-
1
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell. Res. 1961, 25:585-621.
-
(1961)
Exp. Cell. Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley C.B., Futcher A.B., Greider G.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, G.W.3
-
4
-
-
0037086268
-
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
-
te Poele R.H., Okorokov A.L., Jardine L., Cummings J., Joel S.P. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 2002, 62:1876-1883.
-
(2002)
Cancer Res.
, vol.62
, pp. 1876-1883
-
-
te Poele, R.H.1
Okorokov, A.L.2
Jardine, L.3
Cummings, J.4
Joel, S.P.5
-
6
-
-
0000133469
-
Defining cellular senescence in IMR-90 cells: a flow cytometric analysis
-
Sherwood S.W., Rush D., Ellsworth J.L., Schimke R.T. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Natl. Acad. Sci. USA 1998, 85:9086-9090.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 9086-9090
-
-
Sherwood, S.W.1
Rush, D.2
Ellsworth, J.L.3
Schimke, R.T.4
-
7
-
-
84869216902
-
Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment
-
Kim B.C., Lee H.C., Lee J.J., Choi C.M., Kim D.K., Lee J.C., Ko Y.G., Lee J.S. Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment. EMBO J. 2012, 31:4289-4303.
-
(2012)
EMBO J.
, vol.31
, pp. 4289-4303
-
-
Kim, B.C.1
Lee, H.C.2
Lee, J.J.3
Choi, C.M.4
Kim, D.K.5
Lee, J.C.6
Ko, Y.G.7
Lee, J.S.8
-
8
-
-
56649085322
-
SIRT1: roles in aging and cancer
-
Kim E.J., Um S.J. SIRT1: roles in aging and cancer. BMB Rep. 2008, 41:751-756.
-
(2008)
BMB Rep.
, vol.41
, pp. 751-756
-
-
Kim, E.J.1
Um, S.J.2
-
10
-
-
0034703217
-
Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Lin S.J., Defossez P.A., Guarente L. Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae. Science 2000, 289:2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
11
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001, 410:227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
12
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B., Helfand D.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 2004, 101:15998-16003.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, D.L.2
-
13
-
-
0032750220
-
Diverse and dynamic functions of the Sir silencing complex
-
Guarente L. Diverse and dynamic functions of the Sir silencing complex. Nat. Genet. 1999, 23:281-285.
-
(1999)
Nat. Genet.
, vol.23
, pp. 281-285
-
-
Guarente, L.1
-
14
-
-
79956331962
-
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
-
Back J.H., Rezvani H.R., Zhu Y., Guyonnet-Duperat V., Athar M., Ratner D., Kim A.L. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1. J. Biol. Chem. 2011, 286:19100-19108.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 19100-19108
-
-
Back, J.H.1
Rezvani, H.R.2
Zhu, Y.3
Guyonnet-Duperat, V.4
Athar, M.5
Ratner, D.6
Kim, A.L.7
-
15
-
-
84861831957
-
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
-
Yao H., Chung S., Hwang J.W., Rajendrasozhan S., Sundar I.K., Dean D.A., McBurney M.W., Guarente L., Gu W., Rönty M., Kinnula V.L., Rahman I. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J. Clin. Invest. 2012, 122:2032-2045.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 2032-2045
-
-
Yao, H.1
Chung, S.2
Hwang, J.W.3
Rajendrasozhan, S.4
Sundar, I.K.5
Dean, D.A.6
McBurney, M.W.7
Guarente, L.8
Gu, W.9
Rönty, M.10
Kinnula, V.L.11
Rahman, I.12
-
16
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E., Pearson M., Faretta M., Bauer U.M., Frye R.A., Minucci S., Pelicci P.G., Kouzarides T. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 2002, 21:2383-2396.
-
(2002)
EMBO J.
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
Pearson, M.2
Faretta, M.3
Bauer, U.M.4
Frye, R.A.5
Minucci, S.6
Pelicci, P.G.7
Kouzarides, T.8
-
17
-
-
30544445468
-
Sirt1 inhibitor
-
Ota H., Tokunaga E., Chang K., Hikasa M., Iijima K., Eto M., Kozaki K., Akishita M., Ouchi Y., Kaneki M. Sirt1 inhibitor. Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells, Oncogene 2006, 25:176-185.
-
(2006)
Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells, Oncogene
, vol.25
, pp. 176-185
-
-
Ota, H.1
Tokunaga, E.2
Chang, K.3
Hikasa, M.4
Iijima, K.5
Eto, M.6
Kozaki, K.7
Akishita, M.8
Ouchi, Y.9
Kaneki, M.10
-
18
-
-
70449787940
-
Polycomb group complexes-many combinations, many functions
-
Kerppola T.K. Polycomb group complexes-many combinations, many functions. Trends Cell Biol. 2009, 19:692-704.
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 692-704
-
-
Kerppola, T.K.1
-
19
-
-
0019369234
-
A gene product required for correct initiation of segmental determination in Drosophila
-
Struhl G. A gene product required for correct initiation of segmental determination in Drosophila. Nature 1981, 293:36-41.
-
(1981)
Nature
, vol.293
, pp. 36-41
-
-
Struhl, G.1
-
20
-
-
39149130361
-
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
-
Jaenisch R., Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008, 132:567-582.
