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Volumn 10, Issue 1, 2015, Pages

Aneuploidy and chromosomal instability in cancer: A jackpot to chaos

Author keywords

Aneuploidy; Cancer evolution; Chromosome instability; DNA damage; Oncogene; Tumor suppressor

Indexed keywords


EID: 84929833822     PISSN: None     EISSN: 17471028     Source Type: Journal    
DOI: 10.1186/s13008-015-0009-7     Document Type: Review
Times cited : (187)

References (138)
  • 2
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science. 1976;194(4260):23-8.
    • (1976) Science. , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 3
    • 0016692602 scopus 로고
    • Mutation selection and the natural history of cancer
    • Cairns J. Mutation selection and the natural history of cancer. Nature. 1975;255(5505):197-200.
    • (1975) Nature. , vol.255 , Issue.5505 , pp. 197-200
    • Cairns, J.1
  • 4
    • 0030825508 scopus 로고    scopus 로고
    • Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms
    • Mertens F, Johansson B, Hoglund M, Mitelman F. Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res. 1997;57(13):2765-80.
    • (1997) Cancer Res. , vol.57 , Issue.13 , pp. 2765-2780
    • Mertens, F.1    Johansson, B.2    Hoglund, M.3    Mitelman, F.4
  • 5
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396(6712):643-9.
    • (1998) Nature. , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 8
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.
    • (2011) Cell. , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 79957501125 scopus 로고    scopus 로고
    • Human cancers express mutator phenotypes: origin, consequences and targeting
    • Loeb LA. Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer. 2011;11(6):450-7.
    • (2011) Nat Rev Cancer. , vol.11 , Issue.6 , pp. 450-457
    • Loeb, L.A.1
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70.
    • (2000) Cell. , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 76649116203 scopus 로고    scopus 로고
    • The role of genetic diversity in cancer
    • Merlo LM, Maley CC. The role of genetic diversity in cancer. J Clin Invest. 2010;120(2):401-3.
    • (2010) J Clin Invest. , vol.120 , Issue.2 , pp. 401-403
    • Merlo, L.M.1    Maley, C.C.2
  • 15
    • 79956160582 scopus 로고    scopus 로고
    • Paradoxical relationship between chromosomal instability and survival outcome in cancer
    • Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, Tan P, et al. Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res. 2011;71(10):3447-52.
    • (2011) Cancer Res. , vol.71 , Issue.10 , pp. 3447-3452
    • Birkbak, N.J.1    Eklund, A.C.2    Li, Q.3    McClelland, S.E.4    Endesfelder, D.5    Tan, P.6
  • 16
    • 78650848876 scopus 로고    scopus 로고
    • A 12-gene genomic instability signature predicts clinical outcomes in multiple cancer types
    • Mettu RK, Wan YW, Habermann JK, Ried T, Guo NL. A 12-gene genomic instability signature predicts clinical outcomes in multiple cancer types. Int J Biol Markers. 2010;25(4):219-28.
    • (2010) Int J Biol Markers. , vol.25 , Issue.4 , pp. 219-228
    • Mettu, R.K.1    Wan, Y.W.2    Habermann, J.K.3    Ried, T.4    Guo, N.L.5
  • 18
    • 84899622427 scopus 로고    scopus 로고
    • Unravelling mechanisms of p53-mediated tumour suppression
    • Bieging KT, Mello SS, Attardi LD. Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer. 2014;14(5):359-70.
    • (2014) Nat Rev Cancer. , vol.14 , Issue.5 , pp. 359-370
    • Bieging, K.T.1    Mello, S.S.2    Attardi, L.D.3
  • 19
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61(5):759-67.
    • (1990) Cell. , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 20
    • 80053039210 scopus 로고    scopus 로고
    • Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis
    • Rivlin N, Brosh R, Oren M, Rotter V. Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer. 2011;2(4):466-74.
    • (2011) Genes Cancer. , vol.2 , Issue.4 , pp. 466-474
    • Rivlin, N.1    Brosh, R.2    Oren, M.3    Rotter, V.4
  • 21
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 2005;434(7035):907-13.
    • (2005) Nature. , vol.434 , Issue.7035 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3    Zacharatos, P.4    Kotsinas, A.5    Liloglou, T.6
  • 22
    • 26444546442 scopus 로고    scopus 로고
    • An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
    • Miller LD, Smeds J, George J, Vega VB, Vergara L, Ploner A, et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci U S A. 2005;102(38):13550-5.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.38 , pp. 13550-13555
    • Miller, L.D.1    Smeds, J.2    George, J.3    Vega, V.B.4    Vergara, L.5    Ploner, A.6
  • 23
    • 79851510907 scopus 로고    scopus 로고
    • Somatic mutations in cancer prognosis and prediction: lessons from TP53 and EGFR genes
    • Olivier M, Taniere P. Somatic mutations in cancer prognosis and prediction: lessons from TP53 and EGFR genes. Curr Opin Oncol. 2011;23(1):88-92.
    • (2011) Curr Opin Oncol. , vol.23 , Issue.1 , pp. 88-92
    • Olivier, M.1    Taniere, P.2
  • 25
    • 84857192718 scopus 로고    scopus 로고
    • Causes and consequences of aneuploidy in cancer
    • Gordon DJ, Resio B, Pellman D. Causes and consequences of aneuploidy in cancer. Nat Rev Genet. 2012;13(3):189-203.
