Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features

Urologic Oncology: Seminars and Original Investigations

Volumn 29, Issue 3, 2011, Pages 244-251

  Wang, Wei ^a,b   Lin, Tianxin ^a   Huang, Jian ^a   Hu, Weilie ^b   Xu, Kewei ^a   Liu, Jun ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Immunohistochemistry; Mel 18; Prognosis; Progression; Prostate cancer

Indexed keywords

BMI1 PROTEIN; MEL 18 PROTEIN; MESSENGER RNA; MYC PROTEIN; POLYCOMB GROUP PROTEIN; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; AGE; AGED; ARTICLE; BONE METASTASIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GLEASON SCORE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ONCOGENE C MYC; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROSTATECTOMY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SURVIVAL TIME;

AGED; AGED, 80 AND OVER; BONE NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NUCLEAR PROTEINS; POLYMORPHISM, GENETIC; PROGNOSIS; PROSTATECTOMY; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE;

EID: 79955745647     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2009.02.004     Document Type: Article

References (19)

1. Sparmann A., van Lohuizen M. Polycomb silencers control cell fate, development, and cancer. Nat Rev Cancer 2006, 6:846-856.
2. Goebl M.G. The bmi-1 and mel-18 gene products define a new family of DNA-binding proteins involved in cell proliferation and tumorigenesis. Cell 1991, 66:623.
3. Tagawa M., Sakamoto T., Shigemoto K., et al. Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. J Biol Chem 1990, 265:20021-20026.
4. Kanno M., Hasegawa M., Ishida A., et al. mel-18, a polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J 1995, 14:5672-5678.
5. Silva J., García J.M., Peña C., et al. Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. Clin Cancer Res 2006, 12:6929-6936.
6. Guo W.J., Zeng M.S., Yadav A., et al. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res 2007, 67:5083-5089.
7. Guo W.J., Datta S., Band V., et al. Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell 2007, 18:536-546.
8. Zheng S.L., Sun J., Wiklund F., et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med 2008, 358:910-919.
9. Sun J., Chang B.L., Isaacs S.D., et al. Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations. Prostate 2008, 68:1257-1262.
10. Kanno M., Hasegawa M., Ishida A., et al. Mel-18, a polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J 1995, 14:5672-5678.
11. Nogawa M., Yuasa T., Kimura S., et al. Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. J Clin Invest 2005, 115:978-985.
12. Raaphorst F.M. Deregulated expression of polycomb group oncogenes in human malignant lymphomas and epithelial tumours. Hum Mol Genet 2005, 14:93-100.
13. Gil J., Bernard D., Peters G. Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol 2005, 24:117-125.
14. Glinsky G.V., Berezovska O., Glinskii A.B. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 2005, 115:1503-1521.
15. Mohty M., Yong A.S., Szydlo R.M., et al. The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia. Blood 2007, 110:380-383.
16. Ishida A., Asano H., Hasegawa M., et al. Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new "RING-finger" motif. Gene 1993, 129:249-255.
17. Lee J.Y., Jang K.S., Shin D.H., et al. Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer. Cancer Res 2008, 68:4201-4209.
18. Quinn D.I., Henshall S.M., Sutherland R.L. Molecular markers of prostate cancer outcome. Eur J Cancer 2005, 41:858-887.
19. Gurel B., Iwata T., Koh C.M., et al. Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets. Adv Anat Pathol 2008, 15:319-331.