-
(2008)
Cell
, vol.132
, pp. 567-582
-
-
Jaenisch, R.1
Young, R.2
-
21
-
-
33750379420
-
Polycomb silencers control cell fate, development and Cancer
-
Sparmann A., Lohuizen M. Polycomb silencers control cell fate, development and Cancer. Nat. Rev. Cancer 2006, 6:846-856.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 846-856
-
-
Sparmann, A.1
Lohuizen, M.2
-
22
-
-
0034666145
-
HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties
-
Bardos J.I., Saurin A.J., Tissot C., Duprez E., Freemont P.S. HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. J. Biol. Chem. 2000, 275:28785-28792.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28785-28792
-
-
Bardos, J.I.1
Saurin, A.J.2
Tissot, C.3
Duprez, E.4
Freemont, P.S.5
-
23
-
-
0035945657
-
The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3
-
García-Cuéllar M.P., Zilles O., Schreiner S.A., Birke M., Winkler T.H., Slany R.K. The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. Oncogene 2001, 20:411-419.
-
(2001)
Oncogene
, vol.20
, pp. 411-419
-
-
García-Cuéllar, M.P.1
Zilles, O.2
Schreiner, S.A.3
Birke, M.4
Winkler, T.H.5
Slany, R.K.6
-
24
-
-
0035963288
-
The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias
-
Hemenway C.S., de Erkenez A.C., Gould G.C. The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. Oncogene 2001, 20:3798-3805.
-
(2001)
Oncogene
, vol.20
, pp. 3798-3805
-
-
Hemenway, C.S.1
de Erkenez, A.C.2
Gould, G.C.3
-
25
-
-
33947576177
-
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
-
Dietrich N., Bracken A.P., Trinh E., Schjerling C.K., Koseki H., Rappsilber J., Helin K., Hansen K.H. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J. 2007, 26:1637-1648.
-
(2007)
EMBO J.
, vol.26
, pp. 1637-1648
-
-
Dietrich, N.1
Bracken, A.P.2
Trinh, E.3
Schjerling, C.K.4
Koseki, H.5
Rappsilber, J.6
Helin, K.7
Hansen, K.H.8
-
26
-
-
35349011726
-
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
-
Kim E.J., Kho J.H., Kang M.R., Um S.J. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol. Cell 2007, 28:277-290.
-
(2007)
Mol. Cell
, vol.28
, pp. 277-290
-
-
Kim, E.J.1
Kho, J.H.2
Kang, M.R.3
Um, S.J.4
-
27
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., Peacocke M., Campisi J. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 1995, 92:9363-9367.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
Peacocke, M.11
Campisi, J.12
-
28
-
-
34547812030
-
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
-
Lee H.K., Park U.H., Kim E.J., Um S.J. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J. 2007, 26:3545-3557.
-
(2007)
EMBO J.
, vol.26
, pp. 3545-3557
-
-
Lee, H.K.1
Park, U.H.2
Kim, E.J.3
Um, S.J.4
-
29
-
-
77955735894
-
S-phase lengthening induced by p16(INK4a) overexpression in malignant cells with wild-type pRb and p53
-
Chien W.W., Domenech C., Catallo R., Salles G., Ffrench M. S-phase lengthening induced by p16(INK4a) overexpression in malignant cells with wild-type pRb and p53. Cell Cycle 2010, 9:3286-3296.
-
(2010)
Cell Cycle
, vol.9
, pp. 3286-3296
-
-
Chien, W.W.1
Domenech, C.2
Catallo, R.3
Salles, G.4
Ffrench, M.5
-
30
-
-
33645768490
-
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
-
Pruitt K., Zinn R.L., Ohm J.E., McGarvey K.M., Kang S.H., Watkins D.N., Herman J.G., Baylin S.B. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet. 2006, 2:e40.
-
(2006)
PLoS Genet.
, vol.2
-
-
Pruitt, K.1
Zinn, R.L.2
Ohm, J.E.3
McGarvey, K.M.4
Kang, S.H.5
Watkins, D.N.6
Herman, J.G.7
Baylin, S.B.8
-
31
-
-
36248954501
-
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
-
Vaquero A., Scher M., Erdjument-Bromage H., Tempst P., Serrano L., Reinberg D. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 2007, 450:440-444.
-
(2007)
Nature
, vol.450
, pp. 440-444
-
-
Vaquero, A.1
Scher, M.2
Erdjument-Bromage, H.3
Tempst, P.4
Serrano, L.5
Reinberg, D.6
-
32
-
-
7244234099
-
Role of histone H2A ubiquitination in polycomb silencing
-
Wang H., Wang L., Erdjument-Bromage H., Vidal M., Tempst P., Jones R.S., Zhang Y. Role of histone H2A ubiquitination in polycomb silencing. Nature 2004, 431:873-878.
-
(2004)
Nature
, vol.431
, pp. 873-878
-
-
Wang, H.1
Wang, L.2
Erdjument-Bromage, H.3
Vidal, M.4
Tempst, P.5
Jones, R.S.6
Zhang, Y.7
-
33
-
-
1342332096
-
Polycomb CBX7 has a unifying role in cellular lifespan
-
Gil J., Bernard D., Martínez D., Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat. Cell Biol. 2004, 6:67-72.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 67-72
-
-
Gil, J.1
Bernard, D.2
Martínez, D.3
Beach, D.4
|