Uptake and degradation of blood-borne insulin by the olfactory bulb

Peptides

Volumn 20, Issue 3, 1999, Pages 373-378

  Banks, William A ^a   Kastin, Abba J ^b   Pan, Weihong ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Blood brain barrier; CNS; Spinal cord; Transport

Indexed keywords

INSULIN; INSULIN I 125; INSULIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; DRUG DEGRADATION; DRUG TRANSPORT; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; SPINAL CORD;

EID: 0032853213     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(99)00045-5     Document Type: Article

References (48)

1. Adamo M., Raizada M.K., LeRoith D. Insulin and insulin-like growth factor receptors in the nervous system. Mol Neurobiol. 3:1989;71-100.
2. Ajaya B., Haranath P.S.R.K. Effects of insulin administered into cerebrospinal fluid spaces on blood glucose in unanesthetized and anesthestized dogs. Indian J Med Res. 75:1982;607-615.
3. Banks W.A., Jaspan J.B., Huang W., Kastin A.J. Transport of insulin across the blood-brain barrier saturability at euglycemic doses of insulin . Peptides. 18:1997;1423-1429.
4. Banks W.A., Jaspan J.B., Kastin A.J. Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin. Peptides. 18:1997;1577-1584.
5. Banks W.A., Kastin A.J. Measurement of transport of cytokines across the blood-brain barrier. De Souza E.B. Methods in neurosciences, vol. 16. 1993;67-77 Academic Press, San Diego.
6. Banks W.A., Kastin A.J. Physiological consequences of the passage of peptides across the blood-brain barrier. Rev Neurosci. 4:1993;365-372.
7. Banks W.A., Kastin A.J. Differential permeability of the blood-brain barrier to two pancreatic peptides insulin and amylin . Peptides. 19:1998;883-889.
8. Banks W.A., Kastin A.J., Huang W., Jaspan J.B., Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides. 17:1996;305-311.
9. Banks W.A., Kastin A.J., Jaspan J.B. Regional variation in transport of pancreatic polypeptide across the blood-brain barrier of mice. Pharmacol Biochem Behav. 51:1995;139-147.
10. Baskin D.G., Porte D. Jr, Guest K., Dorsa D.M. Regional concentrations of insulin in the rat brain. Endocrinology. 112:1983;898-903.
11. Baskin D.G., Wilcox B.J., Figlewicz D.P., Dorsa D.M. Insulin and insulin-like growth factors in the CNS. Trends Neurosci. 11:1988;107-111.
12. Baura G.D., Foster D.M., Porte D. Jr, Kahn S.E., Bergman R.N., Cobelli C., Schwartz M.W. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo a mechanism for regulated insulin delivery to the brain . J Clin Invest. 92:1993;1824-1830.
13. Blasberg R.G., Fenstermacher J.D., Patlak C.S. Transport of α-aminoisobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metab. 3:1983;8-32.
14. Broadwell R.D., Banks W.A. Cell biological perspective for the transcytosis of peptides and proteins through the mammalian blood-brain fluid barriers. Pardridge W.M. The blood-brain barrier. 1993;165-199 Raven Press Ltd, New York.
15. Cain D.P. Effects of insulin injection on responses of olfactory bulb and amygdala single units to odors. Brain Res. 99:1975;69-83.
16. Cashion M.F., Banks W.A., Kastin A.J. Sequestration of centrally administered insulin by the brain effects of starvation, aluminum and TNF-α Horm Behav. 30:1996;280-286.
17. Duffy K.R., Pardridge W.M. Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Res. 420:1987;32-38.
18. Florant G.L., Richardson R.D., Mahan S., Singer L., Woods S.C. Seasonal changes in CSF insulin levels in marmots insulin may not be a satiety signal for fasting in winter . Am J Physiol. 260:1991;R712-R716.
19. Florant G.L., Singer L., Scheurink A.J.W., Park C.R., Richardson R.D., Woods S.C. Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period. Physiol Behav. 49:1991;335-338.
20. Foster L.A., Ames N.K., Emery R.S. Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I. Physiol Behav. 50:1991;745-749.
21. Frank H.J.L., Jankovic-Vokes T., Pardridge W.M., Morris W.L. Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits. Diabetes. 34:1985;728-733.
22. Frank H.J.L., Pardridge W.M. A direct in vitro demonstration of insulin binding to isolated brain microvessel. Diabetes. 30:1981;757-761.
