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Volumn 3 DEC, Issue , 2013, Pages

Multi-layered cancer chromosomal instability phenotype

Author keywords

Aneuploidy; Cancer; Chromosomal instability; Intra tumor heterogeneity; W CIN

Indexed keywords

ANEUPLOIDY; APOPTOSIS; CANCER INHIBITION; CARCINOGENESIS; CELL ADHESION; CELL DIVISION; CELL HETEROGENEITY; CELL POPULATION; CENTROSOME; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; COPY NUMBER VARIATION; HUMAN; M PHASE CELL CYCLE CHECKPOINT; NEOPLASM; NONHUMAN; PHENOTYPE; REVIEW; TUMOR CELL; TUMOR PROMOTION;

EID: 84892404359     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00302     Document Type: Review
Times cited : (31)

References (137)
  • 1
    • 33750626189 scopus 로고    scopus 로고
    • Does aneuploidy cause cancer?
    • doi: 10.1016/j.ceb.2006.10.002
    • Weaver BA, Cleveland DW. Does aneuploidy cause cancer? Curr Opin Cell Biol (2006) 18(6):658-67. doi: 10.1016/j.ceb.2006.10.002.
    • (2006) Curr Opin Cell Biol , vol.18 , Issue.6 , pp. 658-667
    • Weaver, B.A.1    Cleveland, D.W.2
  • 2
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • doi:10.1126/science.959840
    • Nowell PC. The clonal evolution of tumor cell populations. Science (1976) 194(4260):23-8. doi:10.1126/science.959840.
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 3
    • 84891609336 scopus 로고    scopus 로고
    • Cancer karyotypes: survival of the fittest
    • doi:10.3389/fonc.2013.00148
    • Nicholson JM, Cimini D. Cancer karyotypes: survival of the fittest. Front Oncol (2013) 3:148. doi:10.3389/fonc.2013.00148.
    • (2013) Front Oncol , vol.3 , pp. 148
    • Nicholson, J.M.1    Cimini, D.2
  • 4
    • 0042166174 scopus 로고    scopus 로고
    • Chromosome aberrations in solid tumors
    • doi:10.1038/ng1215
    • Albertson DG, Collins C, McCormick F, Gray JW. Chromosome aberrations in solid tumors. Nat Genet (2003) 34(4):369-76. doi:10.1038/ng1215.
    • (2003) Nat Genet , vol.34 , Issue.4 , pp. 369-376
    • Albertson, D.G.1    Collins, C.2    McCormick, F.3    Gray, J.W.4
  • 5
    • 33748286796 scopus 로고    scopus 로고
    • A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
    • doi:10.1038/ng1861
    • Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet (2006) 38(9):1043-8. doi:10.1038/ng1861.
    • (2006) Nat Genet , vol.38 , Issue.9 , pp. 1043-1048
    • Carter, S.L.1    Eklund, A.C.2    Kohane, I.S.3    Harris, L.N.4    Szallasi, Z.5
  • 6
    • 66649137945 scopus 로고    scopus 로고
    • Chromosomal instability determines taxane response
    • doi:10.1073/pnas.0811835106
    • Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, et al. Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 106(21):8671-6. doi:10.1073/pnas.0811835106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.21 , pp. 8671-8676
    • Swanton, C.1    Nicke, B.2    Schuett, M.3    Eklund, A.C.4    Ng, C.5    Li, Q.6
  • 7
    • 84859726409 scopus 로고    scopus 로고
    • Chromosomal instability and cancer: a complex relationship with therapeutic potential
    • doi:10.1172/JCI59954
    • Bakhoum SF, Compton DA. Chromosomal instability and cancer: a complex relationship with therapeutic potential. J Clin Invest (2012) 122(4):1138-43. doi:10.1172/JCI59954.
    • (2012) J Clin Invest , vol.122 , Issue.4 , pp. 1138-1143
    • Bakhoum, S.F.1    Compton, D.A.2
  • 8
    • 79952233635 scopus 로고    scopus 로고
    • Chromosomal instability confers intrinsic multidrug resistance
    • doi:10.1158/0008-5472.CAN-10-3604
    • Lee AJ, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, et al. Chromosomal instability confers intrinsic multidrug resistance. Cancer Res (2011) 71(5):1858-70. doi:10.1158/0008-5472.CAN-10-3604.
    • (2011) Cancer Res , vol.71 , Issue.5 , pp. 1858-1870
    • Lee, A.J.1    Endesfelder, D.2    Rowan, A.J.3    Walther, A.4    Birkbak, N.J.5    Futreal, P.A.6
  • 9
    • 84861851519 scopus 로고    scopus 로고
    • Cancer chromosomal instability: therapeutic and diagnostic challenges
    • doi:10.1038/embor.2012.61
    • McGranahan N, Burrell RA, Endesfelder D, Novelli MR, Swanton C. Cancer chromosomal instability: therapeutic and diagnostic challenges. EMBO Rep (2012) 13(6):528-38. doi:10.1038/embor.2012.61.
    • (2012) EMBO Rep , vol.13 , Issue.6 , pp. 528-538
    • McGranahan, N.1    Burrell, R.A.2    Endesfelder, D.3    Novelli, M.R.4    Swanton, C.5
  • 10
    • 84873598320 scopus 로고    scopus 로고
    • High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome
    • doi:10.1016/j.ygyno.2012.11.031
    • Cope L, Wu RC, Shih Ie M, Wang TL. High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome. Gynecol Oncol (2013) 128(3):500-5. doi:10.1016/j.ygyno.2012.11.031.
    • (2013) Gynecol Oncol , vol.128 , Issue.3 , pp. 500-505
    • Cope, L.1    Wu, R.C.2    Shih Ie, M.3    Wang, T.L.4
  • 11
    • 84856513068 scopus 로고    scopus 로고
    • Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors
    • doi:10.1158/1078-0432.CCR-11-1610
    • Lagarde P, Perot G, Kauffmann A, Brulard C, Dapremont V, Hostein I, et al. Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors. Clin Cancer Res (2012) 18(3):826-38. doi:10.1158/1078-0432.CCR-11-1610.
    • (2012) Clin Cancer Res , vol.18 , Issue.3 , pp. 826-838
    • Lagarde, P.1    Perot, G.2    Kauffmann, A.3    Brulard, C.4    Dapremont, V.5    Hostein, I.6
  • 12
    • 0033035955 scopus 로고    scopus 로고
    • Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation
    • doi:10.1002/(SICI)1098-2264(199907)25:3<195::AID-GCC1>3.0.CO;2-8
    • Ried T, Heselmeyer-Haddad K, Blegen H, Schrock E, Auer G. Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation. Genes Chromosomes Cancer (1999) 25(3):195-204. doi:10.1002/(SICI)1098-2264(199907)25:3<195::AID-GCC1>3.0.CO;2-8.
    • (1999) Genes Chromosomes Cancer , vol.25 , Issue.3 , pp. 195-204
    • Ried, T.1    Heselmeyer-Haddad, K.2    Blegen, H.3    Schrock, E.4    Auer, G.5
  • 13
    • 84864007881 scopus 로고    scopus 로고
    • Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer
    • doi:10.1200/JCO.2011.38.6490
    • Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, et al. Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer. J Clin Oncol (2012) 30(18):2256-64. doi:10.1200/JCO.2011.38.6490.
    • (2012) J Clin Oncol , vol.30 , Issue.18 , pp. 2256-2264
    • Watanabe, T.1    Kobunai, T.2    Yamamoto, Y.3    Matsuda, K.4    Ishihara, S.5    Nozawa, K.6
  • 14
    • 0342887306 scopus 로고    scopus 로고
    • Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer
    • Kuukasjarvi T, Karhu R, Tanner M, Kahkonen M, Schaffer A, Nupponen N, et al. Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. Cancer Res (1997) 57(8):1597-604.
    • (1997) Cancer Res , vol.57 , Issue.8 , pp. 1597-1604
    • Kuukasjarvi, T.1    Karhu, R.2    Tanner, M.3    Kahkonen, M.4    Schaffer, A.5    Nupponen, N.6
  • 15
    • 0030825508 scopus 로고    scopus 로고
    • Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms
    • Mertens F, Johansson B, Hoglund M, Mitelman F. Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res (1997) 57(13):2765-80.
