Eur Neurol
, vol.33
, pp. 403-408
-
-
Braak, H.1
Braak, E.2
Bohl, J.3
-
23
-
-
84861626301
-
Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes
-
Brundel, M., van den Berg, E., Reijmer, Y. D., de Bresser, J., Kappelle, L. J., and Biessels, G. J. (2012). Cerebral haemodynamics, cognition and brain volumes in patients with type 2 diabetes. J Diabetes Complications 26, 205-209.
-
(2012)
J Diabetes Complications
, vol.26
, pp. 205-209
-
-
Brundel, M.1
van den Berg, E.2
Reijmer, Y.D.3
de Bresser, J.4
Kappelle, L.J.5
Biessels, G.J.6
-
24
-
-
84875449765
-
Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease
-
Chetelat, G., La Joie, R., Villain, N., Perrotin, A., de La Sayette, V., Eustache, F., and Vandenberghe, R. (2013). Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease. Neuroimage Clin 2, 356-365.
-
(2013)
Neuroimage Clin
, vol.2
, pp. 356-365
-
-
Chetelat, G.1
La Joie, R.2
Villain, N.3
Perrotin, A.4
de La Sayette, V.5
Eustache, F.6
Vandenberghe, R.7
-
25
-
-
27644489474
-
P-glycoprotein deficiency at the blood-brain barrier increases amyloidbeta deposition in an Alzheimer disease mouse model
-
Cirrito, J. R., Deane, R., Fagan, A. M., Spinner, M. L., Parsadanian, M., Finn, M. B., Jiang, H., Prior, J. L., Sagare, A., Bales, K. R., Paul, S. M., Zlokovic, B. V., Piwnica-Worms, D., and Holtzman, D. M. (2005). P-glycoprotein deficiency at the blood-brain barrier increases amyloidbeta deposition in an Alzheimer disease mouse model. J Clin Invest 115, 3285-3290.
-
(2005)
J Clin Invest
, vol.115
, pp. 3285-3290
-
-
Cirrito, J.R.1
Deane, R.2
Fagan, A.M.3
Spinner, M.L.4
Parsadanian, M.5
Finn, M.B.6
Jiang, H.7
Prior, J.L.8
Sagare, A.9
Bales, K.R.10
Paul, S.M.11
Zlokovic, B.V.12
Piwnica-Worms, D.13
Holtzman, D.M.14
-
26
-
-
0141529993
-
In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life
-
Cirrito, J. R., May, P. C., O'Dell, M. A., Taylor, J. W., Parsadanian, M., Cramer, J. W., Audia, J. E., Nissen, J. S., Bales, K. R., Paul, S. M., DeMattos, R. B., and Holtzman, D. M. (2003). In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. J Neurosci 23, 8844-8853.
-
(2003)
J Neurosci
, vol.23
, pp. 8844-8853
-
-
Cirrito, J.R.1
May, P.C.2
O'Dell, M.A.3
Taylor, J.W.4
Parsadanian, M.5
Cramer, J.W.6
Audia, J.E.7
Nissen, J.S.8
Bales, K.R.9
Paul, S.M.10
DeMattos, R.B.11
Holtzman, D.M.12
-
27
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42- residue amyloid beta-protein in both transfected cells and transgenic mice
-
Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Sherrington, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P., St George Hyslop, P., and Selkoe, D. J. (1997). Mutant presenilins of Alzheimer's disease increase production of 42- residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 3, 67-72.
-
(1997)
Nat Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St George Hyslop, P.22
Selkoe, D.J.23
more..
-
28
-
-
84922666525
-
Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia
-
Claxton, A., Baker, L. D., Hanson, A., Trittschuh, E. H., Cholerton, B., Morgan, A., Callaghan, M., Arbuckle, M., Behl, C., and Craft, S. (2015). Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. J Alzheimers Dis 44, 897-906.
-
(2015)
J Alzheimers Dis
, vol.44
, pp. 897-906
-
-
Claxton, A.1
Baker, L.D.2
Hanson, A.3
Trittschuh, E.H.4
Cholerton, B.5
Morgan, A.6
Callaghan, M.7
Arbuckle, M.8
Behl, C.9
Craft, S.10
-
29
-
-
12344337754
-
Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy
-
Cornford, E. M., and Hyman, S. (2005). Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy. NeuroRx 2, 27-43.
-
(2005)
NeuroRx
, vol.2
, pp. 27-43
-
-
Cornford, E.M.1
Hyman, S.2
-
30
-
-
84855613853
-
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
-
Craft, S., Baker, L. D., Montine, T. J., Minoshima, S., Watson, G. S., Claxton, A., Arbuckle, M., Callaghan, M., Tsai, E., Plymate, S. R., Green, P. S., Leverenz, J., Cross, D., and Gerton, B. (2012). Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 69, 29-38.
-
(2012)
Arch Neurol
, vol.69
, pp. 29-38
-
-
Craft, S.1
Baker, L.D.2
Montine, T.J.3
Minoshima, S.4
Watson, G.S.5
Claxton, A.6
Arbuckle, M.7
Callaghan, M.8
Tsai, E.9
Plymate, S.R.10
Green, P.S.11
Leverenz, J.12
Cross, D.13
Gerton, B.14
-
31
-
-
3042857903
-
Alzheimer's disease
-
Cummings, J. L. (2004). Alzheimer's disease. N Engl J Med 351, 56-67.
-
(2004)
N Engl J Med
, vol.351
, pp. 56-67
-
-
Cummings, J.L.1
-
32
-
-
84928209333
-
Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations
-
Dash, S., Xiao, C., Morgantini, C., Koulajian, K., and Lewis, G. F. (2015). Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations. Diabetes 64, 766-774.
-
(2015)
Diabetes
, vol.64
, pp. 766-774
-
-
Dash, S.1
Xiao, C.2
Morgantini, C.3
Koulajian, K.4
Lewis, G.F.5
-
33
-
-
84903136322
-
Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
-
De Felice, F. G., and Ferreira, S. T. (2014). Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes 63, 2262-2272.
-
(2014)
Diabetes
, vol.63
, pp. 2262-2272
-
-
De Felice, F.G.1
Ferreira, S.T.2
-
34
-
-
84909971843
-
Lessons from a failed gamma-secretase Alzheimer trial
-
De Strooper, B. (2014). Lessons from a failed gamma-secretase Alzheimer trial. Cell 159, 721-726.
-
(2014)
Cell
, vol.159
, pp. 721-726
-
-
De Strooper, B.1
-
35
-
-
84920771964
-
Learning by failing: ideas and concepts to tackle gamma-secretases in Alzheimer's disease and beyond
-
De Strooper, B., and Chavez Gutierrez, L. (2015). Learning by failing: ideas and concepts to tackle gamma-secretases in Alzheimer's disease and beyond. Annu Rev Pharmacol Toxicol 55, 419-437.
-
(2015)
Annu Rev Pharmacol Toxicol
, vol.55
, pp. 419-437
-
-
De Strooper, B.1
Chavez Gutierrez, L.2
-
36
-
-
65649105035
-
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease
-
Deane, R., Bell, R. D., Sagare, A., and Zlokovic, B. V. (2009). Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets 8, 16-30.
-
(2009)
CNS Neurol Disord Drug Targets
, vol.8
, pp. 16-30
-
-
Deane, R.1
Bell, R.D.2
Sagare, A.3
Zlokovic, B.V.4
-
37
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., Zhu, H., Ghiso, J., Frangione, B., Stern, A., Schmidt, A. M., Armstrong, D. L., Arnold, B., Liliensiek, B., Nawroth, P., Hofman, F., Kindy, M., Stern, D., and Zlokovic, B. (2003). RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 9, 907-913.
-
(2003)
Nat Med
, vol.9
, pp. 907-913
-
-
Deane, R.1
Du Yan, S.2
Submamaryan, R.K.3
LaRue, B.4
Jovanovic, S.5
Hogg, E.6
Welch, D.7
Manness, L.8
Lin, C.9
Yu, J.10
Zhu, H.11
Ghiso, J.12
Frangione, B.13
Stern, A.14
Schmidt, A.M.15
Armstrong, D.L.16
Arnold, B.17
Liliensiek, B.18
Nawroth, P.19
Hofman, F.20
Kindy, M.21
Stern, D.22
Zlokovic, B.23
more..
-
38
-
-
57449084208
-
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
-
Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., and Zlokovic, B. V. (2008). apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 118, 4002-4013.
-
(2008)
J Clin Invest
, vol.118
, pp. 4002-4013
-
-
Deane, R.1
Sagare, A.2
Hamm, K.3
Parisi, M.4
Lane, S.5
Finn, M.B.6
Holtzman, D.M.7
Zlokovic, B.V.8
-
39
-
-
7644225312
-
RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier
-
Deane, R., Wu, Z., and Zlokovic, B. V. (2004). RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke 35, 2628-2631.
-
(2004)
Stroke
, vol.35
, pp. 2628-2631
-
-
Deane, R.1
Wu, Z.2
Zlokovic, B.V.3
-
40
-
-
84899927908
-
Aging-related differences in cerebral capillary blood flow in anesthetized rats
-
Desjardins, M., Berti, R., Lefebvre, J., Dubeau, S., and Lesage, F. (2014). Aging-related differences in cerebral capillary blood flow in anesthetized rats. Neurobiol Aging 35, 1947-1955.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 1947-1955
-
-
Desjardins, M.1
Berti, R.2
Lefebvre, J.3
Dubeau, S.4
Lesage, F.5
-
41
-
-
0030660554
-
Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies
-
Dickson, D. W. (1997). Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies. Neurobiol Aging 18, S21-S26.
-
(1997)
Neurobiol Aging
, vol.18
, pp. S21-S26
-
-
Dickson, D.W.1
-
42
-
-
84897829598
-
Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease
-
Do, T. M., Alata, W., Dodacki, A., Traversy, M. T., Chacun, H., Pradier, L., Scherrmann, J. M., Farinotti, R., Calon, F., and Bourasset, F. (2014). Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease. Neuropharmacology 81, 311-317.
-
(2014)
Neuropharmacology
, vol.81
, pp. 311-317
-
-
Do, T.M.1
Alata, W.2
Dodacki, A.3
Traversy, M.T.4
Chacun, H.5
Pradier, L.6
Scherrmann, J.M.7
Farinotti, R.8
Calon, F.9
Bourasset, F.10
-
43
-
-
84861539923
-
ABCG2- and ABCG4-mediated efflux of amyloid-beta peptide 1-40 at the mouse bloodbrain barrier
-
Do, T. M., Noel-Hudson, M. S., Ribes, S., Besengez, C., Smirnova, M., Cisternino, S., Buyse, M., Calon, F., Chimini, G., Chacun, H., Scherrmann, J. M., Farinotti, R., and Bourasset, F. (2012). ABCG2- and ABCG4-mediated efflux of amyloid-beta peptide 1-40 at the mouse bloodbrain barrier. J Alzheimers Dis 30, 155-166.
