BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Zhang, Xiao Wei ^a,b   Sheng, Ya Ping ^c   Li, Qian ^c   Qin, Wei ^d   Lu, You Wei ^a,b   Cheng, Yu Fan ^a,b   Liu, Bing Ya ^e   Zhang, Feng Chun ^d   Li, Jin ^a,b   Dimri, Goberdhan P ^f   Guo, Wei Jian ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e Shanghai Institute of Digestive Surgery   (China)

^f NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; MEL 18 PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN P16; SHORT HAIRPIN RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; BMI1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; NUCLEAR PROTEIN; ONCOPROTEIN; PCGF2 PROTEIN, HUMAN; REPRESSOR PROTEIN; TUMOR MARKER;

ADULT; ADVANCED CANCER; ARTICLE; CANCER CELL CULTURE; CANCER STAGING; CELL MIGRATION; CELL ONCOGENE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; FEMALE; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; PHENOTYPE; PROGNOSIS; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; UPREGULATION; AGED; CELL AGING; CELL MOTION; CELL TRANSFORMATION; DISEASE COURSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; STOMACH TUMOR; TUMOR CELL LINE;

MAMMALIA;

AGED; CELL AGING; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PHOSPHORYLATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77951206723     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-40     Document Type: Article

References (36)

1. Gil J, Bernard D, Peters G. Role of polycomb group proteins in stem cell self-renewal and cancer. DNA and Cell Biol 2005, 24:117-125.
2. Kim JH, Yoon SY, Jeong SH, Kim SY, Moon SK, Joo JH, Lee Y, Choe IS, Kim JW. Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast 2004, 13:383-388. 10.1016/j.breast.2004.02.010, 15454193.
3. Kim JH, Yoon SY, Kim CN, Joo JH, Moon SK, Choe IS, Choe YK, Kim JW. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. Cancer Lett 2004, 203:217-224. 10.1016/j.canlet.2003.07.009, 14732230.
4. Song LB, Zeng MS, Liao WT, Zhang L, Mo HY, Liu WL, Shao JY, Wu QL, Li MZ, Xia YF, Fu LW, Huang WL, Dimri GP, Band V, Zeng YX. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res 2006, 66:6225-6232. 10.1158/0008-5472.CAN-06-0094, 16778197.
5. Mihic-Probst D, Kuster A, Kilgus S, Bode-Lesniewska B, Ingold-Heppner B, Leung C, Storz M, Seifert B, Marino S, Schraml P, Dummer R, Moch H. Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma. Int J Cancer 2007, 121:1764-1770. 10.1002/ijc.22891, 17597110.
6. Liu JH, Song LB, Zhang X, Guo BH, Feng Y, Li XX, Liao WT, Zeng MS, Huang KH. Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol 2008, 97:267-272. 10.1002/jso.20934, 18041745.
7. Qin ZK, Yang JA, Ye YL, Zhang X, Xu LH, Zhou FJ, Han H, Liu ZW, Song LB, Zeng MS. Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer 2009, 9:61-67. 10.1186/1471-2407-9-61, 2652492, 19228380.
8. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003, 423:255-260. 10.1038/nature01572, 12714970.
9. Park I, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003, 423:302-305. 10.1038/nature01587, 12714971.
10. Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006, 66:6063-6071. 10.1158/0008-5472.CAN-06-0054, 16778178.
11. Dimri GP. What has senescence got to do with cancer?. Cancer Cell 2005, 7:505-512. 10.1016/j.ccr.2005.05.025, 1769521, 15950900.
12. Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol 2003, 23:389-401. 10.1128/MCB.23.1.389-401.2003, 140680, 12482990.
13. Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, Van Lohuizen M, Campisi J, Wazer DE, Band V. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 2002, 62:4736-4745.
14. Guo WJ, Datta S, Band V, Dimri GP. Mel-18, a Polycomb Group Protein Regulates Cell Proliferation and Senescence via Transcriptional Repression of Bmi-1 and c-Myc Oncoproteins. Mol Biol Cell 2007, 18:536-546. 10.1091/mbc.E06-05-0447, 1783768, 17151361.
15. Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and downregulating Akt activity in breast cancer cells. Cancer Res 2007, 67:5083-5089. 10.1158/0008-5472.CAN-06-4368, 2386662, 17545584.
16. Kajiume T, Ohno N, Sera Y, Kawahara Y, Yuge L, Kobayashi M. Reciprocal expression of Bmi1 and Mel-18 is associated with the functioning of primitive hematopoietic cells. Exp Hematol 2009, 37:857-866. 10.1016/j.exphem.2009.04.011, 19409954.
