SCOPUS 정보 검색 플랫폼

Volumn 210, Issue 12, 2013, Pages 2627-2639

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

(20) Muto, Tomoya a,b Sashida, Goro a,c Oshima, Motohiko a,c Wendt, George R a,i Mochizuki Kashio, Makiko a,c Nagata, Yasunobu d Sanada, Masashi d Miyagi, Satoru a,c Saraya, Atsunori a,c Kamio, Asuka e Nagae, Genta e Nakaseko, Chiaki a,b Yokote, Koutaro a Shimoda, Kazuya f Koseki, Haruhiko c,g Suzuki, Yutaka h Sugano, Sumio h Aburatani, Hiroyuki e Ogawa, Seishi d Iwama, Atsushi a,c

a CHIBA UNIVERSITY (Japan)

b CHIBA UNIVERSITY HOSPITAL (Japan)

c JAPAN SCIENCE AND TECHNOLOGY AGENCY (Japan)

d UNIVERSITY OF TOKYO (Japan)

e UNIVERSITY OF TOKYO (Japan)

f UNIVERSITY OF MIYAZAKI (Japan)

g Institute of Physical and Chemical Research (Japan)

h UNIVERSITY OF TOKYO (Japan)

i ITO Foundation for International Education Exchange (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA METHYLTRANSFERASE 3A; GUANOSINE PHOSPHATE; ISOCITRATE DEHYDROGENASE 1; PROTEIN; TET METHYLCYTOSINE DIOXYGENASE 2; TRANSCRIPTION FACTOR EZH1; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASXL1 GENE; BAP1 GENE; CELL COUNT; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME 7; CHROMOSOME 7Q; CHROMOSOME ABERRATION; CHRONIC MYELOMONOCYTIC LEUKEMIA; COHORT ANALYSIS; DISEASE COURSE; EXTRAMEDULLARY HEMATOPOIESIS; GAIN OF FUNCTION MUTATION; GENE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENOME ANALYSIS; HEMATOLOGIC DISEASE; HEMATOPOIETIC STEM CELL; INDEL MUTATION; MOUSE; MULTIPOTENT STEM CELL; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATOR GENE; SOMATIC MUTATION; THROMBOCYTE COUNT;

ANIMALS; COHORT STUDIES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENOME-WIDE ASSOCIATION STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; MYELODYSPLASTIC SYNDROMES; MYELOPROLIFERATIVE DISORDERS; POLYCOMB REPRESSIVE COMPLEX 2; PROTO-ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84888083126 PISSN: 00221007 EISSN: 15409538 Source Type: Journal
DOI: 10.1084/jem.20131144 Document Type: Article

Times cited : (159)

References (37)

1
- 79960227474
- Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
- Abdel-Wahab, O., A. Pardanani, J. Patel, M. Wadleigh, T. Lasho, A. Heguy, M. Beran, D.G. Gilliland, R.L. Levine, and A. Tefferi. 2011. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia. 25:1200-1202. http://dx.doi.org/10 .1038/leu.2011.58
- (2011) Leukemia. , vol.25 , pp. 1200-1202
- Abdel-Wahab, O.¹ Pardanani, A.² Patel, J.³ Wadleigh, M.⁴ Lasho, T.⁵ Heguy, A.⁶ Beran, M.⁷ Gilliland, D.G.⁸ Levine, R.L.⁹ Tefferi, A.¹⁰

2
- 84865152223
- ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
- Abdel-Wahab, O., M. Adli, L.M. LaFave, J. Gao, T. Hricik, A.H. Shih, S. Pandey, J.P. Patel, Y.R. Chung, R. Koche, et al. 2012. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 22:180-193. http://dx.doi.org/10 .1016/j.ccr.2012.06.032
- (2012) Cancer Cell. , vol.22 , pp. 180-193
- Abdel-Wahab, O.¹ Adli, M.² LaFave, L.M.³ Gao, J.⁴ Hricik, T.⁵ Shih, A.H.⁶ Pandey, S.⁷ Patel, J.P.⁸ Chung, Y.R.⁹ Koche, R.¹⁰