-
(2012)
J Alzheimers Dis
, vol.30
, pp. 155-166
-
-
Do, T.M.1
Noel-Hudson, M.S.2
Ribes, S.3
Besengez, C.4
Smirnova, M.5
Cisternino, S.6
Buyse, M.7
Calon, F.8
Chimini, G.9
Chacun, H.10
Scherrmann, J.M.11
Farinotti, R.12
Bourasset, F.13
-
44
-
-
33749157416
-
RAGE, LRP- 1, and amyloid-beta protein in Alzheimer's disease
-
Donahue, J. E., Flaherty, S. L., Johanson, C. E., Duncan, J. A., Silverberg, G. D., Miller, M. C., Tavares, R., Yang, W., Wu, Q., Sabo, E., Hovanesian, V., and Stopa, E. G. (2006). RAGE, LRP- 1, and amyloid-beta protein in Alzheimer's disease. Acta Neuropathol 112, 405-415.
-
(2006)
Acta Neuropathol
, vol.112
, pp. 405-415
-
-
Donahue, J.E.1
Flaherty, S.L.2
Johanson, C.E.3
Duncan, J.A.4
Silverberg, G.D.5
Miller, M.C.6
Tavares, R.7
Yang, W.8
Wu, Q.9
Sabo, E.10
Hovanesian, V.11
Stopa, E.G.12
-
45
-
-
77958594257
-
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice
-
Donkin, J. J., Stukas, S., Hirsch-Reinshagen, V., Namjoshi, D., Wilkinson, A., May, S., Chan, J., Fan, J., Collins, J., and Wellington, C. L. (2010). ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J Biol Chem 285, 34144-34154.
-
(2010)
J Biol Chem
, vol.285
, pp. 34144-34154
-
-
Donkin, J.J.1
Stukas, S.2
Hirsch-Reinshagen, V.3
Namjoshi, D.4
Wilkinson, A.5
May, S.6
Chan, J.7
Fan, J.8
Collins, J.9
Wellington, C.L.10
-
46
-
-
84880712325
-
A phase 3 trial of semagacestat for treatment of Alzheimer's disease
-
Doody, R. S., Raman, R., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., He, F., Sun, X., Thomas, R. G., Aisen, P. S., Siemers, E., Sethuraman, G., and Mohs, R. (2013). A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med 369, 341-350.
-
(2013)
N Engl J Med
, vol.369
, pp. 341-350
-
-
Doody, R.S.1
Raman, R.2
Farlow, M.3
Iwatsubo, T.4
Vellas, B.5
Joffe, S.6
Kieburtz, K.7
He, F.8
Sun, X.9
Thomas, R.G.10
Aisen, P.S.11
Siemers, E.12
Sethuraman, G.13
Mohs, R.14
-
47
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C. M., Perez-tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., Morgan, D., Gordon, M. N., Holcomb, L., Refolo, L., Zenk, B., Hardy, J., and Younkin, S. (1996). Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
48
-
-
0023636719
-
Blood-brain barrier transcytosis of insulin in developing rabbits
-
Duffy, K. R., and Pardridge, W. M. (1987). Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Res 420, 32-38.
-
(1987)
Brain Res
, vol.420
, pp. 32-38
-
-
Duffy, K.R.1
Pardridge, W.M.2
-
49
-
-
84885018413
-
Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease
-
Erickson, M. A., and Banks, W. A. (2013). Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J Cereb Blood Flow Metab 33, 1500-1513.
-
(2013)
J Cereb Blood Flow Metab
, vol.33
, pp. 1500-1513
-
-
Erickson, M.A.1
Banks, W.A.2
-
50
-
-
58549098084
-
Blood-brain barrier: ageing and microvascular disease-- systematic review and meta-analysis
-
Farrall, A. J., and Wardlaw, J. M. (2009). Blood-brain barrier: ageing and microvascular disease-- systematic review and meta-analysis. Neurobiol Aging 30, 337-352.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 337-352
-
-
Farrall, A.J.1
Wardlaw, J.M.2
-
51
-
-
84858631674
-
The many faces of insulin-like peptide signalling in the brain
-
Fernandez, A. M., and Torres-Aleman, I. (2012). The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci 13, 225-239.
-
(2012)
Nat Rev Neurosci
, vol.13
, pp. 225-239
-
-
Fernandez, A.M.1
Torres-Aleman, I.2
-
52
-
-
84895908857
-
Advanced glycation end products (AGEs) are crosssectionally associated with insulin secretion in healthy subjects
-
Forbes, J. M., Sourris, K. C., de Courten, M. P., Dougherty, S. L., Chand, V., Lyons, J. G., Bertovic, D., Coughlan, M. T., Schlaich, M. P., Soldatos, G., Cooper, M. E., Straznicky, N. E., Kingwell, B. A., and de Courten, B. (2014). Advanced glycation end products (AGEs) are crosssectionally associated with insulin secretion in healthy subjects. Amino Acids 46, 321-326.
-
(2014)
Amino Acids
, vol.46
, pp. 321-326
-
-
Forbes, J.M.1
Sourris, K.C.2
de Courten, M.P.3
Dougherty, S.L.4
Chand, V.5
Lyons, J.G.6
Bertovic, D.7
Coughlan, M.T.8
Schlaich, M.P.9
Soldatos, G.10
Cooper, M.E.11
Straznicky, N.E.12
Kingwell, B.A.13
de Courten, B.14
-
53
-
-
0021824451
-
Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits
-
Frank, H. J., Jankovic-Vokes, T., Pardridge, W. M., and Morris, W. L. (1985). Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits. Diabetes 34, 728-733.
-
(1985)
Diabetes
, vol.34
, pp. 728-733
-
-
Frank, H.J.1
Jankovic-Vokes, T.2
Pardridge, W.M.3
Morris, W.L.4
-
54
-
-
84880555817
-
Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence
-
Freiherr, J., Hallschmid, M., Frey, W. H., Brunner, Y. F., Chapman, C. D., Holscher, C., Craft, S., De Felice, F. G., and Benedict, C. (2013). Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs 27, 505-514.
-
(2013)
CNS Drugs
, vol.27
, pp. 505-514
-
-
Freiherr, J.1
Hallschmid, M.2
Frey, W.H.3
Brunner, Y.F.4
Chapman, C.D.5
Holscher, C.6
Craft, S.7
De Felice, F.G.8
Benedict, C.9
-
55
-
-
84902173668
-
Clinical trial of an inhibitor of RAGE-Abeta interactions in Alzheimer disease
-
Galasko, D., Bell, J., Mancuso, J. Y., Kupiec, J. W., Sabbagh, M. N., van Dyck, C., Thomas, R. G., and Aisen, P. S. (2014). Clinical trial of an inhibitor of RAGE-Abeta interactions in Alzheimer disease. Neurology 82, 1536-1542.
-
(2014)
Neurology
, vol.82
, pp. 1536-1542
-
-
Galasko, D.1
Bell, J.2
Mancuso, J.Y.3
Kupiec, J.W.4
Sabbagh, M.N.5
van Dyck, C.6
Thomas, R.G.7
Aisen, P.S.8
-
56
-
-
84931289812
-
Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans
-
Gancheva, S., Koliaki, C., Bierwagen, A., Nowotny, P., Heni, M., Fritsche, A., Haring, H. U., Szendroedi, J., and Roden, M. (2015). Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans. Diabetes
-
(2015)
Diabetes
-
-
Gancheva, S.1
Koliaki, C.2
Bierwagen, A.3
Nowotny, P.4
Heni, M.5
Fritsche, A.6
Haring, H.U.7
Szendroedi, J.8
Roden, M.9
-
57
-
-
32244435907
-
Role of genes and environments for explaining Alzheimer disease
-
Gatz, M., Reynolds, C. A., Fratiglioni, L., Johansson, B., Mortimer, J. A., Berg, S., Fiske, A., and Pedersen, N. L. (2006). Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63, 168-174.
-
(2006)
Arch Gen Psychiatry
, vol.63
, pp. 168-174
-
-
Gatz, M.1
Reynolds, C.A.2
Fratiglioni, L.3
Johansson, B.4
Mortimer, J.A.5
Berg, S.6
Fiske, A.7
Pedersen, N.L.8
-
58
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., and et, A. (1991). Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
59
-
-
33750705653
-
A century of Alzheimer's disease
-
Goedert, M., and Spillantini, M. G. (2006). A century of Alzheimer's disease. Science 314, 777-781.
-
(2006)
Science
, vol.314
, pp. 777-781
-
-
Goedert, M.1
Spillantini, M.G.2
-
60
-
-
78751692575
-
Anti-abeta therapeutics in Alzheimer's disease: the need for a paradigm shift
-
Golde, T. E., Schneider, L. S., and Koo, E. H. (2011). Anti-abeta therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron 69, 203-213.
-
(2011)
Neuron
, vol.69
, pp. 203-213
-
-
Golde, T.E.1
Schneider, L.S.2
Koo, E.H.3
-
61
-
-
84855915021
-
Differential effects of intranasal insulin and caffeine on cerebral blood flow
-
Grichisch, Y., Cavusoglu, M., Preissl, H., Uludag, K., Hallschmid, M., Birbaumer, N., Haring, H. U., Fritsche, A., and Veit, R. (2012). Differential effects of intranasal insulin and caffeine on cerebral blood flow. Hum Brain Mapp 33, 280-287.
-
(2012)
Hum Brain Mapp
, vol.33
, pp. 280-287
-
-
Grichisch, Y.1
Cavusoglu, M.2
Preissl, H.3
Uludag, K.4
Hallschmid, M.5
Birbaumer, N.6
Haring, H.U.7
Fritsche, A.8
Veit, R.9
-
62
-
-
84872445349
-
2012: A watershed year for Alzheimer's disease research
-
Grundman, M., Dibernardo, A., Raghavan, N., Krams, M., and Yuen, E. (2013). 2012: A watershed year for Alzheimer's disease research. J Nutr Health Aging 17, 51-53.
