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Volumn 20, Issue 6, 2010, Pages

Mechanisms of Chromosomal Instability

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; ANIMAL; BIOLOGICAL MODEL; CELL CYCLE; CENTROMERE; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; GENETICS; HUMAN; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NEOPLASM; PATHOLOGY; PHYSIOLOGY; REVIEW; SACCHAROMYCES CEREVISIAE;

EID: 77949579365     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2010.01.034     Document Type: Review
Times cited : (453)

References (140)
  • 1
    • 33646065584 scopus 로고
    • Ueber asymmetrische zelltheilung in epithelkrebsen und deren biologische bedeutung
    • von Hansemann D. Ueber asymmetrische zelltheilung in epithelkrebsen und deren biologische bedeutung. Virschows Arch. Pathol. Anat. 119 (1890) 299-326
    • (1890) Virschows Arch. Pathol. Anat. , vol.119 , pp. 299-326
    • von Hansemann, D.1
  • 2
    • 0002431372 scopus 로고
    • Theodor Boveri, and his book on the problem of the origin of malignant tumors
    • German J. (Ed), Wiley, New York
    • Wolf U. Theodor Boveri, and his book on the problem of the origin of malignant tumors. In: German J. (Ed). Chromosomes and Cancer (1974), Wiley, New York 3-20
    • (1974) Chromosomes and Cancer , pp. 3-20
    • Wolf, U.1
  • 5
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer C., Kinzler K.W., and Vogelstein B. Genetic instability in colorectal cancers. Nature 386 (1997) 623-627
    • (1997) Nature , vol.386 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 6
  • 8
    • 40849096242 scopus 로고    scopus 로고
    • Examining the link between chromosomal instability and aneuploidy in human cells
    • Thompson S.L., and Compton D.A. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell Biol. 180 (2008) 665-672
    • (2008) J. Cell Biol. , vol.180 , pp. 665-672
    • Thompson, S.L.1    Compton, D.A.2
  • 9
    • 2942567685 scopus 로고    scopus 로고
    • Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
    • Kops G.J., Foltz D.R., and Cleveland D.W. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc. Natl. Acad. Sci. 101 (2004) 8699-8704
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 8699-8704
    • Kops, G.J.1    Foltz, D.R.2    Cleveland, D.W.3
  • 10
    • 1842533070 scopus 로고    scopus 로고
    • Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells
    • Michel L., Diaz-Rodriguez E., Narayan G., Hernando E., Murty V.V., and Benezra R. Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells. Proc. Natl. Acad. Sci. 101 (2004) 4459-4464
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 4459-4464
    • Michel, L.1    Diaz-Rodriguez, E.2    Narayan, G.3    Hernando, E.4    Murty, V.V.5    Benezra, R.6
  • 11
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem N.J., Godinho S.A., and Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 460 (2009) 278-282
    • (2009) Nature , vol.460 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 12
    • 0027942033 scopus 로고
    • Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
    • Rieder C.L., Schultz A., Cole R., and Sluder G. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127 (1994) 1301-1310
    • (1994) J. Cell Biol. , vol.127 , pp. 1301-1310
    • Rieder, C.L.1    Schultz, A.2    Cole, R.3    Sluder, G.4
  • 13
    • 0029160299 scopus 로고
    • The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produce by unattached kinetochores
    • Rieder C.L., Cole R.W., Khodjakov A., and Sluder G. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produce by unattached kinetochores. J. Cell Biol. 130 (1995) 941-948
    • (1995) J. Cell Biol. , vol.130 , pp. 941-948
    • Rieder, C.L.1    Cole, R.W.2    Khodjakov, A.3    Sluder, G.4
  • 15
    • 35548995475 scopus 로고    scopus 로고
    • Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle
    • Indjeian V.B., and Murray A.W. Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle. Curr. Biol. 17 (2007) 1837-1846
    • (2007) Curr. Biol. , vol.17 , pp. 1837-1846
    • Indjeian, V.B.1    Murray, A.W.2
  • 16
    • 70349446100 scopus 로고    scopus 로고
    • Computer simulations predict that chromosome movements and rotations accelerate mitotic spindle assembly without compromising accuracy
    • Paul R., Wollman R., Silkworth W.T., Nardi I.K., Cimini D., and Mogilner A. Computer simulations predict that chromosome movements and rotations accelerate mitotic spindle assembly without compromising accuracy. Proc. Natl. Acad. Sci. 106 (2009) 15708-15713