    • (2012) Nat Rev Genet. , vol.13 , Issue.3 , pp. 189-203
    • Gordon, D.J.1    Resio, B.2    Pellman, D.3
  • 26
    • 84874362586 scopus 로고    scopus 로고
    • Replication stress links structural and numerical cancer chromosomal instability
    • Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, et al. Replication stress links structural and numerical cancer chromosomal instability. Nature. 2013;494(7438):492-6.
    • (2013) Nature. , vol.494 , Issue.7438 , pp. 492-496
    • Burrell, R.A.1    McClelland, S.E.2    Endesfelder, D.3    Groth, P.4    Weller, M.C.5    Shaikh, N.6
  • 27
  • 28
    • 84892404359 scopus 로고    scopus 로고
    • Multi-layered cancer chromosomal instability phenotype
    • Roschke AV, Rozenblum E. Multi-layered cancer chromosomal instability phenotype. Front Oncol. 2013;3:302.
    • (2013) Front Oncol. , vol.3 , pp. 302
    • Roschke, A.V.1    Rozenblum, E.2
  • 30
    • 77949773695 scopus 로고    scopus 로고
    • Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
    • Sotillo R, Schvartzman JM, Socci ND, Benezra R. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature. 2010;464(7287):436-40.
    • (2010) Nature. , vol.464 , Issue.7287 , pp. 436-440
    • Sotillo, R.1    Schvartzman, J.M.2    Socci, N.D.3    Benezra, R.4
  • 31
    • 0034687650 scopus 로고    scopus 로고
    • Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy
    • Duesberg P, Stindl R, Hehlmann R. Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc Natl Acad Sci U S A. 2000;97(26):14295-300.
    • (2000) Proc Natl Acad Sci U S A. , vol.97 , Issue.26 , pp. 14295-14300
    • Duesberg, P.1    Stindl, R.2    Hehlmann, R.3
  • 33
    • 10644258336 scopus 로고    scopus 로고
    • Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
    • Hanks S, Coleman K, Reid S, Plaja A, Firth H, Fitzpatrick D, et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet. 2004;36(11):1159-61.
    • (2004) Nat Genet. , vol.36 , Issue.11 , pp. 1159-1161
    • Hanks, S.1    Coleman, K.2    Reid, S.3    Plaja, A.4    Firth, H.5    Fitzpatrick, D.6
  • 35
    • 47149116650 scopus 로고    scopus 로고
    • Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: delineation of clinical subtypes
    • Garcia-Castillo H, Vasquez-Velasquez AI, Rivera H, Barros-Nunez P. Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: delineation of clinical subtypes. Am J Med Genet A. 2008;146A(13):1687-95.
    • (2008) Am J Med Genet A. , vol.146A , Issue.13 , pp. 1687-1695
    • Garcia-Castillo, H.1    Vasquez-Velasquez, A.I.2    Rivera, H.3    Barros-Nunez, P.4
  • 36
    • 77953770988 scopus 로고    scopus 로고
    • Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy
    • Suijkerbuijk SJ, van Osch MH, Bos FL, Hanks S, Rahman N, Kops GJ. Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. Cancer Res. 2010;70(12):4891-900.
    • (2010) Cancer Res. , vol.70 , Issue.12 , pp. 4891-4900
    • Suijkerbuijk, S.J.1    van Osch, M.H.2    Bos, F.L.3    Hanks, S.4    Rahman, N.5    Kops, G.J.6
  • 38
    • 75149140916 scopus 로고    scopus 로고
    • Mitotic chromosomal instability and cancer: mouse modelling of the human disease
    • Schvartzman JM, Sotillo R, Benezra R. Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer. 2010;10(2):102-15.
    • (2010) Nat Rev Cancer. , vol.10 , Issue.2 , pp. 102-115
    • Schvartzman, J.M.1    Sotillo, R.2    Benezra, R.3
  • 39
    • 0026767624 scopus 로고
    • CENP-E is a putative kinetochore motor that accumulates just before mitosis
    • Yen TJ, Li G, Schaar BT, Szilak I, Cleveland DW. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature. 1992;359(6395):536-9.
    • (1992) Nature. , vol.359 , Issue.6395 , pp. 536-539
    • Yen, T.J.1    Li, G.2    Schaar, B.T.3    Szilak, I.4    Cleveland, D.W.5
  • 40
    • 34247333444 scopus 로고    scopus 로고
    • The spindle-assembly checkpoint in space and time
    • Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol. 2007;8(5):379-93.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , Issue.5 , pp. 379-393
    • Musacchio, A.1    Salmon, E.D.2
  • 43
    • 67449143471 scopus 로고    scopus 로고
    • Loss of spindle assembly checkpointmediated inhibition of Cdc20 promotes tumorigenesis in mice
    • Li M, Fang X, Wei Z, York JP, Zhang P. Loss of spindle assembly checkpointmediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol. 2009;185(6):983-94.
    • (2009) J Cell Biol. , vol.185 , Issue.6 , pp. 983-994
    • Li, M.1    Fang, X.2    Wei, Z.3    York, J.P.4    Zhang, P.5
  • 44
    • 33846428426 scopus 로고    scopus 로고
    • Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice
    • Iwanaga Y, Chi YH, Miyazato A, Sheleg S, Haller K, Peloponese Jr JM, et al. Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res. 2007;67(1):160-6.