-
(2013)
J Nutr Health Aging
, vol.17
, pp. 51-53
-
-
Grundman, M.1
Dibernardo, A.2
Raghavan, N.3
Krams, M.4
Yuen, E.5
-
63
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
-
Haass, C., and Selkoe, D. J. (2007). Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8, 101-112.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
64
-
-
0023765850
-
Intracellular pathways of insulin transport across vascular endothelial cells
-
Hachiya, H. L., Halban, P. A., and King, G. L. (1988). Intracellular pathways of insulin transport across vascular endothelial cells. Am J Physiol 255, C459-C464.
-
(1988)
Am J Physiol
, vol.255
, pp. C459-C464
-
-
Hachiya, H.L.1
Halban, P.A.2
King, G.L.3
-
65
-
-
48849083826
-
Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
-
Hallschmid, M., Benedict, C., Schultes, B., Perras, B., Fehm, H. L., Kern, W., and Born, J. (2008). Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders. Regul Pept 149, 79-83.
-
(2008)
Regul Pept
, vol.149
, pp. 79-83
-
-
Hallschmid, M.1
Benedict, C.2
Schultes, B.3
Perras, B.4
Fehm, H.L.5
Kern, W.6
Born, J.7
-
66
-
-
0032883250
-
No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans
-
Hasselbalch, S. G., Knudsen, G. M., Videbaek, C., Pinborg, L. H., Schmidt, J. F., Holm, S., and Paulson, O. B. (1999). No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 48, 1915-1921.
-
(1999)
Diabetes
, vol.48
, pp. 1915-1921
-
-
Hasselbalch, S.G.1
Knudsen, G.M.2
Videbaek, C.3
Pinborg, L.H.4
Schmidt, J.F.5
Holm, S.6
Paulson, O.B.7
-
67
-
-
0344833819
-
Identification of insulin in rat brain
-
Havrankova, J., Schmechel, D., Roth, J., and Brownstein, M. (1978). Identification of insulin in rat brain. Proc Natl Acad Sci U S A 75, 5737-5741.
-
(1978)
Proc Natl Acad Sci U S A
, vol.75
, pp. 5737-5741
-
-
Havrankova, J.1
Schmechel, D.2
Roth, J.3
Brownstein, M.4
-
68
-
-
84893926752
-
Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline
-
Hennebelle, M., Plourde, M., Chouinard-Watkins, R., Castellano, C. A., Barberger-Gateau, P., and Cunnane, S. C. (2014). Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. Proc Nutr Soc 73, 80-86.
-
(2014)
Proc Nutr Soc
, vol.73
, pp. 80-86
-
-
Hennebelle, M.1
Plourde, M.2
Chouinard-Watkins, R.3
Castellano, C.A.4
Barberger-Gateau, P.5
Cunnane, S.C.6
-
69
-
-
4644286910
-
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
-
Ho, L., Qin, W., Pompl, P. N., Xiang, Z., Wang, J., Zhao, Z., Peng, Y., Cambareri, G., Rocher, A., Mobbs, C. V., Hof, P. R., and Pasinetti, G. M. (2004). Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB J 18, 902-904.
-
(2004)
FASEB J
, vol.18
, pp. 902-904
-
-
Ho, L.1
Qin, W.2
Pompl, P.N.3
Xiang, Z.4
Wang, J.5
Zhao, Z.6
Peng, Y.7
Cambareri, G.8
Rocher, A.9
Mobbs, C.V.10
Hof, P.R.11
Pasinetti, G.M.12
-
70
-
-
84899094003
-
Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque
-
Holland, J. P., Liang, S. H., Rotstein, B. H., Collier, T. L., Stephenson, N. A., Greguric, I., and Vasdev, N. (2014). Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque. J Labelled Comp Radiopharm 57, 323-331.
-
(2014)
J Labelled Comp Radiopharm
, vol.57
, pp. 323-331
-
-
Holland, J.P.1
Liang, S.H.2
Rotstein, B.H.3
Collier, T.L.4
Stephenson, N.A.5
Greguric, I.6
Vasdev, N.7
-
71
-
-
67349230450
-
Downregulation of LRP1 [correction of LPR1] at the bloodbrain barrier in streptozotocin-induced diabetic mice
-
Hong, H., Liu, L. P., Liao, J. M., Wang, T. S., Ye, F. Y., Wu, J., Wang, Y. Y., Wang, Y., Li, Y. Q., Long, Y., and Xia, Y. Z. (2009). Downregulation of LRP1 [correction of LPR1] at the bloodbrain barrier in streptozotocin-induced diabetic mice. Neuropharmacology 56, 1054-1059.
-
(2009)
Neuropharmacology
, vol.56
, pp. 1054-1059
-
-
Hong, H.1
Liu, L.P.2
Liao, J.M.3
Wang, T.S.4
Ye, F.Y.5
Wu, J.6
Wang, Y.Y.7
Wang, Y.8
Li, Y.Q.9
Long, Y.10
Xia, Y.Z.11
-
72
-
-
0842309993
-
Increased risk of type 2 diabetes in Alzheimer disease
-
Janson, J., Laedtke, T., Parisi, J. E., O'Brien, P., Petersen, R. C., and Butler, P. C. (2004). Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 53, 474-481.
-
(2004)
Diabetes
, vol.53
, pp. 474-481
-
-
Janson, J.1
Laedtke, T.2
Parisi, J.E.3
O'Brien, P.4
Petersen, R.C.5
Butler, P.C.6
-
73
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., Hoyte, K., Gustafson, A., Liu, Y., Lu, Y., Bhangale, T., Graham, R. R., Huttenlocher, J., Bjornsdottir, G., Andreassen, O. A., Jonsson, E. G., Palotie, A., Behrens, T. W., Magnusson, O. T., Kong, A., Thorsteinsdottir, U., Watts, R. J., and Stefansson, K. (2012). A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488, 96-99.
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
Snaedal, J.4
Jonsson, P.V.5
Bjornsson, S.6
Stefansson, H.7
Sulem, P.8
Gudbjartsson, D.9
Maloney, J.10
Hoyte, K.11
Gustafson, A.12
Liu, Y.13
Lu, Y.14
Bhangale, T.15
Graham, R.R.16
Huttenlocher, J.17
Bjornsdottir, G.18
Andreassen, O.A.19
Jonsson, E.G.20
Palotie, A.21
Behrens, T.W.22
Magnusson, O.T.23
Kong, A.24
Thorsteinsdottir, U.25
Watts, R.J.26
Stefansson, K.27
more..
-
74
-
-
77954955083
-
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
-
Julien, C., Tremblay, C., Phivilay, A., Berthiaume, L., Emond, V., Julien, P., and Calon, F. (2010). High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging 31, 1516-1531.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 1516-1531
-
-
Julien, C.1
Tremblay, C.2
Phivilay, A.3
Berthiaume, L.4
Emond, V.5
Julien, P.6
Calon, F.7
-
75
-
-
78650698306
-
Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease
-
Kadir, A., Marutle, A., Gonzalez, D., Scholl, M., Almkvist, O., Mousavi, M., Mustafiz, T., Darreh-Shori, T., Nennesmo, I., and Nordberg, A. (2011). Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease. Brain 134, 301-317.
-
(2011)
Brain
, vol.134
, pp. 301-317
-
-
Kadir, A.1
Marutle, A.2
Gonzalez, D.3
Scholl, M.4
Almkvist, O.5
Mousavi, M.6
Mustafiz, T.7
Darreh-Shori, T.8
Nennesmo, I.9
Nordberg, A.10
-
76
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., and Malinow, R. (2003). APP processing and synaptic function. Neuron 37, 925-937.
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
77
-
-
84882449725
-
The influence of insulin infusion on the metabolism of amyloid beta peptides in plasma
-
Karczewska-Kupczewska, M., Lelental, N., Adamska, A., Nikolajuk, A., Kowalska, I., Gorska, M., Zimmermann, R., Kornhuber, J., Straczkowski, M., and Lewczuk, P. (2013). The influence of insulin infusion on the metabolism of amyloid beta peptides in plasma. Alzheimers Dement 9, 400-405.
-
(2013)
Alzheimers Dement
, vol.9
, pp. 400-405
-
-
Karczewska-Kupczewska, M.1
Lelental, N.2
Adamska, A.3
Nikolajuk, A.4
Kowalska, I.5
Gorska, M.6
Zimmermann, R.7
Kornhuber, J.8
Straczkowski, M.9
Lewczuk, P.10
-
78
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
-
Karran, E., Mercken, M., and De Strooper, B. (2011). The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 10, 698-712.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
79
-
-
0035016703
-
Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice
-
Kastin, A. J., and Akerstrom, V. (2001). Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology 73, 237-242.
-
(2001)
Neuroendocrinology
, vol.73
, pp. 237-242
-
-
Kastin, A.J.1
Akerstrom, V.2
-
80
-
-
72049127263
-
Cerebrovascular responses to insulin in rats
-
Katakam, P. V., Domoki, F., Lenti, L., Gaspar, T., Institoris, A., Snipes, J. A., and Busija, D. W. (2009). Cerebrovascular responses to insulin in rats. J Cereb Blood Flow Metab 29, 1955-1967.
-
(2009)
J Cereb Blood Flow Metab
, vol.29
, pp. 1955-1967
-
-
Katakam, P.V.1
Domoki, F.2
Lenti, L.3
Gaspar, T.4
Institoris, A.5
Snipes, J.A.6
Busija, D.W.7
-
81
-
-
17044367906
-
Human cerebral blood flow and metabolism in acute insulin-induced hypoglycemia
-
Kennan, R. P., Takahashi, K., Pan, C., Shamoon, H., and Pan, J. W. (2005). Human cerebral blood flow and metabolism in acute insulin-induced hypoglycemia. J Cereb Blood Flow Metab 25, 527-534.
-
(2005)
J Cereb Blood Flow Metab
, vol.25
, pp. 527-534
-
-
Kennan, R.P.1
Takahashi, K.2
Pan, C.3
Shamoon, H.4
Pan, J.W.5
-
82
-
-
0027471840
-
Symmetry of cerebral blood flow and cognitive responses to hypoglycaemia in humans
-
Kerr, D., Stanley, J. C., Barron, M., Thomas, R., Leatherdale, B. A., and Pickard, J. (1993). Symmetry of cerebral blood flow and cognitive responses to hypoglycaemia in humans. Diabetologia 36, 73-78.