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 15708-15713
    • Paul, R.1    Wollman, R.2    Silkworth, W.T.3    Nardi, I.K.4    Cimini, D.5    Mogilner, A.6
  • 17
    • 0242287897 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms
    • Cimini D., Moree B., Canman J., and Salmon E.D. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. J. Cell Sci. 116 (2003) 4213-4225
    • (2003) J. Cell Sci. , vol.116 , pp. 4213-4225
    • Cimini, D.1    Moree, B.2    Canman, J.3    Salmon, E.D.4
  • 18
    • 0035972237 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
    • Cimini D., Howell B., Maddox P., Khodjakov A., Degrassi F., and Salmon E.D. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J. Cell Biol. 153 (2001) 517-527
    • (2001) J. Cell Biol. , vol.153 , pp. 517-527
    • Cimini, D.1    Howell, B.2    Maddox, P.3    Khodjakov, A.4    Degrassi, F.5    Salmon, E.D.6
  • 24
    • 0242468471 scopus 로고    scopus 로고
    • Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells
    • Yu R., Lu W., Chen J., McCabe C.J., and Melmed S. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology 144 (2003) 4991-4998
    • (2003) Endocrinology , vol.144 , pp. 4991-4998
    • Yu, R.1    Lu, W.2    Chen, J.3    McCabe, C.J.4    Melmed, S.5
  • 33
    • 10244251532 scopus 로고    scopus 로고
    • Identification of a human checkpoint gene: hsMad2
    • Li Y., and Benezra R. Identification of a human checkpoint gene: hsMad2. Science 274 (1996) 246-248
    • (1996) Science , vol.274 , pp. 246-248
    • Li, Y.1    Benezra, R.2
  • 34
    • 0034518709 scopus 로고    scopus 로고
    • Correlation of defective mitotic checkpoint with aberrantly reduced expression of Mad2 protein in nasopharyngeal carcinoma cells
    • Wang X., Jin D.Y., Wong Y.C., Cheung A.L.M., Chun A.C.S., Lo A.K.F., Liu Y., and Tsao S.W. Correlation of defective mitotic checkpoint with aberrantly reduced expression of Mad2 protein in nasopharyngeal carcinoma cells. Carcinogenesis 21 (2000) 2293-2297
    • (2000) Carcinogenesis , vol.21 , pp. 2293-2297
    • Wang, X.1    Jin, D.Y.2    Wong, Y.C.3    Cheung, A.L.M.4    Chun, A.C.S.5    Lo, A.K.F.6    Liu, Y.7    Tsao, S.W.8
  • 35
    • 0037085936 scopus 로고    scopus 로고
    • Significance of Mad2 expression to mitotic checkpoint control in ovarian cancer cells
    • Wang X., Jin D.Y., Ng R.W.M., Feng H., Wong Y.C., Cheung A.L., and Tsao S.W. Significance of Mad2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer Res. 62 (2002) 1662-1668
    • (2002) Cancer Res. , vol.62 , pp. 1662-1668
    • Wang, X.1    Jin, D.Y.2    Ng, R.W.M.3    Feng, H.4    Wong, Y.C.5    Cheung, A.L.6    Tsao, S.W.7
  • 37
    • 25844499131 scopus 로고    scopus 로고
    • Frequent mutations of human Mad2, but not Bub1, in gastric cancers cause defective mitotic spindle checkpoint
    • Kim H.S., Park K.H., Kim S.A., Wen J., Park S.W., Park B., Gham C.W., Hyung W.J., Noh S.H., Kim H.K., et al. Frequent mutations of human Mad2, but not Bub1, in gastric cancers cause defective mitotic spindle checkpoint. Mut. Res. 578 (2005) 187-201
    • (2005) Mut. Res. , vol.578 , pp. 187-201
    • Kim, H.S.1    Park, K.H.2    Kim, S.A.3    Wen, J.4    Park, S.W.5    Park, B.6    Gham, C.W.7    Hyung, W.J.8    Noh, S.H.9    Kim, H.K.10
  • 39
    • 0034625268 scopus 로고    scopus 로고
    • Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
    • Dobles M., Liberal V., Scott M.L., Benezra R., and Sorger P.K. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101 (2000) 635-645
    • (2000) Cell , vol.101 , pp. 635-645
    • Dobles, M.1    Liberal, V.2    Scott, M.L.3    Benezra, R.4    Sorger, P.K.5
  • 41
    • 35548957419 scopus 로고    scopus 로고
    • Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
    • Jeganathan K., Malureanu L., Baker D.J., Abaraham S.C., and van Deursen J.M. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J. Cell Biol. 179 (2007) 255-267
    • (2007) J. Cell Biol. , vol.179 , pp. 255-267
    • Jeganathan, K.1    Malureanu, L.2    Baker, D.J.3    Abaraham, S.C.4    van Deursen, J.M.5
  • 42
    • 0034665634 scopus 로고    scopus 로고
    • Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
    • Kalitsis P., Earle E., Fowler K.J., and Choo K.H. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev. 14 (2000) 2277-2282
    • (2000) Genes Dev. , vol.14 , pp. 2277-2282
    • Kalitsis, P.1    Earle, E.2    Fowler, K.J.3    Choo, K.H.4
  • 44
    • 67449143471 scopus 로고    scopus 로고
    • Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice
