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Volumn 35, Issue 11, 2016, Pages 1341-1352

Context-dependent actions of Polycomb repressors in cancer

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HISTONE H3; POLYCOMB GROUP PROTEIN; TRANSCRIPTION FACTOR EZH2; POLYCOMB REPRESSIVE COMPLEX 2; TUMOR SUPPRESSOR PROTEIN;

EID: 84930603937     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.195     Document Type: Review
Times cited : (74)

References (194)
  • 1
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298: 1039-1043.
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 2
    • 0037131523 scopus 로고    scopus 로고
    • Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    • Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 2002; 111: 185-196.
    • (2002) Cell , vol.111 , pp. 185-196
    • Czermin, B.1    Melfi, R.2    McCabe, D.3    Seitz, V.4    Imhof, A.5    Pirrotta, V.6
  • 3
    • 18644383738 scopus 로고    scopus 로고
    • Histone methyltransferase activity of a Drosophila Polycomb group repressor complex
    • Muller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 2002; 111: 197-208.
    • (2002) Cell , vol.111 , pp. 197-208
    • Muller, J.1    Hart, C.M.2    Francis, N.J.3    Vargas, M.L.4    Sengupta, A.5    Wild, B.6
  • 4
    • 0041624288 scopus 로고    scopus 로고
    • Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27
    • Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev 2003; 17: 1823-1828.
    • (2003) Genes Dev , vol.17 , pp. 1823-1828
    • Min, J.1    Zhang, Y.2    Xu, R.M.3
  • 5
    • 0043127085 scopus 로고    scopus 로고
    • Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
    • Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, Khorasanizadeh S. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev 2003; 17: 1870-1881.
    • (2003) Genes Dev , vol.17 , pp. 1870-1881
    • Fischle, W.1    Wang, Y.2    Jacobs, S.A.3    Kim, Y.4    Allis, C.D.5    Khorasanizadeh, S.6
  • 7
    • 84857367297 scopus 로고    scopus 로고
    • RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3
    • Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J et al. RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell 2012; 148: 664-678.
    • (2012) Cell , vol.148 , pp. 664-678
    • Tavares, L.1    Dimitrova, E.2    Oxley, D.3    Webster, J.4    Poot, R.5    Demmers, J.6
  • 8
    • 84902127230 scopus 로고    scopus 로고
    • Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
    • Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LL et al. Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell 2014; 157: 1445-1459.
    • (2014) Cell , vol.157 , pp. 1445-1459
    • Blackledge, N.P.1    Farcas, A.M.2    Kondo, T.3    King, H.W.4    McGouran, J.F.5    Hanssen, L.L.6
  • 9
    • 84902333500 scopus 로고    scopus 로고
    • Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment
    • Cooper S, Dienstbier M, Hassan R, Schermelleh L, Sharif J, Blackledge NP et al. Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment. Cell Rep 2014; 7: 1456-1470.
    • (2014) Cell Rep , vol.7 , pp. 1456-1470
    • Cooper, S.1    Dienstbier, M.2    Hassan, R.3    Schermelleh, L.4    Sharif, J.5    Blackledge, N.P.6
  • 11
    • 84904755423 scopus 로고    scopus 로고
    • Ruled by ubiquitylation: A new order for polycomb recruitment
    • Schwartz YB, Pirrotta V. Ruled by ubiquitylation: a new order for polycomb recruitment. Cell Rep 2014; 8: 321-325.
    • (2014) Cell Rep , vol.8 , pp. 321-325
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 12
    • 84928535677 scopus 로고    scopus 로고
    • The controversial role of the Polycomb group proteins in transcription and cancer: How much do we not understand Polycomb proteins?
    • Scelfo A, Piunti A, Pasini D. The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins? FEBS J 2014; 282: 1703-1722.
    • (2014) FEBS J , vol.282 , pp. 1703-1722
    • Scelfo, A.1    Piunti, A.2    Pasini, D.3
  • 13
    • 80051679799 scopus 로고    scopus 로고
    • Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression
    • Aguilo F, Zhou MM, Walsh MJ. Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression. Cancer Res 2011; 71: 5365-5369.
    • (2011) Cancer Res , vol.71 , pp. 5365-5369
    • Aguilo, F.1    Zhou, M.M.2    Walsh, M.J.3
  • 14
    • 84875418596 scopus 로고    scopus 로고
    • And Polycomb recruitment
    • Brockdorff N, Noncoding RNA. and Polycomb recruitment. RNA 2013; 19: 429-442.
    • (2013) RNA , vol.19 , pp. 429-442
    • Brockdorff, N.1    Noncoding, R.N.A.2
  • 16
    • 84891936130 scopus 로고    scopus 로고
    • Non-coding RNAs as direct and indirect modulators of epigenetic regulation
    • Peschansky VJ, Wahlestedt C. Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics 2014; 9: 3-12.
    • (2014) Epigenetics , vol.9 , pp. 3-12
    • Peschansky, V.J.1    Wahlestedt, C.2
  • 17
    • 84879269755 scopus 로고    scopus 로고
    • Identification and validation of a putative polycomb responsive element in the human genome
    • Bengani H, Mendiratta S, Maini J, Vasanthi D, Sultana H, Ghasemi M et al. Identification and validation of a putative polycomb responsive element in the human genome. PLoS ONE 2013; 8: e67217.
    • (2013) PLoS ONE , vol.8 , pp. e67217
    • Bengani, H.1    Mendiratta, S.2    Maini, J.3    Vasanthi, D.4    Sultana, H.5    Ghasemi, M.6
  • 18
    • 73149111929 scopus 로고    scopus 로고
    • A region of the human HOXD cluster that confers polycomb-group responsiveness
    • Woo CJ, Kharchenko PV, Daheron L, Park PJ, Kingston RE. A region of the human HOXD cluster that confers polycomb-group responsiveness. Cell 2010; 140: 99-110.
    • (2010) Cell , vol.140 , pp. 99-110
    • Woo, C.J.1    Kharchenko, P.V.2    Daheron, L.3    Park, P.J.4    Kingston, R.E.5
  • 19
    • 69449086947 scopus 로고    scopus 로고
    • A vertebrate Polycomb response element governs segmentation of the posterior hindbrain
    • Sing A, Pannell D, Karaiskakis A, Sturgeon K, Djabali M, Ellis J et al. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell 2009; 138: 885-897.
    • (2009) Cell , vol.138 , pp. 885-897
    • Sing, A.1    Pannell, D.2    Karaiskakis, A.3    Sturgeon, K.4    Djabali, M.5    Ellis, J.6
  • 20
    • 84860528446 scopus 로고    scopus 로고
    • A novel human polycomb binding site acts as a functional polycomb response element in Drosophila
    • Cuddapah S, Roh TY, Cui K, Jose CC, Fuller MT, Zhao K et al. A novel human polycomb binding site acts as a functional polycomb response element in Drosophila. PLoS ONE 2012; 7: e36365.
    • (2012) PLoS ONE , vol.7 , pp. e36365
    • Cuddapah, S.1    Roh, T.Y.2    Cui, K.3    Jose, C.C.4    Fuller, M.T.5    Zhao, K.6
  • 21
    • 55449105221 scopus 로고    scopus 로고
    • Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
    • Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet 2008; 4: e1000242.
    • (2008) PLoS Genet , vol.4 , pp. e1000242
    • Ku, M.1    Koche, R.P.2    Rheinbay, E.3    Mendenhall, E.M.4    Endoh, M.5    Mikkelsen, T.S.6
  • 22
    • 84857190178 scopus 로고    scopus 로고
    • An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
    • Lynch MD, Smith AJ, De Gobbi M, Flenley M, Hughes JR, Vernimmen D et al. An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO J 2012; 31: 317-329.
    • (2012) EMBO J , vol.31 , pp. 317-329
    • Lynch, M.D.1    Smith, A.J.2    De Gobbi, M.3    Flenley, M.4    Hughes, J.R.5    Vernimmen, D.6
  • 25
    • 84863011309 scopus 로고    scopus 로고
    • PCGF homologs CBX proteins, and RYBP define functionally distinct PRC1 family complexes
    • Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F et al. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell 2012; 45: 344-356.