    • (2007) Cancer Res. , vol.67 , Issue.1 , pp. 160-166
    • Iwanaga, Y.1    Chi, Y.H.2    Miyazato, A.3    Sheleg, S.4    Haller, K.5    Peloponese, J.M.6
  • 45
    • 0035905811 scopus 로고    scopus 로고
    • MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
    • Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature. 2001;409(6818):355-9.
    • (2001) Nature. , vol.409 , Issue.6818 , pp. 355-359
    • Michel, L.S.1    Liberal, V.2    Chatterjee, A.3    Kirchwegger, R.4    Pasche, B.5    Gerald, W.6
  • 47
    • 35548957419 scopus 로고    scopus 로고
    • Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
    • Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol. 2007;179(2):255-67.
    • (2007) J Cell Biol. , vol.179 , Issue.2 , pp. 255-267
    • Jeganathan, K.1    Malureanu, L.2    Baker, D.J.3    Abraham, S.C.4    van Deursen, J.M.5
  • 48
    • 0037415605 scopus 로고    scopus 로고
    • Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation
    • Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 2003;160(3):341-53.
    • (2003) J Cell Biol. , vol.160 , Issue.3 , pp. 341-353
    • Babu, J.R.1    Jeganathan, K.B.2    Baker, D.J.3    Wu, X.4    Kang-Decker, N.5    van Deursen, J.M.6
  • 50
    • 84871717211 scopus 로고    scopus 로고
    • Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
    • Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol. 2013;15(1):96-102.
    • (2013) Nat Cell Biol. , vol.15 , Issue.1 , pp. 96-102
    • Baker, D.J.1    Dawlaty, M.M.2    Wijshake, T.3    Jeganathan, K.B.4    Malureanu, L.5    van Ree, J.H.6
  • 51
    • 79959416796 scopus 로고    scopus 로고
    • Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
    • Ricke RM, Jeganathan KB, van Deursen JM. Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol. 2011;193(6):1049-64.
    • (2011) J Cell Biol. , vol.193 , Issue.6 , pp. 1049-1064
    • Ricke, R.M.1    Jeganathan, K.B.2    van Deursen, J.M.3
  • 53
    • 9144253124 scopus 로고    scopus 로고
    • Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
    • Dai W, Wang Q, Liu T, Swamy M, Fang Y, Xie S, et al. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res. 2004;64(2):440-5.
    • (2004) Cancer Res. , vol.64 , Issue.2 , pp. 440-445
    • Dai, W.1    Wang, Q.2    Liu, T.3    Swamy, M.4    Fang, Y.5    Xie, S.6
  • 54
    • 8744251327 scopus 로고    scopus 로고
    • DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast
    • Sugimoto I, Murakami H, Tonami Y, Moriyama A, Nakanishi M. DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. J Biol Chem. 2004;279(45):47372-8.
    • (2004) J Biol Chem. , vol.279 , Issue.45 , pp. 47372-47378
    • Sugimoto, I.1    Murakami, H.2    Tonami, Y.3    Moriyama, A.4    Nakanishi, M.5
  • 55
    • 84872265426 scopus 로고    scopus 로고
    • Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p
    • Cairo LV, Ptak C, Wozniak RW. Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p. Mol Cell. 2013;49(1):109-20.
    • (2013) Mol Cell. , vol.49 , Issue.1 , pp. 109-120
    • Cairo, L.V.1    Ptak, C.2    Wozniak, R.W.3
  • 56
    • 33646540000 scopus 로고    scopus 로고
    • BubR1 is involved in regulation of DNA damage responses
    • Fang Y, Liu T, Wang X, Yang YM, Deng H, Kunicki J, et al. BubR1 is involved in regulation of DNA damage responses. Oncogene. 2006;25(25):3598-605.
    • (2006) Oncogene. , vol.25 , Issue.25 , pp. 3598-3605
    • Fang, Y.1    Liu, T.2    Wang, X.3    Yang, Y.M.4    Deng, H.5    Kunicki, J.6
  • 57
    • 3042761646 scopus 로고    scopus 로고
    • BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
    • Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 2004;36(7):744-9.
    • (2004) Nat Genet. , vol.36 , Issue.7 , pp. 744-749
    • Baker, D.J.1    Jeganathan, K.B.2    Cameron, J.D.3    Thompson, M.4    Juneja, S.5    Kopecka, A.6
  • 58
    • 4544353114 scopus 로고    scopus 로고
    • WD repeatcontaining mitotic checkpoint proteins act as transcriptional repressors during interphase
    • Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, et al. WD repeatcontaining mitotic checkpoint proteins act as transcriptional repressors during interphase. FEBS Lett. 2004;575(1-3):23-9.
    • (2004) FEBS Lett. , vol.575 , Issue.1-3 , pp. 23-29
    • Yoon, Y.M.1    Baek, K.H.2    Jeong, S.J.3    Shin, H.J.4    Ha, G.H.5    Jeon, A.H.6
  • 60
    • 84891609336 scopus 로고    scopus 로고
    • Cancer karyotypes: survival of the fittest
    • Nicholson JM, Cimini D. Cancer karyotypes: survival of the fittest. Front Oncol. 2013;3:148.
    • (2013) Front Oncol. , vol.3 , pp. 148
    • Nicholson, J.M.1    Cimini, D.2
  • 61
    • 34548131710 scopus 로고    scopus 로고
    • Effects of aneuploidy on cellular physiology and cell division in haploid yeast
    • Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, Dunham MJ, et al. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science. 2007;317(5840):916-24.