    • Li M., Fang X., Wei Z., York J.P., and Zhang P. Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J. Cell Biol. 185 (2009) 983-994
    • (2009) J. Cell Biol. , vol.185 , pp. 983-994
    • Li, M.1    Fang, X.2    Wei, Z.3    York, J.P.4    Zhang, P.5
  • 46
    • 0037415605 scopus 로고    scopus 로고
    • Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome mis-segregation
    • Babu J.R., Jeganathan K.B., Baker D.J., Wu X., Kang-Decker N., and van Deursen J.M. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome mis-segregation. J. Cell Biol. 160 (2003) 341-353
    • (2003) J. Cell Biol. , vol.160 , pp. 341-353
    • Babu, J.R.1    Jeganathan, K.B.2    Baker, D.J.3    Wu, X.4    Kang-Decker, N.5    van Deursen, J.M.6
  • 49
    • 0034906435 scopus 로고    scopus 로고
    • Aneuploid colon cancer cells have a robust spindle checkpoint
    • Tighe A., Johnson V.L., Albertella M., and Taylor S.S. Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep 2 (2001) 609-614
    • (2001) EMBO Rep , vol.2 , pp. 609-614
    • Tighe, A.1    Johnson, V.L.2    Albertella, M.3    Taylor, S.S.4
  • 50
    • 48449098623 scopus 로고    scopus 로고
    • Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
    • Gascoigne K.E., and Taylor S. Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 12 (2008) 111-122
    • (2008) Cancer Cell , vol.12 , pp. 111-122
    • Gascoigne, K.E.1    Taylor, S.2
  • 51
    • 67749147567 scopus 로고    scopus 로고
    • The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells
    • Brito D.A., and Rieder C.L. The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells. Cell Motil. Cytoskeleton 8 (2009) 437-447
    • (2009) Cell Motil. Cytoskeleton , vol.8 , pp. 437-447
    • Brito, D.A.1    Rieder, C.L.2
  • 53
    • 0032700919 scopus 로고    scopus 로고
    • Differences in mis-segregation rates obtained by scoring ana-telophases or binucleate cells
    • Cimini D., Tanzarella C., and Degrassi F. Differences in mis-segregation rates obtained by scoring ana-telophases or binucleate cells. Mutagenesis 14 (1999) 563-568
    • (1999) Mutagenesis , vol.14 , pp. 563-568
    • Cimini, D.1    Tanzarella, C.2    Degrassi, F.3
  • 54
    • 33644746123 scopus 로고    scopus 로고
    • Molecular requirements for kinetochore-associated microtubule formation in mammalian cells
    • Tulu U.S., Fagerstrom C., Ferenz N.P., and Wadsworth P. Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. Curr. Biol. 16 (2006) 536-541
    • (2006) Curr. Biol. , vol.16 , pp. 536-541
    • Tulu, U.S.1    Fagerstrom, C.2    Ferenz, N.P.3    Wadsworth, P.4
  • 55
    • 33750609316 scopus 로고    scopus 로고
    • Aurora B is enriched at merotelic attachment sites, where it regulates MCAK
    • Knowlton A.L., Lan W., and Stukenberg P.T. Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr. Biol. 16 (2006) 1705-1710
    • (2006) Curr. Biol. , vol.16 , pp. 1705-1710
    • Knowlton, A.L.1    Lan, W.2    Stukenberg, P.T.3
  • 57
    • 68749084849 scopus 로고    scopus 로고
    • Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells
    • Silkworth W.T., Nardi I.K., Scholl L.M., and Cimini D. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS ONE 4 (2009) e6564
    • (2009) PLoS ONE , vol.4
    • Silkworth, W.T.1    Nardi, I.K.2    Scholl, L.M.3    Cimini, D.4
  • 58
    • 38349169905 scopus 로고    scopus 로고
    • Simultaneous Aurora A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumor cells with a MIN phenotype
    • Lentini L., Amato A., Schillaci T., and Di Leonardo A. Simultaneous Aurora A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumor cells with a MIN phenotype. BMC Cancer 7 (2007) 212
    • (2007) BMC Cancer , vol.7 , pp. 212
    • Lentini, L.1    Amato, A.2    Schillaci, T.3    Di Leonardo, A.4
  • 59
    • 34548253898 scopus 로고    scopus 로고
    • High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers
    • Nishida N., Nagasaka T., Koshiwagi K., Boland C.R., and Goel A. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol. Therapy 6 (2007) 525-533
    • (2007) Cancer Biol. Therapy , vol.6 , pp. 525-533
    • Nishida, N.1    Nagasaka, T.2    Koshiwagi, K.3    Boland, C.R.4    Goel, A.5
  • 60
    • 0037048297 scopus 로고    scopus 로고
    • Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability
    • Duensing S., and Munger K. Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability. Oncogene 21 (2002) 6241-6248
    • (2002) Oncogene , vol.21 , pp. 6241-6248
    • Duensing, S.1    Munger, K.2
  • 61
  • 62
    • 35948946506 scopus 로고    scopus 로고