    • (2012) Mol Cell , vol.45 , pp. 344-356
    • Gao, Z.1    Zhang, J.2    Bonasio, R.3    Strino, F.4    Sawai, A.5    Parisi, F.6
  • 26
    • 84906302982 scopus 로고    scopus 로고
    • Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation
    • Jermann P, Hoerner L, Burger L, Schubeler D. Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation. Proc Natl Acad Sci USA 2014; 111: E3415-E3421.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E3415-E3421
    • Jermann, P.1    Hoerner, L.2    Burger, L.3    Schubeler, D.4
  • 27
    • 84884616025 scopus 로고    scopus 로고
    • Ras-induced changes in H3K27me3 occur after those in transcriptional activity
    • Hosogane M, Funayama R, Nishida Y, Nagashima T, Nakayama K. Ras-induced changes in H3K27me3 occur after those in transcriptional activity. PLoS Genet 2013; 9: e1003698.
    • (2013) PLoS Genet , vol.9 , pp. e1003698
    • Hosogane, M.1    Funayama, R.2    Nishida, Y.3    Nagashima, T.4    Nakayama, K.5
  • 28
    • 84865292901 scopus 로고    scopus 로고
    • Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation
    • Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N et al. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 2012; 337: 971-975.
    • (2012) Science , vol.337 , pp. 971-975
    • Yuan, W.1    Wu, T.2    Fu, H.3    Dai, C.4    Wu, H.5    Liu, N.6
  • 29
    • 84905572005 scopus 로고    scopus 로고
    • Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide
    • Riising EM, Comet I, Leblanc B, Wu X, Johansen JV, Helin K. Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide. Mol Cell 2014; 55: 347-360.
    • (2014) Mol Cell , vol.55 , pp. 347-360
    • Riising, E.M.1    Comet, I.2    Leblanc, B.3    Wu, X.4    Johansen, J.V.5    Helin, K.6
  • 30
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010; 42: 181-185.
    • (2010) Nat Genet , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3    Mungall, A.J.4    An, J.5    Goya, R.6
  • 31
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci USA 2010; 107: 20980-20985.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3    Knutson, S.K.4    Pollock, R.M.5    Richon, V.M.6
  • 32
    • 78650062951 scopus 로고    scopus 로고
    • EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
    • Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM et al. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood 2010; 116: 5247-5255.
    • (2010) Blood , vol.116 , pp. 5247-5255
    • Velichutina, I.1    Shaknovich, R.2    Geng, H.3    Johnson, N.A.4    Gascoyne, R.D.5    Melnick, A.M.6
  • 33
    • 79952167230 scopus 로고    scopus 로고
    • Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
    • Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 2011; 117: 2451-2459.
    • (2011) Blood , vol.117 , pp. 2451-2459
    • Yap, D.B.1    Chu, J.2    Berg, T.3    Schapira, M.4    Cheng, S.W.5    Moradian, A.6
  • 34
    • 84863165348 scopus 로고    scopus 로고
    • Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
    • McCabe MT, Graves AP, Ganji G, Diaz E, Halsey WS, Jiang Y et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc Natl Acad Sci USA 2012; 109: 2989-2994.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2989-2994
    • McCabe, M.T.1    Graves, A.P.2    Ganji, G.3    Diaz, E.4    Halsey, W.S.5    Jiang, Y.6
  • 35
    • 84887108791 scopus 로고    scopus 로고
    • Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia
    • Jaffe JD, Wang Y, Chan HM, Zhang J, Huether R, Kryukov GV et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet 2013; 45: 1386-1391.
    • (2013) Nat Genet , vol.45 , pp. 1386-1391
    • Jaffe, J.D.1    Wang, Y.2    Chan, H.M.3    Zhang, J.4    Huether, R.5    Kryukov, G.V.6
  • 37
    • 84877815031 scopus 로고    scopus 로고
    • EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
    • Beguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell 2013; 23: 677-692.
    • (2013) Cancer Cell , vol.23 , pp. 677-692
    • Beguelin, W.1    Popovic, R.2    Teater, M.3    Jiang, Y.4    Bunting, K.L.5    Rosen, M.6
  • 38
    • 84890046467 scopus 로고    scopus 로고
    • Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
    • Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL et al. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J Clin Invest 2013; 123: 5009-5022.
    • (2013) J Clin Invest , vol.123 , pp. 5009-5022
    • Caganova, M.1    Carrisi, C.2    Varano, G.3    Mainoldi, F.4    Zanardi, F.5    Germain, P.L.6
  • 40
    • 84902665681 scopus 로고    scopus 로고
    • A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
    • Berg T, Thoene S, Yap D, Wee T, Schoeler N, Rosten P et al. A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis. Blood 2014; 123: 3914-3924.
    • (2014) Blood , vol.123 , pp. 3914-3924
    • Berg, T.1    Thoene, S.2    Yap, D.3    Wee, T.4    Schoeler, N.5    Rosten, P.6
  • 41
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012; 492: 108-112.
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3    Korenchuk, S.4    Thompson, C.5    Van Aller, G.S.6
  • 42
    • 84884532954 scopus 로고    scopus 로고
    • Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
    • Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 2013; 9: 643-650.
    • (2013) Nat Chem Biol , vol.9 , pp. 643-650
    • Kim, W.1    Bird, G.H.2    Neff, T.3    Guo, G.4    Kerenyi, M.A.5    Walensky, L.D.6
  • 43
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-726.
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3    Hidalgo-Curtis, C.E.4    Bryant, C.5    Jones, A.V.6
  • 46
    • 84878921669 scopus 로고    scopus 로고
    • Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies
    • Khan SN, Jankowska AM, Mahfouz R, Dunbar AJ, Sugimoto Y, Hosono N et al. Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies. Leukemia 2013; 27: 1301-1309.
    • (2013) Leukemia , vol.27 , pp. 1301-1309
    • Khan, S.N.1    Jankowska, A.M.2    Mahfouz, R.3    Dunbar, A.J.4    Sugimoto, Y.5    Hosono, N.6
  • 47
    • 84856596417 scopus 로고    scopus 로고
    • Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
    • Score J, Hidalgo-Curtis C, Jones AV, Winkelmann N, Skinner A, Ward D et al. Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. Blood 2012; 119: 1208-1213.
    • (2012) Blood , vol.119 , pp. 1208-1213
    • Score, J.1    Hidalgo-Curtis, C.2    Jones, A.V.3    Winkelmann, N.4    Skinner, A.5    Ward, D.6
  • 50
    • 79955810336 scopus 로고    scopus 로고
    • Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in 480% of patients with TET2 and EZH2 being of high prognostic relevance
    • Grossmann V, Kohlmann A, Eder C, Haferlach C, Kern W, Cross NC et al. Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in 480% of patients with TET2 and EZH2 being of high prognostic relevance. Leukemia 2011; 25: 877-879.
    • (2011) Leukemia , vol.25 , pp. 877-879
    • Grossmann, V.1    Kohlmann, A.2    Eder, C.3    Haferlach, C.4    Kern, W.5    Cross, N.C.6
  • 51
    • 84908275738 scopus 로고    scopus 로고
    • The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: An international study of 797 patients
    • Guglielmelli P, Lasho TL, Rotunno G, Score J, Mannarelli C, Pancrazzi A et al. The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients. Leukemia 2014; 28: 1804-1810.
    • (2014) Leukemia , vol.28 , pp. 1804-1810
    • Guglielmelli, P.1    Lasho, T.L.2    Rotunno, G.3    Score, J.4    Mannarelli, C.5    Pancrazzi, A.6
  • 52
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX
    • Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 2011; 118: 3932-3941.
    • (2011) EZH2, and DNMT3A. Blood , vol.118 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3    Szpurka, H.4    Huang, Y.5    Traina, F.6
  • 53
    • 84888083126 scopus 로고    scopus 로고
    • Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders
    • Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y et al. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. J Exp Med 2013; 210: 2627-2639.
    • (2013) J Exp Med , vol.210 , pp. 2627-2639
    • Muto, T.1    Sashida, G.2    Oshima, M.3    Wendt, G.R.4    Mochizuki-Kashio, M.5    Nagata, Y.6
  • 54
    • 84903178102 scopus 로고    scopus 로고
    • Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
    • Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y et al. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nat Commun 2014; 5: 4177.
    • (2014) Nat Commun , vol.5 , pp. 4177
    • Sashida, G.1    Harada, H.2    Matsui, H.3    Oshima, M.4    Yui, M.5    Harada, Y.6
  • 55
    • 84864567410 scopus 로고    scopus 로고
    • Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
    • Tanaka S, Miyagi S, Sashida G, Chiba T, Yuan J, Mochizuki-Kashio M et al. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood 2012; 120: 1107-1117.
