Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Nature Medicine

Volumn 18, Issue 2, 2012, Pages 296-301

  Ntziachristos, Panagiotis ^a,b   Tsirigos, Aristotelis ^c   Vlierberghe, Pieter Van ^d   Nedjic, Jelena ^a,b   Trimarchi, Thomas ^a,b   Flaherty, Maria Sol ^d   Ferres Marco, Dolors ^e   Da Ros, Vanina ^e   Tang, Zuojian ^a   Siegle, Jasmin ^a,b   Asp, Patrik ^b   Hadler, Michael ^d   Rigo, Isaura ^d   De Keersmaecker, Kim ^f,g   Patel, Jay ^h   Huynh, Tien ^c   Utro, Filippo ^c   Poglio, Sandrine ^i,j,k,l   Samon, Jeremy B ^d   Paietta, Elisabeth ^m   Racevskis, Janis ^m   Rowe, Jacob M ⁿ   Rabadan, Raul ^o   Levine, Ross L ^h   Brown, Stuart ^a   Pflumio, Francoise ^i,j,k,l   Dominguez, Maria ^e   Ferrando, Adolfo ^d   Aifantis, Iannis ^a,b   more..

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c IBM T J WATSON RESEARCH CENTER   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^f DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^g UNIVERSITY OF LEUVEN   (Belgium)

^h MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

ⁱ Universite Paris Sud   (France)

^j INSERM   (France)

^k UNIVERSITÉ PARIS DESCARTES   (France)

^l UNIVERSITÉ PARIS SACLAY   (France)

^m MONTEFIORE MEDICAL CENTER   (United States)

ⁿ RAMBAM MEDICAL CENTER   (Israel)

^o Och Spine at New York Presbyterian Hospitals   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH1 RECEPTOR; POLYCOMB REPRESSIVE COMPLEX 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR SUZ12; UNCLASSIFIED DRUG; CARRIER PROTEIN; DNA BINDING PROTEIN; EZH2 PROTEIN, HUMAN; EZH2 PROTEIN, MOUSE; HISTONE LYSINE METHYLTRANSFERASE; NOTCH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; POLYCOMB GROUP PROTEIN; REPRESSOR PROTEIN; SUZ12 PROTEIN, HUMAN; SUZ12 PROTEIN, MOUSE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CELL TRANSFORMATION; CONTROLLED STUDY; CROSS LINKING; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INACTIVATION; GENE TRANSLOCATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; LOSS OF FUNCTION MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THYMOCYTE; TRANSCRIPTION REGULATION; ANIMAL; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC EPIGENESIS; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CARRIER PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; MICE; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTOR, NOTCH1; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84856747744     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2651     Document Type: Article

References (40)

1. Aster, J.C., Blacklow, S.C. & Pear, W.S. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J. Pathol. 223, 262-273 (2011).
2. Margueron, R. & Reinberg, D. The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349 (2011).
3. Orlando, V. Polycomb, epigenomes and control of cell identity. Cell 112, 599-606 (2003).
4. Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007). (Pubitemid 46802390)
5. Aifantis, I., Raetz, E. & Buonamici, S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat. Rev. Immunol. 8, 380-390 (2008). (Pubitemid 351595220)
6. Paganin, M. & Ferrando, A. Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia. Blood Rev. 25, 83-90 (2010).
7. Carpenter, A.C. & Bosselut, R. Decision checkpoints in the thymus. Nat. Immunol. 11, 666-673 (2010).
8. Weng, A.P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004). (Pubitemid 39336870)
9. Thompson, B.J. et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J. Exp. Med. 204, 1825-1835 (2007). (Pubitemid 47236320)
10. Chase, A. & Cross, N.C. Aberrations of EZH2 in cancer. Clin. Cancer Res. 17, 2613-2618 (2011).
11. Ernst, T. et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat. Genet. 42, 722-726 (2010).
12. Nikoloski, G. et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat. Genet. 42, 665-667 (2010).
13. Bracken, A.P., Dietrich, N., Pasini, D., Hansen, K.H. & Helin, K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20, 1123-1136 (2006).
14. Cao, R. & Zhang, Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57-67 (2004). (Pubitemid 38850219)
15. Chase, A. & Cross, N.C. Aberrations of EZH2 in cancer. Clin. Cancer Res. 17, 2613-2618 (2011).
16. Yap, D.B. et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 117, 2451-2459 (2011).
17. Morin, R.D. et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat. Genet. 42, 181-185 (2010).
18. Berger, A.H., Knudson, A.G. & Pandolfi, P.P. A continuum model for tumour suppression. Nature 476, 163-169 (2011).
19. Sulis, M.L. et al. NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL. Blood 112, 733-740 (2008).
20. Palomero, T. et al. NOTCH1 directly regulates c-MYC and activates a feed-forwardloop transcriptional network promoting leukemic cell growth. Proc. Natl. Acad. Sci. USA 103, 18261-18266 (2006). (Pubitemid 44871646)
21. Wendorff, A.A. et al. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33, 671-684 (2010).
22. Buonamici, S. et al. CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature 459, 1000-1004 (2009).
23. Kuo, M.H. et al. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature 383, 269-272 (1996).
24. Santos-Rosa, H. et al. Active genes are tri-methylated at K4 of histone H3. Nature 419, 407-411 (2002).
25. Rada-Iglesias, A., et al. A unique chromatin signature uncovers early developmental enhancers in humans. Nature 470, 279-283 (2010).
26. Peng, J.C. et al. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139, 1290-1302 (2009).
27. Landeira, D. et al. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat. Cell Biol. 12, 618-624 (2010).
28. Ferres-Marco, D. et al. Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 439, 430-436 (2006). (Pubitemid 43152828)
29. Palomero, T. et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat. Med. 13, 1203-1210 (2007). (Pubitemid 47530629)
30. Dietzl, G. et al. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448, 151-156 (2007). (Pubitemid 47067374)
31. Lopez, J., Percharde, M., Coley, H.M., Webb, A. & Crook, T. The context and potential of epigenetics in oncology. Br. J. Cancer 100, 571-577 (2009).
32. Rodríguez-Paredes, M. & Esteller, M. Cancer epigenetics reaches mainstream oncology. Nat. Med. 17, 330-339 (2011).
33. Natoli, G., Testa, G. & De Santa, F. The future therapeutic potential of histone demethylases: A critical analysis. Curr. Opin. Drug Discov. Devel. 12, 607-615 (2009).
34. Rahl, P.B. et al. c-Myc regulates transcriptional pause release. Cell 141, 432-445 (2010).
35. Klinakis, A. et al. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl. Acad. Sci. USA 103, 9262-9267 (2006). (Pubitemid 43902566)
36. Tu, Y., Stolovitzky, G. & Klein, U. Quantitative noise analysis for gene expression microarray experiments. Proc. Natl. Acad. Sci. USA 99, 14031-14036 (2002). (Pubitemid 35257619)
37. Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589-595 (2010).
38. Tsirigos, A., Haiminen, N., Bilal, E. & Utro, F. GenomicTools: a computational platform for developing high-throughput analytics in genomics. Bioinformatics published online, doi:10.1093/bioinformatics/btr646 (22 November 2011).
39. Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).
40. Gerby, B. et al. Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations. Leukemia 25, 1249-1258 (2011).