    • Overexpression of Eg5 causes genomic instability and tumor formation in mice
    • Castillo A., Morse III H.C., Godfrey V.L., Naeem R., and Justice M.J. Overexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Res. 67 (2007) 10138-10147
    • (2007) Cancer Res. , vol.67 , pp. 10138-10147
    • Castillo, A.1    Morse III, H.C.2    Godfrey, V.L.3    Naeem, R.4    Justice, M.J.5
  • 63
    • 0041672310 scopus 로고    scopus 로고
    • Molecular phenotype of spontaneously arising 4N (G2-Tetraploid) intermediates of neoplastic progression in Barrett's esophagus
    • Barrett M.T., Pritchard D., Palanca-Wessels C., Anderson J., Reid B.J., and Rabinovitch P.S. Molecular phenotype of spontaneously arising 4N (G2-Tetraploid) intermediates of neoplastic progression in Barrett's esophagus. Cancer Res. 63 (2003) 4211-4217
    • (2003) Cancer Res. , vol.63 , pp. 4211-4217
    • Barrett, M.T.1    Pritchard, D.2    Palanca-Wessels, C.3    Anderson, J.4    Reid, B.J.5    Rabinovitch, P.S.6
  • 65
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • Fujiwara T., Bandi M., Nitta M., Ivanova E.V., Bronson R.T., and Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437 (2005) 1043-1046
    • (2005) Nature , vol.437 , pp. 1043-1046
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5    Pellman, D.6
  • 66
    • 0027932906 scopus 로고
    • Elements of error correction in mitosis: microtubule capture, release, and tension
    • Nicklas R.B., and Ward S.C. Elements of error correction in mitosis: microtubule capture, release, and tension. J. Cell Biol. 126 (1994) 1241-1253
    • (1994) J. Cell Biol. , vol.126 , pp. 1241-1253
    • Nicklas, R.B.1    Ward, S.C.2
  • 67
    • 58149334818 scopus 로고    scopus 로고
    • Genome stability is ensured by temporal control of kinetochore-microtubule dynamics
    • Bakhoum S.F., Thompson S.L., Manning A.L., and Compton D.A. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat. Cell Biol. 11 (2009) 27-35
    • (2009) Nat. Cell Biol. , vol.11 , pp. 27-35
    • Bakhoum, S.F.1    Thompson, S.L.2    Manning, A.L.3    Compton, D.A.4
  • 68
    • 0028786819 scopus 로고
    • Kinetochore microtubule dynamics and the metaphase-anaphase transition
    • Zhai Y., Kronebusch P.J., and Borisy G.G. Kinetochore microtubule dynamics and the metaphase-anaphase transition. J. Cell Biol. 131 (1995) 721-734
    • (1995) J. Cell Biol. , vol.131 , pp. 721-734
    • Zhai, Y.1    Kronebusch, P.J.2    Borisy, G.G.3
  • 69
    • 33750612373 scopus 로고    scopus 로고
    • Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors
    • Cimini D., Wan X.H., Hirel C.B., and Salmon E.D. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr. Biol. 16 (2006) 1711-1718
    • (2006) Curr. Biol. , vol.16 , pp. 1711-1718
    • Cimini, D.1    Wan, X.H.2    Hirel, C.B.3    Salmon, E.D.4
  • 70
    • 0038746733 scopus 로고    scopus 로고
    • The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
    • Hauf S., Cole R.W., LaTerra S., Zimmer C., Schnapp G., Walter R., Heckel A., van Meel J., Rieder C.L., and Peters J.M. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 161 (2003) 281-294
    • (2003) J. Cell Biol. , vol.161 , pp. 281-294
    • Hauf, S.1    Cole, R.W.2    LaTerra, S.3    Zimmer, C.4    Schnapp, G.5    Walter, R.6    Heckel, A.7    van Meel, J.8    Rieder, C.L.9    Peters, J.M.10
  • 72
    • 33751232957 scopus 로고    scopus 로고
    • The conserved KMN network constitutes the core microtubule-binding site of the kinetochore
    • Cheeseman I.M., Chappie J.S., Wilson-Kubalek E.M., and Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127 (2006) 983-997
    • (2006) Cell , vol.127 , pp. 983-997
    • Cheeseman, I.M.1    Chappie, J.S.2    Wilson-Kubalek, E.M.3    Desai, A.4
  • 73
    • 33751227843 scopus 로고    scopus 로고
    • Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
    • DeLuca J.G., Gall W.E., Ciferri C., Cimini D., Musacchio A., and Salmon E.D. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127 (2006) 969-982
    • (2006) Cell , vol.127 , pp. 969-982
    • DeLuca, J.G.1    Gall, W.E.2    Ciferri, C.3    Cimini, D.4    Musacchio, A.5    Salmon, E.D.6
  • 74
    • 0037175401 scopus 로고    scopus 로고
    • hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells
    • DeLuca J.G., Moree B., Hickey J.M., Kilmartin J.V., and Salmon E.D. hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J. Cell Biol. 159 (2002) 549-555
    • (2002) J. Cell Biol. , vol.159 , pp. 549-555
    • DeLuca, J.G.1    Moree, B.2    Hickey, J.M.3    Kilmartin, J.V.4    Salmon, E.D.5
  • 75