    • (2012) Blood , vol.120 , pp. 1107-1117
    • Tanaka, S.1    Miyagi, S.2    Sashida, G.3    Chiba, T.4    Yuan, J.5    Mochizuki-Kashio, M.6
  • 58
    • 84859295400 scopus 로고    scopus 로고
    • A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
    • Simon C, Chagraoui J, Krosl J, Gendron P, Wilhelm B, Lemieux S et al. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev 2012; 26: 651-656.
    • (2012) Genes Dev , vol.26 , pp. 651-656
    • Simon, C.1    Chagraoui, J.2    Krosl, J.3    Gendron, P.4    Wilhelm, B.5    Lemieux, S.6
  • 59
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    • Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012; 482: 226-231.
    • (2012) Nature , vol.482 , pp. 226-231
    • Schwartzentruber, J.1    Korshunov, A.2    Liu, X.Y.3    Jones, D.T.4    Pfaff, E.5    Jacob, K.6
  • 60
    • 84862777410 scopus 로고    scopus 로고
    • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and nonbrainstem glioblastomas
    • Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and nonbrainstem glioblastomas. Nat Genet 2012; 44: 251-253.
    • (2012) Nat Genet , vol.44 , pp. 251-253
    • Wu, G.1    Broniscer, A.2    McEachron, T.A.3    Lu, C.4    Paugh, B.S.5    Becksfort, J.6
  • 61
    • 84882273357 scopus 로고    scopus 로고
    • Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas
    • Venneti S, Garimella MT, Sullivan LM, Martinez D, Huse JT, Heguy A et al. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol 2013; 23: 558-564.
    • (2013) Brain Pathol , vol.23 , pp. 558-564
    • Venneti, S.1    Garimella, M.T.2    Sullivan, L.M.3    Martinez, D.4    Huse, J.T.5    Heguy, A.6
  • 62
    • 84877299145 scopus 로고    scopus 로고
    • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    • Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev 2013; 27: 985-990.
    • (2013) Genes Dev , vol.27 , pp. 985-990
    • Chan, K.M.1    Fang, D.2    Gan, H.3    Hashizume, R.4    Yu, C.5    Schroeder, M.6
  • 63
    • 84877785024 scopus 로고    scopus 로고
    • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    • Lewis PW, Muller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 2013; 340: 857-861.
    • (2013) Science , vol.340 , pp. 857-861
    • Lewis, P.W.1    Muller, M.M.2    Koletsky, M.S.3    Cordero, F.4    Lin, S.5    Banaszynski, L.A.6
  • 64
    • 84887617868 scopus 로고    scopus 로고
    • Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    • Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 2013; 24: 660-672.
    • (2013) Cancer Cell , vol.24 , pp. 660-672
    • Bender, S.1    Tang, Y.2    Lindroth, A.M.3    Hovestadt, V.4    Jones, D.T.5    Kool, M.6
  • 65
    • 84919458472 scopus 로고    scopus 로고
    • Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
    • Funato K, Major T, Lewis PW, Allis CD, Tabar V. Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation. Science 2014; 346: 1529-1533.
    • (2014) Science , vol.346 , pp. 1529-1533
    • Funato, K.1    Major, T.2    Lewis, P.W.3    Allis, C.D.4    Tabar, V.5
  • 66
    • 33749234357 scopus 로고    scopus 로고
    • TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells
    • Eisele G, Wischhusen J, Mittelbronn M, Meyermann R, Waldhauer I, Steinle A et al. TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells. Brain 2006; 129: 2416-2425.
    • (2006) Brain , vol.129 , pp. 2416-2425
    • Eisele, G.1    Wischhusen, J.2    Mittelbronn, M.3    Meyermann, R.4    Waldhauer, I.5    Steinle, A.6
  • 67
    • 33846815345 scopus 로고    scopus 로고
    • Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
    • Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA et al. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 2007; 53: 503-517.
    • (2007) Neuron , vol.53 , pp. 503-517
    • Ligon, K.L.1    Huillard, E.2    Mehta, S.3    Kesari, S.4    Liu, H.5    Alberta, J.A.6
  • 68
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012; 483: 474-478.
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3    Rohle, D.4    Turcan, S.5    Abdel-Wahab, O.6
  • 69
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011; 19: 17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6
  • 70
    • 84886741979 scopus 로고    scopus 로고
    • 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft
    • Borodovsky A, Salmasi V, Turcan S, Fabius AW, Baia GS, Eberhart CG et al. 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. Oncotarget 2013; 4: 1737-1747.
    • (2013) Oncotarget , vol.4 , pp. 1737-1747
    • Borodovsky, A.1    Salmasi, V.2    Turcan, S.3    Fabius, A.W.4    Baia, G.S.5    Eberhart, C.G.6
  • 71
    • 84886744421 scopus 로고    scopus 로고
    • Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine
    • Turcan S, Fabius AW, Borodovsky A, Pedraza A, Brennan C, Huse J et al. Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Oncotarget 2013; 4: 1729-1736.
    • (2013) Oncotarget , vol.4 , pp. 1729-1736
    • Turcan, S.1    Fabius, A.W.2    Borodovsky, A.3    Pedraza, A.4    Brennan, C.5    Huse, J.6
  • 72
    • 84867606428 scopus 로고    scopus 로고
    • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    • Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012; 22: 425-437.
    • (2012) Cancer Cell , vol.22 , pp. 425-437
    • Sturm, D.1    Witt, H.2    Hovestadt, V.3    Khuong-Quang, D.A.4    Jones, D.T.5    Konermann, C.6
  • 73
  • 74
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 2012; 483: 479-483.
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3    Walsh, L.A.4    Fang, F.5    Yilmaz, E.6
  • 75
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013; 340: 626-630.
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3    Turcan, S.4    Grommes, C.5    Campos, C.6
  • 76
    • 84961291627 scopus 로고    scopus 로고
    • Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
    • Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med 2014; 20: 1394-1396.
    • (2014) Nat Med , vol.20 , pp. 1394-1396
    • Hashizume, R.1    Andor, N.2    Ihara, Y.3    Lerner, R.4    Gan, H.5    Chen, X.6
  • 77
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    • Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, van Lohuizen M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev 1999; 13: 2678-2690.
    • (1999) Genes Dev , vol.13 , pp. 2678-2690
    • Jacobs, J.J.1    Scheijen, B.2    Voncken, J.W.3    Kieboom, K.4    Berns, A.5    Van Lohuizen, M.6
  • 79
    • 0025727771 scopus 로고
    • Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in e mu-myc transgenic mice
    • Haupt Y, Alexander WS, Barri G, Klinken SP, Adams JM. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 1991; 65: 753-763.
    • (1991) Cell , vol.65 , pp. 753-763
    • Haupt, Y.1    Alexander, W.S.2    Barri, G.3    Klinken, S.P.4    Adams, J.M.5
  • 81
    • 35148840173 scopus 로고    scopus 로고
    • Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma
    • Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J et al. Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell 2007; 12: 328-341.
    • (2007) Cancer Cell , vol.12 , pp. 328-341
    • Bruggeman, S.W.1    Hulsman, D.2    Tanger, E.3    Buckle, T.4    Blom, M.5    Zevenhoven, J.6
  • 83
    • 72849130207 scopus 로고    scopus 로고
    • The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelialmesenchymal transition in human nasopharyngeal epithelial cells
    • Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ et al. The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelialmesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest 2009; 119: 3626-3636.
    • (2009) J Clin Invest , vol.119 , pp. 3626-3636
    • Song, L.B.1    Li, J.2    Liao, W.T.3    Feng, Y.4    Yu, C.P.5    Hu, L.J.6
  • 84
    • 84872825428 scopus 로고    scopus 로고
    • The relationship between Bmi-1 and the epithelial-mesenchymal transition in lung squamous cell carcinoma
    • Huang J, Qiu Y, Chen G, Huang L, He J. The relationship between Bmi-1 and the epithelial-mesenchymal transition in lung squamous cell carcinoma. Med Oncol 2012; 29: 1606-1613.
    • (2012) Med Oncol , vol.29 , pp. 1606-1613
    • Huang, J.1    Qiu, Y.2    Chen, G.3    Huang, L.4    He, J.5
  • 85
    • 84860552122 scopus 로고    scopus 로고
    • Aktmediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer
    • Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY et al. Aktmediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest 2012; 122: 1920-1932.
    • (2012) J Clin Invest , vol.122 , pp. 1920-1932
    • Nacerddine, K.1    Beaudry, J.B.2    Ginjala, V.3    Westerman, B.4    Mattiroli, F.5    Song, J.Y.6
  • 86
    • 77955381770 scopus 로고    scopus 로고
    • BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery
    • Facchino S, Abdouh M, Chatoo W, Bernier G. BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. J Neurosci 2010; 30: 10096-10111.
