Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway

Diabetes

Volumn 61, Issue 12, 2012, Pages 3126-3138

  Son, Sung Min ^a   Song, Hyundong ^a   Byun, Jayoung ^a   Park, Kyong Soo ^a   Jang, Hak Chul ^a,b   Park, Young Joo ^a   Mook Jung, Inhee ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CULTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOCYTOCHEMISTRY; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; DIABETES MELLITUS, TYPE 2; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; PHAGOSOMES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84870213683     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1735     Document Type: Article

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