    • (2007) Science. , vol.317 , Issue.5840 , pp. 916-924
    • Torres, E.M.1    Sokolsky, T.2    Tucker, C.M.3    Chan, L.Y.4    Boselli, M.5    Dunham, M.J.6
  • 62
    • 78649636162 scopus 로고    scopus 로고
    • Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer
    • Pavelka N, Rancati G, Li R. Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol. 2010;22(6):809-15.
    • (2010) Curr Opin Cell Biol. , vol.22 , Issue.6 , pp. 809-815
    • Pavelka, N.1    Rancati, G.2    Li, R.3
  • 63
    • 84868103798 scopus 로고    scopus 로고
    • New insights into the troubles of aneuploidy
    • Siegel JJ, Amon A. New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol. 2012;28:189-214.
    • (2012) Annu Rev Cell Dev Biol. , vol.28 , pp. 189-214
    • Siegel, J.J.1    Amon, A.2
  • 65
    • 84866296846 scopus 로고    scopus 로고
    • Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap
    • Chen G, Rubinstein B, Li R. Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap. Bioessays. 2012;34(10):893-900.
    • (2012) Bioessays. , vol.34 , Issue.10 , pp. 893-900
    • Chen, G.1    Rubinstein, B.2    Li, R.3
  • 66
    • 84890312311 scopus 로고    scopus 로고
    • Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos
    • Potapova TA, Zhu J, Li R. Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos. Cancer Metastasis Rev. 2013;32(3-4):377-89.
    • (2013) Cancer Metastasis Rev. , vol.32 , Issue.3-4 , pp. 377-389
    • Potapova, T.A.1    Zhu, J.2    Li, R.3
  • 67
    • 84876740482 scopus 로고    scopus 로고
    • Karyotypic changes as drivers and catalyzers of cellular evolvability: a perspective from non-pathogenic yeasts
    • Rancati G, Pavelka N. Karyotypic changes as drivers and catalyzers of cellular evolvability: a perspective from non-pathogenic yeasts. Semin Cell Dev Biol. 2013;24(4):332-8.
    • (2013) Semin Cell Dev Biol. , vol.24 , Issue.4 , pp. 332-338
    • Rancati, G.1    Pavelka, N.2
  • 68
    • 33746506280 scopus 로고    scopus 로고
    • Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    • Selmecki A, Forche A, Berman J. Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science. 2006;313(5785):367-70.
    • (2006) Science. , vol.313 , Issue.5785 , pp. 367-370
    • Selmecki, A.1    Forche, A.2    Berman, J.3
  • 69
    • 41749113291 scopus 로고    scopus 로고
    • An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
    • Selmecki A, Gerami-Nejad M, Paulson C, Forche A, Berman J. An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. Mol Microbiol. 2008;68(3):624-41.
    • (2008) Mol Microbiol. , vol.68 , Issue.3 , pp. 624-641
    • Selmecki, A.1    Gerami-Nejad, M.2    Paulson, C.3    Forche, A.4    Berman, J.5
  • 70
    • 56349088536 scopus 로고    scopus 로고
    • Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor
    • Rancati G, Pavelka N, Fleharty B, Noll A, Trimble R, Walton K, et al. Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell. 2008;135(5):879-93.
    • (2008) Cell. , vol.135 , Issue.5 , pp. 879-893
    • Rancati, G.1    Pavelka, N.2    Fleharty, B.3    Noll, A.4    Trimble, R.5    Walton, K.6
  • 71
    • 78149423336 scopus 로고    scopus 로고
    • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
    • Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, et al. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature. 2010;468(7321):321-5.
    • (2010) Nature. , vol.468 , Issue.7321 , pp. 321-325
    • Pavelka, N.1    Rancati, G.2    Zhu, J.3    Bradford, W.D.4    Saraf, A.5    Florens, L.6
  • 72
    • 84862777815 scopus 로고    scopus 로고
    • Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy
    • Chen G, Bradford WD, Seidel CW, Li R. Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature. 2012;482(7384):246-50.
    • (2012) Nature. , vol.482 , Issue.7384 , pp. 246-250
    • Chen, G.1    Bradford, W.D.2    Seidel, C.W.3    Li, R.4
  • 73
    • 84925884863 scopus 로고    scopus 로고
    • Aneuploidy in pluripotent stem cells and implications for cancerous transformation
    • Na J, Baker D, Zhang J, Andrews PW, Barbaric I. Aneuploidy in pluripotent stem cells and implications for cancerous transformation. Protein Cell. 2014;5(8):569-79.
    • (2014) Protein Cell. , vol.5 , Issue.8 , pp. 569-579
    • Na, J.1    Baker, D.2    Zhang, J.3    Andrews, P.W.4    Barbaric, I.5
  • 74
    • 84904262196 scopus 로고    scopus 로고
    • Time-lapse analysis of human embryonic stem cells reveals multiple bottlenecks restricting colony formation and their relief upon culture adaptation
    • Barbaric I, Biga V, Gokhale PJ, Jones M, Stavish D, Glen A, et al. Time-lapse analysis of human embryonic stem cells reveals multiple bottlenecks restricting colony formation and their relief upon culture adaptation. Stem Cell Rep. 2014;3(1):142-55.