    • (1997) Cancer Res , vol.57 , Issue.13 , pp. 2765-2780
    • Mertens, F.1    Johansson, B.2    Hoglund, M.3    Mitelman, F.4
  • 16
  • 17
    • 2442637585 scopus 로고    scopus 로고
    • High-resolution analysis of gene copy number alterations in human prostate cancer using CGH on cDNA microarrays: impact of copy number on gene expression
    • doi:10.1593/neo.03439
    • Wolf M, Mousses S, Hautaniemi S, Karhu R, Huusko P, Allinen M, et al. High-resolution analysis of gene copy number alterations in human prostate cancer using CGH on cDNA microarrays: impact of copy number on gene expression. Neoplasia (2004) 6(3):240-7. doi:10.1593/neo.03439.
    • (2004) Neoplasia , vol.6 , Issue.3 , pp. 240-247
    • Wolf, M.1    Mousses, S.2    Hautaniemi, S.3    Karhu, R.4    Huusko, P.5    Allinen, M.6
  • 18
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • doi:10.1038/nature08822
    • Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. The landscape of somatic copy-number alteration across human cancers. Nature (2010) 463(7283):899-905. doi:10.1038/nature08822.
    • (2010) Nature , vol.463 , Issue.7283 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3    Wei, G.4    Raychaudhuri, S.5    Donovan, J.6
  • 19
    • 84857530286 scopus 로고    scopus 로고
    • Genome-wide copy number analysis in primary breast cancer
    • doi:10.1517/14728222.2011.636739
    • Ueno T, Emi M, Sato H, Ito N, Muta M, Kuroi K, et al. Genome-wide copy number analysis in primary breast cancer. Expert Opin Ther Targets (2012) 16(Suppl 1):S31-5. doi:10.1517/14728222.2011.636739.
    • (2012) Expert Opin Ther Targets , vol.16 , Issue.SUPPL. 1
    • Ueno, T.1    Emi, M.2    Sato, H.3    Ito, N.4    Muta, M.5    Kuroi, K.6
  • 20
    • 84890312233 scopus 로고    scopus 로고
    • The detection and implication of genome instability in cancer
    • doi:10.1007/s10555-013-9429-5
    • Pikor L, Thu K, Vucic E, Lam W. The detection and implication of genome instability in cancer. Cancer Metastasis Rev (2013) 32(3-4):341-52. doi:10.1007/s10555-013-9429-5.
    • (2013) Cancer Metastasis Rev , vol.32 , Issue.3-4 , pp. 341-352
    • Pikor, L.1    Thu, K.2    Vucic, E.3    Lam, W.4
  • 21
    • 84886257639 scopus 로고    scopus 로고
    • Cancer development, progression, and therapy: an epigenetic overview
    • doi:10.3390/ijms141021087
    • Sarkar S, Horn G, Moulton K, Oza A, Byler S, Kokolus S, et al. Cancer development, progression, and therapy: an epigenetic overview. Int J Mol Sci (2013) 14(10):21087-113. doi:10.3390/ijms141021087.
    • (2013) Int J Mol Sci , vol.14 , Issue.10 , pp. 21087-21113
    • Sarkar, S.1    Horn, G.2    Moulton, K.3    Oza, A.4    Byler, S.5    Kokolus, S.6
  • 22
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Network TCGA. doi:10.1038/nature11252
    • Network TCGA. Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 487(7407):330-7. doi:10.1038/nature11252.
    • (2012) Nature , vol.487 , Issue.7407 , pp. 330-337
  • 23
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Network TCGAR. doi:10.1038/nature12113
    • Network TCGAR. Integrated genomic characterization of endometrial carcinoma. Nature (2013) 497(7447):67-73. doi:10.1038/nature12113.
    • (2013) Nature , vol.497 , Issue.7447 , pp. 67-73
  • 24
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Network TCGAR. doi:10.1038/nature10166
    • Network TCGAR. Integrated genomic analyses of ovarian carcinoma. Nature (2011) 474(7353):609-15. doi:10.1038/nature10166.
    • (2011) Nature , vol.474 , Issue.7353 , pp. 609-615
  • 25
    • 0036078663 scopus 로고    scopus 로고
    • Coping with complexity. Multivariate analysis of tumor karyotypes.
    • doi:10.1016/S0165-4608(01)00645-8
    • Hoglund M, Gisselsson D, Sall T, Mitelman F. Coping with complexity. Multivariate analysis of tumor karyotypes. Cancer Genet Cytogenet (2002) 135(2):103-9. doi:10.1016/S0165-4608(01)00645-8.
    • (2002) Cancer Genet Cytogenet , vol.135 , Issue.2 , pp. 103-109
    • Hoglund, M.1    Gisselsson, D.2    Sall, T.3    Mitelman, F.4
  • 26
    • 41949139438 scopus 로고    scopus 로고
    • Comparative lesion sequencing provides insights into tumor evolution
    • doi:10.1073/pnas.0712345105
    • Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 105(11):4283-8. doi:10.1073/pnas.0712345105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.11 , pp. 4283-4288
    • Jones, S.1    Chen, W.D.2    Parmigiani, G.3    Diehl, F.4    Beerenwinkel, N.5    Antal, T.6
  • 27
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer
    • doi:10.1146/annurev-pathol-020712-163923
    • Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol (2013) 8:277-302. doi:10.1146/annurev-pathol-020712-163923.
    • (2013) Annu Rev Pathol , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 28
    • 0018141482 scopus 로고
    • Tumor heterogeneity and the biology of cancer invasion and metastasis
    • Fidler IJ. Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res (1978) 38(9):2651-60.
    • (1978) Cancer Res , vol.38 , Issue.9 , pp. 2651-2660
    • Fidler, I.J.1
  • 29
    • 0024231125 scopus 로고
    • Multiple unrelated clonal chromosome abnormalities in an in situ squamous cell carcinoma of the skin
    • doi:10.1016/0165-4608(88)90137-9
    • Heim S, Jin Y, Mandahl N, Biorklund A, Wennerberg J, Jonsson N, et al. Multiple unrelated clonal chromosome abnormalities in an in situ squamous cell carcinoma of the skin. Cancer Genet Cytogenet (1988) 36(2):149-53. doi:10.1016/0165-4608(88)90137-9.
    • (1988) Cancer Genet Cytogenet , vol.36 , Issue.2 , pp. 149-153
    • Heim, S.1    Jin, Y.2    Mandahl, N.3    Biorklund, A.4    Wennerberg, J.5    Jonsson, N.6
  • 31
    • 0029042985 scopus 로고
    • Chromosome abnormalities in bilateral breast carcinomas. Cytogenetic evaluation of the clonal origin of multiple primary tumors.
    • doi:10.1002/1097-0142(19950715)76:2<250::AID-CNCR2820760215>3.0.CO;2-W
    • Pandis N, Teixeira MR, Gerdes AM, Limon J, Bardi G, Andersen JA, et al. Chromosome abnormalities in bilateral breast carcinomas. Cytogenetic evaluation of the clonal origin of multiple primary tumors. Cancer (1995) 76(2):250-8. doi:10.1002/1097-0142(19950715)76:2<250::AID-CNCR2820760215>3.0.CO;2-W.
    • (1995) Cancer , vol.76 , Issue.2 , pp. 250-258
    • Pandis, N.1    Teixeira, M.R.2    Gerdes, A.M.3    Limon, J.4    Bardi, G.5    Andersen, J.A.6
  • 32
    • 0033560868 scopus 로고    scopus 로고
    • Intratumoral heterogeneity in breast carcinoma revealed by laser-microdissection and comparative genomic hybridization
    • doi:10.1016/S0165-4608(98)00205-2
    • Aubele M, Mattis A, Zitzelsberger H, Walch A, Kremer M, Hutzler P, et al. Intratumoral heterogeneity in breast carcinoma revealed by laser-microdissection and comparative genomic hybridization. Cancer Genet Cytogenet (1999) 110(2):94-102. doi:10.1016/S0165-4608(98)00205-2.