    • (2010) J Neurosci , vol.30 , pp. 10096-10111
    • Facchino, S.1    Abdouh, M.2    Chatoo, W.3    Bernier, G.4
  • 87
    • 79956086415 scopus 로고    scopus 로고
    • BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair
    • Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M et al. BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol 2011; 31: 1972-1982.
    • (2011) Mol Cell Biol , vol.31 , pp. 1972-1982
    • Ginjala, V.1    Nacerddine, K.2    Kulkarni, A.3    Oza, J.4    Hill, S.J.5    Yao, M.6
  • 88
    • 84877836210 scopus 로고    scopus 로고
    • In vivo RNAi screen for BMI1 targets identifies TGF-beta/BMP-ER stress pathways as key regulators of neural-and malignant glioma-stem cell homeostasis. Cancer
    • Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW et al. In vivo RNAi screen for BMI1 targets identifies TGF-beta/BMP-ER stress pathways as key regulators of neural-and malignant glioma-stem cell homeostasis. Cancer Cell 2013; 23: 660-676.
    • (2013) Cell , vol.23 , pp. 660-676
    • Gargiulo, G.1    Cesaroni, M.2    Serresi, M.3    De Vries, N.4    Hulsman, D.5    Bruggeman, S.W.6
  • 89
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang Y, Chen CR, Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003; 11: 915-926.
    • (2003) Mol Cell , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massague, J.3
  • 90
    • 84864655726 scopus 로고    scopus 로고
    • Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
    • Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES et al. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. Nat Med 2012; 18: 1232-1238.
    • (2012) Nat Med , vol.18 , pp. 1232-1238
    • Stock, K.1    Kumar, J.2    Synowitz, M.3    Petrosino, S.4    Imperatore, R.5    Smith, E.S.6
  • 92
    • 0025773264 scopus 로고
    • Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z) 2
    • van Lohuizen M, Frasch M, Wientjens E, Berns A. Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 1991; 353: 353-355.
    • (1991) Nature , vol.353 , pp. 353-355
    • Van Lohuizen, M.1    Frasch, M.2    Wientjens, E.3    Berns, A.4
  • 93
    • 0034992693 scopus 로고    scopus 로고
    • Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression
    • Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M et al. Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development 2001; 128: 1587-1597.
    • (2001) Development , vol.128 , pp. 1587-1597
    • Akasaka, T.1    Van Lohuizen, M.2    Van Der Lugt, N.3    Mizutani-Koseki, Y.4    Kanno, M.5    Taniguchi, M.6
  • 94
    • 29144487990 scopus 로고    scopus 로고
    • Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing
    • Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005; 20: 845-854.
    • (2005) Mol Cell , vol.20 , pp. 845-854
    • Cao, R.1    Tsukada, Y.2    Zhang, Y.3
  • 95
    • 78049346649 scopus 로고    scopus 로고
    • Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex
    • Qian T, Lee JY, Park JH, Kim HJ, Kong G. Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex. Oncogene 2010; 29: 5818-5827.
    • (2010) Oncogene , vol.29 , pp. 5818-5827
    • Qian, T.1    Lee, J.Y.2    Park, J.H.3    Kim, H.J.4    Kong, G.5
  • 96
    • 84896738974 scopus 로고    scopus 로고
    • Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts
    • Pemberton H, Anderton E, Patel H, Brookes S, Chandler H, Palermo R et al. Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts. Genome Biol 2014; 15: R23.
    • (2014) Genome Biol , vol.15 , pp. R23
    • Pemberton, H.1    Anderton, E.2    Patel, H.3    Brookes, S.4    Chandler, H.5    Palermo, R.6
  • 97
    • 0032519809 scopus 로고    scopus 로고
    • Stage-specific expression of polycomb group genes in human bone marrow cells
    • Lessard J, Baban S, Sauvageau G. Stage-specific expression of polycomb group genes in human bone marrow cells. Blood 1998; 91: 1216-1224.
    • (1998) Blood , vol.91 , pp. 1216-1224
    • Lessard, J.1    Baban, S.2    Sauvageau, G.3
  • 98
    • 67049136167 scopus 로고    scopus 로고
    • Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells
    • Kajiume T, Ohno N, Sera Y, Kawahara Y, Yuge L, Kobayashi M. Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells. Exp Hematol 2009; 37: 857-66 e2.
    • (2009) Exp Hematol , vol.37 , pp. 857-66e2
    • Kajiume, T.1    Ohno, N.2    Sera, Y.3    Kawahara, Y.4    Yuge, L.5    Kobayashi, M.6
  • 99
    • 77449159608 scopus 로고    scopus 로고
    • Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1
    • Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H et al. Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 2010; 6: 279-286.
    • (2010) Cell Stem Cell , vol.6 , pp. 279-286
    • Oguro, H.1    Yuan, J.2    Ichikawa, H.3    Ikawa, T.4    Yamazaki, S.5    Kawamoto, H.6
  • 100
    • 80052571043 scopus 로고    scopus 로고
    • Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells
    • Stojic L, Jasencakova Z, Prezioso C, Stutzer A, Bodega B, Pasini D et al. Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells. Epigenetics Chromatin 2011; 4: 16.
    • (2011) Epigenetics Chromatin , vol.4 , pp. 16
    • Stojic, L.1    Jasencakova, Z.2    Prezioso, C.3    Stutzer, A.4    Bodega, B.5    Pasini, D.6
  • 101
    • 84855516244 scopus 로고    scopus 로고
    • Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells
    • Morey L, Pascual G, Cozzuto L, Roma G, Wutz A, Benitah SA et al. Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells. Cell Stem Cell 2012; 10: 47-62.
    • (2012) Cell Stem Cell , vol.10 , pp. 47-62
    • Morey, L.1    Pascual, G.2    Cozzuto, L.3    Roma, G.4    Wutz, A.5    Benitah, S.A.6
  • 102
    • 79955745647 scopus 로고    scopus 로고
    • Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features
    • Wang W, Lin T, Huang J, Hu W, Xu K, Liu J. Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features. Urol Oncol 2011; 29: 244-251.
    • (2011) Urol Oncol , vol.29 , pp. 244-251
    • Wang, W.1    Lin, T.2    Huang, J.3    Hu, W.4    Xu, K.5    Liu, J.6
  • 103
    • 72449192414 scopus 로고    scopus 로고
    • The novel tumorsuppressor Mel-18 in prostate cancer: Its functional polymorphism, expression and clinical significance
    • Wang W, Yuasa T, Tsuchiya N, Ma Z, Maita S, Narita S et al. The novel tumorsuppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance. Int J Cancer 2009; 125: 2836-2843.
    • (2009) Int J Cancer , vol.125 , pp. 2836-2843
    • Wang, W.1    Yuasa, T.2    Tsuchiya, N.3    Ma, Z.4    Maita, S.5    Narita, S.6
  • 104
    • 34347233480 scopus 로고    scopus 로고
    • Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells
    • Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V et al. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res 2007; 67: 5083-5089.
    • (2007) Cancer Res , vol.67 , pp. 5083-5089
    • Guo, W.J.1    Zeng, M.S.2    Yadav, A.3    Song, L.B.4    Guo, B.H.5    Band, V.6
  • 105
    • 84957579503 scopus 로고    scopus 로고
    • Molecular profiles of pre-and postoperative breast cancer tumours reveal differentially expressed genes
    • Riis ML, Luders T, Markert EK, Haakensen VD, Nesbakken AJ, Kristensen VN et al. Molecular profiles of pre-and postoperative breast cancer tumours reveal differentially expressed genes. ISRN Oncol 2012; 2012: 450267.
    • (2012) ISRN Oncol , vol.2012 , pp. 450267
    • Riis, M.L.1    Luders, T.2    Markert, E.K.3    Haakensen, V.D.4    Nesbakken, A.J.5    Kristensen, V.N.6
  • 106
    • 84922395068 scopus 로고    scopus 로고
    • Expression and clinicopathological significance of Mel-18 mRNA in colorectal cancer
    • Tao J, Liu YL, Zhang G, Ma YY, Cui BB, Yang YM. Expression and clinicopathological significance of Mel-18 mRNA in colorectal cancer. Tumour Biol 2014; 35: 9619-9625.