    • 0037183886 scopus 로고    scopus 로고
    • Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2
    • Martin-Lluesma S., Stucke V.M., and Nigg E.A. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297 (2002) 2267-2270
    • (2002) Science , vol.297 , pp. 2267-2270
    • Martin-Lluesma, S.1    Stucke, V.M.2    Nigg, E.A.3
  • 76
    • 0031873388 scopus 로고    scopus 로고
    • Mitotic centromere-associated kinesin is important for anaphase chromosome segregation
    • Maney T., Hunter A.W., Wagenbach M., and Wordeman L. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J. Cell Biol. 142 (1998) 787-801
    • (1998) J. Cell Biol. , vol.142 , pp. 787-801
    • Maney, T.1    Hunter, A.W.2    Wagenbach, M.3    Wordeman, L.4
  • 77
    • 1542373746 scopus 로고    scopus 로고
    • Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments
    • Kline-Smith S.L., Khodjakov A., Hergert P., and Walczak C.E. Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol. Biol. Cell 15 (2004) 1145-1159
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1145-1159
    • Kline-Smith, S.L.1    Khodjakov, A.2    Hergert, P.3    Walczak, C.E.4
  • 78
    • 27144451193 scopus 로고    scopus 로고
    • Efficient mitosis in human cells lacking poleward microtubule flux
    • Ganem N.J., Upton K., and Compton D.A. Efficient mitosis in human cells lacking poleward microtubule flux. Curr. Biol. 15 (2005) 1827-1832
    • (2005) Curr. Biol. , vol.15 , pp. 1827-1832
    • Ganem, N.J.1    Upton, K.2    Compton, D.A.3
  • 79
    • 34547726131 scopus 로고    scopus 로고
    • The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distict roles during mitosis in human cells
    • Manning A.L., Ganem N.J., Bakhoum S.F., Wagenbach M., Wordeman L., and Compton D.A. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distict roles during mitosis in human cells. Mol. Biol. Cell 18 (2007) 2970-2979
    • (2007) Mol. Biol. Cell , vol.18 , pp. 2970-2979
    • Manning, A.L.1    Ganem, N.J.2    Bakhoum, S.F.3    Wagenbach, M.4    Wordeman, L.5    Compton, D.A.6
  • 81
    • 62149111407 scopus 로고    scopus 로고
    • Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates
    • Liu D., Vader G., Vromans M.J., Lampson M.A., and Lens S.M. Sensing chromosome bi-orientation by spatial separation of Aurora B kinase from kinetochore substrates. Science 323 (2009) 1350-1353
    • (2009) Science , vol.323 , pp. 1350-1353
    • Liu, D.1    Vader, G.2    Vromans, M.J.3    Lampson, M.A.4    Lens, S.M.5
  • 82
    • 34548481992 scopus 로고    scopus 로고
    • Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function
    • Zhang X., Lan W., Ems-McClung S.C., Stukenberg P.T., and Walczak C.E. Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function. Mol. Biol. Cell 18 (2007) 3264-3276
    • (2007) Mol. Biol. Cell , vol.18 , pp. 3264-3276
    • Zhang, X.1    Lan, W.2    Ems-McClung, S.C.3    Stukenberg, P.T.4    Walczak, C.E.5
  • 83
    • 70450176266 scopus 로고    scopus 로고
    • Deviant kinetochore microtubule dynamics underlie chromosomal instability
    • Bakhoum S.F., Genovese G., and Compton D.A. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr. Biol. 19 (2009) 1937-1942
    • (2009) Curr. Biol. , vol.19 , pp. 1937-1942
    • Bakhoum, S.F.1    Genovese, G.2    Compton, D.A.3
  • 85
    • 0001665802 scopus 로고    scopus 로고
    • CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint
    • Yao X., Abrieu A., Zheng Y., Sullivan K.F., and Cleveland D.W. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat. Cell Biol. 2 (2000) 484-491
    • (2000) Nat. Cell Biol. , vol.2 , pp. 484-491
    • Yao, X.1    Abrieu, A.2    Zheng, Y.3    Sullivan, K.F.4    Cleveland, D.W.5
  • 86
    • 27844472684 scopus 로고    scopus 로고
    • Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint
    • Holt S.V., Vernolle M.A.S., Hussein D., Wozniak M.J., Allan V.J., and Taylor S.S. Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint. J. Cell Sci. 118 (2005) 4889-4900
    • (2005) J. Cell Sci. , vol.118 , pp. 4889-4900
    • Holt, S.V.1    Vernolle, M.A.S.2    Hussein, D.3    Wozniak, M.J.4    Allan, V.J.5    Taylor, S.S.6
  • 87
    • 55949096605 scopus 로고    scopus 로고
    • Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
    • Diaz-Rodriguez E., Sotillo R., Scvartzman J.-M., and Benezra R. Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc. Natl. Acad. Sci. USA 105 (2008) 16719-16724
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 16719-16724
    • Diaz-Rodriguez, E.1    Sotillo, R.2    Scvartzman, J.-M.3    Benezra, R.4
  • 91