    • (1999) Cancer Genet Cytogenet , vol.110 , Issue.2 , pp. 94-102
    • Aubele, M.1    Mattis, A.2    Zitzelsberger, H.3    Walch, A.4    Kremer, M.5    Hutzler, P.6
  • 33
    • 0029900138 scopus 로고    scopus 로고
    • Early proliferation enhancement by monosomy 10 and intratumor heterogeneity in malignant human gliomas as revealed by smear preparations from biopsies
    • doi:10.1002/(SICI)1098-2264(199607)16:3<180::AID-GCC4>3.0.CO;2-V
    • Steilen-Gimbel H, Henn W, Kolles H, Moringlane JR, Feiden W, Steudel WI, et al. Early proliferation enhancement by monosomy 10 and intratumor heterogeneity in malignant human gliomas as revealed by smear preparations from biopsies. Genes Chromosomes Cancer (1996) 16(3):180-4. doi:10.1002/(SICI)1098-2264(199607)16:3<180::AID-GCC4>3.0.CO;2-V.
    • (1996) Genes Chromosomes Cancer , vol.16 , Issue.3 , pp. 180-184
    • Steilen-Gimbel, H.1    Henn, W.2    Kolles, H.3    Moringlane, J.R.4    Feiden, W.5    Steudel, W.I.6
  • 34
    • 0028641327 scopus 로고
    • Cytogenetic intratumor heterogeneity in soft tissue tumors
    • doi:10.1016/0165-4608(94)90080-9
    • Orndal C, Rydholm A, Willen H, Mitelman F, Mandahl N. Cytogenetic intratumor heterogeneity in soft tissue tumors. Cancer Genet Cytogenet (1994) 78(2):127-37. doi:10.1016/0165-4608(94)90080-9.
    • (1994) Cancer Genet Cytogenet , vol.78 , Issue.2 , pp. 127-37
    • Orndal, C.1    Rydholm, A.2    Willen, H.3    Mitelman, F.4    Mandahl, N.5
  • 35
    • 0345055783 scopus 로고    scopus 로고
    • Cytogenetic analysis of pancreatic carcinomas: intratumor heterogeneity and nonrandom pattern of chromosome aberrations
    • doi:10.1002/(SICI)1098-2264(199810)23:2<81::AID-GCC1>3.0.CO;2-0
    • Gorunova L, Hoglund M, Andren-Sandberg A, Dawiskiba S, Jin Y, Mitelman F, et al. Cytogenetic analysis of pancreatic carcinomas: intratumor heterogeneity and nonrandom pattern of chromosome aberrations. Genes Chromosomes Cancer (1998) 23(2):81-99. doi:10.1002/(SICI)1098-2264(199810)23:2<81::AID-GCC1>3.0.CO;2-0.
    • (1998) Genes Chromosomes Cancer , vol.23 , Issue.2 , pp. 81-99
    • Gorunova, L.1    Hoglund, M.2    Andren-Sandberg, A.3    Dawiskiba, S.4    Jin, Y.5    Mitelman, F.6
  • 36
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • doi:10.1038/nature09807
    • Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, et al. Tumour evolution inferred by single-cell sequencing. Nature (2011) 472(7341):90-4. doi:10.1038/nature09807.
    • (2011) Nature , vol.472 , Issue.7341 , pp. 90-94
    • Navin, N.1    Kendall, J.2    Troge, J.3    Andrews, P.4    Rodgers, L.5    McIndoo, J.6
  • 37
    • 84863230091 scopus 로고    scopus 로고
    • Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
    • doi:10.1016/j.cell.2012.02.025
    • Xu X, Hou Y, Yin X, Bao L, Tang A, Song L, et al. Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 148(5):886-95. doi:10.1016/j.cell.2012.02.025.
    • (2012) Cell , vol.148 , Issue.5 , pp. 886-895
    • Xu, X.1    Hou, Y.2    Yin, X.3    Bao, L.4    Tang, A.5    Song, L.6
  • 38
    • 84863229772 scopus 로고    scopus 로고
    • Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
    • doi:10.1016/j.cell.2012.02.028
    • Hou Y, Song L, Zhu P, Zhang B, Tao Y, Xu X, et al. Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 148(5):873-85. doi:10.1016/j.cell.2012.02.028.
    • (2012) Cell , vol.148 , Issue.5 , pp. 873-885
    • Hou, Y.1    Song, L.2    Zhu, P.3    Zhang, B.4    Tao, Y.5    Xu, X.6
  • 39
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • doi:10.1016/j.cell.2010.11.055
    • Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 144(1):27-40. doi:10.1016/j.cell.2010.11.055.
    • (2011) Cell , vol.144 , Issue.1 , pp. 27-40
    • Stephens, P.J.1    Greenman, C.D.2    Fu, B.3    Yang, F.4    Bignell, G.R.5    Mudie, L.J.6
  • 40
    • 0032969473 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases
    • doi:10.1002/(SICI)1098-2264(199904)24:4<306::AID-GCC3>3.0.CO;2-5
    • Al-Mulla F, Keith WN, Pickford IR, Going JJ, Birnie GD. Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases. Genes Chromosomes Cancer (1999) 24(4):306-14. doi:10.1002/(SICI)1098-2264(199904)24:4<306::AID-GCC3>3.0.CO;2-5.
    • (1999) Genes Chromosomes Cancer , vol.24 , Issue.4 , pp. 306-314
    • Al-Mulla, F.1    Keith, W.N.2    Pickford, I.R.3    Going, J.J.4    Birnie, G.D.5
  • 41
    • 84873565928 scopus 로고    scopus 로고
    • Minor clone provides a reservoir for relapse in multiple myeloma
    • doi:10.1038/leu.2012.226
    • Magrangeas F, Avet-Loiseau H, Gouraud W, Lode L, Decaux O, Godmer P, et al. Minor clone provides a reservoir for relapse in multiple myeloma. Leukemia (2013) 27(2):473-81. doi:10.1038/leu.2012.226.
    • (2013) Leukemia , vol.27 , Issue.2 , pp. 473-481
    • Magrangeas, F.1    Avet-Loiseau, H.2    Gouraud, W.3    Lode, L.4    Decaux, O.5    Godmer, P.6
  • 42
    • 67349248619 scopus 로고    scopus 로고
    • Molecular classification of solid tumours: towards pathway-driven therapeutics
    • doi:10.1038/sj.bjc.6605031
    • Swanton C, Caldas C. Molecular classification of solid tumours: towards pathway-driven therapeutics. Br J Cancer (2009) 100(10):1517-22. doi:10.1038/sj.bjc.6605031.
    • (2009) Br J Cancer , vol.100 , Issue.10 , pp. 1517-1522
    • Swanton, C.1    Caldas, C.2
  • 43
    • 84878882344 scopus 로고    scopus 로고
    • Re: intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • doi:10.1016/j.eururo.2013.04.025
    • Logothetis CJ. Re: intratumor heterogeneity and branched evolution revealed by multiregion sequencing. Eur Urol (2013) 64(1):170. doi:10.1016/j.eururo.2013.04.025.
    • (2013) Eur Urol , vol.64 , Issue.1 , pp. 170
    • Logothetis, C.J.1
  • 45
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • doi:10.1038/386623a0
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature (1997) 386(6625):623-7. doi:10.1038/386623a0.
    • (1997) Nature , vol.386 , Issue.6625 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 46
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • doi:10.1038/25292
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature (1998) 396(6712):643-9. doi:10.1038/25292.
    • (1998) Nature , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 47
    • 38549086464 scopus 로고    scopus 로고
    • Defining 'chromosomal instability'
    • doi:10.1016/j.tig.2007.11.006
    • Geigl JB, Obenauf AC, Schwarzbraun T, Speicher MR. Defining 'chromosomal instability'. Trends Genet (2008) 24(2):64-9. doi:10.1016/j.tig.2007.11.006.
    • (2008) Trends Genet , vol.24 , Issue.2 , pp. 64-69
    • Geigl, J.B.1    Obenauf, A.C.2    Schwarzbraun, T.3    Speicher, M.R.4
  • 48
    • 40849096242 scopus 로고    scopus 로고
    • Examining the link between chromosomal instability and aneuploidy in human cells
    • doi:10.1083/jcb.200712029
    • Thompson SL, Compton DA. Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol (2008) 180(4):665-72. doi:10.1083/jcb.200712029.