    • (2014) Tumour Biol , vol.35 , pp. 9619-9625
    • Tao, J.1    Liu, Y.L.2    Zhang, G.3    Ma, Y.Y.4    Cui, B.B.5    Yang, Y.M.6
  • 107
    • 77951206723 scopus 로고    scopus 로고
    • BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer
    • Zhang XW, Sheng YP, Li Q, Qin W, Lu YW, Cheng YF et al. BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer. Mol Cancer 2010; 9: 40.
    • (2010) Mol Cancer , vol.9 , pp. 40
    • Zhang, X.W.1    Sheng, Y.P.2    Li, Q.3    Qin, W.4    Lu, Y.W.5    Cheng, Y.F.6
  • 108
    • 78049483623 scopus 로고    scopus 로고
    • Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma
    • Lu YW, Li J, Guo WJ. Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma. J Exp Clin Cancer Res 2010; 29: 143.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 143
    • Lu, Y.W.1    Li, J.2    Guo, W.J.3
  • 109
    • 0032191954 scopus 로고    scopus 로고
    • Mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25
    • Tetsu O, Ishihara H, Kanno R, Kamiyasu M, Inoue H, Tokuhisa T et al. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity 1998; 9: 439-448.
    • (1998) Immunity , vol.9 , pp. 439-448
    • Tetsu, O.1    Ishihara, H.2    Kanno, R.3    Kamiyasu, M.4    Inoue, H.5    Tokuhisa, T.6
  • 110
    • 33846850149 scopus 로고    scopus 로고
    • Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins
    • Guo WJ, Datta S, Band V, Dimri GP. Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell 2007; 18: 536-546.
    • (2007) Mol Biol Cell , vol.18 , pp. 536-546
    • Guo, W.J.1    Datta, S.2    Band, V.3    Dimri, G.P.4
  • 111
    • 0028840713 scopus 로고
    • Taniguchi M. Mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity
    • Kanno M, Hasegawa M, Ishida A, Isono K, Taniguchi M. mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J 1995; 14: 5672-5678.
    • (1995) EMBO J , vol.14 , pp. 5672-5678
    • Kanno, M.1    Hasegawa, M.2    Ishida, A.3    Isono, K.4
  • 112
    • 49249089903 scopus 로고    scopus 로고
    • Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer
    • Lee JY, Jang KS, Shin DH, Oh MY, Kim HJ, Kim Y et al. Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer. Cancer Res 2008; 68: 4201-4209.
    • (2008) Cancer Res , vol.68 , pp. 4201-4209
    • Lee, J.Y.1    Jang, K.S.2    Shin, D.H.3    Oh, M.Y.4    Kim, H.J.5    Kim, Y.6
  • 113
    • 78649461311 scopus 로고    scopus 로고
    • Low expression of Mel-18 predicts poor prognosis in patients with breast cancer
    • Guo BH, Zhang X, Zhang HZ, Lin HL, Feng Y, Shao JY et al. Low expression of Mel-18 predicts poor prognosis in patients with breast cancer. Ann Oncol 2010; 21: 2361-2369.
    • (2010) Ann Oncol , vol.21 , pp. 2361-2369
    • Guo, B.H.1    Zhang, X.2    Zhang, H.Z.3    Lin, H.L.4    Feng, Y.5    Shao, J.Y.6
  • 114
    • 84895924719 scopus 로고    scopus 로고
    • Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer
    • Lee JY, Park MK, Park JH, Lee HJ, Shin DH, Kang Y et al. Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. Oncogene 2014; 33: 1325-1335.
    • (2014) Oncogene , vol.33 , pp. 1325-1335
    • Lee, J.Y.1    Park, M.K.2    Park, J.H.3    Lee, H.J.4    Shin, D.H.5    Kang, Y.6
  • 115
    • 84870346423 scopus 로고    scopus 로고
    • Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway
    • Won HY, Lee JY, Shin DH, Park JH, Nam JS, Kim HC et al. Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway. FASEB J 2012; 26: 5002-5013.
    • (2012) FASEB J , vol.26 , pp. 5002-5013
    • Won, H.Y.1    Lee, J.Y.2    Shin, D.H.3    Park, J.H.4    Nam, J.S.5    Kim, H.C.6
  • 116
    • 80755140181 scopus 로고    scopus 로고
    • Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1alpha mediated by the PTEN/PI3K/Akt pathway
    • Park JH, Lee JY, Shin DH, Jang KS, Kim HJ, Kong G. Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1alpha mediated by the PTEN/PI3K/Akt pathway. Oncogene 2011; 30: 4578-4589.
    • (2011) Oncogene , vol.30 , pp. 4578-4589
    • Park, J.H.1    Lee, J.Y.2    Shin, D.H.3    Jang, K.S.4    Kim, H.J.5    Kong, G.6
  • 117
    • 0029891279 scopus 로고    scopus 로고
    • A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton
    • Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H. A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development 1996; 122: 1513-1522.
    • (1996) Development , vol.122 , pp. 1513-1522
    • Akasaka, T.1    Kanno, M.2    Balling, R.3    Mieza, M.A.4    Taniguchi, M.5    Koseki, H.6
  • 118
    • 36749098443 scopus 로고    scopus 로고
    • Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3
    • Miki J, Fujimura Y, Koseki H, Kamijo T. Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3. Genes Cells 2007; 12: 1371-1382.
    • (2007) Genes Cells , vol.12 , pp. 1371-1382
    • Miki, J.1    Fujimura, Y.2    Koseki, H.3    Kamijo, T.4
  • 119
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999; 397: 164-168.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 120
    • 0142091482 scopus 로고    scopus 로고
    • Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF
    • Kranc KR, Bamforth SD, Braganca J, Norbury C, van Lohuizen M, Bhattacharya S. Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol 2003; 23: 7658-7666.
    • (2003) Mol Cell Biol , vol.23 , pp. 7658-7666
    • Kranc, K.R.1    Bamforth, S.D.2    Braganca, J.3    Norbury, C.4    Van Lohuizen, M.5    Bhattacharya, S.6
  • 122
    • 78650964531 scopus 로고    scopus 로고
    • Recognition and specificity determinants of the human cbx chromodomains
    • Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S et al. Recognition and specificity determinants of the human cbx chromodomains. J Biol Chem 2011; 286: 521-529.
    • (2011) J Biol Chem , vol.286 , pp. 521-529
    • Kaustov, L.1    Ouyang, H.2    Amaya, M.3    Lemak, A.4    Nady, N.5    Duan, S.6
  • 123
    • 24644470607 scopus 로고    scopus 로고
    • CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus
    • Bernard D, Martinez-Leal JF, Rizzo S, Martinez D, Hudson D, Visakorpi T et al. CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. Oncogene 2005; 24: 5543-5551.
    • (2005) Oncogene , vol.24 , pp. 5543-5551
    • Bernard, D.1    Martinez-Leal, J.F.2    Rizzo, S.3    Martinez, D.4    Hudson, D.5    Visakorpi, T.6
  • 124
    • 1342332096 scopus 로고    scopus 로고
    • Polycomb CBX7 has a unifying role in cellular lifespan
    • Gil J, Bernard D, Martinez D, Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol 2004; 6: 67-72.
    • (2004) Nat Cell Biol , vol.6 , pp. 67-72
    • Gil, J.1    Bernard, D.2    Martinez, D.3    Beach, D.4
  • 126
    • 84899998613 scopus 로고    scopus 로고
    • Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation
    • Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A et al. Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Int J Cancer 2014; 135: 308-318.
    • (2014) Int J Cancer , vol.135 , pp. 308-318
    • Shinjo, K.1    Yamashita, Y.2    Yamamoto, E.3    Akatsuka, S.4    Uno, N.5    Kamiya, A.6
  • 127
    • 77953096072 scopus 로고    scopus 로고
    • Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
    • Yap KL, Li S, Munoz-Cabello AM, Raguz S, Zeng L, Mujtaba S et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell 2010; 38: 662-674.
    • (2010) Mol Cell , vol.38 , pp. 662-674
    • Yap, K.L.1    Li, S.2    Munoz-Cabello, A.M.3    Raguz, S.4    Zeng, L.5    Mujtaba, S.6
  • 128
    • 14644423234 scopus 로고    scopus 로고
    • Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3
    • Suarez-Merino B, Hubank M, Revesz T, Harkness W, Hayward R, Thompson D et al. Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3. Neuro-oncol 2005; 7: 20-31.
    • (2005) Neuro-oncol , vol.7 , pp. 20-31
    • Suarez-Merino, B.1    Hubank, M.2    Revesz, T.3    Harkness, W.4    Hayward, R.5    Thompson, D.6
  • 129
    • 53049103365 scopus 로고    scopus 로고
    • Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer
    • Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F et al. Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Cancer Res 2008; 68: 6770-6778.