    • 34250833558 scopus 로고    scopus 로고
    • Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubules motor complexes
    • Vergnolle M.A., and Taylor S.S. Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubules motor complexes. Curr. Biol. 17 (2007) 1173-1179
    • (2007) Curr. Biol. , vol.17 , pp. 1173-1179
    • Vergnolle, M.A.1    Taylor, S.S.2
  • 92
    • 0346849717 scopus 로고    scopus 로고
    • Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by dominant mutation in APC
    • Green R.A., and Kaplan K.B. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by dominant mutation in APC. J. Cell Biol. 163 (2003) 949-961
    • (2003) J. Cell Biol. , vol.163 , pp. 949-961
    • Green, R.A.1    Kaplan, K.B.2
  • 94
    • 33745542004 scopus 로고    scopus 로고
    • Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
    • Draviam V.M., Shapiro I., Aldridge B., and Sorger P.K. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J. 25 (2006) 2814-2827
    • (2006) EMBO J. , vol.25 , pp. 2814-2827
    • Draviam, V.M.1    Shapiro, I.2    Aldridge, B.3    Sorger, P.K.4
  • 95
    • 36849029848 scopus 로고    scopus 로고
    • MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover
    • Wordeman L., Wagenbach M., and von Dassow G. MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover. J. Cell Biol. 179 (2007) 869-879
    • (2007) J. Cell Biol. , vol.179 , pp. 869-879
    • Wordeman, L.1    Wagenbach, M.2    von Dassow, G.3
  • 96
    • 38349083255 scopus 로고    scopus 로고
    • Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli
    • Takacs C.M., Baird J.R., Hughes E.G., Kent S.S., Benchabane H., Paik R., and Ahmed Y. Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli. Science 319 (2008) 333-336
    • (2008) Science , vol.319 , pp. 333-336
    • Takacs, C.M.1    Baird, J.R.2    Hughes, E.G.3    Kent, S.S.4    Benchabane, H.5    Paik, R.6    Ahmed, Y.7
  • 97
    • 13444261036 scopus 로고    scopus 로고
    • Truncating APC mutations have dominat effects on proliferation, spindle checkpoint control, survival chromosome stability
    • Tighe A., Johnson V.L., and Taylor S.S. Truncating APC mutations have dominat effects on proliferation, spindle checkpoint control, survival chromosome stability. J. Cell Sci. 117 (2004) 6339-6353
    • (2004) J. Cell Sci. , vol.117 , pp. 6339-6353
    • Tighe, A.1    Johnson, V.L.2    Taylor, S.S.3
  • 98
    • 0032506125 scopus 로고    scopus 로고
    • Genetic instability of cancer cells is proportional to their degree of aneuploidy
    • Duesberg P., Rausch C., Rasnick D., and Hehlmann R. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc. Natl. Acad. Sci. USA 95 (1998) 13692-13697
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13692-13697
    • Duesberg, P.1    Rausch, C.2    Rasnick, D.3    Hehlmann, R.4
  • 101
    • 76349126361 scopus 로고    scopus 로고
    • Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
    • Thompson S.L., and Compton D.A. Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J. Cell Biol. 188 (2010) 369-381
    • (2010) J. Cell Biol. , vol.188 , pp. 369-381
    • Thompson, S.L.1    Compton, D.A.2
  • 105
    • 0033575920 scopus 로고    scopus 로고
    • Deregulated cyclin E induces chromosome instability
    • Spruck C.H., Won K.A., and Reed S.I. Deregulated cyclin E induces chromosome instability. Nature 401 (1999) 297-300
    • (1999) Nature , vol.401 , pp. 297-300
    • Spruck, C.H.1    Won, K.A.2    Reed, S.I.3
  • 107
    • 33748286796 scopus 로고    scopus 로고
    • A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
    • Carter S.L., Eklund A.C., Kohane I.S., Harris L.N., and Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat. Genet. 38 (2006) 1043-1048
    • (2006) Nat. Genet. , vol.38 , pp. 1043-1048
    • Carter, S.L.1    Eklund, A.C.2    Kohane, I.S.3    Harris, L.N.4    Szallasi, Z.5
  • 108
    • 23844493744 scopus 로고    scopus 로고
    • Generating chromosome instability through the simultaneous deletion of Mad2 and p53
    • Burds A.A., Lutum A.S., and Sorger P.K. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc. Natl. Acad. Sci. USA 102 (2005) 11296-11301
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 11296-11301
    • Burds, A.A.1    Lutum, A.S.2    Sorger, P.K.3
  • 111
    • 62049083112 scopus 로고    scopus 로고
    • Mouse embryonic fibroblasts null for the Kruppel-like factor 4 gene are genetically unstable
    • Hagos E.G., Ghaleb A.M., Dalton W.B., Bialkowska A.B., and Yang V.W. Mouse embryonic fibroblasts null for the Kruppel-like factor 4 gene are genetically unstable. Oncogene 28 (2009) 1197-1205