3
- 79959794787
- Clinical effect of point mutations in myelodysplastic syndromes
- Bejar, R., K. Stevenson, O. Abdel-Wahab, N. Galili, B. Nilsson, G. Garcia-Manero, H. Kantarjian, A. Raza, R.L. Levine, D. Neuberg, and B.L. Ebert. 2011. Clinical effect of point mutations in myelodysplastic syndromes. N. Engl. J. Med. 364:2496-2506. http://dx.doi.org/10.1056/NEJMoa1013343
- (2011) N. Engl. J. Med. , vol.364 , pp. 2496-2506
- Bejar, R.¹ Stevenson, K.² Abdel-Wahab, O.³ Galili, N.⁴ Nilsson, B.⁵ Garcia-Manero, G.⁶ Kantarjian, H.⁷ Raza, A.⁸ Levine, R.L.⁹ Neuberg, D.¹⁰ Ebert, B.L.¹¹

4
- 33646070846
- A bivalent chromatin structure marks key developmental genes in embryonic stem cells
- Bernstein, B.E., T.S. Mikkelsen, X. Xie, M. Kamal, D.J. Huebert, J. Cuff, B. Fry, A. Meissner, M. Wernig, K. Plath, et al. 2006. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 125:315-326. http://dx.doi.org/10.1016/j.cell.2006.02.041
- (2006) Cell. , vol.125 , pp. 315-326
- Bernstein, B.E.¹ Mikkelsen, T.S.² Xie, X.³ Kamal, M.⁴ Huebert, D.J.⁵ Cuff, J.⁶ Fry, B.⁷ Meissner, A.⁸ Wernig, M.⁹ Plath, K.¹⁰

5
- 84555207349
- Dnmt3a is essential for hematopoietic stem cell differentiation
- Challen, G.A., D. Sun, M. Jeong, M. Luo, J. Jelinek, J.S. Berg, C. Bock, A. Vasanthakumar, H. Gu, Y. Xi, et al. 2012. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat. Genet. 44:23-31. http://dx.doi.org/10.1038/ng.1009
- (2012) Nat. Genet. , vol.44 , pp. 23-31
- Challen, G.A.¹ Sun, D.² Jeong, M.³ Luo, M.⁴ Jelinek, J.⁵ Berg, J.S.⁶ Bock, C.⁷ Vasanthakumar, A.⁸ Gu, H.⁹ Xi, Y.¹⁰

6
- 54049118823
- Oncogenic mutations of ALK kinase in neuroblastoma
- Chen, Y., J. Takita, Y.L. Choi, M. Kato, M. Ohira, M. Sanada, L. Wang, M. Soda, A. Kikuchi, T. Igarashi, et al. 2008. Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 455:971-974. http://dx.doi .org/10.1038/nature07399
- (2008) Nature. , vol.455 , pp. 971-974
- Chen, Y.¹ Takita, J.² Choi, Y.L.³ Kato, M.⁴ Ohira, M.⁵ Sanada, M.⁶ Wang, L.⁷ Soda, M.⁸ Kikuchi, A.⁹ Igarashi, T.¹⁰

7
- 84868157863
- Epigenetic alterations in hematopoietic malignancies
- Chung, Y.R., E. Schatoff, and O. Abdel-Wahab. 2012. Epigenetic alterations in hematopoietic malignancies. Int. J. Hematol. 96:413-427. http://dx.doi.org/10.1007/s12185-012-1181-z
- (2012) Int. J. Hematol. , vol.96 , pp. 413-427
- Chung, Y.R.¹ Schatoff, E.² Abdel-Wahab, O.³

8
- 84866467141
- Loss of the tumor suppressor BAP1 causes myeloid transformation
- Dey, A., D. Seshasayee, R. Noubade, D.M. French, J. Liu, M.S. Chaurushiya, D.S. Kirkpatrick, V.C. Pham, J.R. Lill, C.E. Bakalarski, et al. 2012. Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 337:1541-1546. http://dx.doi.org/10.1126/science.1221711
- (2012) Science , vol.337 , pp. 1541-1546
- Dey, A.D.¹ Seshasayee, R.² Noubade, D.M.³ French, J.⁴ Liu, M.S.⁵ Chaurushiya, D.S.⁶ Kirkpatrick, V.C.⁷ Pham, J.R.⁸ Lill, C.E.⁹ Bakalarski et, al.¹⁰

9
- 77955085750
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- Ernst, T., A.J. Chase, J. Score, C.E. Hidalgo-Curtis, C. Bryant, A.V. Jones, K. Waghorn, K. Zoi, F.M. Ross, A. Reiter, et al. 2010. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat. Genet. 42:722-726. http://dx.doi.org/10.1038/ng.621
- (2010) Nat. Genet. , vol.42 , pp. 722-726
- Ernst, T.¹ Chase, A.J.² Score, J.³ Hidalgo-Curtis, C.E.⁴ Bryant, C.⁵ Jones, A.V.⁶ Waghorn, K.⁷ Zoi, K.⁸ Ross, F.M.⁹ Reiter, A.¹⁰