-
(1993)
Diabetologia
, vol.36
, pp. 73-78
-
-
Kerr, D.1
Stanley, J.C.2
Barron, M.3
Thomas, R.4
Leatherdale, B.A.5
Pickard, J.6
-
83
-
-
84860390335
-
Insulin sensitivity of the human brain
-
Ketterer, C., Tschritter, O., Preissl, H., Heni, M., Haring, H. U., and Fritsche, A. (2011). Insulin sensitivity of the human brain. Diabetes Res Clin Pract 93 Suppl 1, S47-S51.
-
(2011)
Diabetes Res Clin Pract
, vol.93
, pp. S47-S51
-
-
Ketterer, C.1
Tschritter, O.2
Preissl, H.3
Heni, M.4
Haring, H.U.5
Fritsche, A.6
-
84
-
-
71449125786
-
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
-
Kim, J., Castellano, J. M., Jiang, H., Basak, J. M., Parsadanian, M., Pham, V., Mason, S. M., Paul, S. M., and Holtzman, D. M. (2009). Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64, 632-644.
-
(2009)
Neuron
, vol.64
, pp. 632-644
-
-
Kim, J.1
Castellano, J.M.2
Jiang, H.3
Basak, J.M.4
Parsadanian, M.5
Pham, V.6
Mason, S.M.7
Paul, S.M.8
Holtzman, D.M.9
-
85
-
-
0021907605
-
Receptor-mediated transport of insulin across endothelial cells
-
King, G. L., and Johnson, S. M. (1985). Receptor-mediated transport of insulin across endothelial cells. Science 227, 1583-1586.
-
(1985)
Science
, vol.227
, pp. 1583-1586
-
-
King, G.L.1
Johnson, S.M.2
-
86
-
-
84903173931
-
Insulin action in brain regulates systemic metabolism and brain function
-
Kleinridders, A., Ferris, H. A., Cai, W., and Kahn, C. R. (2014). Insulin action in brain regulates systemic metabolism and brain function. Diabetes 63, 2232-2243.
-
(2014)
Diabetes
, vol.63
, pp. 2232-2243
-
-
Kleinridders, A.1
Ferris, H.A.2
Cai, W.3
Kahn, C.R.4
-
87
-
-
0242693294
-
Neuropathology of cognitively normal elderly
-
Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., McDonald, W. C., Braak, H., and Petersen, R. C. (2003). Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol 62, 1087-1095.
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 1087-1095
-
-
Knopman, D.S.1
Parisi, J.E.2
Salviati, A.3
Floriach-Robert, M.4
Boeve, B.F.5
Ivnik, R.J.6
Smith, G.E.7
Dickson, D.W.8
Johnson, K.A.9
Petersen, L.E.10
McDonald, W.C.11
Braak, H.12
Petersen, R.C.13
-
88
-
-
77956525555
-
Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain
-
Kondo, M., Shiono, M., Itoh, G., Takei, N., Matsushima, T., Maeda, M., Taru, H., Hata, S., Yamamoto, T., Saito, Y., and Suzuki, T. (2010). Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain. Mol Neurodegener 5, 35.
-
(2010)
Mol Neurodegener
, vol.5
, pp. 35
-
-
Kondo, M.1
Shiono, M.2
Itoh, G.3
Takei, N.4
Matsushima, T.5
Maeda, M.6
Taru, H.7
Hata, S.8
Yamamoto, T.9
Saito, Y.10
Suzuki, T.11
-
89
-
-
84913582567
-
Impairment of paravascular clearance pathways in the aging brain
-
Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., Plog, B. A., Ding, F., Deane, R., and Nedergaard, M. (2014). Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 76, 845-861.
-
(2014)
Ann Neurol
, vol.76
, pp. 845-861
-
-
Kress, B.T.1
Iliff, J.J.2
Xia, M.3
Wang, M.4
Wei, H.S.5
Zeppenfeld, D.6
Xie, L.7
Kang, H.8
Xu, Q.9
Liew, J.A.10
Plog, B.A.11
Ding, F.12
Deane, R.13
Nedergaard, M.14
-
90
-
-
35148859731
-
MDR1-PGlycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier
-
Kuhnke, D., Jedlitschky, G., Grube, M., Krohn, M., Jucker, M., Mosyagin, I., Cascorbi, I., Walker, L. C., Kroemer, H. K., Warzok, R. W., and Vogelgesang, S. (2007). MDR1-PGlycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol 17, 347-353.
-
(2007)
Brain Pathol
, vol.17
, pp. 347-353
-
-
Kuhnke, D.1
Jedlitschky, G.2
Grube, M.3
Krohn, M.4
Jucker, M.5
Mosyagin, I.6
Cascorbi, I.7
Walker, L.C.8
Kroemer, H.K.9
Warzok, R.W.10
Vogelgesang, S.11
-
91
-
-
33745405013
-
Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease
-
Kulstad, J. J., Green, P. S., Cook, D. G., Watson, G. S., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Rhoads, K., Mehta, P. D., and Craft, S. (2006). Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease. Neurology 66, 1506-1510.
-
(2006)
Neurology
, vol.66
, pp. 1506-1510
-
-
Kulstad, J.J.1
Green, P.S.2
Cook, D.G.3
Watson, G.S.4
Reger, M.A.5
Baker, L.D.6
Plymate, S.R.7
Asthana, S.8
Rhoads, K.9
Mehta, P.D.10
Craft, S.11
-
92
-
-
67349108867
-
Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance
-
Laatsch, A., Merkel, M., Talmud, P. J., Grewal, T., Beisiegel, U., and Heeren, J. (2009). Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Atherosclerosis 204, 105-111.
-
(2009)
Atherosclerosis
, vol.204
, pp. 105-111
-
-
Laatsch, A.1
Merkel, M.2
Talmud, P.J.3
Grewal, T.4
Beisiegel, U.5
Heeren, J.6
-
93
-
-
84864318274
-
Beyond amyloid: the future of therapeutics for Alzheimer's disease
-
Lane, R. F., Shineman, D. W., Steele, J. W., Lee, L. B., and Fillit, H. M. (2012). Beyond amyloid: the future of therapeutics for Alzheimer's disease. Adv Pharmacol 64, 213-271.
-
(2012)
Adv Pharmacol
, vol.64
, pp. 213-271
-
-
Lane, R.F.1
Shineman, D.W.2
Steele, J.W.3
Lee, L.B.4
Fillit, H.M.5
-
94
-
-
84906931766
-
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
-
Li, H., Guo, Q., Inoue, T., Polito, V. A., Tabuchi, K., Hammer, R. E., Pautler, R. G., Taffet, G. E., and Zheng, H. (2014). Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow. Mol Neurodegener 9, 28.
-
(2014)
Mol Neurodegener
, vol.9
, pp. 28
-
-
Li, H.1
Guo, Q.2
Inoue, T.3
Polito, V.A.4
Tabuchi, K.5
Hammer, R.E.6
Pautler, R.G.7
Taffet, G.E.8
Zheng, H.9
-
95
-
-
84921718391
-
Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances
-
Liu, L., and Liu, X. D. (2014). Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances. Front Pharmacol 5, 273.
-
(2014)
Front Pharmacol
, vol.5
, pp. 273
-
-
Liu, L.1
Liu, X.D.2
-
96
-
-
84864976166
-
Immunotherapy for Alzheimer disease: the challenge of adverse effects
-
Liu, Y. H., Giunta, B., Zhou, H. D., Tan, J., and Wang, Y. J. (2012). Immunotherapy for Alzheimer disease: the challenge of adverse effects. Nat Rev Neurol 8, 465-469.
-
(2012)
Nat Rev Neurol
, vol.8
, pp. 465-469
-
-
Liu, Y.H.1
Giunta, B.2
Zhou, H.D.3
Tan, J.4
Wang, Y.J.5
-
97
-
-
84883412703
-
Continuation of exercise is necessary to inhibit high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice
-
Maesako, M., Uemura, K., Iwata, A., Kubota, M., Watanabe, K., Uemura, M., Noda, Y., Asada-Utsugi, M., Kihara, T., Takahashi, R., Shimohama, S., and Kinoshita, A. (2013). Continuation of exercise is necessary to inhibit high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. PLoS One 8, e72796.
-
(2013)
PLoS One
, vol.8
-
-
Maesako, M.1
Uemura, K.2
Iwata, A.3
Kubota, M.4
Watanabe, K.5
Uemura, M.6
Noda, Y.7
Asada-Utsugi, M.8
Kihara, T.9
Takahashi, R.10
Shimohama, S.11
Kinoshita, A.12
-
98
-
-
0014214923
-
Insulin in the cerebrospinal fluid
-
Margolis, R. U., and Altszuler, N. (1967). Insulin in the cerebrospinal fluid. Nature 215, 1375-1376.
-
(1967)
Nature
, vol.215
, pp. 1375-1376
-
-
Margolis, R.U.1
Altszuler, N.2
-
99
-
-
84886098063
-
Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer's disease
-
Mehta, D. C., Short, J. L., and Nicolazzo, J. A. (2013). Altered brain uptake of therapeutics in a triple transgenic mouse model of Alzheimer's disease. Pharm Res 30, 2868-2879.
-
(2013)
Pharm Res
, vol.30
, pp. 2868-2879
-
-
Mehta, D.C.1
Short, J.L.2
Nicolazzo, J.A.3
-
100
-
-
84887611153
-
Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta
-
Michaud, J. P., Bellavance, M. A., Prefontaine, P., and Rivest, S. (2013). Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep 5, 646-653.
-
(2013)
Cell Rep
, vol.5
, pp. 646-653
-
-
Michaud, J.P.1
Bellavance, M.A.2
Prefontaine, P.3
Rivest, S.4
-
101
-
-
0027967822
-
Identification and distribution of insulin receptors on cultured bovine brain microvessel endothelial cells: possible function in insulin processing in the blood-brain barrier
-
Miller, D. W., Keller, B. T., and Borchardt, R. T. (1994). Identification and distribution of insulin receptors on cultured bovine brain microvessel endothelial cells: possible function in insulin processing in the blood-brain barrier. J Cell Physiol 161, 333-341.
-
(1994)
J Cell Physiol
, vol.161
, pp. 333-341
-
-
Miller, D.W.1
Keller, B.T.2
Borchardt, R.T.3
-
102
-
-
54049094343
-
Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
-
Miller, M. C., Tavares, R., Johanson, C. E., Hovanesian, V., Donahue, J. E., Gonzalez, L., Silverberg, G. D., and Stopa, E. G. (2008). Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease. Brain Res 1230, 273-280.
-
(2008)
Brain Res
, vol.1230
, pp. 273-280
-
-
Miller, M.C.1
Tavares, R.2
Johanson, C.E.3
Hovanesian, V.4
Donahue, J.E.5
Gonzalez, L.6
Silverberg, G.D.7
Stopa, E.G.8
-
103
-
-
0025908356
-
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
-
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., van Belle, G., and Berg, L. (1991). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486.