    • (2014) Stem Cell Rep. , vol.3 , Issue.1 , pp. 142-155
    • Barbaric, I.1    Biga, V.2    Gokhale, P.J.3    Jones, M.4    Stavish, D.5    Glen, A.6
  • 75
    • 84911442522 scopus 로고    scopus 로고
    • Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells
    • Ben-David U, Arad G, Weissbein U, Mandefro B, Maimon A, Golan-Lev T, et al. Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells. Nat Commun. 2014;5:4825.
    • (2014) Nat Commun. , vol.5 , pp. 4825
    • Ben-David, U.1    Arad, G.2    Weissbein, U.3    Mandefro, B.4    Maimon, A.5    Golan-Lev, T.6
  • 76
    • 80053300903 scopus 로고    scopus 로고
    • Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes
    • Nawata H, Kashino G, Tano K, Daino K, Shimada Y, Kugoh H, et al. Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. PLoS One. 2011;6(9):e25319.
    • (2011) PLoS One. , vol.6 , Issue.9
    • Nawata, H.1    Kashino, G.2    Tano, K.3    Daino, K.4    Shimada, Y.5    Kugoh, H.6
  • 77
    • 0033153475 scopus 로고    scopus 로고
    • Mouse autosomal trisomy: two's company, three's a crowd
    • Hernandez D, Fisher EM. Mouse autosomal trisomy: two's company, three's a crowd. Trends Genet. 1999;15(6):241-7.
    • (1999) Trends Genet. , vol.15 , Issue.6 , pp. 241-247
    • Hernandez, D.1    Fisher, E.M.2
  • 78
    • 84863892710 scopus 로고    scopus 로고
    • Human aneuploidy: mechanisms and new insights into an age-old problem
    • Nagaoka SI, Hassold TJ, Hunt PA. Human aneuploidy: mechanisms and new insights into an age-old problem. Nat Rev Genet. 2012;13(7):493-504.
    • (2012) Nat Rev Genet. , vol.13 , Issue.7 , pp. 493-504
    • Nagaoka, S.I.1    Hassold, T.J.2    Hunt, P.A.3
  • 80
    • 17444446946 scopus 로고    scopus 로고
    • Widespread aneuploidy revealed by DNA microarray expression profiling
    • Hughes TR, Roberts CJ, Dai H, Jones AR, Meyer MR, Slade D, et al. Widespread aneuploidy revealed by DNA microarray expression profiling. Nat Genet. 2000;25(3):333-7.
    • (2000) Nat Genet. , vol.25 , Issue.3 , pp. 333-337
    • Hughes, T.R.1    Roberts, C.J.2    Dai, H.3    Jones, A.R.4    Meyer, M.R.5    Slade, D.6
  • 82
    • 84885158978 scopus 로고    scopus 로고
    • The cancer biology of whole-chromosome instability
    • Duijf PH, Benezra R. The cancer biology of whole-chromosome instability. Oncogene. 2013;32(40):4727-36.
    • (2013) Oncogene. , vol.32 , Issue.40 , pp. 4727-4736
    • Duijf, P.H.1    Benezra, R.2
  • 83
    • 67649522162 scopus 로고    scopus 로고
    • Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
    • Holland AJ, Cleveland DW. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol. 2009;10(7):478-87.
    • (2009) Nat Rev Mol Cell Biol. , vol.10 , Issue.7 , pp. 478-487
    • Holland, A.J.1    Cleveland, D.W.2
  • 86
    • 84887992179 scopus 로고    scopus 로고
    • Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome
    • Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, et al. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013;155(4):948-62.
    • (2013) Cell. , vol.155 , Issue.4 , pp. 948-962
    • Davoli, T.1    Xu, A.W.2    Mengwasser, K.E.3    Sack, L.M.4    Yoon, J.C.5    Park, P.J.6
  • 87
    • 63149148209 scopus 로고    scopus 로고
    • Constitutional aneuploidy and cancer predisposition
    • Ganmore I, Smooha G, Izraeli S. Constitutional aneuploidy and cancer predisposition. Hum Mol Genet. 2009;18(R1):R84-93.
    • (2009) Hum Mol Genet. , vol.18 , Issue.R1 , pp. R84-93
    • Ganmore, I.1    Smooha, G.2    Izraeli, S.3
  • 88
    • 0342905433 scopus 로고    scopus 로고
    • Risks of leukaemia and solid tumours in individuals with Down's syndrome
    • Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet. 2000;355(9199):165-9.
    • (2000) Lancet. , vol.355 , Issue.9199 , pp. 165-169
    • Hasle, H.1    Clemmensen, I.H.2    Mikkelsen, M.3
  • 89
    • 0030901159 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia and chromosome 21
    • Berger R. Acute lymphoblastic leukemia and chromosome 21. Cancer Genet Cytogenet. 1997;94(1):8-12.
    • (1997) Cancer Genet Cytogenet. , vol.94 , Issue.1 , pp. 8-12
    • Berger, R.1
  • 92
    • 65349165222 scopus 로고    scopus 로고
    • ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
    • Stankiewicz MJ, Crispino JD. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood. 2009;113(14):3337-47.
    • (2009) Blood. , vol.113 , Issue.14 , pp. 3337-3347
    • Stankiewicz, M.J.1    Crispino, J.D.2
  • 93
    • 74049098309 scopus 로고    scopus 로고
    • Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains
    • Kuhn DE, Nuovo GJ, Terry Jr AV, Martin MM, Malana GE, Sansom SE, et al. Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem. 2010;285(2):1529-43.
