Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3

Genes to Cells

Volumn 12, Issue 12, 2007, Pages 1371-1382

  Miki, Jun ^a   Fujimura, Yu Ichi ^b   Koseki, Haruhiko ^b   Kamijo, Takehiko ^a,c  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Institute of Physical and Chemical Research   (Japan)

^c CHIBA CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; GENE PRODUCT; PROTEIN MEL18; PROTEIN P53; PROTEIN RING1B; TRANSCRIPTION FACTOR E2F3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL AGING; CELL CULTURE; CONTROLLED STUDY; FIBROBLAST; GENE DELETION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL AGING; E2F3 TRANSCRIPTION FACTOR; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION REGULATION; MICE; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEIN P53;

EID: 36749098443     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2007.01135.x     Document Type: Article

References (33)

1. Akasaka, T., Kanno, M., Balling, R., Mieza, M.A., Taniguchi, M. & Koseki, H. (1996) A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development 122, 1513-1522.
2. Aslanian, A., Iaquinta, P.J., Verona, R. & Lees, J.A. (2004) Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev. 23, 1413-1422.
3. Cao, R., Tsukada, Y. & Zhang Y. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20, 845-854.
4. Core, N., Bel, S., Gaunt, S.J., Aurrand-Lions, M., Pearce, J., Fisher, A. & Djabali, M. (1997) Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 124, 721-729.
5. Core, N., Joly, F., Boned, A. & Djabali, M. (2004) Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice. Oncogene 23, 7660-7668.
6. Fujimura, Y., Isono, K., Vidal, M., Endoh, M., Kajita, H., Mizutani-Koseki, Y., Takihara, Y., van Lohuizen, M., Otte, A., Jenuwein, T., Deschamps, J. & Koseki, H. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133, 2371-2381.
7. Gondo, Y., Nakamura, K., Nakao, K., Sasaoka, T., Ito, K., Kimura, M. & Katsuki, M. (1994) Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination. Biochem. Biophys. Res. Commun. 202, 830-837.
8. Hernandez-Munoz, I., Lund, A.H., van der Stoop, P., Boutsma, E., Muijrers, I., Verhoeven, E., Nusinow, D.A., Panning, B., Marahrens, Y. & van Lohuizen. M. (2005) Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/ SPOP ubiquitin E3 ligase. Proc. Natl. Acad. Sci. USA 102, 7635-7640.
9. Humbert, P.O., Verona, R., Trimarchi, J.M., Rogers, C., Dandapani, S. & Lees, J.A. (1998) E2f3 is critical for normal cellular proliferation. Genes Dev. 12, 690-703.
10. Isono, K., Fujimura, Y., Shinga, J., Yamaki, M., O-Wang, J., Takihara, Y., Murahashi, Y., Takada, Y., Mizutani-Koseki, Y. & Koseki, H. (2005) Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol. Cell. Biol. 25, 6694-6706.
11. Itahana, K., Zou, Y., Itahana, Y., Martinez, J.L., Beausejour, C., Jacobs, J.J., Van Lohuizen, M., Band, V., Campisi, J. & Dimri, G.P. (2003) Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell. Biol. 23, 389-401.
12. Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., van Lohuizen, M. & Nakauchi, H. (2004) Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 21, 843-851.
13. Jacobs, J.J. & van Lohuizen, M. (2002) Polycomb repression: From cellular memory to cellular proliferation and cancer. Biochim. Biophys. Acta 1602, 151-161.
14. Jacobs, J.J., Kieboom, K., Marino, S., DePinho, R.A. & van Lohuizen, M. (1999) The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-168.
15. Kamijo, T., Weber, J.D., Zambetti, G., Zindy, F., Roussel, M.F. & Sherr, C.J. (1998) Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. USA 95, 8292-8297.
16. Kamijo, T., Zindy, F., Roussel, M.F., Quelle, D.E., Downing, J.R., Ashmun, R.A., Grosveld, G. & Sherr, C.J. (1997) Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649-659.
17. Kanno, M., Hasegawa, M., Ishida, A., Isono, K. & Taniguchi, M. (1995) mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J. 14, 5672-5678.
18. Leone, G., DeGregori. J., Yan. Z., Jakoi. L., Ishida, S., Williams, R.S. & Nevins, J.R. (1998) E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev. 12, 2120-2130.
19. Lessard, J., Schumacher, A., Thorsteinsdottir, U., van Lohuizen, M., Magnuson, T. & Sauvageau, G. (1999) Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev. 13, 2691-2703.
20. Levine, S.S., King, I.F. & Kingston, R.E. (2004) Division of labor in polycomb group repression. Trends Biochem. Sci. 29, 478-485.
21. Machida, T., Fujita, T., Ooo, M.L., Ohira, M., Isogai, E., Mihara, M., Hirato, J., Tomotsune, D., Hirata, T., Fujimori, M., Adachi, W. & Nakagawara, A. (2006) Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas. Oncogene 25, 1931-1942.
22. Nakazawa, Y., Kamijo, T., Koike, K. & Noda, T. (2003) ARF tumor suppressor induces mitochondria-dependent apoptosis by modulation of mitochondrial Bcl-2 family proteins. J. Biol. Chem. 278, 27888-27895.
23. Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D.M. & Nakatani, Y. (2002) A complex with chromatin modifiers that occupies E2F-and Myc-responsive genes in G0 cells. Science 296, 1132-1136.
24. Ohta, H., Sawada, A., Kim, J.Y., Tokimasa, S., Nishiguchi, S., Humphries, R.K., Hara, J. & Takihara, Y. (2002) Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. J. Exp. Med. 195, 759-770.
25. Park, I.K., Qian, D., Kiel, M., Becker, M.W., Pihalja, M., Weissman, I.L., Morrison, S.J. & Clarke, M.F. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423, 302-305.
26. Pohlers, M., Truss, M., Frede, U., Scholz, A., Strehle, M., Kuban, R.J., Hoffmann, B., Morkel, M., Birchmeier, C. & Hagemeier, C. (2005) A role for E2F6 in the restriction of male-germ-cell-specific gene expression. Curr Biol. 15, 1051-1057.
27. Sears, R.C. & Nevins, J.R. (2002) Signaling networks that link cell proliferation and cell fate. J. Biol. Chem. 277, 11617-11620.
28. Sherr, C.J. & DePinho, R.A. (2000) Cellular senescence: Mitotic clock or culture shock? Cell 102, 407-410.
29. Suzuki, M., Mizutani-Koseki, Y., Fujimura, Y., Miyagishima, H., Kaneko, T., Takada, Y., Akasaka, T., Tanzawa, H., Takihara, Y., Nakano, M., Masumoto, H., Vidal, M., Isono, K. & Koseki, H. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129, 4171-4183.
30. Trimarchi, J.M., Fairchild, B., Wen, J. & Lees, J.A. (2001) The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc. Natl. Acad. Sci. USA 98, 1519-1524.
31. van der Lugt, N.M., Domen, J., Linders, K., van Roon, M., Robanus-Maandag, E., te Riele, H., van der Valk, M., Deschamps, J., Sofroniew, M., van Lohuizen, M. & Berns, A. (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8, 757-769.
32. Wang, H., Wang, L., Erdjument-Bromage, H., Vidal, M., Tempst, P., Jones, R.S. & Zhang, Y. (2004) Role of histone H2A ubiquitination in Polycomb silencing. Nature 431, 873-878.
33. Zindy, F., Eischen, C.M., Randle, D.H., Kamijo, T., Cleveland, J.L., Sherr, C.J. & Roussel, M.F. (1998) Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12, 2424-2433.