    • (2008) Cancer Res , vol.68 , pp. 6770-6778
    • Pallante, P.1    Federico, A.2    Berlingieri, M.T.3    Bianco, M.4    Ferraro, A.5    Forzati, F.6
  • 130
    • 70149100658 scopus 로고    scopus 로고
    • Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein
    • Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M et al. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Cancer Res 2009; 69: 7079-7087.
    • (2009) Cancer Res , vol.69 , pp. 7079-7087
    • Federico, A.1    Pallante, P.2    Bianco, M.3    Ferraro, A.4    Esposito, F.5    Monti, M.6
  • 131
    • 77955710683 scopus 로고    scopus 로고
    • Identification of a new pathway for tumor progression: MicroRNA-181b up-regulation and CBX7 down-regulation by HMGA1 protein
    • Mansueto G, Forzati F, Ferraro A, Pallante P, Bianco M, Esposito F et al. Identification of a new pathway for tumor progression: MicroRNA-181b up-regulation and CBX7 down-regulation by HMGA1 protein. Genes Cancer 2010; 1: 210-224.
    • (2010) Genes Cancer , vol.1 , pp. 210-224
    • Mansueto, G.1    Forzati, F.2    Ferraro, A.3    Pallante, P.4    Bianco, M.5    Esposito, F.6
  • 132
    • 77951877780 scopus 로고    scopus 로고
    • Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer
    • Karamitopoulou E, Pallante P, Zlobec I, Tornillo L, Carafa V, Schaffner T et al. Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Eur J Cancer 2010; 46: 1438-1444.
    • (2010) Eur J Cancer , vol.46 , pp. 1438-1444
    • Karamitopoulou, E.1    Pallante, P.2    Zlobec, I.3    Tornillo, L.4    Carafa, V.5    Schaffner, T.6
  • 133
    • 55149119362 scopus 로고    scopus 로고
    • Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance
    • Hinz S, Kempkensteffen C, Christoph F, Krause H, Schrader M, Schostak M et al. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. Tumour Biol 2008; 29: 323-329.
    • (2008) Tumour Biol , vol.29 , pp. 323-329
    • Hinz, S.1    Kempkensteffen, C.2    Christoph, F.3    Krause, H.4    Schrader, M.5    Schostak, M.6
  • 134
    • 77955715212 scopus 로고    scopus 로고
    • The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients
    • Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A et al. The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients. Eur J Cancer 2010; 46: 2304-2313.
    • (2010) Eur J Cancer , vol.46 , pp. 2304-2313
    • Pallante, P.1    Terracciano, L.2    Carafa, V.3    Schneider, S.4    Zlobec, I.5    Lugli, A.6
  • 135
    • 84894093372 scopus 로고    scopus 로고
    • Altered expression of polycomb group genes in glioblastoma multiforme
    • Li G, Warden C, Zou Z, Neman J, Krueger JS, Jain A et al. Altered expression of polycomb group genes in glioblastoma multiforme. PLoS ONE 2013; 8: e80970.
    • (2013) PLoS ONE , vol.8 , pp. e80970
    • Li, G.1    Warden, C.2    Zou, Z.3    Neman, J.4    Krueger, J.S.5    Jain, A.6
  • 137
  • 138
    • 0031049215 scopus 로고    scopus 로고
    • Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice
    • Core N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A et al. Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 1997; 124: 721-729.
    • (1997) Development , vol.124 , pp. 721-729
    • Core, N.1    Bel, S.2    Gaunt, S.J.3    Aurrand-Lions, M.4    Pearce, J.5    Fisher, A.6
  • 140
    • 23944494628 scopus 로고    scopus 로고
    • Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression
    • Katoh-Fukui Y, Owaki A, Toyama Y, Kusaka M, Shinohara Y, Maekawa M et al. Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Blood 2005; 106: 1612-1620.
    • (2005) Blood , vol.106 , pp. 1612-1620
    • Katoh-Fukui, Y.1    Owaki, A.2    Toyama, Y.3    Kusaka, M.4    Shinohara, Y.5    Maekawa, M.6
  • 142
    • 7044220120 scopus 로고    scopus 로고
    • Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice
    • Core N, Joly F, Boned A, Djabali M. Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice. Oncogene 2004; 23: 7660-7668.
    • (2004) Oncogene , vol.23 , pp. 7660-7668
    • Core, N.1    Joly, F.2    Boned, A.3    Djabali, M.4
  • 143
    • 84908885440 scopus 로고    scopus 로고
    • Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: Initial evidence of an oncogenic role
    • Clermont PL, Sun L, Crea F, Thu KL, Zhang A, Parolia A et al. Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role. Br J Cancer 2014; 111: 1663-1672.
    • (2014) Br J Cancer , vol.111 , pp. 1663-1672
    • Clermont, P.L.1    Sun, L.2    Crea, F.3    Thu, K.L.4    Zhang, A.5    Parolia, A.6
  • 144
    • 84901388312 scopus 로고    scopus 로고
    • Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma
    • Parris TZ, Aziz L, Kovacs A, Hajizadeh S, Nemes S, Semaan M et al. Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma. BMC Cancer 2014; 14: 324.
    • (2014) BMC Cancer , vol.14 , pp. 324
    • Parris, T.Z.1    Aziz, L.2    Kovacs, A.3    Hajizadeh, S.4    Nemes, S.5    Semaan, M.6
  • 145
    • 84892571659 scopus 로고    scopus 로고
    • Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma
    • Parris TZ, Kovacs A, Aziz L, Hajizadeh S, Nemes S, Semaan M et al. Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma. Int J Cancer 2014; 134: 1617-1629.
    • (2014) Int J Cancer , vol.134 , pp. 1617-1629
    • Parris, T.Z.1    Kovacs, A.2    Aziz, L.3    Hajizadeh, S.4    Nemes, S.5    Semaan, M.6
  • 146
    • 84892795727 scopus 로고    scopus 로고
    • Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma
    • Wang B, Tang J, Liao D, Wang G, Zhang M, Sang Y et al. Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma. Ann Surg Oncol 2013; 20: S684-S692.
    • (2013) Ann Surg Oncol , vol.20 , pp. S684-S692
    • Wang, B.1    Tang, J.2    Liao, D.3    Wang, G.4    Zhang, M.5    Sang, Y.6
  • 147
    • 84898421345 scopus 로고    scopus 로고
    • Cbx4 governs HIF-1alpha to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity
    • Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z et al. Cbx4 governs HIF-1alpha to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. Cancer Cell 2014; 25: 118-131.
    • (2014) Cancer Cell , vol.25 , pp. 118-131
    • Li, J.1    Xu, Y.2    Long, X.D.3    Wang, W.4    Jiao, H.K.5    Mei, Z.6
  • 148
    • 0037418829 scopus 로고    scopus 로고
    • The polycomb protein Pc2 is a SUMO E3
    • Kagey MH, Melhuish TA, Wotton D. The polycomb protein Pc2 is a SUMO E3. Cell 2003; 113: 127-137.
    • (2003) Cell , vol.113 , pp. 127-137
    • Kagey, M.H.1    Melhuish, T.A.2    Wotton, D.3
  • 149
    • 84878547644 scopus 로고    scopus 로고
    • MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells
    • Maethner E, Garcia-Cuellar MP, Breitinger C, Takacova S, Divoky V, Hess JL et al. MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells. Cell Rep 2013; 3: 1553-1566.
    • (2013) Cell Rep , vol.3 , pp. 1553-1566
    • Maethner, E.1    Garcia-Cuellar, M.P.2    Breitinger, C.3    Takacova, S.4    Divoky, V.5    Hess, J.L.6
  • 150
    • 84878220728 scopus 로고    scopus 로고
    • CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1
    • Lee SH, Um SJ, Kim EJ. CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1. Cancer Lett 2013; 335: 397-403.
    • (2013) Cancer Lett , vol.335 , pp. 397-403
    • Lee, S.H.1    Um, S.J.2    Kim, E.J.3
  • 151
    • 84876485242 scopus 로고    scopus 로고
    • Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
    • Klauke K, Radulovic V, Broekhuis M, Weersing E, Zwart E, Olthof S et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol 2013; 15: 353-362.
    • (2013) Nat Cell Biol , vol.15 , pp. 353-362
    • Klauke, K.1    Radulovic, V.2    Broekhuis, M.3    Weersing, E.4    Zwart, E.5    Olthof, S.6
  • 153
    • 79953311668 scopus 로고    scopus 로고
    • Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells
    • Vandamme J, Volkel P, Rosnoblet C, Le Faou P, Angrand PO. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics 2011; 10: M110.002642.