-
(1991)
Neurology
, vol.41
, pp. 479-486
-
-
Mirra, S.S.1
Heyman, A.2
McKeel, D.3
Sumi, S.M.4
Crain, B.J.5
Brownlee, L.M.6
Vogel, F.S.7
Hughes, J.P.8
van Belle, G.9
Berg, L.10
-
104
-
-
84921326695
-
Blood-brain barrier breakdown in the aging human hippocampus
-
Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., Harrington, M. G., Chui, H. C., Law, M., and Zlokovic, B. V. (2015). Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302.
-
(2015)
Neuron
, vol.85
, pp. 296-302
-
-
Montagne, A.1
Barnes, S.R.2
Sweeney, M.D.3
Halliday, M.R.4
Sagare, A.P.5
Zhao, Z.6
Toga, A.W.7
Jacobs, R.E.8
Liu, C.Y.9
Amezcua, L.10
Harrington, M.G.11
Chui, H.C.12
Law, M.13
Zlokovic, B.V.14
-
105
-
-
84910026958
-
Methylene blue modulates beta-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice
-
Mori, T., Koyama, N., Segawa, T., Maeda, M., Maruyama, N., Kinoshita, N., Hou, H., Tan, J., and Town, T. (2014). Methylene blue modulates beta-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice. J Biol Chem 289, 30303-30317.
-
(2014)
J Biol Chem
, vol.289
, pp. 30303-30317
-
-
Mori, T.1
Koyama, N.2
Segawa, T.3
Maeda, M.4
Maruyama, N.5
Kinoshita, N.6
Hou, H.7
Tan, J.8
Town, T.9
-
106
-
-
84939888715
-
The relevance of beta-amyloid on markers of Alzheimer's disease in clinically normal individuals and factors that influence these associations
-
Mormino, E. C. (2014). The relevance of beta-amyloid on markers of Alzheimer's disease in clinically normal individuals and factors that influence these associations. Neuropsychol Rev 24, 300-312.
-
(2014)
Neuropsychol Rev
, vol.24
, pp. 300-312
-
-
Mormino, E.C.1
-
107
-
-
84922479199
-
Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease
-
Morris, G. P., Clark, I. A., and Vissel, B. (2014). Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease. Acta Neuropathol Commun 2, 135.
-
(2014)
Acta Neuropathol Commun
, vol.2
, pp. 135
-
-
Morris, G.P.1
Clark, I.A.2
Vissel, B.3
-
108
-
-
69149089066
-
The role of nutrition in Alzheimer's disease: epidemiological evidence
-
Morris, M. C. (2009). The role of nutrition in Alzheimer's disease: epidemiological evidence. Eur J Neurol 16 Suppl 1, 1-7.
-
(2009)
Eur J Neurol
, vol.16
, pp. 1-7
-
-
Morris, M.C.1
-
109
-
-
84903729422
-
Dietary fat composition and dementia risk
-
Morris, M. C., and Tangney, C. C. (2014). Dietary fat composition and dementia risk. Neurobiol Aging 35 Suppl 2, S59-S64.
-
(2014)
Neurobiol Aging
, vol.35
, pp. S59-S64
-
-
Morris, M.C.1
Tangney, C.C.2
-
110
-
-
84872730067
-
Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis-but what lies beyond?
-
Mullane, K., and Williams, M. (2013). Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis-but what lies beyond? Biochem Pharmacol 85, 289-305.
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 289-305
-
-
Mullane, K.1
Williams, M.2
-
111
-
-
79960302973
-
Basal insulin: physiology, pharmacology, and clinical implications
-
Niswender, K. D. (2011). Basal insulin: physiology, pharmacology, and clinical implications. Postgrad Med 123, 17-26.
-
(2011)
Postgrad Med
, vol.123
, pp. 17-26
-
-
Niswender, K.D.1
-
112
-
-
33746462348
-
Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes
-
Novak, V., Last, D., Alsop, D. C., Abduljalil, A. M., Hu, K., Lepicovsky, L., Cavallerano, J., and Lipsitz, L. A. (2006). Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes. Diabetes Care 29, 1529-1534.
-
(2006)
Diabetes Care
, vol.29
, pp. 1529-1534
-
-
Novak, V.1
Last, D.2
Alsop, D.C.3
Abduljalil, A.M.4
Hu, K.5
Lepicovsky, L.6
Cavallerano, J.7
Lipsitz, L.A.8
-
113
-
-
84857097475
-
Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes
-
Novak, V., Zhao, P., Manor, B., Sejdic, E., Alsop, D., Abduljalil, A., Roberson, P. K., Munshi, M., and Novak, P. (2011). Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care 34, 2438-2441.
-
(2011)
Diabetes Care
, vol.34
, pp. 2438-2441
-
-
Novak, V.1
Zhao, P.2
Manor, B.3
Sejdic, E.4
Alsop, D.5
Abduljalil, A.6
Roberson, P.K.7
Munshi, M.8
Novak, P.9
-
114
-
-
84901725111
-
Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults
-
Nugent, S., Castellano, C. A., Goffaux, P., Whittingstall, K., Lepage, M., Paquet, N., Bocti, C., Fulop, T., and Cunnane, S. C. (2014). Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults. Am J Physiol Endocrinol Metab 306, E1315-E1321.
-
(2014)
Am J Physiol Endocrinol Metab
, vol.306
, pp. E1315-E1321
-
-
Nugent, S.1
Castellano, C.A.2
Goffaux, P.3
Whittingstall, K.4
Lepage, M.5
Paquet, N.6
Bocti, C.7
Fulop, T.8
Cunnane, S.C.9
-
115
-
-
0017757318
-
The blood-brain barrier
-
Oldendorf, W. H. (1977). The blood-brain barrier. Exp Eye Res 25 Suppl, 177-190.
-
(1977)
Exp Eye Res
, vol.25
, pp. 177-190
-
-
Oldendorf, W.H.1
-
116
-
-
84895108019
-
Assessment of dynamic cerebral autoregulation and cerebrovascular CO2 reactivity in ageing by measurements of cerebral blood flow and cortical oxygenation
-
Oudegeest-Sander, M. H., van Beek, A. H., Abbink, K., Olde Rikkert, M. G., Hopman, M. T., and Claassen, J. A. (2014). Assessment of dynamic cerebral autoregulation and cerebrovascular CO2 reactivity in ageing by measurements of cerebral blood flow and cortical oxygenation. Exp Physiol 99, 586-598.
-
(2014)
Exp Physiol
, vol.99
, pp. 586-598
-
-
Oudegeest-Sander, M.H.1
van Beek, A.H.2
Abbink, K.3
Olde Rikkert, M.G.4
Hopman, M.T.5
Claassen, J.A.6
-
117
-
-
84935468213
-
Cerebrospinal fluid levels of Alzheimer's disease biomarkers in middleaged patients with type 1 diabetes
-
Ouwens, D. M., van Duinkerken, E., Schoonenboom, S. N., Herzfeld de Wiza, D., Klein, M., van Golen, L., Pouwels, P. J., Barkhof, F., Moll, A. C., Snoek, F. J., Teunissen, C. E., Scheltens, P., and Diamant, M. (2014). Cerebrospinal fluid levels of Alzheimer's disease biomarkers in middleaged patients with type 1 diabetes. Diabetologia 57, 2208-2214.
-
(2014)
Diabetologia
, vol.57
, pp. 2208-2214
-
-
Ouwens, D.M.1
van Duinkerken, E.2
Schoonenboom, S.N.3
Herzfeld de Wiza, D.4
Klein, M.5
van Golen, L.6
Pouwels, P.J.7
Barkhof, F.8
Moll, A.C.9
Snoek, F.J.10
Teunissen, C.E.11
Scheltens, P.12
Diamant, M.13
-
118
-
-
84907978955
-
Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid beta-amyloid 42: a crossvalidation study against amyloid positron emission tomography
-
Palmqvist, S., Zetterberg, H., Blennow, K., Vestberg, S., Andreasson, U., Brooks, D. J., Owenius, R., Hagerstrom, D., Wollmer, P., Minthon, L., and Hansson, O. (2014). Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid beta-amyloid 42: a crossvalidation study against amyloid positron emission tomography. JAMA Neurol 71, 1282-1289.
-
(2014)
JAMA Neurol
, vol.71
, pp. 1282-1289
-
-
Palmqvist, S.1
Zetterberg, H.2
Blennow, K.3
Vestberg, S.4
Andreasson, U.5
Brooks, D.J.6
Owenius, R.7
Hagerstrom, D.8
Wollmer, P.9
Minthon, L.10
Hansson, O.11
-
119
-
-
84871691509
-
Insulin has multiple antiamyloidogenic effects on human neuronal cells
-
Pandini, G., Pace, V., Copani, A., Squatrito, S., Milardi, D., and Vigneri, R. (2013). Insulin has multiple antiamyloidogenic effects on human neuronal cells. Endocrinology 154, 375-387.
-
(2013)
Endocrinology
, vol.154
, pp. 375-387
-
-
Pandini, G.1
Pace, V.2
Copani, A.3
Squatrito, S.4
Milardi, D.5
Vigneri, R.6
-
120
-
-
0022764022
-
Receptor-mediated peptide transport through the blood-brain barrier
-
Pardridge, W. M. (1986). Receptor-mediated peptide transport through the blood-brain barrier. Endocr Rev 7, 314-330.
-
(1986)
Endocr Rev
, vol.7
, pp. 314-330
-
-
Pardridge, W.M.1
-
121
-
-
80051764731
-
Drug transport in brain via the cerebrospinal fluid
-
Pardridge, W. M. (2011). Drug transport in brain via the cerebrospinal fluid. Fluids Barriers CNS 8, 7.
-
(2011)
Fluids Barriers CNS
, vol.8
, pp. 7
-
-
Pardridge, W.M.1
-
122
-
-
34547791784
-
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
-
Paul, J., Strickland, S., and Melchor, J. P. (2007). Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 204, 1999-2008.
-
(2007)
J Exp Med
, vol.204
, pp. 1999-2008
-
-
Paul, J.1
Strickland, S.2
Melchor, J.P.3
-
123
-
-
0034716488
-
Amyloid-beta junkies
-
Perry, G., Nunomura, A., Raina, A. K., and Smith, M. A. (2000). Amyloid-beta junkies. Lancet 355(9205), 757.