    • (2010) J Biol Chem. , vol.285 , Issue.2 , pp. 1529-1543
    • Kuhn, D.E.1    Nuovo, G.J.2    Terry, A.V.3    Martin, M.M.4    Malana, G.E.5    Sansom, S.E.6
  • 94
    • 77649143631 scopus 로고    scopus 로고
    • miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia
    • Klusmann JH, Li Z, Bohmer K, Maroz A, Koch ML, Emmrich S, et al. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 2010;24(5):478-90.
    • (2010) Genes Dev. , vol.24 , Issue.5 , pp. 478-490
    • Klusmann, J.H.1    Li, Z.2    Bohmer, K.3    Maroz, A.4    Koch, M.L.5    Emmrich, S.6
  • 95
    • 0037817354 scopus 로고    scopus 로고
    • Are solid tumours different in children with Down's syndrome?
    • Satge D, Sasco AJ, Lacour B. Are solid tumours different in children with Down's syndrome? Int J Cancer. 2003;106(2):297-8.
    • (2003) Int J Cancer. , vol.106 , Issue.2 , pp. 297-298
    • Satge, D.1    Sasco, A.J.2    Lacour, B.3
  • 96
    • 38049069895 scopus 로고    scopus 로고
    • Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome
    • Sussan TE, Yang A, Li F, Ostrowski MC, Reeves RH. Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature. 2008;451(7174):73-5.
    • (2008) Nature. , vol.451 , Issue.7174 , pp. 73-75
    • Sussan, T.E.1    Yang, A.2    Li, F.3    Ostrowski, M.C.4    Reeves, R.H.5
  • 97
    • 79956087421 scopus 로고    scopus 로고
    • Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome
    • Yang A, Reeves RH. Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome. Cancer Res. 2011;71(10):3573-81.
    • (2011) Cancer Res. , vol.71 , Issue.10 , pp. 3573-3581
    • Yang, A.1    Reeves, R.H.2
  • 98
    • 67649506317 scopus 로고    scopus 로고
    • Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
    • Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, et al. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009;459(7250):1126-30.
    • (2009) Nature. , vol.459 , Issue.7250 , pp. 1126-1130
    • Baek, K.H.1    Zaslavsky, A.2    Lynch, R.C.3    Britt, C.4    Okada, Y.5    Siarey, R.J.6
  • 99
    • 84887617850 scopus 로고    scopus 로고
    • A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis
    • Shin J, Lee JC, Baek KH. A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. Cancer Lett. 2014;342(1):70-81.
    • (2014) Cancer Lett. , vol.342 , Issue.1 , pp. 70-81
    • Shin, J.1    Lee, J.C.2    Baek, K.H.3
  • 100
    • 40749104900 scopus 로고    scopus 로고
    • Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study
    • Schoemaker MJ, Swerdlow AJ, Higgins CD, Wright AF, Jacobs PA, Group UKCC. Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study. Lancet Oncol. 2008;9(3):239-46.
    • (2008) Lancet Oncol. , vol.9 , Issue.3 , pp. 239-246
    • Schoemaker, M.J.1    Swerdlow, A.J.2    Higgins, C.D.3    Wright, A.F.4    Jacobs, P.A.5
  • 103
    • 84928138338 scopus 로고    scopus 로고
    • Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast
    • Blank HM, Sheltzer JM, Meehl CM, Amon A. Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast. Mol Biol Cell. 2015;26(8):1440-51.
    • (2015) Mol Biol Cell. , vol.26 , Issue.8 , pp. 1440-1451
    • Blank, H.M.1    Sheltzer, J.M.2    Meehl, C.M.3    Amon, A.4
  • 104
    • 84863691442 scopus 로고    scopus 로고
    • Karyotypic determinants of chromosome instability in aneuploid budding yeast
    • Zhu J, Pavelka N, Bradford WD, Rancati G, Li R. Karyotypic determinants of chromosome instability in aneuploid budding yeast. PLoS Genet. 2012;8(5):e1002719.
    • (2012) PLoS Genet. , vol.8 , Issue.5
    • Zhu, J.1    Pavelka, N.2    Bradford, W.D.3    Rancati, G.4    Li, R.5
  • 105
    • 3142615823 scopus 로고    scopus 로고
    • Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural instability in tumor cell chromosomes through asynchronous replication and breakage within late-replicating regions
    • Kost-Alimova M, Fedorova L, Yang Y, Klein G, Imreh S. Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural instability in tumor cell chromosomes through asynchronous replication and breakage within late-replicating regions. Genes Chromosomes Cancer. 2004;40(4):316-24.
    • (2004) Genes Chromosomes Cancer. , vol.40 , Issue.4 , pp. 316-324
    • Kost-Alimova, M.1    Fedorova, L.2    Yang, Y.3    Klein, G.4    Imreh, S.5
  • 106
    • 84868290476 scopus 로고    scopus 로고
    • Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
    • Stingele S, Stoehr G, Peplowska K, Cox J, Mann M, Storchova Z. Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells. Mol Syst Biol. 2012;8:608.