    • (2009) Oncogene , vol.28 , pp. 1197-1205
    • Hagos, E.G.1    Ghaleb, A.M.2    Dalton, W.B.3    Bialkowska, A.B.4    Yang, V.W.5
  • 112
    • 40449085773 scopus 로고    scopus 로고
    • Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells
    • Wang P., Lushnikova T., Odvody J., Greiner T.C., Jones S.N., and Eischen C.M. Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells. Oncogene 27 (2007) 1590-1598
    • (2007) Oncogene , vol.27 , pp. 1590-1598
    • Wang, P.1    Lushnikova, T.2    Odvody, J.3    Greiner, T.C.4    Jones, S.N.5    Eischen, C.M.6
  • 113
    • 53649084945 scopus 로고    scopus 로고
    • MdmX regulates transformation and chromosomal stability in p53-deficient cells
    • Matijasevic Z., Krzywicka-Racka A., Sluder G., and Jones S.J. MdmX regulates transformation and chromosomal stability in p53-deficient cells. Cell Cycle 7 (2008) 1-7
    • (2008) Cell Cycle , vol.7 , pp. 1-7
    • Matijasevic, Z.1    Krzywicka-Racka, A.2    Sluder, G.3    Jones, S.J.4
  • 114
    • 36549085093 scopus 로고    scopus 로고
    • RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells
    • Tedeschi A., Ciciarello M., Mangiacasale R., Roscioli E., Rensen W.M., and Lavia P. RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells. J. Cell Sci. 120 (2007) 3748-3761
    • (2007) J. Cell Sci. , vol.120 , pp. 3748-3761
    • Tedeschi, A.1    Ciciarello, M.2    Mangiacasale, R.3    Roscioli, E.4    Rensen, W.M.5    Lavia, P.6
  • 115
    • 0033525007 scopus 로고    scopus 로고
    • Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
    • Hinchcliffe E.H., Li C., Thompson E.A., Maller J.L., and Sluder G. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283 (1999) 851-854
    • (1999) Science , vol.283 , pp. 851-854
    • Hinchcliffe, E.H.1    Li, C.2    Thompson, E.A.3    Maller, J.L.4    Sluder, G.5
  • 116
    • 0033055061 scopus 로고    scopus 로고
    • Cyclin-dependent kinase controls of centrosome duplication
    • Lacey K.R., Jackson P.K., and Stearns T. Cyclin-dependent kinase controls of centrosome duplication. Proc. Natl. Acad. Sci. USA 96 (1999) 2817-2822
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2817-2822
    • Lacey, K.R.1    Jackson, P.K.2    Stearns, T.3
  • 118
    • 29244460649 scopus 로고    scopus 로고
    • CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability
    • Kemp Z., Rowan A., Chambers W., Wortham N., Halford S., Sieber O., Mortensen N., von Herbay A., Gunther T., Ilyas M., et al. CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. Cancer Res. 65 (2005) 11361-11366
    • (2005) Cancer Res. , vol.65 , pp. 11361-11366
    • Kemp, Z.1    Rowan, A.2    Chambers, W.3    Wortham, N.4    Halford, S.5    Sieber, O.6    Mortensen, N.7    von Herbay, A.8    Gunther, T.9    Ilyas, M.10
  • 120
    • 77953919322 scopus 로고    scopus 로고
    • Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group
    • 10.1111/j.1582-4934.2009.00905.x
    • Heilig C.E., Loffler H., Mahlknecht U., Janssen J.W., Ho A.D., Jauch A., and Kramer A. Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group. J. Cell. Mol. Med. (2009) 10.1111/j.1582-4934.2009.00905.x
    • (2009) J. Cell. Mol. Med.
    • Heilig, C.E.1    Loffler, H.2    Mahlknecht, U.3    Janssen, J.W.4    Ho, A.D.5    Jauch, A.6    Kramer, A.7
  • 121
    • 61749087143 scopus 로고    scopus 로고
    • Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients
    • Choi C.M., Seo K.W., Jang S.J., Oh Y.M., Shim T.S., Kim W.S., Lee D.S., and Lee S.D. Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients. Lung Cancer 64 (2009) 66-70
    • (2009) Lung Cancer , vol.64 , pp. 66-70
    • Choi, C.M.1    Seo, K.W.2    Jang, S.J.3    Oh, Y.M.4    Shim, T.S.5    Kim, W.S.6    Lee, D.S.7    Lee, S.D.8
  • 123
    • 70350244838 scopus 로고    scopus 로고
    • Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy
    • McClelland S.E., Burrell R.A., and Swanton C. Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy. Cell Cycle 8 (2009) 3262-3266
    • (2009) Cell Cycle , vol.8 , pp. 3262-3266
    • McClelland, S.E.1    Burrell, R.A.2    Swanton, C.3
  • 124
    • 70350371493 scopus 로고    scopus 로고
    • Aneuploidy in mitosis of PtK1 cells is generated by random loss and nondisjunction of individual chromosomes
    • Torosantucci L., de Santis Puzzonia M., Cenciarelli C., Rens W., and Degrassi F. Aneuploidy in mitosis of PtK1 cells is generated by random loss and nondisjunction of individual chromosomes. J. Cell Sci. 122 (2009) 3455-3461
    • (2009) J. Cell Sci. , vol.122 , pp. 3455-3461