    • (2008) J Cell Biol , vol.180 , Issue.4 , pp. 665-772
    • Thompson, S.L.1    Compton, D.A.2
  • 49
    • 0036145806 scopus 로고    scopus 로고
    • Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability
    • doi:10.1038/sj.neo.7900197
    • Roschke AV, Stover K, Tonon G, Schaffer AA, Kirsch IR. Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability. Neoplasia (2002) 4(1):19-31. doi:10.1038/sj.neo.7900197.
    • (2002) Neoplasia , vol.4 , Issue.1 , pp. 19-31
    • Roschke, A.V.1    Stover, K.2    Tonon, G.3    Schaffer, A.A.4    Kirsch, I.R.5
  • 50
    • 0035972237 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
    • doi:10.1083/jcb.153.3.517
    • Cimini D, Howell B, Maddox P, Khodjakov A, Degrassi F, Salmon ED. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol (2001) 153(3):517-27. doi:10.1083/jcb.153.3.517.
    • (2001) J Cell Biol , vol.153 , Issue.3 , pp. 517-527
    • Cimini, D.1    Howell, B.2    Maddox, P.3    Khodjakov, A.4    Degrassi, F.5    Salmon, E.D.6
  • 51
    • 81055141515 scopus 로고    scopus 로고
    • Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors
    • doi:10.1073/pnas.1109720108
    • Thompson SL, Compton DA. Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors. Proc Natl Acad Sci U S A (2011) 108(44):17974-8. doi:10.1073/pnas.1109720108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.44 , pp. 17974-17978
    • Thompson, S.L.1    Compton, D.A.2
  • 52
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • doi:10.1038/nature08136
    • Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 460(7252):278-82. doi:10.1038/nature08136.
    • (2009) Nature , vol.460 , Issue.7252 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 53
    • 68749084849 scopus 로고    scopus 로고
    • Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells
    • doi:10.1371/journal.pone.0006564
    • Silkworth WT, Nardi IK, Scholl LM, Cimini D. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 4(8):e6564. doi:10.1371/journal.pone.0006564.
    • (2009) PLoS One , vol.4 , Issue.8
    • Silkworth, W.T.1    Nardi, I.K.2    Scholl, L.M.3    Cimini, D.4
  • 54
    • 76349126361 scopus 로고    scopus 로고
    • Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
    • doi:10.1083/jcb.200905057
    • Thompson SL, Compton DA. Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol (2010) 188(3):369-81. doi:10.1083/jcb.200905057.
    • (2010) J Cell Biol , vol.188 , Issue.3 , pp. 369-381
    • Thompson, S.L.1    Compton, D.A.2
  • 55
    • 80053011752 scopus 로고    scopus 로고
    • How mitotic errors contribute to karyotypic diversity in cancer
    • doi:10.1016/B978-0-12-387688-1.00003-X
    • Nicholson JM, Cimini D. How mitotic errors contribute to karyotypic diversity in cancer. Adv Cancer Res (2011) 112:43-75. doi:10.1016/B978-0-12-387688-1.00003-X.
    • (2011) Adv Cancer Res , vol.112 , pp. 43-75
    • Nicholson, J.M.1    Cimini, D.2
  • 56
    • 79958733630 scopus 로고    scopus 로고
    • Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition
    • doi:10.1016/j.ccr.2011.04.017
    • Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R. Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell (2011) 19(6):701-14. doi:10.1016/j.ccr.2011.04.017.
    • (2011) Cancer Cell , vol.19 , Issue.6 , pp. 701-714
    • Schvartzman, J.M.1    Duijf, P.H.2    Sotillo, R.3    Coker, C.4    Benezra, R.5
  • 57
    • 84862538643 scopus 로고    scopus 로고
    • Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation
    • doi:10.1091/mbc.E11-12-1013
    • Hood EA, Kettenbach AN, Gerber SA, Compton DA. Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. Mol Biol Cell (2012) 23(12):2264-74. doi:10.1091/mbc.E11-12-1013.
    • (2012) Mol Biol Cell , vol.23 , Issue.12 , pp. 2264-2274
    • Hood, E.A.1    Kettenbach, A.N.2    Gerber, S.A.3    Compton, D.A.4
  • 58
    • 84859587548 scopus 로고    scopus 로고
    • Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells
    • doi:10.1016/j.cub.2012.02.030
    • Kabeche L, Compton DA. Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells. Curr Biol (2012) 22(7):638-44. doi:10.1016/j.cub.2012.02.030.
    • (2012) Curr Biol , vol.22 , Issue.7 , pp. 638-644
    • Kabeche, L.1    Compton, D.A.2
  • 59
    • 84871935248 scopus 로고    scopus 로고
    • Centrosomes, chromosome instability (CIN) and aneuploidy
    • doi:10.1016/j.ceb.2012.10.006
    • Vitre BD, Cleveland DW. Centrosomes, chromosome instability (CIN) and aneuploidy. Curr Opin Cell Biol (2012) 24(6):809-15. doi:10.1016/j.ceb.2012.10.006.
    • (2012) Curr Opin Cell Biol , vol.24 , Issue.6 , pp. 809-815
    • Vitre, B.D.1    Cleveland, D.W.2
  • 61
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Network TCGAR. doi:10.1038/nature07385
    • Network TCGAR. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 455(7216):1061-8. doi:10.1038/nature07385.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 62
    • 84891649842 scopus 로고    scopus 로고
    • A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability
    • doi:10.3389/fonc.2013.00164
    • Orr B, Compton DA. A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability. Front Oncol (2013) 3:164. doi:10.3389/fonc.2013.00164.
    • (2013) Front Oncol , vol.3 , pp. 164
    • Orr, B.1    Compton, D.A.2
  • 63
    • 40849149557 scopus 로고    scopus 로고
    • Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
    • doi:10.1073/pnas.0712384105
    • Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, et al. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A (2008) 105(9):3443-8. doi:10.1073/pnas.0712384105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.9 , pp. 3443-3448
    • Barber, T.D.1    McManus, K.2    Yuen, K.W.3    Reis, M.4    Parmigiani, G.5    Shen, D.6
  • 64
    • 38449089415 scopus 로고    scopus 로고
    • Mitotic checkpoint defects in human cancers and their implications to chemotherapy
    • doi:10.2741/2827
    • Wang X, Cheung HW, Chun AC, Jin DY, Wong YC. Mitotic checkpoint defects in human cancers and their implications to chemotherapy. Front Biosci (2008) 13:2103-14. doi:10.2741/2827.
    • (2008) Front Biosci , vol.13 , pp. 2103-2114
    • Wang, X.1    Cheung, H.W.2    Chun, A.C.3    Jin, D.Y.4    Wong, Y.C.5
  • 65
    • 51649112324 scopus 로고    scopus 로고
    • Studying chromosome instability in the mouse
    • doi:10.1016/j.bbcan.2008.07.004
    • Foijer F, Draviam VM, Sorger PK. Studying chromosome instability in the mouse. Biochim Biophys Acta (2008) 1786(1):73-82. doi:10.1016/j.bbcan.2008.07.004.
    • (2008) Biochim Biophys Acta , vol.1786 , Issue.1 , pp. 73-82
    • Foijer, F.1    Draviam, V.M.2    Sorger, P.K.3
  • 66
    • 70249109233 scopus 로고    scopus 로고
    • Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice
    • doi:10.1093/carcin/bgp081
    • Rao CV, Yamada HY, Yao Y, Dai W. Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice. Carcinogenesis (2009) 30(9):1469-74. doi:10.1093/carcin/bgp081.
    • (2009) Carcinogenesis , vol.30 , Issue.9 , pp. 1469-1474
    • Rao, C.V.1    Yamada, H.Y.2    Yao, Y.3    Dai, W.4
  • 67
    • 67449119410 scopus 로고    scopus 로고
    • The role of aneuploidy in promoting and suppressing tumors
    • doi:10.1083/jcb.200905098
    • Weaver BA, Cleveland DW. The role of aneuploidy in promoting and suppressing tumors. J Cell Biol (2009) 185(6):935-7. doi:10.1083/jcb.200905098.