    • (2011) Mol Cell Proteomics , vol.10 , pp. M110002642
    • Vandamme, J.1    Volkel, P.2    Rosnoblet, C.3    Le Faou, P.4    Angrand, P.O.5
  • 154
    • 79953281617 scopus 로고    scopus 로고
    • Mapping cancer origins
    • Gilbertson RJ. Mapping cancer origins. Cell 2011; 145: 25-29.
    • (2011) Cell , vol.145 , pp. 25-29
    • Gilbertson, R.J.1
  • 155
    • 84921412405 scopus 로고    scopus 로고
    • Prolonged Ezh2 depletion in glioblastoma causes a robust switch in cell fate resulting in tumor progression
    • de Vries NA, Hulsman D, Akhtar W, de Jong J, Miles DC, Blom M et al. Prolonged Ezh2 depletion in glioblastoma causes a robust switch in cell fate resulting in tumor progression. Cell Rep 2015; 10: 383-397.
    • (2015) Cell Rep , vol.10 , pp. 383-397
    • De Vries, N.A.1    Hulsman, D.2    Akhtar, W.3    De Jong, J.4    Miles, D.C.5    Blom, M.6
  • 156
    • 84908321120 scopus 로고    scopus 로고
    • PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
    • De Raedt T, Beert E, Pasmant E, Luscan A, Brems H, Ortonne N et al. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature 2014; 514: 247-251.
    • (2014) Nature , vol.514 , pp. 247-251
    • De Raedt, T.1    Beert, E.2    Pasmant, E.3    Luscan, A.4    Brems, H.5    Ortonne, N.6
  • 157
    • 79251589918 scopus 로고    scopus 로고
    • Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer
    • Guo BH, Feng Y, Zhang R, Xu LH, Li MZ, Kung HF et al. Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer 2011; 10: 10.
    • (2011) Mol Cancer , vol.10 , pp. 10
    • Guo, B.H.1    Feng, Y.2    Zhang, R.3    Xu, L.H.4    Li, M.Z.5    Kung, H.F.6
  • 158
    • 36549060556 scopus 로고    scopus 로고
    • Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients
    • Silva J, Garcia V, Garcia JM, Pena C, Dominguez G, Diaz R et al. Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients. Breast Cancer Res 2007; 9: R55.
    • (2007) Breast Cancer Res , vol.9 , pp. R55
    • Silva, J.1    Garcia, V.2    Garcia, J.M.3    Pena, C.4    Dominguez, G.5    Diaz, R.6
  • 159
    • 33845800260 scopus 로고    scopus 로고
    • Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract
    • Tateishi K, Ohta M, Kanai F, Guleng B, Tanaka Y, Asaoka Y et al. Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract. Clin Cancer Res 2006; 12: 6960-6966.
    • (2006) Clin Cancer Res , vol.12 , pp. 6960-6966
    • Tateishi, K.1    Ohta, M.2    Kanai, F.3    Guleng, B.4    Tanaka, Y.5    Asaoka, Y.6
  • 160
    • 77953232638 scopus 로고    scopus 로고
    • Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer
    • Li DW, Tang HM, Fan JW, Yan DW, Zhou CZ, Li SX et al. Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer. J Cancer Res Clin Oncol 2010; 136: 997-1006.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 997-1006
    • Li, D.W.1    Tang, H.M.2    Fan, J.W.3    Yan, D.W.4    Zhou, C.Z.5    Li, S.X.6
  • 161
    • 33846982558 scopus 로고    scopus 로고
    • Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL
    • van Galen JC, Muris JJ, Oudejans JJ, Vos W, Giroth CP, Ossenkoppele GJ et al. Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL. J Clin Pathol 2007; 60: 167-172.
    • (2007) J Clin Pathol , vol.60 , pp. 167-172
    • Van Galen, J.C.1    Muris, J.J.2    Oudejans, J.J.3    Vos, W.4    Giroth, C.P.5    Ossenkoppele, G.J.6
  • 162
    • 39749120638 scopus 로고    scopus 로고
    • Bmi-1 expression predicts prognosis for patients with gastric carcinoma
    • Liu JH, Song LB, Zhang X, Guo BH, Feng Y, Li XX et al. Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol 2008; 97: 267-272.
    • (2008) J Surg Oncol , vol.97 , pp. 267-272
    • Liu, J.H.1    Song, L.B.2    Zhang, X.3    Guo, B.H.4    Feng, Y.5    Li, X.X.6
  • 163
    • 84896301545 scopus 로고    scopus 로고
    • Expression of B-cell-specific Moloney murine leukemia virus integration site 1 mRNA and protein in gastric cancer
    • Liu PW, Lin Y, Chen XY. Expression of B-cell-specific Moloney murine leukemia virus integration site 1 mRNA and protein in gastric cancer. J Dig Dis 2014; 15: 166-173.
    • (2014) J Dig Dis , vol.15 , pp. 166-173
    • Liu, P.W.1    Lin, Y.2    Chen, X.Y.3
  • 164
    • 77950657234 scopus 로고    scopus 로고
    • Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
    • Yang GF, He WP, Cai MY, He LR, Luo JH, Deng HX et al. Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma. BMC Cancer 2010; 10: 133.
    • (2010) BMC Cancer , vol.10 , pp. 133
    • Yang, G.F.1    He, W.P.2    Cai, M.Y.3    He, L.R.4    Luo, J.H.5    Deng, H.X.6
  • 165
    • 42049105538 scopus 로고    scopus 로고
    • Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues
    • Zhang F, Sui L, Xin T. Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues. Exp Oncol 2008; 30: 70-74.
    • (2008) Exp Oncol , vol.30 , pp. 70-74
    • Zhang, F.1    Sui, L.2    Xin, T.3
  • 166
    • 84874265490 scopus 로고    scopus 로고
    • Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma
    • Proctor E, Waghray M, Lee CJ, Heidt DG, Yalamanchili M, Li C et al. Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma. PLoS ONE 2013; 8: e55820.
    • (2013) PLoS ONE , vol.8 , pp. e55820
    • Proctor, E.1    Waghray, M.2    Lee, C.J.3    Heidt, D.G.4    Yalamanchili, M.5    Li, C.6
  • 167
    • 77954631291 scopus 로고    scopus 로고
    • Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer
    • Song W, Tao K, Li H, Jin C, Song Z, Li J et al. Bmi-1 is related to proliferation, survival and poor prognosis in pancreatic cancer. Cancer Sci 2010; 101: 1754-1760.
    • (2010) Cancer Sci , vol.101 , pp. 1754-1760
    • Song, W.1    Tao, K.2    Li, H.3    Jin, C.4    Song, Z.5    Li, J.6
  • 168
    • 34247560765 scopus 로고    scopus 로고
    • Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia
    • Chowdhury M, Mihara K, Yasunaga S, Ohtaki M, Takihara Y, Kimura A. Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia. Leukemia 2007; 21: 1116-1122.
    • (2007) Leukemia , vol.21 , pp. 1116-1122
    • Chowdhury, M.1    Mihara, K.2    Yasunaga, S.3    Ohtaki, M.4    Takihara, Y.5    Kimura, A.6
  • 169
    • 30144443995 scopus 로고    scopus 로고
    • Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis
    • Mihara K, Chowdhury M, Nakaju N, Hidani S, Ihara A, Hyodo H et al. Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis. Blood 2006; 107: 305-308.
    • (2006) Blood , vol.107 , pp. 305-308
    • Mihara, K.1    Chowdhury, M.2    Nakaju, N.3    Hidani, S.4    Ihara, A.5    Hyodo, H.6
  • 170
    • 79956145260 scopus 로고    scopus 로고
    • Overexpression of the EZH2 RING1 and BMI1 genes is common in myelodysplastic syndromes: Relation to adverse epigenetic alteration and poor prognostic scoring
    • Xu F, Li X, Wu L, Zhang Q, Yang R, Yang Y et al. Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring. Ann Hematol 2011; 90: 643-653.
    • (2011) Ann Hematol , vol.90 , pp. 643-653
    • Xu, F.1    Li, X.2    Wu, L.3    Zhang, Q.4    Yang, R.5    Yang, Y.6
  • 171
    • 33748951908 scopus 로고    scopus 로고
    • Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer
    • Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV. Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer. Cell Cycle 2006; 5: 1886-1901.