10
- 84856746717
- Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
- Herrera-Merchan, A., L. Arranz, J.M. Ligos, A. de Molina, O. Dominguez, and S. Gonzalez. 2012. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Nat Commun. 3:623. http://dx.doi.org/10.1038/ncomms1623
- (2012) Nat Commun. , vol.3 , pp. 623
- Herrera-Merchan, A.¹ Arranz, L.² Ligos, J.M.³ De Molina, A.⁴ Dominguez, O.⁵ Gonzalez, S.⁶

11
- 84868340057
- Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest
- Hidalgo, I., A. Herrera-Merchan, J.M. Ligos, L. Carramolino, J. Nuñez, F. Martinez, O. Dominguez, M. Torres, and S. Gonzalez. 2012. Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest. Cell Stem Cell. 11:649-662. http://dx.doi .org/10.1016/j.stem.2012.08.001
- (2012) Cell Stem Cell. , vol.11 , pp. 649-662
- Hidalgo, I.¹ Herrera-Merchan, A.² Ligos, J.M.³ Carramolino, L.⁴ Nuñez, J.⁵ Martinez, F.⁶ Dominguez, O.⁷ Torres, M.⁸ Gonzalez, S.⁹

12
- 77957757417
- A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
- Kim, J., A.J. Woo, J. Chu, J.W. Snow, Y. Fujiwara, C.G. Kim, A.B. Cantor, and S.H. Orkin. 2010. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 143:313-324. http://dx.doi.org/10.1016/j.cell.2010.09.010
- (2010) Cell. , vol.143 , pp. 313-324
- Kim, J.¹ Woo, A.J.² Chu, J.³ Snow, J.W.⁴ Fujiwara, Y.⁵ Kim, C.G.⁶ Cantor, A.B.⁷ Orkin, S.H.⁸

13
- 78650175023
- Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
- Ko, M., Y. Huang, A.M. Jankowska, U.J. Pape, M. Tahiliani, H.S. Bandukwala, J. An, E.D. Lamperti, K.P. Koh, R. Ganetzky, et al. 2010. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 468:839-843. http://dx.doi.org/10.1038/nature09586
- (2010) Nature. , vol.468 , pp. 839-843
- Ko, M.¹ Huang, Y.² Jankowska, A.M.³ Pape, U.J.⁴ Tahiliani, M.⁵ Bandukwala, H.S.⁶ An, J.⁷ Lamperti, E.D.⁸ Koh, K.P.⁹ Ganetzky, R.¹⁰

14
- 77954910364
- Role of the polycomb group proteins in hematopoietic stem cells
- Konuma, T., H. Oguro, and A. Iwama. 2010. Role of the polycomb group proteins in hematopoietic stem cells. Dev. Growth Differ. 52:505-516. http://dx.doi.org/10.1111/j.1440-169X.2010.01191.x
- (2010) Dev. Growth Differ. , vol.52 , pp. 505-516
- Konuma, T.¹ Oguro, H.² Iwama, A.³

15
- 55449105221
- Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
- Ku, M., R.P. Koche, E. Rheinbay, E.M. Mendenhall, M. Endoh, T.S. Mikkelsen, A. Presser, C. Nusbaum, X. Xie, A.S. Chi, et al. 2008. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 4:e1000242. http://dx.doi.org/10.1371/journal.pgen.1000242
- (2010) PLoS Genet. , vol.4
- Ku, M.¹ Koche, R.P.² Rheinbay, E.³ Mendenhall, E.M.⁴ Endoh, M.⁵ Mikkelsen, T.S.⁶ Presser, A.⁷ Nusbaum, C.⁸ Xie, X.⁹ Chi, A.S.¹⁰

16
- 84874444936
- PBX3 is an important cofactor of HOXA9 in leukemogenesis
- Li, Z., Z. Zhang, Y. Li, S. Arnovitz, P. Chen, H. Huang, X. Jiang, G.M. Hong, R.B. Kunjamma, H. Ren, et al. 2013. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 121:1422-1431 http://dx.doi.org/10.1182/blood-2012-07-442004
- (2013) Blood , vol.121 , pp. 1422-1431
- Li, Z.¹ Zhang, Z.² Li, Y.³ Arnovitz, S.⁴ Chen, P.⁵ Huang, H.⁶ Jiang, X.⁷ Hong, G.M.⁸ Kunjamma, R.B.⁹ Ren, H.¹⁰