    • (2009) J Cell Biol , vol.185 , Issue.6 , pp. 935-937
    • Weaver, B.A.1    Cleveland, D.W.2
  • 68
    • 0035905811 scopus 로고    scopus 로고
    • MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
    • doi:10.1038/35053094
    • Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature (2001) 409(6818):355-9. doi:10.1038/35053094.
    • (2001) Nature , vol.409 , Issue.6818 , pp. 355-359
    • Michel, L.S.1    Liberal, V.2    Chatterjee, A.3    Kirchwegger, R.4    Pasche, B.5    Gerald, W.6
  • 69
    • 9144253124 scopus 로고    scopus 로고
    • Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
    • doi:10.1158/0008-5472.CAN-03-3119
    • Dai W, Wang Q, Liu T, Swamy M, Fang Y, Xie S, et al. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res (2004) 64(2):440-5. doi:10.1158/0008-5472.CAN-03-3119.
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 440-445
    • Dai, W.1    Wang, Q.2    Liu, T.3    Swamy, M.4    Fang, Y.5    Xie, S.6
  • 70
    • 10644258336 scopus 로고    scopus 로고
    • Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
    • doi:10.1038/ng1449
    • Hanks S, Coleman K, Reid S, Plaja A, Firth H, Fitzpatrick D, et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet (2004) 36(11):1159-61. doi:10.1038/ng1449.
    • (2004) Nat Genet , vol.36 , Issue.11 , pp. 1159-1161
    • Hanks, S.1    Coleman, K.2    Reid, S.3    Plaja, A.4    Firth, H.5    Fitzpatrick, D.6
  • 71
    • 33645225290 scopus 로고    scopus 로고
    • Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition
    • doi:10.4161/cc.5.4.2483
    • Jeganathan KB, Baker DJ, van Deursen JM. Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle (2006) 5(4):366-70. doi:10.4161/cc.5.4.2483.
    • (2006) Cell Cycle , vol.5 , Issue.4 , pp. 366-370
    • Jeganathan, K.B.1    Baker, D.J.2    van Deursen, J.M.3
  • 72
    • 0037415605 scopus 로고    scopus 로고
    • Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation
    • doi:10.1083/jcb.200211048
    • Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol (2003) 160(3):341-53. doi:10.1083/jcb.200211048.
    • (2003) J Cell Biol , vol.160 , Issue.3 , pp. 341-353
    • Babu, J.R.1    Jeganathan, K.B.2    Baker, D.J.3    Wu, X.4    Kang-Decker, N.5    van Deursen, J.M.6
  • 73
    • 3042761646 scopus 로고    scopus 로고
    • BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
    • doi:10.1038/ng1382
    • Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet (2004) 36(7):744-9. doi:10.1038/ng1382.
    • (2004) Nat Genet , vol.36 , Issue.7 , pp. 744-749
    • Baker, D.J.1    Jeganathan, K.B.2    Cameron, J.D.3    Thompson, M.4    Juneja, S.5    Kopecka, A.6
  • 74
    • 51649083703 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation, aneuploidy, and cancer
    • doi:10.1016/j.bbcan.2008.05.003
    • Cimini D. Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta (2008) 1786(1):32-40. doi:10.1016/j.bbcan.2008.05.003.
    • (2008) Biochim Biophys Acta , vol.1786 , Issue.1 , pp. 32-40
    • Cimini, D.1
  • 75
    • 58149334818 scopus 로고    scopus 로고
    • Genome stability is ensured by temporal control of kinetochore-microtubule dynamics
    • doi:10.1038/ncb1809
    • Bakhoum SF, Thompson SL, Manning AL, Compton DA. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat Cell Biol (2009) 11(1):27-35. doi:10.1038/ncb1809.
    • (2009) Nat Cell Biol , vol.11 , Issue.1 , pp. 27-35
    • Bakhoum, S.F.1    Thompson, S.L.2    Manning, A.L.3    Compton, D.A.4
  • 76
    • 70450176266 scopus 로고    scopus 로고
    • Deviant kinetochore microtubule dynamics underlie chromosomal instability
    • doi:10.1016/j.cub.2009.09.055
    • Bakhoum SF, Genovese G, Compton DA. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr Biol (2009) 19(22):1937-42. doi:10.1016/j.cub.2009.09.055.
    • (2009) Curr Biol , vol.19 , Issue.22 , pp. 1937-42
    • Bakhoum, S.F.1    Genovese, G.2    Compton, D.A.3
  • 77
    • 68249133956 scopus 로고    scopus 로고
    • Cancer: CINful centrosomes
    • doi:10.1016/j.cub.2009.06.039
    • Bakhoum SF, Compton DA. Cancer: CINful centrosomes. Curr Biol (2009) 19(15):R642-5. doi:10.1016/j.cub.2009.06.039.
    • (2009) Curr Biol , vol.19 , Issue.15
    • Bakhoum, S.F.1    Compton, D.A.2
  • 78
    • 0036831681 scopus 로고    scopus 로고
    • Centrosome aberrations: cause or consequence of cancer progression?
    • doi:10.1038/nrc924
    • Nigg EA. Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer (2002) 2(11):815-25. doi:10.1038/nrc924.
    • (2002) Nat Rev Cancer , vol.2 , Issue.11 , pp. 815-825
    • Nigg, E.A.1
  • 79
    • 0035188129 scopus 로고    scopus 로고
    • Managing the centrosome numbers game: from chaos to stability in cancer cell division
    • doi:10.1016/S0962-8924(00)01872-9
    • Brinkley BR. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol (2001) 11(1):18-21. doi:10.1016/S0962-8924(00)01872-9.
    • (2001) Trends Cell Biol , vol.11 , Issue.1 , pp. 18-21
    • Brinkley, B.R.1
  • 80
    • 0020401629 scopus 로고
    • Mitosis in a cell with multiple centrioles
    • doi:10.1083/jcb.94.3.549
    • Ring D, Hubble R, Kirschner M. Mitosis in a cell with multiple centrioles. J Cell Biol (1982) 94(3):549-56. doi:10.1083/jcb.94.3.549.
    • (1982) J Cell Biol , vol.94 , Issue.3 , pp. 549-556
    • Ring, D.1    Hubble, R.2    Kirschner, M.3
  • 81
    • 0033989262 scopus 로고    scopus 로고
    • Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations
    • doi:10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P
    • Ghadimi BM, Sackett DL, Difilippantonio MJ, Schrock E, Neumann T, Jauho A, et al. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer (2000) 27(2):183-90. doi:10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P.
    • (2000) Genes Chromosomes Cancer , vol.27 , Issue.2 , pp. 183-190
    • Ghadimi, B.M.1    Sackett, D.L.2    Difilippantonio, M.J.3    Schrock, E.4    Neumann, T.5    Jauho, A.6
  • 82
    • 70349326634 scopus 로고    scopus 로고
    • Pericentromeric sister chromatid cohesion promotes kinetochore biorientation
    • doi:10.1091/mbc.E09-04-0330
    • Ng TM, Waples WG, Lavoie BD, Biggins S. Pericentromeric sister chromatid cohesion promotes kinetochore biorientation. Mol Biol Cell (2009) 20(17):3818-27. doi:10.1091/mbc.E09-04-0330.
    • (2009) Mol Biol Cell , vol.20 , Issue.17 , pp. 3818-3827
    • Ng, T.M.1    Waples, W.G.2    Lavoie, B.D.3    Biggins, S.4
  • 83
    • 0242468471 scopus 로고    scopus 로고
    • Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells
    • doi:10.1210/en.2003-0305
    • Yu R, Lu W, Chen J, McCabe CJ, Melmed S. Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology (2003) 144(11):4991-8. doi:10.1210/en.2003-0305.
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4991-4998
    • Yu, R.1    Lu, W.2    Chen, J.3    McCabe, C.J.4    Melmed, S.5
  • 84
    • 51349147655 scopus 로고    scopus 로고
    • Overexpression of separase induces aneuploidy and mammary tumorigenesis
    • doi:10.1073/pnas.0801610105
    • Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, et al. Overexpression of separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A (2008) 105(35):13033-8. doi:10.1073/pnas.0801610105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.35 , pp. 13033-13038
    • Zhang, N.1    Ge, G.2    Meyer, R.3    Sethi, S.4    Basu, D.5    Pradhan, S.6
  • 85
    • 79958718625 scopus 로고    scopus 로고
    • Oncogene-induced mitotic stress: p53 and pRb get mad too
    • doi:10.1016/j.ccr.2011.05.023
    • Malumbres M. Oncogene-induced mitotic stress: p53 and pRb get mad too. Cancer Cell (2011) 19(6):691-2. doi:10.1016/j.ccr.2011.05.023.