17. Lee JY, Jang KS, Shin DH, Oh MY, Kim HJ, Kim Y, Kong G. Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer. Cancer Res 2008, 68:4201-4209. 10.1158/0008-5472.CAN-07-2570, 18519679.
18. Tetsu O, Ishihara H, Kanno R, Kamiyasu M, Inoue H, Tokuhisa T, Taniguchi M, Kanno M. Mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity 1998, 9:439-448. 10.1016/S1074-7613(00)80627-5, 9806630.
19. Wang W, Lin T, Huang J, Hu W, Xu K, Liu J. Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features. Urol Oncol 2009,
20. Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD. Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. Mol Cell Biol 2007, 27:4968-4979. 10.1128/MCB.02244-06, 1951487, 17452456.
21. Silva J, García JM, Peña C, García V, Domínguez G, Suárez D, Camacho FI, Espinosa R, Provencio M, España P, Bonilla F. Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. Clin Cancer Res 2006, 12:6929-6936. 10.1158/1078-0432.CCR-06-0788, 17145810.
22. Dimri GP, Itahana K, Acosta M, Campisi J. Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol 2000, 20:273-285. 10.1128/MCB.20.1.273-285.2000, 85083, 10594030.
23. Hao JH, Gu QL, Liu BY, Li JF, Chen XH, Ji YB, Zhu ZG, Lin YZ. Inhibition of the proliferation of human gastric cancer cells SGC-7901 in vitro and in vivo using Bcl-2 siRNA. Chin Med J (Engl) 2007, 120:2105-2111.
24. Datta S, Hoenerhoff MJ, Bommi P, Sainger R, Guo WJ, Dimri M, Band H, Band V, Green JE, Dimri GP. Bmi-1 Cooperates with H-Ras to Transform Human Mammary Epithelial Cells via Dysregulation of Multiple Growth-Regulatory Pathways. Cancer Res 2007, 67:10286-10295. 10.1158/0008-5472.CAN-07-1636, 2424172, 17974970.
25. Wang Q, Li WL, You P, Su J, Zhu MH, Xie DF, Zhu HY, He ZY, Li JX, Ding XY, Wang X, Hu YP. Oncoprotein BMI-1 induces the malignant transformation of HaCaT cells. J Cell Biochem 2009, 106:16-24. 10.1002/jcb.21969, 19021148.
26. Boukarabila H, Saurin AJ, Batsché E, Mossadegh N, van Lohuizen M, Otte AP, Pradel J, Muchardt C, Sieweke M, Duprez E. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev 2009, 23:1195-1206. 10.1101/gad.512009, 2685534, 19451220.
27. Bhattacharya R, Nicoloso M, Arvizo R, Wang E, Cortez A, Rossi S, Calin GA, Mukherjee P. MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer. Cancer Res 2009, 69:9090-9095. 10.1158/0008-5472.CAN-09-2552, 19903841.
28. Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 2008, 68:9125-9130. 10.1158/0008-5472.CAN-08-2629, 19010882.
29. Zhao J, Luo XD, Da CL, Xin Y. Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion. World J Gastroenterol 2009, 15:2145-2150. 10.3748/wjg.15.2145, 2678586, 19418588.
30. Douglas D, Hsu JH, Hung L, Cooper A, Abdueva D, van Doorninck J, Peng G, Shimada H, Triche TJ, Lawlor ER. BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression. Cancer Res 2008, 68:6507-6515. 10.1158/0008-5472.CAN-07-6152, 2570201, 18701473.
31. Luo D, Zhang B, Lv L, Xiang S, Liu Y, Ji J, Deng D. Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas. Lab Invest 2006, 86:591-598.
32. Fu ZJ, Ma ZY, Wang QR, Lei DP, Wang R, Liu CX, Pan XL. Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node metastases in laryngeal squamous cell carcinoma in Chinese patients. Clin Exp Metastasis 2008, 25:887-892. 10.1007/s10585-008-9207-x, 18787961.
33. Schulz P, Scholz A, Rexin A, Hauff P, Schirner M, Wiedenmann B, Detjen K. Inducible re-expression of p16 in an orthotopic mouse model of pancreatic cancer inhibits lymphangiogenesis and lymphatic metastasis. Br J Cancer 2008, 99:110-117. 10.1038/sj.bjc.6604457, 2453030, 18577984.
34. Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005, 171:1023-1234. 10.1083/jcb.200505087, 2171329, 16365168.
35. Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH, Evers BM. Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci USA 2008, 105:20315-20320. 10.1073/pnas.0810715105, 2629319, 19075230.
36. Kim EK, Yun SJ, Do KH, Kim MS, Cho M, Suh DS, Kim CD, Kim JH, Birnbaum MJ, Bae SS. Lysophosphatidic acid induces cell migration through the selective activation of Akt1. Exp Mol Med 2008, 40:445-452. 10.3858/emm.2008.40.4.445, 2679274, 18779657.