17
- 84055218931
- Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
- Mochizuki-Kashio, M., Y. Mishima, S. Miyagi, M. Negishi, A. Saraya, T. Konuma, J. Shinga, H. Koseki, and A. Iwama. 2011. Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood. 118:6553-6561. http://dx.doi.org/10.1182/blood-2011-03-340554
- (2011) Blood. , vol.118 , pp. 6553-6561
- Mochizuki-Kashio, M.¹ Mishima, Y.² Miyagi, S.³ Negishi, M.⁴ Saraya, A.⁵ Konuma, T.⁶ Shinga, J.⁷ Koseki, H.⁸ Iwama, A.⁹

18
- 79960064353
- Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
- Moran-Crusio, K., L. Reavie, A. Shih, O. Abdel-Wahab, D. Ndiaye-Lobry, C. Lobry, M.E. Figueroa, A. Vasanthakumar, J. Patel, X. Zhao, et al. 2011. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 20:11-24. http://dx.doi.org/10.1016/j.ccr.2011.06.001
- (2011) Cancer Cell. , vol.20 , pp. 11-24
- Moran-Crusio, K.¹ Reavie, L.² Shih, A.³ Abdel-Wahab, O.⁴ Ndiaye-Lobry, D.⁵ Lobry, C.⁶ Figueroa, M.E.⁷ Vasanthakumar, A.⁸ Patel, J.⁹ Zhao, X.¹⁰

19
- 75749124332
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- Morin, R.D., N.A. Johnson, T.M. Severson, A.J. Mungall, J. An, R. Goya, J.E. Paul, M. Boyle, B.W. Woolcock, F. Kuchenbauer, et al. 2010. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat. Genet. 42:181-185. http://dx.doi.org/10.1038/ng.518
- (2010) Nat. Genet. , vol.42 , pp. 181-185
- Morin, R.D.¹ Johnson, N.A.² Severson, T.M.³ Mungall, A.J.⁴ An, J.⁵ Goya, R.⁶ Paul, J.E.⁷ Boyle, M.⁸ Woolcock, B.W.⁹ Kuchenbauer, F.¹⁰

20
- 22244453416
- A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays
- Nannya, Y., M. Sanada, K. Nakazaki, N. Hosoya, L. Wang, A. Hangaishi, M. Kurokawa, S. Chiba, D.K. Bailey, G.C. Kennedy, and S. Ogawa. 2005. A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res. 65:6071-6079. http://dx.doi.org/10.1158/0008-5472.CAN-05-0465
- (2005) Cancer Res. , vol.65 , pp. 6071-6079
- Nannya, Y.¹ Sanada, M.² Nakazaki, K.³ Hosoya, N.⁴ Wang, L.⁵ Hangaishi, A.⁶ Kurokawa, M.⁷ Chiba, S.⁸ Bailey, D.K.⁹ Kennedy, G.C.¹⁰ Ogawa, S.¹¹

21
- 84859475727
- Polycomb repressive complex 2 is required for MLL-AF9 leukemia
- Neff, T., A.U. Sinha, M.J. Kluk, N. Zhu, M.H. Khattab, L. Stein, H. Xie, S.H. Orkin, and S.A. Armstrong. 2012. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc. Natl. Acad. Sci. USA. 109:5028-5033. http://dx.doi.org/10.1073/pnas.1202258109
- (2012) Proc. Natl. Acad. Sci. USA. , vol.109 , pp. 5028-5033
- Neff, T.¹ Sinha, A.U.² Kluk, M.J.³ Zhu, N.⁴ Khattab, M.H.⁵ Stein, L.⁶ Xie, H.⁷ Orkin, S.H.⁸ Armstrong, S.A.⁹

22
- 77955087290
- Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
- Nikoloski, G., S.M. Langemeijer, R.P. Kuiper, R. Knops, M. Massop, E.R. Tönnissen, A. van der Heijden, T.N. Scheele, P. Vandenberghe, T. de Witte, et al. 2010. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat. Genet. 42:665-667. http://dx.doi.org/10.1038/ng.620
- (2010) Nat. Genet. , vol.42 , pp. 665-667
- Nikoloski, G.¹ Langemeijer, S.M.² Kuiper, R.P.³ Knops, R.⁴ Massop, M.⁵ Tönnissen, E.R.⁶ Van Der Heijden, A.⁷ Scheele, T.N.⁸ Vandenberghe, P.⁹ De Witte, T.¹⁰