    • (2011) Cancer Cell , vol.19 , Issue.6 , pp. 691-692
    • Malumbres, M.1
  • 86
    • 84862891760 scopus 로고    scopus 로고
    • Chromosome instability and deregulated proliferation: an unavoidable duo
    • doi:10.1007/s00018-011-0910-4
    • Coschi CH, Dick FA. Chromosome instability and deregulated proliferation: an unavoidable duo. Cell Mol Life Sci (2012) 69(12):2009-24. doi:10.1007/s00018-011-0910-4.
    • (2012) Cell Mol Life Sci , vol.69 , Issue.12 , pp. 2009-2024
    • Coschi, C.H.1    Dick, F.A.2
  • 87
    • 84874362586 scopus 로고    scopus 로고
    • Replication stress links structural and numerical cancer chromosomal instability
    • doi:10.1038/nature11935
    • Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, et al. Replication stress links structural and numerical cancer chromosomal instability. Nature (2013) 494(7438):492-6. doi:10.1038/nature11935.
    • (2013) Nature , vol.494 , Issue.7438 , pp. 492-496
    • Burrell, R.A.1    McClelland, S.E.2    Endesfelder, D.3    Groth, P.4    Weller, M.C.5    Shaikh, N.6
  • 88
    • 80052185338 scopus 로고    scopus 로고
    • Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress
    • doi:10.1016/j.molonc.2011.05.002
    • Dereli-Oz A, Versini G, Halazonetis TD. Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress. Mol Oncol (2011) 5(4):308-14. doi:10.1016/j.molonc.2011.05.002.
    • (2011) Mol Oncol , vol.5 , Issue.4 , pp. 308-314
    • Dereli-Oz, A.1    Versini, G.2    Halazonetis, T.D.3
  • 89
    • 34047274772 scopus 로고    scopus 로고
    • Tetraploidy, aneuploidy and cancer
    • doi:10.1016/j.gde.2007.02.011
    • Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev (2007) 17(2):157-62. doi:10.1016/j.gde.2007.02.011.
    • (2007) Curr Opin Genet Dev , vol.17 , Issue.2 , pp. 157-162
    • Ganem, N.J.1    Storchova, Z.2    Pellman, D.3
  • 90
    • 34547433234 scopus 로고    scopus 로고
    • Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations
    • doi:10.1073/pnas.0700631104
    • Gao C, Furge K, Koeman J, Dykema K, Su Y, Cutler ML, et al. Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations. Proc Natl Acad Sci U S A (2007) 104(21):8995-9000. doi:10.1073/pnas.0700631104.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.21 , pp. 8995-9000
    • Gao, C.1    Furge, K.2    Koeman, J.3    Dykema, K.4    Su, Y.5    Cutler, M.L.6
  • 91
    • 49849103726 scopus 로고    scopus 로고
    • Aneuploidy: cells losing their balance
    • doi:10.1534/genetics.108.090878
    • Torres EM, Williams BR, Amon A. Aneuploidy: cells losing their balance. Genetics (2008) 179(2):737-46. doi:10.1534/genetics.108.090878.
    • (2008) Genetics , vol.179 , Issue.2 , pp. 737-746
    • Torres, E.M.1    Williams, B.R.2    Amon, A.3
  • 92
    • 34548131710 scopus 로고    scopus 로고
    • Effects of aneuploidy on cellular physiology and cell division in haploid yeast
    • doi:10.1126/science.1142210
    • Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, Dunham MJ, et al. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science (2007) 317(5840):916-24. doi:10.1126/science.1142210.
    • (2007) Science , vol.317 , Issue.5840 , pp. 916-924
    • Torres, E.M.1    Sokolsky, T.2    Tucker, C.M.3    Chan, L.Y.4    Boselli, M.5    Dunham, M.J.6
  • 94
    • 80053364894 scopus 로고    scopus 로고
    • Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    • doi:10.1126/science.1210214
    • Janssen A, van der Burg M, Szuhai K, Kops GJ, Medema RH. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (2011) 333(6051):1895-8. doi:10.1126/science.1210214.
    • (2011) Science , vol.333 , Issue.6051 , pp. 1895-1898
    • Janssen, A.1    van der Burg, M.2    Szuhai, K.3    Kops, G.J.4    Medema, R.H.5
  • 95
    • 84856424908 scopus 로고    scopus 로고
    • DNA breaks and chromosome pulverization from errors in mitosis
    • doi:10.1038/nature10802
    • Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, et al. DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 482(7383):53-8. doi:10.1038/nature10802.
    • (2012) Nature , vol.482 , Issue.7383 , pp. 53-58
    • Crasta, K.1    Ganem, N.J.2    Dagher, R.3    Lantermann, A.B.4    Ivanova, E.V.5    Pan, Y.6
  • 97
    • 80054054260 scopus 로고    scopus 로고
    • The aneuploidy paradox: costs and benefits of an incorrect karyotype
    • doi:10.1016/j.tig.2011.07.003
    • Sheltzer JM, Amon A. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet (2011) 27(11):446-53. doi:10.1016/j.tig.2011.07.003.
    • (2011) Trends Genet , vol.27 , Issue.11 , pp. 446-453
    • Sheltzer, J.M.1    Amon, A.2
  • 98
    • 84873314664 scopus 로고    scopus 로고
    • Gene copy-number alterations: a cost-benefit analysis
    • doi:10.1016/j.cell.2012.11.043
    • Tang YC, Amon A. Gene copy-number alterations: a cost-benefit analysis. Cell (2013) 152(3):394-405. doi:10.1016/j.cell.2012.11.043.
    • (2013) Cell , vol.152 , Issue.3 , pp. 394-405
    • Tang, Y.C.1    Amon, A.2
  • 99
    • 79951689086 scopus 로고    scopus 로고
    • Identification of aneuploidy-selective antiproliferation compounds
    • doi:10.1016/j.cell.2011.01.017
    • Tang YC, Williams BR, Siegel JJ, Amon A. Identification of aneuploidy-selective antiproliferation compounds. Cell (2011) 144(4):499-512. doi:10.1016/j.cell.2011.01.017.
    • (2011) Cell , vol.144 , Issue.4 , pp. 499-512
    • Tang, Y.C.1    Williams, B.R.2    Siegel, J.J.3    Amon, A.4
  • 100
    • 84868290476 scopus 로고    scopus 로고
    • Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
    • doi:10.1038/msb.2012.40
    • Stingele S, Stoehr G, Peplowska K, Cox J, Mann M, Storchova Z. Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells. Mol Syst Biol (2012) 8:608. doi:10.1038/msb.2012.40.
    • (2012) Mol Syst Biol , vol.8 , pp. 608
    • Stingele, S.1    Stoehr, G.2    Peplowska, K.3    Cox, J.4    Mann, M.5    Storchova, Z.6
  • 101
    • 84864497571 scopus 로고    scopus 로고
    • Transcriptional consequences of aneuploidy
    • doi:10.1073/pnas.1209227109
    • Sheltzer JM, Torres EM, Dunham MJ, Amon A. Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A (2012) 109(31):12644-9. doi:10.1073/pnas.1209227109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.31 , pp. 12644-12649
    • Sheltzer, J.M.1    Torres, E.M.2    Dunham, M.J.3    Amon, A.4
  • 102
    • 4944234694 scopus 로고    scopus 로고
    • Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells
    • doi:10.1158/0008-5472.CAN-04-0474
    • Upender MB, Habermann JK, McShane LM, Korn EL, Barrett JC, Difilippantonio MJ, et al. Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res (2004) 64(19):6941-9. doi:10.1158/0008-5472.CAN-04-0474.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 6941-6949
    • Upender, M.B.1    Habermann, J.K.2    McShane, L.M.3    Korn, E.L.4    Barrett, J.C.5    Difilippantonio, M.J.6
  • 103
    • 55349112533 scopus 로고    scopus 로고
    • Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
    • doi:10.1126/science.1160058
    • Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, et al. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science (2008) 322(5902):703-9. doi:10.1126/science.1160058.
