MicroRNA regulation of Cbx7 mediates a switch of polycomb orthologs during ESC differentiation

Cell Stem Cell

Volumn 10, Issue 1, 2012, Pages 33-46

  O'Loghlen, Ana ^a   Muñoz Cabello, Ana M ^a   Gaspar Maia, Alexandre ^b   Wu, Hsan Au ^b   Banito, Ana ^a   Kunowska, Natalia ^a   Racek, Tomas ^c   Pemberton, Helen N ^c   Beolchi, Patrizia ^a   Lavial, Fabrice ^a   Masui, Osamu ^d   Vermeulen, Michiel ^e,f   Carroll, Thomas ^a   Graumann, Johannes ^e,g   Heard, Edith ^d   Dillon, Niall ^a   Azuara, Veronique ^a   Snijders, Ambrosius P ^a   Peters, Gordon ^c   Bernstein, Emily ^b   Gil, Jesus ^a   more..

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c CRUK London Research Institute   (United Kingdom)

^d INSTITUT CURIE   (France)

^e MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g WEILL CORNELL MEDICAL COLLEGE   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; ALPHA TUBULIN; BETA ACTIN; BETA TUBULIN; MICRORNA; OCTAMER TRANSCRIPTION FACTOR 4; POLYCOMB GROUP PROTEIN; PROTEIN CBX2; PROTEIN CBX4; PROTEIN CBX6; PROTEIN CBX7; PROTEIN CBX8; PROTEIN PRC1; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL RENEWAL; CHROMATIN; CONTROLLED STUDY; DOWN REGULATION; DROSOPHILA; EMBRYONIC STEM CELL; GENOME; HUMAN; HUMAN CELL; MULTIGENE FAMILY; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; X CHROMOSOME INACTIVATION;

ANIMALS; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, X; DOWN-REGULATION; EMBRYONIC STEM CELLS; HUMANS; MICE; MICRORNAS; REPRESSOR PROTEINS; X CHROMOSOME INACTIVATION;

MAMMALIA;

EID: 84862908896     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2011.12.004     Document Type: Article

References (33)