23
- 33749350639
- Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice
- Oguro, H., A. Iwama, Y. Morita, T. Kamijo, M. van Lohuizen, and H. Nakauchi. 2006. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J. Exp. Med. 203:2247-2253. http://dx.doi.org/10.1084/jem.20052477
- (2006) J. Exp. Med. , vol.203 , pp. 2247-2253
- Oguro, H.¹ Iwama, A.² Morita, Y.³ Kamijo, T.⁴ Van Lohuizen, M.⁵ Nakauchi, H.⁶

24
- 77449159608
- Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1
- Oguro, H., J. Yuan, H. Ichikawa, T. Ikawa, S. Yamazaki, H. Kawamoto, H. Nakauchi, and A. Iwama. 2010. Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell. 6:279-286. http://dx.doi.org/10 .1016/j.stem.2010.01.005
- (2010) Cell Stem Cell. , vol.6 , pp. 279-286
- Oguro, H.¹ Yuan, J.² Ichikawa, H.³ Ikawa, T.⁴ Yamazaki, S.⁵ Kawamoto, H.⁶ Nakauchi, H.⁷ Iwama, A.⁸

25
- 84860364648
- Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes
- Oguro, H., J. Yuan, S. Tanaka, S. Miyagi, M. Mochizuki-Kashio, H. Ichikawa, S. Yamazaki, H. Koseki, H. Nakauchi, and A. Iwama. 2012. Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes. J. Exp. Med. 209:445-454. http://dx.doi.org/10.1084/jem.20111709
- (2012) J. Exp. Med. , vol.209 , pp. 445-454
- Oguro, H.¹ Yuan, J.² Tanaka, S.³ Miyagi, S.⁴ Mochizuki-Kashio, M.⁵ Ichikawa, H.⁶ Yamazaki, S.⁷ Koseki, H.⁸ Nakauchi, H.⁹ Iwama, A.¹⁰

26
- 0037314097
- Matrix2png: a utility for visualizing matrix data
- Pavlidis, P., and W.S. Noble. 2003. Matrix2png: a utility for visualizing matrix data. Bioinformatics. 19:295-296. http://dx.doi.org/10.1093/bioinformatics/19.2.295
- (2003) Bioinformatics. , vol.19 , pp. 295-296
- Pavlidis, P.¹ Noble, W.S.²

27
- 33846057724
- NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
- Pruitt, K.D., T. Tatusova, and D.R. Maglott. 2007. NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res. 35:D61-D65. http://dx.doi.org/10.1093/nar/gkl842
- (2007) Nucleic Acids Res. , vol.35
- Pruitt, K.D.¹ Tatusova, T.² Maglott, D.R.³

28
- 84870221419
- The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes
- Raza, A., and N. Galili. 2012. The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes. Nat. Rev. Cancer. 12:849-859. http://dx.doi.org/10.1038/nrc3321
- (2012) Nat. Rev. Cancer. , vol.12 , pp. 849-859
- Raza, A.¹ Galili, N.²

29
- 84865520089
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- Sasaki, M., C.B. Knobbe, J.C. Munger, E.F. Lind, D. Brenner, A. Brüstle, I.S. Harris, R. Holmes, A. Wakeham, J. Haight, et al. 2012. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 488:656-659. http://dx.doi.org/10.1038/nature11323
- (2012) Nature. , vol.488 , pp. 656-659
- Sasaki, M.¹ Knobbe, C.B.² Munger, J.C.³ Lind, E.F.⁴ Brenner, D.⁵ Brüstle, A.⁶ Harris, I.S.⁷ Holmes, R.⁸ Wakeham, A.⁹ Haight, J.¹⁰

30
- 77956222562
- Polycomb group proteins: multifaceted regulators of somatic stem cells and cancer
- Sauvageau, M., and G. Sauvageau. 2010. Polycomb group proteins: multifaceted regulators of somatic stem cells and cancer. Cell Stem Cell. 7:299-313. http://dx.doi.org/10.1016/j.stem.2010.08.002
- (2010) Cell Stem Cell. , vol.7 , pp. 299-313
- Sauvageau, M.¹ Sauvageau, G.²