    • (2012) Mol Syst Biol. , vol.8 , pp. 608
    • Stingele, S.1    Stoehr, G.2    Peplowska, K.3    Cox, J.4    Mann, M.5    Storchova, Z.6
  • 107
    • 4944234694 scopus 로고    scopus 로고
    • Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells
    • Upender MB, Habermann JK, McShane LM, Korn EL, Barrett JC, Difilippantonio MJ, et al. Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res. 2004;64(19):6941-9.
    • (2004) Cancer Res. , vol.64 , Issue.19 , pp. 6941-6949
    • Upender, M.B.1    Habermann, J.K.2    McShane, L.M.3    Korn, E.L.4    Barrett, J.C.5    Difilippantonio, M.J.6
  • 108
    • 40849096242 scopus 로고    scopus 로고
    • Examining the link between chromosomal instability and aneuploidy in human cells
    • Thompson SL, Compton DA. Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol. 2008;180(4):665-72.
    • (2008) J Cell Biol. , vol.180 , Issue.4 , pp. 665-672
    • Thompson, S.L.1    Compton, D.A.2
  • 110
    • 79954600431 scopus 로고    scopus 로고
    • Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13
    • Reish O, Regev M, Kanesky A, GirafiS, Mashevich M. Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13. Cytogenet Genome Res. 2011;133(2-4):184-9.
    • (2011) Cytogenet Genome Res. , vol.133 , Issue.2-4 , pp. 184-189
    • Reish, O.1    Regev, M.2    Kanesky, A.3    Girafi, S.4    Mashevich, M.5
  • 111
  • 112
    • 84891363070 scopus 로고    scopus 로고
    • Whole chromosome gain does not in itself confer cancer-like chromosomal instability
    • Valind A, Jin Y, Baldetorp B, Gisselsson D. Whole chromosome gain does not in itself confer cancer-like chromosomal instability. Proc Natl Acad Sci U S A. 2013;110(52):21119-23.
    • (2013) Proc Natl Acad Sci U S A. , vol.110 , Issue.52 , pp. 21119-21123
    • Valind, A.1    Jin, Y.2    Baldetorp, B.3    Gisselsson, D.4
  • 115
    • 80053364894 scopus 로고    scopus 로고
    • Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    • Janssen A, van der Burg M, Szuhai K, Kops GJ, Medema RH. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science. 2011;333(6051):1895-8.
    • (2011) Science. , vol.333 , Issue.6051 , pp. 1895-1898
    • Janssen, A.1    van der Burg, M.2    Szuhai, K.3    Kops, G.J.4    Medema, R.H.5
  • 116
    • 76349126361 scopus 로고    scopus 로고
    • Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
    • Thompson SL, Compton DA. Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol. 2010;188(3):369-81.
    • (2010) J Cell Biol. , vol.188 , Issue.3 , pp. 369-381
    • Thompson, S.L.1    Compton, D.A.2
  • 117
    • 0017737269 scopus 로고
    • Terminal phase of cytokinesis in D-98 s cells
    • Mullins JM, Biesele JJ. Terminal phase of cytokinesis in D-98 s cells. J Cell Biol. 1977;73(3):672-84.
    • (1977) J Cell Biol. , vol.73 , Issue.3 , pp. 672-684
    • Mullins, J.M.1    Biesele, J.J.2
  • 118
    • 27144518175 scopus 로고    scopus 로고
    • Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines
    • Shi Q, King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature. 2005;437(7061):1038-42.
    • (2005) Nature. , vol.437 , Issue.7061 , pp. 1038-1042
    • Shi, Q.1    King, R.W.2
  • 119
    • 68749084849 scopus 로고    scopus 로고
    • Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells
    • Silkworth WT, Nardi IK, Scholl LM, Cimini D. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One. 2009;4(8):e6564.
    • (2009) PLoS One. , vol.4 , Issue.8
    • Silkworth, W.T.1    Nardi, I.K.2    Scholl, L.M.3    Cimini, D.4
  • 120
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009;460(7252):278-82.
    • (2009) Nature. , vol.460 , Issue.7252 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 121
    • 84908399662 scopus 로고    scopus 로고
    • DNA-damage response during mitosis induces whole-chromosome missegregation
    • Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA. DNA-damage response during mitosis induces whole-chromosome missegregation. Cancer Discov. 2014;4(11):1281-9.
    • (2014) Cancer Discov. , vol.4 , Issue.11 , pp. 1281-1289
    • Bakhoum, S.F.1    Kabeche, L.2    Murnane, J.P.3    Zaki, B.I.4    Compton, D.A.5
  • 122
    • 15444370589 scopus 로고    scopus 로고
    • Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
    • Rao CV, Yang YM, Swamy MV, Liu T, Fang Y, Mahmood R, et al. Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci U S A. 2005;102(12):4365-70.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.12 , pp. 4365-4370
    • Rao, C.V.1    Yang, Y.M.2    Swamy, M.V.3    Liu, T.4    Fang, Y.5    Mahmood, R.6
  • 123
    • 24344490148 scopus 로고    scopus 로고
    • Pituitary hypoplasia in Pttg-/-mice is protective for Rb+/-pituitary tumorigenesis
    • Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S. Pituitary hypoplasia in Pttg-/-mice is protective for Rb+/-pituitary tumorigenesis. Mol Endocrinol. 2005;19(9):2371-9.