1. Azuara, V., Perry, P., Sauer, S., Spivakov, M., Jørgensen, H.F., John, R.M., Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M., and Fisher, A.G. (2006). Chromatin signatures of pluripotent cell lines. Nat. Cell Biol. 8, 532-538.
2. Banito, A., Rashid, S.T., Acosta, J.C., Li, S., Pereira, C.F., Geti, I., Pinho, S., Silva, J.C., Azuara, V., Walsh, M., et al. (2009). Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 23, 2134-2139.
3. Bernstein, B.E., Mikkelsen, T.S., Xie, X., Kamal, M., Huebert, D.J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006a). A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326.
4. Bernstein, E., Duncan, E.M., Masui, O., Gil, J., Heard, E., and Allis, C.D. (2006b). Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol. Cell. Biol. 26, 2560-2569.
5. Boyer, L.A., Lee, T.I., Cole, M.F., Johnstone, S.E., Levine, S.S., Zucker, J.P., Guenther, M.G., Kumar, R.M., Murray, H.L., Jenner, R.G., et al. (2005). Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947-956. (Pubitemid 41345211)
6. Boyer, L.A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L.A., Lee, T.I., Levine, S.S., Wernig, M., Tajonar, A., Ray, M.K., et al. (2006). Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-353. (Pubitemid 44050199)
7. Bracken, A.P., Dietrich, N., Pasini, D., Hansen, K.H., and Helin, K. (2006). Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20, 1123-1136.
8. Brodersen, P., and Voinnet, O. (2009). Revisiting the principles of microRNA target recognition and mode of action. Nat. Rev. Mol. Cell Biol. 10, 141-148.
9. Caretti, G., Di Padova, M., Micales, B., Lyons, G.E., and Sartorelli, V. (2004). The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 18, 2627-2638. (Pubitemid 39453102)
10. Chen, C.Z., Li, L., Lodish, H.F., and Bartel, D.P. (2004). MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83-86. (Pubitemid 38055775)
11. Dietrich, N., Bracken, A.P., Trinh, E., Schjerling, C.K., Koseki, H., Rappsilber, J., Helin, K., and Hansen, K.H. (2007). Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J. 26, 1637-1648. (Pubitemid 46480949)
12. Gil, J., Bernard, D., Martínez, D., and Beach, D. (2004). Polycomb CBX7 has a unifying role in cellular lifespan. Nat. Cell Biol. 6, 67-72. (Pubitemid 38425732)
13. Glud, M., Manfé, V., Biskup, E., Holst, L., Dirksen, A.M., Hastrup, N., Nielsen, F.C., Drzewiecki, K.T., and Gniadecki, R. (2011). MicroRNA miR-125b induces senescence in human melanoma cells. Melanoma Res. 21, 253-256.
14. He, L., and Hannon, G.J. (2004). MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. 5, 522-531. (Pubitemid 38868508)
15. Juan, A.H., Kumar, R.M., Marx, J.G., Young, R.A., and Sartorelli, V. (2009). Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol. Cell 36, 61-74.
16. Le, M.T., Xie, H., Zhou, B., Chia, P.H., Rizk, P., Um, M., Udolph, G., Yang, H., Lim, B., and Lodish, H.F. (2009). MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol. Cell. Biol. 29, 5290-5305.
17. Lee, T.I., Jenner, R.G., Boyer, L.A., Guenther, M.G., Levine, S.S., Kumar, R.M., Chevalier, B., Johnstone, S.E., Cole, M.F., Isono, K., et al. (2006). Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125, 301-313. (Pubitemid 44313811)
18. Leeb, M., Pasini, D., Novatchkova, M., Jaritz, M., Helin, K., and Wutz, A. (2010). Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev. 24, 265-276.
19. Maertens, G.N., El Messaoudi-Aubert, S., Racek, T., Stock, J.K., Nicholls, J., Rodriguez-Niedenführ, M., Gil, J., and Peters, G. (2009). Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS ONE 4, e6380.
20. Marson, A., Levine, S.S., Cole, M.F., Frampton, G.M., Brambrink, T., Johnstone, S., Guenther, M.G., Johnston, W.K., Wernig, M., Newman, J., et al. (2008). Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 134, 521-533.
21. Masui, O., Bonnet, I., Le Baccon, P., Brito, I., Pollex, T., Murphy, N., Hupé, P., Barillot, E., Belmont, A.S., and Heard, E. (2011). Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation. Cell 145, 447-458.
22. Melton, C., and Blelloch, R. (2010). MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation. Adv. Exp. Med. Biol. 695, 105-117.
23. Mikkelsen, T.S., Ku, M., Jaffe, D.B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.K., Koche, R.P., et al. (2007). Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448, 553-560. (Pubitemid 47206934)
24. Morey, L., and Helin, K. (2010). Polycomb group protein-mediated repression of transcription. Trends Biochem. Sci. 35, 323-332.
25. Naguibneva, I., Ameyar-Zazoua, M., Polesskaya, A., Ait-Si-Ali, S., Groisman, R., Souidi, M., Cuvellier, S., and Harel-Bellan, A. (2006). The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat. Cell Biol. 8, 278-284. (Pubitemid 43336070)
26. Rybak, A., Fuchs, H., Smirnova, L., Brandt, C., Pohl, E.E., Nitsch, R., and Wulczyn, F.G. (2008). A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat. Cell Biol. 10, 987-993.
27. Sen, G.L., Webster, D.E., Barragan, D.I., Chang, H.Y., and Khavari, P.A. (2008). Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev. 22, 1865-1870. (Pubitemid 352008635)
28. Simon, J.A., and Kingston, R.E. (2009). Mechanisms of polycomb gene silencing: knowns and unknowns. Nat. Rev. Mol. Cell Biol. 10, 697-708.
29. Sparmann, A., and van Lohuizen, M. (2006). Polycomb silencers control cell fate, development and cancer. Nat. Rev. Cancer 6, 846-856. (Pubitemid 44629896)
30. Vermeulen, M., Eberl, H.C., Matarese, F., Marks, H., Denissov, S., Butter, F., Lee, K.K., Olsen, J.V., Hyman, A.A., Stunnenberg, H.G., and Mann, M. (2010). Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142, 967-980.
31. Voorhoeve, P.M., le Sage, C., Schrier, M., Gillis, A.J., Stoop, H., Nagel, R., Liu, Y.P., van Duijse, J., Drost, J., Griekspoor, A., et al. (2006). A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124, 1169-1181.
32. Whitcomb, S.J., Basu, A., Allis, C.D., and Bernstein, E. (2007). Polycomb Group proteins: an evolutionary perspective. Trends Genet. 23, 494-502. (Pubitemid 47503450)
33. Yap, K.L., Li, S., Muñoz-Cabello, A.M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M.J., and Zhou, M.M. (2010). Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol. Cell 38, 662-674.