    • (2008) Science , vol.322 , Issue.5902 , pp. 703-709
    • Williams, B.R.1    Prabhu, V.R.2    Hunter, K.E.3    Glazier, C.M.4    Whittaker, C.A.5    Housman, D.E.6
  • 104
    • 78149423336 scopus 로고    scopus 로고
    • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
    • doi:10.1038/nature09529
    • Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, et al. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature (2010) 468(7321):321-5. doi:10.1038/nature09529.
    • (2010) Nature , vol.468 , Issue.7321 , pp. 321-325
    • Pavelka, N.1    Rancati, G.2    Zhu, J.3    Bradford, W.D.4    Saraf, A.5    Florens, L.6
  • 105
    • 0022841695 scopus 로고
    • The cellular level of yeast ribosomal protein L25 is controlled principally by rapid degradation of excess protein
    • doi:10.1007/BF00405095
    • elBaradi TT, van der Sande CA, Mager WH, Raue HA, Planta RJ. The cellular level of yeast ribosomal protein L25 is controlled principally by rapid degradation of excess protein. Curr Genet (1986) 10(10):733-9. doi:10.1007/BF00405095.
    • (1986) Curr Genet , vol.10 , Issue.10 , pp. 733-739
    • elBaradi, T.T.1    van der Sande, C.A.2    Mager, W.H.3    Raue, H.A.4    Planta, R.J.5
  • 106
    • 67650505043 scopus 로고    scopus 로고
    • Aneuploidy: cancer's fatal flaw?
    • doi:10.1158/0008-5472.CAN-09-0944
    • Williams BR, Amon A. Aneuploidy: cancer's fatal flaw? Cancer Res (2009) 69(13):5289-91. doi:10.1158/0008-5472.CAN-09-0944.
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5289-5291
    • Williams, B.R.1    Amon, A.2
  • 107
    • 77956271440 scopus 로고    scopus 로고
    • The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis
    • doi:10.1073/pnas.1005960107
    • Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, et al. The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 107(32):14188-93. doi:10.1073/pnas.1005960107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.32 , pp. 14188-14193
    • Li, M.1    Fang, X.2    Baker, D.J.3    Guo, L.4    Gao, X.5    Wei, Z.6
  • 109
    • 0036169078 scopus 로고    scopus 로고
    • Targeted inactivation of p53 in human cells does not result in aneuploidy
    • Bunz F, Fauth C, Speicher MR, Dutriaux A, Sedivy JM, Kinzler KW, et al. Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res (2002) 62(4):1129-33.
    • (2002) Cancer Res , vol.62 , Issue.4 , pp. 1129-1133
    • Bunz, F.1    Fauth, C.2    Speicher, M.R.3    Dutriaux, A.4    Sedivy, J.M.5    Kinzler, K.W.6
  • 110
    • 84857192718 scopus 로고    scopus 로고
    • Causes and consequences of aneuploidy in cancer
    • doi:10.1038/nrg3123
    • Gordon DJ, Resio B, Pellman D. Causes and consequences of aneuploidy in cancer. Nat Rev Genet (2012) 13(3):189-203. doi:10.1038/nrg3123.
    • (2012) Nat Rev Genet , vol.13 , Issue.3 , pp. 189-203
    • Gordon, D.J.1    Resio, B.2    Pellman, D.3
  • 111
    • 33749506269 scopus 로고    scopus 로고
    • Genome-wide genetic analysis of polyploidy in yeast
    • doi:10.1038/nature05178
    • Storchova Z, Breneman A, Cande J, Dunn J, Burbank K, O'Toole E, et al. Genome-wide genetic analysis of polyploidy in yeast. Nature (2006) 443(7111):541-7. doi:10.1038/nature05178.
    • (2006) Nature , vol.443 , Issue.7111 , pp. 541-547
    • Storchova, Z.1    Breneman, A.2    Cande, J.3    Dunn, J.4    Burbank, K.5    O'Toole, E.6
  • 112
  • 113
    • 80051871652 scopus 로고    scopus 로고
    • Aneuploidy drives genomic instability in yeast
    • doi:10.1126/science.1206412
    • Sheltzer JM, Blank HM, Pfau SJ, Tange Y, George BM, Humpton TJ, et al. Aneuploidy drives genomic instability in yeast. Science (2011) 333(6045):1026-30. doi:10.1126/science.1206412.
    • (2011) Science , vol.333 , Issue.6045 , pp. 1026-1030
    • Sheltzer, J.M.1    Blank, H.M.2    Pfau, S.J.3    Tange, Y.4    George, B.M.5    Humpton, T.J.6
  • 114
    • 84885158978 scopus 로고    scopus 로고
    • The cancer biology of whole-chromosome instability
    • doi:10.1038/onc.2012.616
    • Duijf PH, Benezra R. The cancer biology of whole-chromosome instability. Oncogene (2013) 32(40):4727-36. doi:10.1038/onc.2012.616.
    • (2013) Oncogene , vol.32 , Issue.40 , pp. 4727-4736
    • Duijf, P.H.1    Benezra, R.2
  • 115
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • doi:10.1016/j.cell.2010.01.025
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell (2010) 140(6):883-99. doi:10.1016/j.cell.2010.01.025.
    • (2010) Cell , vol.140 , Issue.6 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 116
    • 77958006661 scopus 로고    scopus 로고
    • Targeting karyotypic complexity and chromosomal instability of cancer cells
    • doi:10.2174/1389450111007011341
    • Roschke AV, Kirsch IR. Targeting karyotypic complexity and chromosomal instability of cancer cells. Curr Drug Targets (2010) 11(10):1341-50. doi:10.2174/1389450111007011341.
    • (2010) Curr Drug Targets , vol.11 , Issue.10 , pp. 1341-1350
    • Roschke, A.V.1    Kirsch, I.R.2
  • 117
    • 84890312311 scopus 로고    scopus 로고
    • Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos
    • doi:10.1007/s10555-013-9436-6
    • Potapova TA, Zhu J, Li R. Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos. Cancer Metastasis Rev (2013) 32(3-4):377-89. doi:10.1007/s10555-013-9436-6.
    • (2013) Cancer Metastasis Rev , vol.32 , Issue.3-4 , pp. 377-389
    • Potapova, T.A.1    Zhu, J.2    Li, R.3
  • 118
    • 75149140916 scopus 로고    scopus 로고
    • Mitotic chromosomal instability and cancer: mouse modelling of the human disease
    • doi:10.1038/nrc2781
    • Schvartzman JM, Sotillo R, Benezra R. Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer (2010) 10(2):102-15. doi:10.1038/nrc2781.
    • (2010) Nat Rev Cancer , vol.10 , Issue.2 , pp. 102-115
    • Schvartzman, J.M.1    Sotillo, R.2    Benezra, R.3
  • 119
    • 84868103798 scopus 로고    scopus 로고
    • New insights into the troubles of aneuploidy
    • doi:10.1146/annurev-cellbio-101011-155807
    • Siegel JJ, Amon A. New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol (2012) 28:189-214. doi:10.1146/annurev-cellbio-101011-155807.
    • (2012) Annu Rev Cell Dev Biol , vol.28 , pp. 189-214
    • Siegel, J.J.1    Amon, A.2
  • 120
    • 63149148209 scopus 로고    scopus 로고
    • Constitutional aneuploidy and cancer predisposition
    • doi:10.1093/hmg/ddp084
    • Ganmore I, Smooha G, Izraeli S. Constitutional aneuploidy and cancer predisposition. Hum Mol Genet (2009) 18(R1):R84-93. doi:10.1093/hmg/ddp084.
    • (2009) Hum Mol Genet , vol.18 , Issue.R1
    • Ganmore, I.1    Smooha, G.2    Izraeli, S.3
  • 121
    • 84861880210 scopus 로고    scopus 로고
    • Chromosomal instability and aneuploidy in cancer: from yeast to man
    • doi:10.1038/embor.2012.65
    • Pfau SJ, Amon A. Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep (2012) 13(6):515-27. doi:10.1038/embor.2012.65.