-
(2000)
Lancet
, vol.355
, Issue.9205
, pp. 757
-
-
Perry, G.1
Nunomura, A.2
Raina, A.K.3
Smith, M.A.4
-
124
-
-
0025755283
-
Insulin in the cerebrospinal fluid
-
Plata-Salaman, C. R. (1991). Insulin in the cerebrospinal fluid. Neurosci Biobehav Rev 15, 243-258.
-
(1991)
Neurosci Biobehav Rev
, vol.15
, pp. 243-258
-
-
Plata-Salaman, C.R.1
-
125
-
-
79952754657
-
Longacting insulin analogs: a review of "real-world" effectiveness in patients with type 2 diabetes
-
Pollock, R. F., Erny-Albrecht, K. M., Kalsekar, A., Bruhn, D., and Valentine, W. J. (2011). Longacting insulin analogs: a review of "real-world" effectiveness in patients with type 2 diabetes. Curr Diabetes Rev 7, 61-74.
-
(2011)
Curr Diabetes Rev
, vol.7
, pp. 61-74
-
-
Pollock, R.F.1
Erny-Albrecht, K.M.2
Kalsekar, A.3
Bruhn, D.4
Valentine, W.J.5
-
126
-
-
84880525521
-
Increased in vivo amyloid-beta42 production, exchange, and loss in presenilin mutation carriers
-
Potter, R., Patterson, B. W., Elbert, D. L., Ovod, V., Kasten, T., Sigurdson, W., Mawuenyega, K., Blazey, T., Goate, A., Chott, R., Yarasheski, K. E., Holtzman, D. M., Morris, J. C., Benzinger, T.L., and Bateman, R. J. (2013). Increased in vivo amyloid-beta42 production, exchange, and loss in presenilin mutation carriers. Sci Transl Med 5, 189ra77.
-
(2013)
Sci Transl Med
, vol.5
-
-
Potter, R.1
Patterson, B.W.2
Elbert, D.L.3
Ovod, V.4
Kasten, T.5
Sigurdson, W.6
Mawuenyega, K.7
Blazey, T.8
Goate, A.9
Chott, R.10
Yarasheski, K.E.11
Holtzman, D.M.12
Morris, J.C.13
Benzinger, T.L.14
Bateman, R.J.15
-
127
-
-
0029939760
-
Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological brain activation
-
Powers, W. J., Hirsch, I. B., and Cryer, P. E. (1996). Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological brain activation. Am J Physiol 270, H554-H559.
-
(1996)
Am J Physiol
, vol.270
, pp. H554-H559
-
-
Powers, W.J.1
Hirsch, I.B.2
Cryer, P.E.3
-
128
-
-
0037385370
-
Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain
-
Preston, S. D., Steart, P. V., Wilkinson, A., Nicoll, J. A., and Weller, R. O. (2003). Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol Appl Neurobiol 29, 106-117.
-
(2003)
Neuropathol Appl Neurobiol
, vol.29
, pp. 106-117
-
-
Preston, S.D.1
Steart, P.V.2
Wilkinson, A.3
Nicoll, J.A.4
Weller, R.O.5
-
129
-
-
67349184808
-
Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease
-
Price, J. L., McKeel, D. W. J., Buckles, V. D., Roe, C. M., Xiong, C., Grundman, M., Hansen, L. A., Petersen, R. C., Parisi, J. E., Dickson, D. W., Smith, C. D., Davis, D. G., Schmitt, F. A., Markesbery, W. R., Kaye, J., Kurlan, R., Hulette, C., Kurland, B. F., Higdon, R., Kukull, W., and Morris, J. C. (2009). Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging 30, 1026-1036.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1026-1036
-
-
Price, J.L.1
McKeel, D.W.J.2
Buckles, V.D.3
Roe, C.M.4
Xiong, C.5
Grundman, M.6
Hansen, L.A.7
Petersen, R.C.8
Parisi, J.E.9
Dickson, D.W.10
Smith, C.D.11
Davis, D.G.12
Schmitt, F.A.13
Markesbery, W.R.14
Kaye, J.15
Kurlan, R.16
Hulette, C.17
Kurland, B.F.18
Higdon, R.19
Kukull, W.20
Morris, J.C.21
more..
-
130
-
-
84896788180
-
Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease
-
Pujadas, L., Rossi, D., Andres, R., Teixeira, C. M., Serra-Vidal, B., Parcerisas, A., Maldonado, R., Giralt, E., Carulla, N., and Soriano, E. (2014). Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease. Nat Commun 5, 3443.
-
(2014)
Nat Commun
, vol.5
, pp. 3443
-
-
Pujadas, L.1
Rossi, D.2
Andres, R.3
Teixeira, C.M.4
Serra-Vidal, B.5
Parcerisas, A.6
Maldonado, R.7
Giralt, E.8
Carulla, N.9
Soriano, E.10
-
131
-
-
84904874633
-
Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice
-
Ramos-Rodriguez, J. J., Ortiz-Barajas, O., Gamero-Carrasco, C., de la Rosa, P. R., Infante-Garcia, C., Zopeque-Garcia, N., Lechuga-Sancho, A. M., and Garcia-Alloza, M. (2014). Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice. Psychoneuroendocrinology 48, 123-135.
-
(2014)
Psychoneuroendocrinology
, vol.48
, pp. 123-135
-
-
Ramos-Rodriguez, J.J.1
Ortiz-Barajas, O.2
Gamero-Carrasco, C.3
de la Rosa, P.R.4
Infante-Garcia, C.5
Zopeque-Garcia, N.6
Lechuga-Sancho, A.M.7
Garcia-Alloza, M.8
-
132
-
-
31844434789
-
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
-
Reger, M. A., Watson, G. S., Frey, W. H., Baker, L. D., Cholerton, B., Keeling, M. L., Belongia, D. A., Fishel, M. A., Plymate, S. R., Schellenberg, G. D., Cherrier, M. M., and Craft, S. (2006). Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 27, 451-458.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 451-458
-
-
Reger, M.A.1
Watson, G.S.2
Frey, W.H.3
Baker, L.D.4
Cholerton, B.5
Keeling, M.L.6
Belongia, D.A.7
Fishel, M.A.8
Plymate, S.R.9
Schellenberg, G.D.10
Cherrier, M.M.11
Craft, S.12
-
133
-
-
47849123972
-
Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memoryimpaired older adults
-
Reger, M. A., Watson, G. S., Green, P. S., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Cherrier, M. M., Schellenberg, G. D., Frey, W. H., and Craft, S. (2008). Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memoryimpaired older adults. J Alzheimers Dis 13, 323-331.
-
(2008)
J Alzheimers Dis
, vol.13
, pp. 323-331
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Baker, L.D.4
Cholerton, B.5
Fishel, M.A.6
Plymate, S.R.7
Cherrier, M.M.8
Schellenberg, G.D.9
Frey, W.H.10
Craft, S.11
-
134
-
-
0347719366
-
Functional brain abnormalities in young adults at genetic risk for lateonset Alzheimer's dementia
-
Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., and Hardy, J. (2004). Functional brain abnormalities in young adults at genetic risk for lateonset Alzheimer's dementia. Proc Natl Acad Sci U S A 101, 284-289.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 284-289
-
-
Reiman, E.M.1
Chen, K.2
Alexander, G.E.3
Caselli, R.J.4
Bandy, D.5
Osborne, D.6
Saunders, A.M.7
Hardy, J.8
-
135
-
-
77950538370
-
Cognition, reserve, and amyloid deposition in normal aging
-
Rentz, D. M., Locascio, J. J., Becker, J. A., Moran, E. K., Eng, E., Buckner, R. L., Sperling, R. A., and Johnson, K. A. (2010). Cognition, reserve, and amyloid deposition in normal aging. Ann Neurol 67, 353-364.
-
(2010)
Ann Neurol
, vol.67
, pp. 353-364
-
-
Rentz, D.M.1
Locascio, J.J.2
Becker, J.A.3
Moran, E.K.4
Eng, E.5
Buckner, R.L.6
Sperling, R.A.7
Johnson, K.A.8
-
136
-
-
33750731675
-
100 years and counting: prospects for defeating Alzheimer's disease
-
Roberson, E. D., and Mucke, L. (2006). 100 years and counting: prospects for defeating Alzheimer's disease. Science 314, 781-784.
-
(2006)
Science
, vol.314
, pp. 781-784
-
-
Roberson, E.D.1
Mucke, L.2
-
137
-
-
84913553780
-
Amyloid-beta efflux from the central nervous system into the plasma
-
Roberts, K. F., Elbert, D. L., Kasten, T. P., Patterson, B. W., Sigurdson, W. C., Connors, R. E., Ovod, V., Munsell, L. Y., Mawuenyega, K. G., Miller-Thomas, M. M., Moran, C. J., Cross, D. T., Derdeyn, C. P., and Bateman, R. J. (2014). Amyloid-beta efflux from the central nervous system into the plasma. Ann Neurol 76, 837-844.
-
(2014)
Ann Neurol
, vol.76
, pp. 837-844
-
-
Roberts, K.F.1
Elbert, D.L.2
Kasten, T.P.3
Patterson, B.W.4
Sigurdson, W.C.5
Connors, R.E.6
Ovod, V.7
Munsell, L.Y.8
Mawuenyega, K.G.9
Miller-Thomas, M.M.10
Moran, C.J.11
Cross, D.T.12
Derdeyn, C.P.13
Bateman, R.J.14
-
138
-
-
2542443382
-
Lessons from the AN 1792 Alzheimer vaccine: lest we forget
-
Robinson, S. R., Bishop, G. M., Lee, H. G., and Munch, G. (2004). Lessons from the AN 1792 Alzheimer vaccine: lest we forget. Neurobiol Aging 25, 609-615.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 609-615
-
-
Robinson, S.R.1
Bishop, G.M.2
Lee, H.G.3
Munch, G.4
-
139
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., and et al. (1995). Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
Levesque, G.4
Ikeda, M.5
Liang, Y.6
Chi, H.7
Lin, C.8
Holman, K.9
Tsuda, T.10
-
140
-
-
84920682029
-
Cerebral perfusion in insulin resistance and type 2 diabetes
-
Rusinek, H., Ha, J., Yau, P. L., Storey, P., Tirsi, A., Tsui, W. H., Frosch, O., Azova, S., and Convit, A. (2015). Cerebral perfusion in insulin resistance and type 2 diabetes. J Cereb Blood Flow Metab 35, 95-102.