31
- 55949124844
- EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
- Shen, X., Y. Liu, Y.J. Hsu, Y. Fujiwara, J. Kim, X. Mao, G.C. Yuan, and S.H. Orkin. 2008. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell. 32:491-502. http://dx.doi.org/10.1016/j.molcel.2008.10.016
- (2008) Mol. Cell. , vol.32 , pp. 491-502
- Shen, X.¹ Liu, Y.² Hsu, Y.J.³ Fujiwara, Y.⁴ Kim, J.⁵ Mao, X.⁶ Yuan, G.C.⁷ Orkin, S.H.⁸

32
- 84867403602
- TET2 is essential for survival and hematopoietic stem cell homeostasis
- Shide, K., T. Kameda, H. Shimoda, T. Yamaji, H. Abe, A. Kamiunten, M. Sekine, T. Hidaka, K. Katayose, Y. Kubuki, et al. 2012. TET2 is essential for survival and hematopoietic stem cell homeostasis. Leukemia. 26:2216-2223. http://dx.doi.org/10.1038/leu.2012.94
- (2012) Leukemia. , vol.26 , pp. 2216-2223
- Shide, K.¹ Kameda, T.² Shimoda, H.³ Yamaji, T.⁴ Abe, H.⁵ Kamiunten, A.⁶ Sekine, M.⁷ Hidaka, T.⁸ Katayose, K.⁹ Kubuki, Y.¹⁰

33
- 84866378702
- The role of mutations in epigenetic regulators in myeloid malignancies
- Shih, A.H., O. Abdel-Wahab, J.P. Patel, and R.L. Levine. 2012. The role of mutations in epigenetic regulators in myeloid malignancies. Nat. Rev. Cancer. 12:599-612. http://dx.doi.org/10.1038/nrc3343
- (2012) Nat. Rev. Cancer. , vol.12 , pp. 599-612
- Shih, A.H.¹ Abdel-Wahab, O.² Patel, J.P.³ Levine, R.L.⁴

34
- 27344435774
- Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles
- Subramanian, A., P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E.S. Lander, and J.P. Mesirov. 2005. Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA. 102:15545-15550. http://dx.doi. org/10.1073/pnas.0506580102
- (2005) Proc. Natl. Acad. Sci. USA. , vol.102 , pp. 15545-15550
- Subramanian, A.¹ Tamayo, P.² Mootha, V.K.³ Mukherjee, S.⁴ Ebert, B.L.⁵ Gillette, M.A.⁶ Paulovich, A.⁷ Pomeroy, S.L.⁸ Golub, T.R.⁹ Lander, E.S.¹⁰ Mesirov, J.P.¹¹

35
- 84864567410
- Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
- Tanaka, S., S. Miyagi, G. Sashida, T. Chiba, J. Yuan, M. Mochizuki-Kashio, Y. Suzuki, S. Sugano, C. Nakaseko, K. Yokote, et al. 2012. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood. 120:1107-1117. http://dx.doi.org/10.1182/blood-2011-11-394932
- (2012) Blood. , vol.120 , pp. 1107-1117
- Tanaka, S.¹ Miyagi, S.² Sashida, G.³ Chiba, T.⁴ Yuan, J.⁵ Mochizuki-Kashio, M.⁶ Suzuki, Y.⁷ Sugano, S.⁸ Nakaseko, C.⁹ Yokote, K.¹⁰

36
- 77953079694
- Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes
- Tremblay, M., C.S. Tremblay, S. Herblot, P.D. Aplan, J. Hébert, C. Perreault, and T. Hoang. 2010. Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev. 24:1093-1105. http://dx.doi.org/10.1101/gad.1897910
- (2010) Genes Dev. , vol.24 , pp. 1093-1105
- Tremblay, M.¹ Tremblay, C.S.² Herblot, S.³ Aplan, P.D.⁴ Hébert, J.⁵ Perreault, C.⁶ Hoang, T.⁷

37
- 34347229790
- Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays
- Yamamoto, G., Y. Nannya, M. Kato, M. Sanada, R.L. Levine, N. Kawamata, A. Hangaishi, M. Kurokawa, S. Chiba, D.G. Gilliland, et al. 2007. Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am. J. Hum. Genet. 81:114-126. http://dx.doi.org/10.1086/518809
- (2007) Am. J. Hum. Genet. , vol.81 , pp. 114-126
- Yamamoto, G.¹ Nannya, Y.² Kato, M.³ Sanada, M.⁴ Levine, R.L.⁵ Kawamata, N.⁶ Hangaishi, A.⁷ Kurokawa, M.⁸ Chiba, S.⁹ Gilliland, D.G.¹⁰

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.