    • (2012) EMBO Rep , vol.13 , Issue.6 , pp. 515-527
    • Pfau, S.J.1    Amon, A.2
  • 122
    • 40749104900 scopus 로고    scopus 로고
    • Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study
    • doi:10.1016/S1470-2045(08)70033-0
    • Schoemaker MJ, Swerdlow AJ, Higgins CD, Wright AF, Jacobs PA. Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study. Lancet Oncol (2008) 9(3):239-46. doi:10.1016/S1470-2045(08)70033-0.
    • (2008) Lancet Oncol , vol.9 , Issue.3 , pp. 239-246
    • Schoemaker, M.J.1    Swerdlow, A.J.2    Higgins, C.D.3    Wright, A.F.4    Jacobs, P.A.5
  • 123
    • 79954600431 scopus 로고    scopus 로고
    • Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13
    • doi:10.1159/000323504
    • Reish O, Regev M, Kanesky A, Girafi S, Mashevich M. Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13. Cytogenet Genome Res (2011) 133(2-4):184-9. doi:10.1159/000323504.
    • (2011) Cytogenet Genome Res , vol.133 , Issue.2-4 , pp. 184-189
    • Reish, O.1    Regev, M.2    Kanesky, A.3    Girafi, S.4    Mashevich, M.5
  • 124
    • 55849123268 scopus 로고    scopus 로고
    • Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance
    • Roschke AV, Glebov OK, Lababidi S, Gehlhaus KS, Weinstein JN, Kirsch IR. Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance. Neoplasia (2008) 10(11):1222-30.
    • (2008) Neoplasia , vol.10 , Issue.11 , pp. 1222-1230
    • Roschke, A.V.1    Glebov, O.K.2    Lababidi, S.3    Gehlhaus, K.S.4    Weinstein, J.N.5    Kirsch, I.R.6
  • 125
    • 84870560047 scopus 로고    scopus 로고
    • Proliferation and tissue remodeling in cancer: the hallmarks revisited
    • doi:10.1038/cddis.2012.140
    • Markert EK, Levine AJ, Vazquez A. Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis (2012) 3:e397. doi:10.1038/cddis.2012.140.
    • (2012) Cell Death Dis , vol.3
    • Markert, E.K.1    Levine, A.J.2    Vazquez, A.3
  • 126
    • 70350244838 scopus 로고    scopus 로고
    • Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy
    • doi:10.4161/cc.8.20.9690
    • McClelland SE, Burrell RA, Swanton C. Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy. Cell Cycle (2009) 8(20):3262-6. doi:10.4161/cc.8.20.9690.
    • (2009) Cell Cycle , vol.8 , Issue.20 , pp. 3262-3266
    • McClelland, S.E.1    Burrell, R.A.2    Swanton, C.3
  • 127
    • 0033388315 scopus 로고    scopus 로고
    • Genetic instability and darwinian selection in tumours
    • doi:10.1016/S0962-8924(99)01661-X
    • Cahill DP, Kinzler KW, Vogelstein B, Lengauer C. Genetic instability and darwinian selection in tumours. Trends Cell Biol (1999) 9(12):M57-60. doi:10.1016/S0962-8924(99)01661-X.
    • (1999) Trends Cell Biol , vol.9 , Issue.12
    • Cahill, D.P.1    Kinzler, K.W.2    Vogelstein, B.3    Lengauer, C.4
  • 128
    • 78649636162 scopus 로고    scopus 로고
    • Dr. Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.
    • doi:10.1016/j.ceb.2010.06.003
    • Pavelka N, Rancati G, Li R. Dr. Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol (2010) 22(6):809-15. doi:10.1016/j.ceb.2010.06.003.
    • (2010) Curr Opin Cell Biol , vol.22 , Issue.6 , pp. 809-815
    • Pavelka, N.1    Rancati, G.2    Li, R.3
  • 129
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: an old hypothesis revisited
    • doi:10.1038/nrm2455
    • Schafer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol (2008) 9(8):628-38. doi:10.1038/nrm2455.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.8 , pp. 628-638
    • Schafer, M.1    Werner, S.2
  • 130
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • doi:10.1093/carcin/bgp127
    • Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis (2009) 30(7):1073-81. doi:10.1093/carcin/bgp127.
    • (2009) Carcinogenesis , vol.30 , Issue.7 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 131
    • 50049085789 scopus 로고    scopus 로고
    • Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
    • doi:10.1101/gad.1700908
    • Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev (2008) 22(16):2189-203. doi:10.1101/gad.1700908.
    • (2008) Genes Dev , vol.22 , Issue.16 , pp. 2189-2203
    • Kwon, M.1    Godinho, S.A.2    Chandhok, N.S.3    Ganem, N.J.4    Azioune, A.5    Thery, M.6
  • 132
    • 34447116953 scopus 로고    scopus 로고
    • Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen
    • doi:10.1158/0008-5472.CAN-07-0663
    • Rebacz B, Larsen TO, Clausen MH, Ronnest MH, Loffler H, Ho AD, et al. Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen. Cancer Res (2007) 67(13):6342-50. doi:10.1158/0008-5472.CAN-07-0663.
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6342-6350
    • Rebacz, B.1    Larsen, T.O.2    Clausen, M.H.3    Ronnest, M.H.4    Loffler, H.5    Ho, A.D.6
  • 133
    • 66249107708 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells
    • doi:10.1021/jm801517j
    • Ronnest MH, Rebacz B, Markworth L, Terp AH, Larsen TO, Kramer A, et al. Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells. J Med Chem (2009) 52(10):3342-7. doi:10.1021/jm801517j.
    • (2009) J Med Chem , vol.52 , Issue.10 , pp. 3342-3347
    • Ronnest, M.H.1    Rebacz, B.2    Markworth, L.3    Terp, A.H.4    Larsen, T.O.5    Kramer, A.6
  • 134
    • 14544308364 scopus 로고    scopus 로고
    • Karyotypic "state" as a potential determinant for anticancer drug discovery
    • doi:10.1073/pnas.0405578102
    • Roschke AV, Lababidi S, Tonon G, Gehlhaus KS, Bussey K, Weinstein JN, et al. Karyotypic "state" as a potential determinant for anticancer drug discovery. Proc Natl Acad Sci U S A (2005) 102(8):2964-9. doi:10.1073/pnas.0405578102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.8 , pp. 2964-2969
    • Roschke, A.V.1    Lababidi, S.2    Tonon, G.3    Gehlhaus, K.S.4    Bussey, K.5    Weinstein, J.N.6
  • 135
    • 25144447723 scopus 로고    scopus 로고
    • Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability
    • doi:10.4161/cc.4.5.1687
    • Roschke AV, Kirsch IR. Targeting cancer cells by exploiting karyotypic complexity and chromosomal instability. Cell Cycle (2005) 4(5):679-82. doi:10.4161/cc.4.5.1687.
    • (2005) Cell Cycle , vol.4 , Issue.5 , pp. 679-682
    • Roschke, A.V.1    Kirsch, I.R.2
  • 136
    • 27644442883 scopus 로고    scopus 로고
    • Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells
    • doi:10.1158/1535-7163.MCT-05-0224
    • Wallqvist A, Huang R, Covell DG, Roschke AV, Gelhaus KS, Kirsch IR. Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells. Mol Cancer Ther (2005) 4(10):1559-68. doi:10.1158/1535-7163.MCT-05-0224.
    • (2005) Mol Cancer Ther , vol.4 , Issue.10 , pp. 1559-1568
    • Wallqvist, A.1    Huang, R.2    Covell, D.G.3    Roschke, A.V.4    Gelhaus, K.S.5    Kirsch, I.R.6
  • 137
    • 78049261497 scopus 로고    scopus 로고
    • Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer
    • doi:10.1002/jcb.22781
    • Burrell RA, Juul N, Johnston SR, Reis-Filho JS, Szallasi Z, Swanton C. Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer. J Cell Biochem (2010) 111(4):782-90. doi:10.1002/jcb.22781.
    • (2010) J Cell Biochem , vol.111 , Issue.4 , pp. 782-790
    • Burrell, R.A.1    Juul, N.2    Johnston, S.R.3    Reis-Filho, J.S.4    Szallasi, Z.5    Swanton, C.6


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