23. Gammeltoft S., Staun-Olsen P., Ottesen B., Fahrenkrug J. Insulin receptors in rat brain cortex. Kinetic evidence for a receptor subtype in the central nervous system. Peptides. 5:1998;937-944.
24. Gupta G., Azam M., Baquer N.Z. Modulation of rat brain insulin receptor kinase activity in diabetes. Neurochem Int. 20:1992;487-492.
25. Gutierrez E.G., Banks W.A., Kastin A.J. Murine tumor necrosis factor (TNF) alpha is transported from blood to brain in the mouse. J Neuroimmunol. 47:1993;169-176.
26. Heidenreich K.A., Zahniser N.R., Berhanu P., Brandenburg D., Olefsky J.M. Structural differences between insulin receptors in the brain and peripheral target tissues. J Biol Chem. 258:1983;8527-8530.
27. Henneberg N., Hoyer S. Short-term or long-term intracerebroventricular (ICV) infusion of insulin exhibits a discrete anabolic effect on cerebral energy metabolism in the rat. Neurosci Lett. 175:1994;153-156.
28. Hill J.M., Lesniak M.A., Pert C.B., Roth J. Autoradiographic localization of insulin receptors in rat brain prominence in olfactory and limbic areas . Neuroscience. 17:1998;1127-1138.
29. 125I]insulin receptor binding sites in developing and adult rat brain. J Comp Neurol. 15:1993;375-397.
30. Keller B.T., Borchardt R.T. Cultured bovine brain capillary endothelial cells (BBCEC) - a blood-brain barrier model for studying the binding and internalization of insulin and insulin-like growth factor 1. Fed Proc. 46:1987;416.
31. Kwok R.P., Juorio A.V. Effects of insulin on rat brain noradrenaline. Neurochem Res. 13:1988;887-892.
32. Maness L.M., Banks W.A., Zadina J.E., Kastin A.J. Selective transport of blood-borne IL-1α into the posterior division of the septum of the mouse brain. Brain Res. 700:1995;83-88.
33. Marks J.L., Eastman C.J. Effect of starvation on insulin receptors in rat brain. Neuroscience. 30:1989;551-556.
34. Marks J.L., Eastman C.J. Ontogeny of insulin binding in different regions of the rat brain. Dev Neurosci. 12:1990;349-358.
35. Marks J.L., Porte D. Jr, Stahl W.L., Baskin D.G. Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology. 127:1990;3234-3236.
36. Matsumoto H., Rhoads D.E. Specific binding of insulin to membranes from dendrodendritic synaptosomes of rat olfactory bulb. J Neurochem. 54:1990;347-350.
37. Miller D.W., Borchardt R.T. Distribution of insulin binding sites on cultured bovine brain microvessel endothelial cells and their possible role in the transport of insulin across the blood-brain barrier. J Cell Biol. 115:1991;261a.
38. Montefusco O., Assini M.C., Missale C. Insulin-mediated effects of glucose on dopamine metabolism. Acta Diabetol Lat. 20:1983;71-77.
39. Morley JE, Silver AJ. Role of the endocrine brain in the control of eating and drinking. In: Motta M, editor. Brain endocrinology, 2nd Edition. New York: Raven Press, 1991;431-47.
40. Muntzel M.S., Morgan D.A., Mark A.L., Johnson A.K. Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity. Am J Physiol. 267:1994;R1350-R1355.
41. Patlak C.S., Blasberg R.G., Fenstermacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 3:1983;1-7.
42. Perassi N.I., Loyber I., Palma J.A. Insulin sensitivity and glucose tolerance in rats without olfactory bulbs. Neuroendocrinology. 9:1972;83-89.
43. Schwartz M.W., Bergman R.N., Kahn S.E., Taborsky G.L. Jr, Fisher L.D., Sipols A.J., Woods S.C., Steil G.M., Porte D. Jr. Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. J Clin Invest. 88:1991;1272-1281.
44. Schwartz M.W., Figlewicz D.P., Baskin D.G., Woods S.C., Porte D. Jr. Insulin in the brain a hormonal regulator of energy balance . Endocr Rev. 13:1992;387-414.
45. Schwartz M.W., Figlewicz D.P., Baskin D.G., Woods S.C., Porte D. Jr. Insulin and the central regulation of energy balance update 1994 . Endocr Rev. 2:1994;109-113.
46. 125I-insulin binding is decreased in olfactory bulbs of aged rats. Neuropeptides. 17:1990;193-196.
47. Triguero D., Buciak J., Pardridge W.M. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem. 54:1990;1882-1888.
48. Werther G.A., Hogg A., Oldfield B.J., McKinley M.J., Figdor R., Allen A.M., Mendelsohn F.A. Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology. 121:1987;1562-1570.