    • (2006) Cell Cycle , vol.5 , pp. 1886-1901
    • Berezovska, O.P.1    Glinskii, A.B.2    Yang, Z.3    Li, X.M.4    Hoffman, R.M.5    Glinsky, G.V.6
  • 172
    • 34250706864 scopus 로고    scopus 로고
    • Polycomb-group oncogenes EZH2 BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
    • van Leenders GJ, Dukers D, Hessels D, van den Kieboom SW, Hulsbergen CA, Witjes JA et al. Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features. Eur Urol 2007; 52: 455-463.
    • (2007) Eur Urol , vol.52 , pp. 455-463
    • Van Leenders, G.J.1    Dukers, D.2    Hessels, D.3    Van Den Kieboom, S.W.4    Hulsbergen, C.A.5    Witjes, J.A.6
  • 173
    • 34249692139 scopus 로고    scopus 로고
    • The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia
    • Mohty M, Yong AS, Szydlo RM, Apperley JF, Melo JV. The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia. Blood 2007; 110: 380-383.
    • (2007) Blood , vol.110 , pp. 380-383
    • Mohty, M.1    Yong, A.S.2    Szydlo, R.M.3    Apperley, J.F.4    Melo, J.V.5
  • 174
    • 84916920282 scopus 로고    scopus 로고
    • H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma
    • Chen S, Chen J, Zhan Q, Zhu Y, Chen H, Deng X et al. H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma. Oncotarget 2014; 5: 10421-10433.
    • (2014) Oncotarget , vol.5 , pp. 10421-10433
    • Chen, S.1    Chen, J.2    Zhan, Q.3    Zhu, Y.4    Chen, H.5    Deng, X.6
  • 175
    • 84917696389 scopus 로고    scopus 로고
    • RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo
    • Wang W, Cheng J, Qin JJ, Voruganti S, Nag S, Fan J et al. RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo. Oncotarget 2014; 5: 11604-11619.
    • (2014) Oncotarget , vol.5 , pp. 11604-11619
    • Wang, W.1    Cheng, J.2    Qin, J.J.3    Voruganti, S.4    Nag, S.5    Fan, J.6
  • 176
    • 84908208783 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: Another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression
    • Oh EJ, Yang WI, Cheong JW, Choi SE, Yoon SO. Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression. Hum Pathol 2014; 45: 2043-2050.
    • (2014) Hum Pathol , vol.45 , pp. 2043-2050
    • Oh, E.J.1    Yang, W.I.2    Cheong, J.W.3    Choi, S.E.4    Yoon, S.O.5
  • 178
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006; 24: 268-273.
    • (2006) J Clin Oncol , vol.24 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6
  • 179
    • 33644765912 scopus 로고    scopus 로고
    • Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
    • Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A et al. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res 2006; 12: 1168-1174.
    • (2006) Clin Cancer Res , vol.12 , pp. 1168-1174
    • Collett, K.1    Eide, G.E.2    Arnes, J.3    Stefansson, I.M.4    Eide, J.5    Braaten, A.6
  • 180
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003; 100: 11606-11611.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 181
    • 84907200746 scopus 로고    scopus 로고
    • Prognostic value of polycomb proteins EZH2 BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer
    • Benard A, Goossens-Beumer IJ, van Hoesel AQ, Horati H, Putter H, Zeestraten EC et al. Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer. PLoS ONE 2014; 9: e108265.
    • (2014) PLoS ONE , vol.9 , pp. e108265
    • Benard, A.1    Goossens-Beumer, I.J.2    Van Hoesel, A.Q.3    Horati, H.4    Putter, H.5    Zeestraten, E.C.6
  • 182
    • 79959267832 scopus 로고    scopus 로고
    • Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
    • Takawa M, Masuda K, Kunizaki M, Daigo Y, Takagi K, Iwai Y et al. Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Cancer Sci 2011; 102: 1298-1305.
    • (2011) Cancer Sci , vol.102 , pp. 1298-1305
    • Takawa, M.1    Masuda, K.2    Kunizaki, M.3    Daigo, Y.4    Takagi, K.5    Iwai, Y.6
  • 183
    • 77953176278 scopus 로고    scopus 로고
    • EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis
    • Wang CG, Ye YJ, Yuan J, Liu FF, Zhang H, Wang S. EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis. World J Gastroenterol 2010; 16: 2421-2427.
    • (2010) World J Gastroenterol , vol.16 , pp. 2421-2427
    • Wang, C.G.1    Ye, Y.J.2    Yuan, J.3    Liu, F.F.4    Zhang, H.5    Wang, S.6
  • 184
    • 58149214373 scopus 로고    scopus 로고
    • Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2
    • Ougolkov AV, Bilim VN, Billadeau DD. Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin Cancer Res 2008; 14: 6790-6796.
    • (2008) Clin Cancer Res , vol.14 , pp. 6790-6796
    • Ougolkov, A.V.1    Bilim, V.N.2    Billadeau, D.D.3
  • 185
    • 84890308623 scopus 로고    scopus 로고
    • EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma
    • Behrens C, Solis LM, Lin H, Yuan P, Tang X, Kadara H et al. EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma. Clin Cancer Res 2013; 19: 6556-6565.
    • (2013) Clin Cancer Res , vol.19 , pp. 6556-6565
    • Behrens, C.1    Solis, L.M.2    Lin, H.3    Yuan, P.4    Tang, X.5    Kadara, H.6
  • 186
    • 84878548632 scopus 로고    scopus 로고
    • Quantitative analysis of EZH2 expression and its correlations with lung cancer patients' clinical pathological characteristics
    • Wan L, Li X, Shen H, Bai X. Quantitative analysis of EZH2 expression and its correlations with lung cancer patients' clinical pathological characteristics. Clin Transl Oncol 2013; 15: 132-138.
    • (2013) Clin Transl Oncol , vol.15 , pp. 132-138
    • Wan, L.1    Li, X.2    Shen, H.3    Bai, X.4
  • 187
    • 79958219307 scopus 로고    scopus 로고
    • EZH2 protein: A promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies
    • Cai MY, Tong ZT, Zheng F, Liao YJ, Wang Y, Rao HL et al. EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut 2011; 60: 967-976.
    • (2011) Gut , vol.60 , pp. 967-976
    • Cai, M.Y.1    Tong, Z.T.2    Zheng, F.3    Liao, Y.J.4    Wang, Y.5    Rao, H.L.6
  • 188
    • 84896727282 scopus 로고    scopus 로고
    • Prognostic value of EZH2 expression and activity in renal cell carcinoma: A prospective study
    • Liu L, Xu Z, Zhong L, Wang H, Jiang S, Long Q et al. Prognostic value of EZH2 expression and activity in renal cell carcinoma: a prospective study. PLoS ONE 2013; 8: e81484.
    • (2013) PLoS ONE , vol.8 , pp. e81484
    • Liu, L.1    Xu, Z.2    Zhong, L.3    Wang, H.4    Jiang, S.5    Long, Q.6
  • 189
  • 190
    • 84928572472 scopus 로고    scopus 로고
    • The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors
    • Zingg D, Debbache J, Schaefer SM, Tuncer E, Frommel SC, Cheng P et al. The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors. Nat Commun 2015; 6: 6051.
    • (2015) Nat Commun , vol.6 , pp. 6051
    • Zingg, D.1    Debbache, J.2    Schaefer, S.M.3    Tuncer, E.4    Frommel, S.C.5    Cheng, P.6
  • 192
    • 77957193274 scopus 로고    scopus 로고
    • Clinical significance of Polycomb gene expression in brain tumors
    • Crea F, Hurt EM, Farrar WL. Clinical significance of Polycomb gene expression in brain tumors. Mol Cancer 2010; 9: 265.
    • (2010) Mol Cancer , vol.9 , pp. 265
    • Crea, F.1    Hurt, E.M.2    Farrar, W.L.3
  • 193
    • 84908666344 scopus 로고    scopus 로고
    • PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
    • Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada CN, Lin M et al. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet 2014; 46: 1227-1232.
    • (2014) Nat Genet , vol.46 , pp. 1227-1232
    • Lee, W.1    Teckie, S.2    Wiesner, T.3    Ran, L.4    Prieto Granada, C.N.5    Lin, M.6
  • 194
    • 84865863019 scopus 로고    scopus 로고
    • K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    • Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol 2012; 124: 439-447.
    • (2012) Acta Neuropathol , vol.124 , pp. 439-447
    • Khuong-Quang, D.A.1    Buczkowicz, P.2    Rakopoulos, P.3    Liu, X.Y.4    Fontebasso, A.M.5    Bouffet, E.6


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