    • (2005) Mol Endocrinol. , vol.19 , Issue.9 , pp. 2371-2379
    • Chesnokova, V.1    Kovacs, K.2    Castro, A.V.3    Zonis, S.4    Melmed, S.5
  • 124
    • 35948943082 scopus 로고    scopus 로고
    • Aneuploidy: instigator and inhibitor of tumorigenesis
    • Weaver BA, Cleveland DW. Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 2007;67(21):10103-5.
    • (2007) Cancer Res. , vol.67 , Issue.21 , pp. 10103-10105
    • Weaver, B.A.1    Cleveland, D.W.2
  • 125
    • 77956271440 scopus 로고    scopus 로고
    • The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis
    • Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, et al. The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A. 2010;107(32):14188-93.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.32 , pp. 14188-14193
    • Li, M.1    Fang, X.2    Baker, D.J.3    Guo, L.4    Gao, X.5    Wei, Z.6
  • 126
    • 60549094835 scopus 로고    scopus 로고
    • Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice
    • Chi YH, Ward JM, Cheng LI, Yasunaga J, Jeang KT. Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice. Int J Cancer. 2009;124(6):1483-9.
    • (2009) Int J Cancer. , vol.124 , Issue.6 , pp. 1483-1489
    • Chi, Y.H.1    Ward, J.M.2    Cheng, L.I.3    Yasunaga, J.4    Jeang, K.T.5
  • 127
    • 70749158525 scopus 로고    scopus 로고
    • Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity
    • Baker DJ, Jin F, Jeganathan KB, van Deursen JM. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell. 2009;16(6):475-86.
    • (2009) Cancer Cell. , vol.16 , Issue.6 , pp. 475-486
    • Baker, D.J.1    Jin, F.2    Jeganathan, K.B.3    van Deursen, J.M.4
  • 128
    • 84907190842 scopus 로고    scopus 로고
    • Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress
    • Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, et al. Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. Proc Natl Acad Sci U S A. 2014;111(37):13427-32.
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , Issue.37 , pp. 13427-13432
    • Foijer, F.1    Xie, S.Z.2    Simon, J.E.3    Bakker, P.L.4    Conte, N.5    Davis, S.H.6
  • 129
    • 84874412079 scopus 로고    scopus 로고
    • Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia
    • Dekanty A, Barrio L, Muzzopappa M, Auer H, Milan M. Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia. Proc Natl Acad Sci U S A. 2012;109(50):20549-54.
    • (2012) Proc Natl Acad Sci U S A. , vol.109 , Issue.50 , pp. 20549-20554
    • Dekanty, A.1    Barrio, L.2    Muzzopappa, M.3    Auer, H.4    Milan, M.5
  • 130
    • 0028180125 scopus 로고
    • 17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy
    • Blount PL, Galipeau PC, Sanchez CA, Neshat K, Levine DS, Yin J, et al. 17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy. Cancer Res. 1994;54(9):2292-5.
    • (1994) Cancer Res. , vol.54 , Issue.9 , pp. 2292-2295
    • Blount, P.L.1    Galipeau, P.C.2    Sanchez, C.A.3    Neshat, K.4    Levine, D.S.5    Yin, J.6
  • 131
    • 84946040120 scopus 로고    scopus 로고
    • COSMIC: exploring the world's knowledge of somatic mutations in human cancer
    • Forbes SA, Beare D, Gunasekaran P, Leung K, Bindal N, Boutselakis H, et al. COSMIC: exploring the world's knowledge of somatic mutations in human cancer. Nucleic Acids Res. 2015;43(Database issue):D805-11.
    • (2015) Nucleic Acids Res. , vol.43 , Issue.DATABASE ISSUE , pp. D805-D811
    • Forbes, S.A.1    Beare, D.2    Gunasekaran, P.3    Leung, K.4    Bindal, N.5    Boutselakis, H.6
  • 135
    • 84876998223 scopus 로고    scopus 로고
    • p21 both attenuates and drives senescence and aging in BubR1 progeroid mice
    • Baker DJ, Weaver RL, van Deursen JM. p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep. 2013;3(4):1164-74.
    • (2013) Cell Rep. , vol.3 , Issue.4 , pp. 1164-1174
    • Baker, D.J.1    Weaver, R.L.2    van Deursen, J.M.3
  • 136
    • 0034748340 scopus 로고    scopus 로고
    • Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division
    • Wang Z, Yu R, Melmed S. Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol Endocrinol. 2001;15(11):1870-9.
    • (2001) Mol Endocrinol. , vol.15 , Issue.11 , pp. 1870-1879
    • Wang, Z.1    Yu, R.2    Melmed, S.3
  • 137
    • 17844400784 scopus 로고    scopus 로고
    • Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice
    • Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K, et al. Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol. 2005;19(5):1383-91.
    • (2005) Mol Endocrinol. , vol.19 , Issue.5 , pp. 1383-1391
    • Abbud, R.A.1    Takumi, I.2    Barker, E.M.3    Ren, S.G.4    Chen, D.Y.5    Wawrowsky, K.6
  • 138
    • 33748740748 scopus 로고    scopus 로고
    • Pituitary tumor transforming gene overexpression facilitates pituitary tumor development
    • Donangelo I, Gutman S, Horvath E, Kovacs K, Wawrowsky K, Mount M, et al. Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology. 2006;147(10):4781-91.
    • (2006) Endocrinology. , vol.147 , Issue.10 , pp. 4781-4791
    • Donangelo, I.1    Gutman, S.2    Horvath, E.3    Kovacs, K.4    Wawrowsky, K.5    Mount, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.