-
(2015)
J Cereb Blood Flow Metab
, vol.35
, pp. 95-102
-
-
Rusinek, H.1
Ha, J.2
Yau, P.L.3
Storey, P.4
Tirsi, A.5
Tsui, W.H.6
Frosch, O.7
Azova, S.8
Convit, A.9
-
141
-
-
84873307614
-
Neurovascular dysfunction and faulty amyloid beta-peptide clearance in Alzheimer disease
-
Sagare, A. P., Bell, R. D., and Zlokovic, B. V. (2012). Neurovascular dysfunction and faulty amyloid beta-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med 2
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Sagare, A.P.1
Bell, R.D.2
Zlokovic, B.V.3
-
142
-
-
84909582049
-
New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy
-
Saito, S., and Ihara, M. (2014). New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. Front Aging Neurosci 6, 290
-
(2014)
Front Aging Neurosci
, vol.6
, pp. 290
-
-
Saito, S.1
Ihara, M.2
-
143
-
-
84921439513
-
The benefit of docosahexaenoic acid for the adult brain in aging and dementia
-
Salem, N. J., Vandal, M., and Calon, F. (2015). The benefit of docosahexaenoic acid for the adult brain in aging and dementia. Prostaglandins Leukot Essent Fatty Acids 92, 15-22.
-
(2015)
Prostaglandins Leukot Essent Fatty Acids
, vol.92
, pp. 15-22
-
-
Salem, N.J.1
Vandal, M.2
Calon, F.3
-
144
-
-
0032032493
-
Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester
-
Savage, M. J., Trusko, S. P., Howland, D. S., Pinsker, L. R., Mistretta, S., Reaume, A. G., Greenberg, B. D., Siman, R., and Scott, R. W. (1998). Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J Neurosci 18, 1743-1752.
-
(1998)
J Neurosci
, vol.18
, pp. 1743-1752
-
-
Savage, M.J.1
Trusko, S.P.2
Howland, D.S.3
Pinsker, L.R.4
Mistretta, S.5
Reaume, A.G.6
Greenberg, B.D.7
Siman, R.8
Scott, R.W.9
-
145
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lannfelt, L., Selkoe, D., and Younkin, S. (1996). Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2, 864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
146
-
-
84898048515
-
Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation
-
Schilling, T. M., Ferreira de Sa, D. S., Westerhausen, R., Strelzyk, F., Larra, M. F., Hallschmid, M., Savaskan, E., Oitzl, M. S., Busch, H. P., Naumann, E., and Schachinger, H. (2014). Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation. Hum Brain Mapp 35, 1944-1956.
-
(2014)
Hum Brain Mapp
, vol.35
, pp. 1944-1956
-
-
Schilling, T.M.1
Ferreira de Sa, D.S.2
Westerhausen, R.3
Strelzyk, F.4
Larra, M.F.5
Hallschmid, M.6
Savaskan, E.7
Oitzl, M.S.8
Busch, H.P.9
Naumann, E.10
Schachinger, H.11
-
147
-
-
31744448129
-
Mechanisms to explain the reverse perivascular transport of solutes out of the brain
-
Schley, D., Carare-Nnadi, R., Please, C. P., Perry, V. H., and Weller, R. O. (2006). Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol 238, 962-974.
-
(2006)
J Theor Biol
, vol.238
, pp. 962-974
-
-
Schley, D.1
Carare-Nnadi, R.2
Please, C.P.3
Perry, V.H.4
Weller, R.O.5
-
148
-
-
0034695098
-
The biology of the receptor for advanced glycation end products and its ligands
-
Schmidt, A. M., Yan, S. D., Yan, S. F., and Stern, D. M. (2000). The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 1498, 99-111.
-
(2000)
Biochim Biophys Acta
, vol.1498
, pp. 99-111
-
-
Schmidt, A.M.1
Yan, S.D.2
Yan, S.F.3
Stern, D.M.4
-
149
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe, D. J. (2001). Clearing the brain's amyloid cobwebs. Neuron 32, 177-180.
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
150
-
-
80052501210
-
Resolving controversies on the path to Alzheimer's therapeutics
-
Selkoe, D. J. (2011). Resolving controversies on the path to Alzheimer's therapeutics. Nat Med 17, 1060-1065.
-
(2011)
Nat Med
, vol.17
, pp. 1060-1065
-
-
Selkoe, D.J.1
-
151
-
-
84858046578
-
Neuropathological alterations in Alzheimer disease
-
Serrano-Pozo, A., Frosch, M. P., Masliah, E., and Hyman, B. T. (2011). Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med 1, a006189.
-
(2011)
Cold Spring Harb Perspect Med
, vol.1
-
-
Serrano-Pozo, A.1
Frosch, M.P.2
Masliah, E.3
Hyman, B.T.4
-
152
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J. F., Bruni, A. C., Montesi, M. P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R. J., Wasco, W., Da Silva, H. A., Haines, J. L., Perkicak-Vance, M. A., Tanzi, R. E., Roses, A. D., Fraser, P. E., Rommens, J. M., and St George-Hyslop, P. H. (1995). Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
Tsuda, T.11
Mar, L.12
Foncin, J.F.13
Bruni, A.C.14
Montesi, M.P.15
Sorbi, S.16
Rainero, I.17
Pinessi, L.18
Nee, L.19
Chumakov, I.20
Pollen, D.21
Brookes, A.22
Sanseau, P.23
Polinsky, R.J.24
Wasco, W.25
Da Silva, H.A.26
Haines, J.L.27
Perkicak-Vance, M.A.28
Tanzi, R.E.29
Roses, A.D.30
Fraser, P.E.31
Rommens, J.M.32
St George-Hyslop, P.H.33
more..
-
153
-
-
7444265179
-
Brain insulin impairs amyloid-beta(1-40) clearance from the brain
-
Shiiki, T., Ohtsuki, S., Kurihara, A., Naganuma, H., Nishimura, K., Tachikawa, M., Hosoya, K., and Terasaki, T. (2004). Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J Neurosci 24, 9632-9637.
-
(2004)
J Neurosci
, vol.24
, pp. 9632-9637
-
-
Shiiki, T.1
Ohtsuki, S.2
Kurihara, A.3
Naganuma, H.4
Nishimura, K.5
Tachikawa, M.6
Hosoya, K.7
Terasaki, T.8
-
154
-
-
0031922362
-
A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia
-
Skoog, I., Wallin, A., Fredman, P., Hesse, C., Aevarsson, O., Karlsson, I., Gottfries, C. G., and Blennow, K. (1998). A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia. Neurology 50, 966-971.
-
(1998)
Neurology
, vol.50
, pp. 966-971
-
-
Skoog, I.1
Wallin, A.2
Fredman, P.3
Hesse, C.4
Aevarsson, O.5
Karlsson, I.6
Gottfries, C.G.7
Blennow, K.8
-
155
-
-
84870213683
-
Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway
-
Son, S. M., Song, H., Byun, J., Park, K. S., Jang, H. C., Park, Y. J., and Mook-Jung, I. (2012). Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway. Diabetes 61, 3126- 3138.
-
(2012)
Diabetes
, vol.61
, pp. 3126-3138
-
-
Son, S.M.1
Song, H.2
Byun, J.3
Park, K.S.4
Jang, H.C.5
Park, Y.J.6
Mook-Jung, I.7
-
156
-
-
0034509668
-
Genetic factors in the genesis of Alzheimer's disease
-
St George-Hyslop, P. H. (2000). Genetic factors in the genesis of Alzheimer's disease. Ann N Y Acad Sci 924, 1-7.
-
(2000)
Ann N Y Acad Sci
, vol.924
, pp. 1-7
-
-
St George-Hyslop, P.H.1
-
157
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
-
Steen, E., Terry, B. M., Rivera, E. J., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., and de la Monte, S. M. (2005). Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis 7, 63-80.
-
(2005)
J Alzheimers Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
de la Monte, S.M.9
-
158
-
-
84867603343
-
Cognitive reserve in ageing and Alzheimer's disease
-
Stern, Y. (2012). Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol 11, 1006- 1012.
-
(2012)
Lancet Neurol
, vol.11
, pp. 1006-1012
-
-
Stern, Y.1
-
159
-
-
84877312059
-
Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules
-
Strazielle, N., and Ghersi-Egea, J. F. (2013). Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules. Mol Pharm 10, 1473-1491.
-
(2013)
Mol Pharm
, vol.10
, pp. 1473-1491
-
-
Strazielle, N.1
Ghersi-Egea, J.F.2
-
160
-
-
84897547991
-
High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease
-
Stukas, S., Robert, J., and Wellington, C. L. (2014). High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease. Cell Metab 19, 574-591.
-
(2014)
Cell Metab
, vol.19
, pp. 574-591
-
-
Stukas, S.1
Robert, J.2
Wellington, C.L.3
-
161
-
-
84922907372
-
Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats
-
Sun, Y. N., Liu, L. B., Xue, Y. X., and Wang, P. (2015). Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats. J Neurosci Res 93, 666-677.
-
(2015)
J Neurosci Res
, vol.93
, pp. 666-677
-
-
Sun, Y.N.1
Liu, L.B.2
Xue, Y.X.3
Wang, P.4
-
162
-
-
0016908973
-
Possible role of insulin in the transport of tyrosine and tryptophan from blood to brain
-
Tagliamonte, A., DeMontis, M. G., Olianas, M., Onali, P. L., and Gessa, G. L. (1976). Possible role of insulin in the transport of tyrosine and tryptophan from blood to brain. Adv Exp Med Biol 69, 89-94.
-
(1976)
Adv Exp Med Biol
, vol.69
, pp. 89-94
-
-
Tagliamonte, A.1
DeMontis, M.G.2
Olianas, M.3
Onali, P.L.4
Gessa, G.L.5
-
163
-
-
79952776352
-
Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping
-
Taheri, S., Gasparovic, C., Shah, N. J., and Rosenberg, G. A. (2011). Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping. Magn Reson Med 65, 1036-1042.
-
(2011)
Magn Reson Med
, vol.65
, pp. 1036-1042
-
-
Taheri, S.1
Gasparovic, C.2
Shah, N.J.3
Rosenberg, G.A.4
-
164
-
-
67349212434
-
P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta
-
Tai, L. M., Loughlin, A. J., Male, D. K., and Romero, I. A. (2009). P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta. J Cereb Blood Flow Metab 29, 1079-1083.
