Stage-specific expression of polycomb group genes in human bone marrow cells

Blood

Volumn 91, Issue 4, 1998, Pages 1216-1224

  Lessard, Julie ^b   Baban, Soheyl ^b   Sauvageau, Guy ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; GENE EXPRESSION; HEMATOPOIESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

EID: 0032519809     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.4.1216     Document Type: Article

References (55)

1. Krumlauf R: Hox genes in vertebrate development. Cell 78:191, 1994
2. Simon J, Chiang A, Bender W: Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products. Development 114:493, 1992
3. Lewis EB: A gene complex controlling segmentation in Drosophila. Nature 276:565, 1978
4. Jürgens G: A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316:153, 1985
5. Dura JM, Brock HW, Santamaria P: Polyhomeotic: A gene of Drosophila melanogaster required for correct expression of segmental identity. Mol Gen Genet 198:213, 1985
6. Duncan IM: Polycomblike: A gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster. Genetics 102:49, 1982
7. Struhl G: A gene product required for correct initiation of segmental determination in Drosophila. Nature 293:36, 1981
8. Jones RS, Gelbart WM: Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster. Genetics 126:185, 1990
9. Phillips MD, Shearn A: Mutations in polycombeotic, a Drosophila polycomb-group gene, cause a wide range of maternal and zygotic phenotypes. Genetics 125:91, 1990
10. Gehring W: A recessive lethal with a homeotic effect in Drosophila melanogaster. Drosophila Inf Serv 45:103, 1970
11. Girton JR, Jeon SH: Novel embryonic and adult homeotic phenotypes are produced by pleiohomeotic mutations in Drosophila. Dev Biol 161:393, 1994
12. Breen TR, Duncan IM: Maternal expression of genes that regulate the bithorax complex of Drosophila melanogaster. Dev Biol 118:442, 1986
13. Ingham PW: A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila. Cell 37:815, 1984
14. Santamaria P, Randsholt NB: Characterization of a region of the X chromosome of Drosophila including multi sex combs (mxc), a Polycomb group gene which also functions as a tumour suppressor. Mol Gen Genet 246:282, 1995
15. Soto MC, Chou TB, Bender W: Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster. Genetics 140:231, 1995
16. Struhl G: Genes controlling segmental specification in the Drosophila thorax. Proc Natl Acad Sci USA 79:7380, 1982
17. Alkema MJ, van der Lugt NM, Bobeldijk RC, Berns A, van Lohuizen M: Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature 374:724, 1995
18. Saunders WS, Chue C, Goebl M, Craig C, Clark RF, Powers JA, Eissenberg JC, Elgin SC, Rothfield NF, Earnshaw WC: Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity. J Cell Sci 104:573, 1993
19. van Lohuizen M, Frasch M, Wientjens E, Berns A: Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 353:353, 1991
20. Akasaka T: The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity 7:135, 1997
21. Shumacher A, Faust C, Magnuson T: Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature 383: 250,1996
22. Paro R, Hogness DS: The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc Natl Acad Sci USA 88:263, 1991
23. Coré N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, Djabali M: Altered cellular proliferation and mesoderm patterning in polycomb-M33 deficient mice. Development 124:721, 1997
24. Simon J: Locking in stable states of gene expression: Transcriptional control during Drosophila development [review]. Curr Opin Cell Biol 7:376, 1995
25. Gaunt SJ, Singh PB: Homeogene expression patterns and chromosomal imprinting [review]. Trends Genet 6:208, 1990
26. Messmer S, Franke A, Paro R: Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev 6:1241, 1992
27. Paro R: Imprinting a determined state into the chromatin of Drosophila [review]. Trends Genet 6:416, 1990
28. Reuter G, Giarre M, Farah J, Gausz J, Spierer A, Spierer P: Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature 344:219, 1990
29. Orlando V, Paro R: Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin. Cell 75:1187, 1993
30. McCall K, Bender W: Probes of chromatin accessibility in the Drosophila bithorax complex respond differently to Polycomb-mediated repression. EMBO J 15:569, 1996
31. Denell RE, Frederick RD: Homoeosis in Drosophila: A description of the Polycomb lethal syndrome. Dev Biol 97:34, 1983
32. Struhl G: Role of the esc+ gene product in ensuring the selective expression of segment-specific homeotic genes in Drosophila. J Embryol Exp Morphol 76:297, 1983
33. Struhl G, Akam M: Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila. EMBO J 4:3259, 1985
34. Wedeen C, Harding K, Levine M: Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila. Cell 44:739, 1986
35. Castelli-Gair JE, Garcia-Bellido A: Interactions of Polycomb and trithorax with cis regulatory regions of Ultrabithorax during the development of Drosophila melanogaster. EMBO J 9:4267, 1990
36. Pirrotta V, Rastelli L: White gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila [review]. Bioessays 16:549, 1994
37. Adler PN, Martin EC, Charlton J, Jones K: Phenotypic consequences and genetic interactions of a null mutation in the Drosophila Posterior Sex Combs gene. Dev Genet 12:349, 1991
38. Dura JM, Ingham P: Tissue-and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene. Development 103:733, 1988
39. Moazed D, O'Farrell PH: Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila. Development 116:805, 1992
40. Smouse D, Goodman C, Mahowald A, Perrimon N: Polyhomeotic: A gene required for the embryonic development of axon pathways in the central nervous system of Drosophila. Genes Dev 2:830, 1988
41. Gateff E: The genetics and epigenetics of neoplasms in Drosophila [review]. Biol Rev Cambridge Phil Soc 53:123, 1978
42. Gateff E, Mechler BM: Tumor-suppressor genes of Drosophila melanogaster [review]. Crit Rev Oncogen 1:221, 1989
43. van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, van der Valk M, Deschamps J, Sofroniew M, van Lohuizen M, et al: Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8:757, 1994
44. Hobert O, Jallal B, Ullrich A: Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol Cell Biol 16:3066,1996
45. Thorsteinsdottir U, Sauvageau G, Hough MR, Lawrence HJ, Largman C, Humphries RK: Overexpression of HOXA 1O in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol Cell Biol 17:495, 1997
46. Sauvageau G, Thorsteinsdottir U, Hough MR, Hugo P, Lawrence HJ, Largman C, Humphries RK: Over-expression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation. Immunity 6:13, 1997
47. Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK: Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 91:12223, 1994
48. Perkins A, Kongsuwan K, Visvader J, Adams JM, Cory S: Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia. Proc Natl Acad Sci USA 87:8398, 1990
49. Perkins AC, Cory S: Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. EMBO J 12:3835, 1993
50. Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen I-M, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD: Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15; p15) in human myeloid leukaemia. Nat Genet 12:154, 1996
51. Nakamura T, Largaespada DA, Shaughnessy JD, Jenkins NA, Copeland NG: Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet 12:149, 1996
52. Lansdorp PM, Sutherland HJ, Eaves CJ: Selective expression of CD45 isoforms on functional subpopulations of CD34 + hemopoietic cells from human bone marrow. J Exp Med 172:363, 1990
53. Brady G, Barbara M, Iscove N: Representative in vitro cDNA amplification from individual hemopoietic cells and colonies. Methods Mol Cell Biol 2:1, 1990
54. Kanno M, Hasegawa M, Ishida A, Isono K, Taniguchi M: mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. EMBO J 14:5672,1995
55. Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK: Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9:1753, 1995