    • Torosantucci, L.1    de Santis Puzzonia, M.2    Cenciarelli, C.3    Rens, W.4    Degrassi, F.5
  • 125
    • 73149101630 scopus 로고    scopus 로고
    • Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells
    • Janssen A., Kops G.J., and Medema R.H. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc. Natl. Acad. Sci. USA 106 (2009) 19108-19113
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 19108-19113
    • Janssen, A.1    Kops, G.J.2    Medema, R.H.3
  • 130
    • 0042978646 scopus 로고    scopus 로고
    • Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
    • Weaver B.A.A., Bonday Z.Q., Putkey F.R., Kops G.J.P.L., Silk A.D., and Cleveland D.W. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J. Cell Biol. 162 (2003) 551-563
    • (2003) J. Cell Biol. , vol.162 , pp. 551-563
    • Weaver, B.A.A.1    Bonday, Z.Q.2    Putkey, F.R.3    Kops, G.J.P.L.4    Silk, A.D.5    Cleveland, D.W.6
  • 131
    • 19644379975 scopus 로고    scopus 로고
    • Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy
    • Tomonaga T., Matushita K., Ishibashi M., Nezu M., Shimada H., Ochiai T., Yoda K., and Nomura F. Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Res. 65 (2005) 4683-4689
    • (2005) Cancer Res. , vol.65 , pp. 4683-4689
    • Tomonaga, T.1    Matushita, K.2    Ishibashi, M.3    Nezu, M.4    Shimada, H.5    Ochiai, T.6    Yoda, K.7    Nomura, F.8
  • 132
    • 41949093895 scopus 로고    scopus 로고
    • ECRG2 disruption leads to centrosome amplification and spindle checkpoint defects contributing chromosome instability
    • Cheng X., Shen Z., Yang J., Lu S.H., and Cui Y. ECRG2 disruption leads to centrosome amplification and spindle checkpoint defects contributing chromosome instability. J. Biol. Chem. 283 (2008) 5888-5898
    • (2008) J. Biol. Chem. , vol.283 , pp. 5888-5898
    • Cheng, X.1    Shen, Z.2    Yang, J.3    Lu, S.H.4    Cui, Y.5
  • 133
    • 46449099476 scopus 로고    scopus 로고
    • The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability
    • Du J., Cai X., Yao J., Ding X., Wu Q., Pei S., Jiang K., Zhang Y., Wang W., Shi Y., et al. The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability. Oncogene 27 (2008) 4107-4114
    • (2008) Oncogene , vol.27 , pp. 4107-4114
    • Du, J.1    Cai, X.2    Yao, J.3    Ding, X.4    Wu, Q.5    Pei, S.6    Jiang, K.7    Zhang, Y.8    Wang, W.9    Shi, Y.10
  • 134
    • 44349083131 scopus 로고    scopus 로고
    • Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells
    • Wu G., Lin Y.T., Wei R., Chen Y., Shan Z., and Lee W.H. Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. Mol. Cell. Biol. 28 (2008) 3652-3662
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 3652-3662
    • Wu, G.1    Lin, Y.T.2    Wei, R.3    Chen, Y.4    Shan, Z.5    Lee, W.H.6
  • 135
    • 47949101916 scopus 로고    scopus 로고
    • Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption
    • Wang X., Di K., Zhang X., Han H.Y., Wong Y.C., Leung S.C., and Ling M.T. Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption. Oncogene 27 (2008) 4456-4466
    • (2008) Oncogene , vol.27 , pp. 4456-4466
    • Wang, X.1    Di, K.2    Zhang, X.3    Han, H.Y.4    Wong, Y.C.5    Leung, S.C.6    Ling, M.T.7
  • 138
    • 36348945248 scopus 로고    scopus 로고
    • PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores
    • Montembault E., Dutertre S., Prigent C., and Giet R. PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. J. Cell Biol. 179 (2007) 601-609
    • (2007) J. Cell Biol. , vol.179 , pp. 601-609
    • Montembault, E.1    Dutertre, S.2    Prigent, C.3    Giet, R.4
  • 139
    • 58549118935 scopus 로고    scopus 로고
    • TMAP/CKAP2 is essential for proper chromosome segregation
    • Hong K.U., Kim E., Bae C.D., and Park J. TMAP/CKAP2 is essential for proper chromosome segregation. Cell Cycle 8 (2009) 314-324
    • (2009) Cell Cycle , vol.8 , pp. 314-324
    • Hong, K.U.1    Kim, E.2    Bae, C.D.3    Park, J.4
  • 140
    • 0030895613 scopus 로고    scopus 로고
    • Topoisomerase II inhibition in mitosis produces numerical and structural chromosomal aberrations in human fibroblasts
    • Cimini D., Antoccia A., Tanzarella C., and Degrassi F. Topoisomerase II inhibition in mitosis produces numerical and structural chromosomal aberrations in human fibroblasts. Cytogenet. Cell Genet. 76 (1997) 61-67
    • (1997) Cytogenet. Cell Genet. , vol.76 , pp. 61-67
    • Cimini, D.1    Antoccia, A.2    Tanzarella, C.3    Degrassi, F.4


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