-
(2009)
J Cereb Blood Flow Metab
, vol.29
, pp. 1079-1083
-
-
Tai, L.M.1
Loughlin, A.J.2
Male, D.K.3
Romero, I.A.4
-
165
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
Talbot, K., Wang, H. Y., Kazi, H., Han, L. Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., Arvanitakis, Z., Schneider, J. A., Wolf, B. A., Bennett, D. A., Trojanowski, J. Q., and Arnold, S. E. (2012). Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122, 1316-1338.
-
(2012)
J Clin Invest
, vol.122
, pp. 1316-1338
-
-
Talbot, K.1
Wang, H.Y.2
Kazi, H.3
Han, L.Y.4
Bakshi, K.P.5
Stucky, A.6
Fuino, R.L.7
Kawaguchi, K.R.8
Samoyedny, A.J.9
Wilson, R.S.10
Arvanitakis, Z.11
Schneider, J.A.12
Wolf, B.A.13
Bennett, D.A.14
Trojanowski, J.Q.15
Arnold, S.E.16
-
166
-
-
0027217321
-
The influence of hypoglycaemia on regional cerebral blood flow and cerebral volume in type 1 (insulin-dependent) diabetes mellitus
-
Tallroth, G., Ryding, E., and Agardh, C. D. (1993). The influence of hypoglycaemia on regional cerebral blood flow and cerebral volume in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 36, 530-535.
-
(1993)
Diabetologia
, vol.36
, pp. 530-535
-
-
Tallroth, G.1
Ryding, E.2
Agardh, C.D.3
-
167
-
-
84862806815
-
Pharmacotherapies for Alzheimer's disease: beyond cholinesterase inhibitors
-
Tayeb, H. O., Yang, H. D., Price, B. H., and Tarazi, F. I. (2012). Pharmacotherapies for Alzheimer's disease: beyond cholinesterase inhibitors. Pharmacol Ther 134, 8-25.
-
(2012)
Pharmacol Ther
, vol.134
, pp. 8-25
-
-
Tayeb, H.O.1
Yang, H.D.2
Price, B.H.3
Tarazi, F.I.4
-
168
-
-
84889059035
-
Diabetes augments in vivo microvascular blood flow dynamics after stroke
-
Tennant, K. A., and Brown, C. E. (2013). Diabetes augments in vivo microvascular blood flow dynamics after stroke. J Neurosci 33, 19194-19204.
-
(2013)
J Neurosci
, vol.33
, pp. 19194-19204
-
-
Tennant, K.A.1
Brown, C.E.2
-
169
-
-
38049018185
-
Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease
-
Tremblay, C., Pilote, M., Phivilay, A., Emond, V., Bennett, D. A., and Calon, F. (2007). Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis 12, 377-390.
-
(2007)
J Alzheimers Dis
, vol.12
, pp. 377-390
-
-
Tremblay, C.1
Pilote, M.2
Phivilay, A.3
Emond, V.4
Bennett, D.A.5
Calon, F.6
-
170
-
-
80052185880
-
Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease
-
Tremblay, C., St-Amour, I., Schneider, J., Bennett, D. A., and Calon, F. (2011). Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease. J Neuropathol Exp Neurol 70, 788-798.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 788-798
-
-
Tremblay, C.1
St-Amour, I.2
Schneider, J.3
Bennett, D.A.4
Calon, F.5
-
171
-
-
0024345665
-
Distribution of insulin receptor-like immunoreactivity in the rat forebrain
-
Unger, J., McNeill, T. H., Moxley, R. T., White, M., Moss, A., and Livingston, J. N. (1989). Distribution of insulin receptor-like immunoreactivity in the rat forebrain. Neuroscience 31, 143-157.
-
(1989)
Neuroscience
, vol.31
, pp. 143-157
-
-
Unger, J.1
McNeill, T.H.2
Moxley, R.T.3
White, M.4
Moss, A.5
Livingston, J.N.6
-
172
-
-
84899462816
-
Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2
-
Vandal, M., Alata, W., Tremblay, C., Rioux-Perreault, C., Salem, N. J., Calon, F., and Plourde, M. (2014a). Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. J Neurochem 129, 516-526.
-
(2014)
J Neurochem
, vol.129
, pp. 516-526
-
-
Vandal, M.1
Alata, W.2
Tremblay, C.3
Rioux-Perreault, C.4
Salem, N.J.5
Calon, F.6
Plourde, M.7
-
173
-
-
84911895310
-
Insulin reverses the highfat diet-induced increase in brain Abeta and improves memory in an animal model of Alzheimer disease
-
Vandal, M., White, P. J., Tremblay, C., St-Amour, I., Chevrier, G., Emond, V., Lefrancois, D., Virgili, J., Planel, E., Giguere, Y., Marette, A., and Calon, F. (2014b). Insulin reverses the highfat diet-induced increase in brain Abeta and improves memory in an animal model of Alzheimer disease. Diabetes 63, 4291-4301.
-
(2014)
Diabetes
, vol.63
, pp. 4291-4301
-
-
Vandal, M.1
White, P.J.2
Tremblay, C.3
St-Amour, I.4
Chevrier, G.5
Emond, V.6
Lefrancois, D.7
Virgili, J.8
Planel, E.9
Giguere, Y.10
Marette, A.11
Calon, F.12
-
174
-
-
33748252298
-
Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls
-
Wang, H., Golob, E. J., and Su, M. Y. (2006). Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls. J Magn Reson Imaging 24, 695-700.
-
(2006)
J Magn Reson Imaging
, vol.24
, pp. 695-700
-
-
Wang, H.1
Golob, E.J.2
Su, M.Y.3
-
175
-
-
84905508201
-
Insulin inhibits Abeta production through modulation of APP processing in a cellular model of Alzheimer's disease
-
Wang, X., Yu, S., Gao, S. J., Hu, J. P., Wang, Y., and Liu, H. X. (2014). Insulin inhibits Abeta production through modulation of APP processing in a cellular model of Alzheimer's disease. Neuro Endocrinol Lett 35, 224-229.
-
(2014)
Neuro Endocrinol Lett
, vol.35
, pp. 224-229
-
-
Wang, X.1
Yu, S.2
Gao, S.J.3
Hu, J.P.4
Wang, Y.5
Liu, H.X.6
-
176
-
-
0038038865
-
Insulin increases CSF Abeta42 levels in normal older adults
-
Watson, G. S., Peskind, E. R., Asthana, S., Purganan, K., Wait, C., Chapman, D., Schwartz, M. W., Plymate, S., and Craft, S. (2003). Insulin increases CSF Abeta42 levels in normal older adults. Neurology 60, 1899-1903.
-
(2003)
Neurology
, vol.60
, pp. 1899-1903
-
-
Watson, G.S.1
Peskind, E.R.2
Asthana, S.3
Purganan, K.4
Wait, C.5
Chapman, D.6
Schwartz, M.W.7
Plymate, S.8
Craft, S.9
-
177
-
-
63249115678
-
The blood-brain barrier in brain homeostasis and neurological diseases
-
Weiss, N., Miller, F., Cazaubon, S., and Couraud, P. O. (2009). The blood-brain barrier in brain homeostasis and neurological diseases. Biochim Biophys Acta 1788, 842-857.
-
(2009)
Biochim Biophys Acta
, vol.1788
, pp. 842-857
-
-
Weiss, N.1
Miller, F.2
Cazaubon, S.3
Couraud, P.O.4
-
178
-
-
57049154546
-
Lymphatic drainage of the brain and the pathophysiology of neurological disease
-
Weller, R. O., Djuanda, E., Yow, H. Y., and Carare, R. O. (2009). Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol 117, 1-14.
-
(2009)
Acta Neuropathol
, vol.117
, pp. 1-14
-
-
Weller, R.O.1
Djuanda, E.2
Yow, H.Y.3
Carare, R.O.4
-
179
-
-
84880256692
-
Evidence for impaired amyloid beta clearance in Alzheimer's disease
-
Wildsmith, K. R., Holley, M., Savage, J. C., Skerrett, R., and Landreth, G. E. (2013). Evidence for impaired amyloid beta clearance in Alzheimer's disease. Alzheimers Res Ther 5, 33.
-
(2013)
Alzheimers Res Ther
, vol.5
, pp. 33
-
-
Wildsmith, K.R.1
Holley, M.2
Savage, J.C.3
Skerrett, R.4
Landreth, G.E.5
-
180
-
-
0033711475
-
Insulin enhancement of opioid peptide transport across the blood-brain barrier and assessment of analgesic effect
-
Witt, K. A., Huber, J. D., Egleton, R. D., and Davis, T. P. (2000). Insulin enhancement of opioid peptide transport across the blood-brain barrier and assessment of analgesic effect. J Pharmacol Exp Ther 295, 972-978.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 972-978
-
-
Witt, K.A.1
Huber, J.D.2
Egleton, R.D.3
Davis, T.P.4
-
181
-
-
84885775321
-
Sleep drives metabolite clearance from the adult brain
-
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O'Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., Takano, T., Deane, R., and Nedergaard, M. (2013). Sleep drives metabolite clearance from the adult brain. Science 342, 373-377.
-
(2013)
Science
, vol.342
, pp. 373-377
-
-
Xie, L.1
Kang, H.2
Xu, Q.3
Chen, M.J.4
Liao, Y.5
Thiyagarajan, M.6
O'Donnell, J.7
Christensen, D.J.8
Nicholson, C.9
Iliff, J.J.10
Takano, T.11
Deane, R.12
Nedergaard, M.13
-
182
-
-
33646793301
-
Reciprocal interactions of insulin and insulin-like growth factor I in receptor-mediated transport across the blood-brain barrier
-
Yu, Y., Kastin, A. J., and Pan, W. (2006). Reciprocal interactions of insulin and insulin-like growth factor I in receptor-mediated transport across the blood-brain barrier. Endocrinology 147, 2611-2615.
-
(2006)
Endocrinology
, vol.147
, pp. 2611-2615
-
-
Yu, Y.1
Kastin, A.J.2
Pan, W.3
-
183
-
-
84907861812
-
The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications
-
Zemva, J., and Schubert, M. (2014). The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications. CNS Neurol Disord Drug Targets 13, 322-337.
-
(2014)
CNS Neurol Disord Drug Targets
, vol.13
, pp. 322-337
-
-
Zemva, J.1
Schubert, M.2
-
184
-
-
79953836673
-
Sink hypothesis and therapeutic strategies for attenuating Abeta levels
-
Zhang, Y., and Lee, D. H. (2011). Sink hypothesis and therapeutic strategies for attenuating Abeta levels. Neuroscientist 17, 163-173.
-
(2011)
Neuroscientist
, vol.17
, pp. 163-173
-
-
Zhang, Y.1
Lee, D.H.2
|