Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural instability in tumor cell chromosomes through asynchronous replication and breakage within late-replicating regions

Genes Chromosomes and Cancer

Volumn 40, Issue 4, 2004, Pages 316-324

  Kost Alimova, Maria ^a,b   Fedorova, Ludmila ^a   Yang, Ying ^a   Klein, George ^a   Imreh, Stefan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GENETICS; CENTROMERE; CHROMOSOME 3P; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME LOSS; CHROMOSOME REPLICATION; CHROMOSOME STRUCTURE; CHROMOSOME TRANSLOCATION; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SUPERNUMERARY CHROMOSOME; TUMOR CELL; TUMOR GROWTH;

ANEUPLOIDY; ANIMALS; CARCINOMA, RENAL CELL; CELL CYCLE; CELL LINE, TUMOR; CENTROMERE; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 3; DNA REPLICATION TIMING; DNA, NEOPLASM; FIBROSARCOMA; HUMANS; HYBRID CELLS; KIDNEY NEOPLASMS; MICE; NEOPLASM TRANSPLANTATION; S PHASE; TRANSLOCATION, GENETIC;

EID: 3142615823     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.20054     Document Type: Article

References (32)

1. Amiel A, Litmanovich T, Gaber E, Lishner M, Avivi L, Fejgin MD. 1997. Asynchronous replication of p53 and 21q22 loci in chronic lymphocytic leukemia. Hum Genet 101:219-222.
2. Arlt MF, Casper AM, Glover TW. 2003. Common fragile sites. Cytogenet Genome Res 100:92-100.
3. Barbosa AC, Otto PA, Vianna-Morgante AM. 2000. Replication timing of homologous alpha-satellite DNA in Roberts syndrome. Chrom Res 8:645-650.
4. Cuthbert AP, Trott DA, Ekong RM, Jezzard S, England NL, Themis M, Todd CM, Newbold RF. 1995. Construction and characterization of a highly stable human: rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies. Cytogenet Cell Genet 71:68-76.
5. Fabarius A, Hehlmann R, Duesberg PH. 2003. Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy. Cancer Genet Cytogenet 143:59-72.
6. Fedorova L, Kost-Alimova M, Gizatullin RZ, Alimov A, Zabarovska VI, Szeles A, Protopopov AI, Vorobieva NV, Kashuba VI, Klein G and others. 1997. Assignment and ordering of twenty-three unique Not1-linking clones containing expressed genes including the guanosine 5′-monophosphate synthetase gene to human chromosome 3. Eur J Hum Genet 5:110-116.
7. Gisselsson D. 2003. Chromosome instability in cancer: how, when, and why? Adv Cancer Res 87:1-29.
8. Gisselsson D, Jonson T, Petersen A, Strombeck B, Dal Cin P, Hoglund M, Mitelman F, Mertens F, Mandahl N. 2001. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci USA 98:12683-12688.
9. Handt O, Sutherland GR, Richards RI. 2000. Fragile sites and minisatellite repeat instability. Mol Genet Metab 70:99-105.
10. Hansen RS, Canfield FK, Fjeld AD, Mumm S, Laird CD, Gartler SM. 1997. A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication. Proc Natl Acad Sci U S A 94:4587-4592.
11. Hellman A, Rahat A, Scherer SW, Darvasi A, Tsui LC, Kerem B. 2000. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability. Mol Cell Biol 20:4420-4427.
12. Horvath JE, Bailey JA, Locke DP, Eichler EE. 2001. Lessons from the human genome: transitions between euchromatin and heretochromatin. Hum Mol Genet 10:2215-2223.
13. Imreh S, Kholodnyuk I, Allikmetts R, Stanbridge EJ, Zabarovsky ER, Klein G. 1994. Nonrandom loss of human chromosome 3 fragments from mouse-human microcell hybrids following progressive growth in SCID mice. Genes Chromosomes Cancer 11: 237-245.
14. Imreh S, Klein G, Zabarovsky ER. 2003. Search for unknown tumor-antagonizing genes. Genes Chromosomes Cancer 38:307-321.
15. Jackson MS, Rocchi M, Thompson G, Hearn T, Crosier M, Guy J, Kirk D, Mulligan L, Ricco A, Piccininni S, Marzella R, Viggiano L, Archidiacono N. 1999. Sequences flanking the centromere of human chromosome 10 are a complex patchwork of arm-specific sequences, stable duplications and unstable sequences with homologies to telomeric and other centromeric locations. Hum Mol Genet 8:205-215.
16. Korenstein-Ilan A, Amiel A, Lalezari S, Lishner M, Avivi L. 2002. Allele-specific replication associated with aneuploidy in blood cells of patients with hematologic malignancies. Cancer Genet Cytogenet 139:97-103.
17. Le Beau MM, Rassool FV, Neilly ME, Espinosa R, 3rd, Glover TW, Smith DI, McKeithan TW. 1998. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum Mol Genet 7:755-761.
18. Lengauer C, Kinzler KW, Vogelstein B. 1998. Genetic instabilities in human cancers. Nature 396:643-649.
19. Loupart ML, Krause SA, Heck MS. 2000. Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants. Current Biology 10:1547-1556.
20. Mitelman F, Johansson B, Mertens F, editors. 2001. Mitelman Database of Chromosome Aberrations in Cancer. Available from: http://cgap.nci.nih.gov/ Chromosomes/Mitelman
21. Padilla-Nash HM, Heselmeyer-Haddad K, Wangsa D, Zhang H, Ghadimi BM, Macville M, Augustus M, Schrock E, Hilgenfeld E, Ried T. 2001. Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms. Genes Chromosomes Cancer 30:349-363.
22. Pflumm MF, Botchan MR. 2001. Ore mutants arrest in metaphase with abnormally condensed chromosomes. Development 128:1697-1707.
23. Richards RI. 2001. Fragile and unstable chromosomes in cancer: causes and consequences. Trends Genet 17:339-345.
24. Ried T, Just KE, Holtgreve-Grez H, du Manoir S, Speicher MR, Schrock E, Latham C, Blegen H, Zetterberg A, Cremer T, Auer G. 1995. Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res 55:5415-5423.
25. Ried T, Heselmeyer-Haddad K, Blegen H, Schrock E, Auer G. 1999. Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation. Genes Chromosomes Cancer 25:195-204.
26. Rimessi P, Gualandi F, Morelli C, Trabanelli C, Wu Q, Possati L, Montesi M, Barrett JC, Barbanti-Brodano G. 1994. Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies three regions on 3p involved in ovarian cancer. Oncogene 9:3467-3474.
27. Satoh H, Lamb PW, Dong JT, Everitt J, Boreiko C, Oshimura M, Barrett JC. 1993. Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer. Mol Carcinog 7:157-164.
28. Saxon PJ, Stanbridge EJ. 1987. Transfer and selective retention of single specific human chromosomes via microcell-mediated chromosome transfer. Methods in Enzymology 151:313-325.
29. Shimizu M, Yokota J, Mori N, Shuin T, Shinoda M, Terada M, Oshimura M. 1990. Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR. Oncogene 5:185-194.
30. Smith L, Plug A, Thayer M. 2001. Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations. Proc Natl Acad Sci USA 98:13300-13305.
31. Wang L, Darling J, Zhang JS, Huang H, Liu W, Smith DI. 1999. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum Mol Genet 8:431-437.
32. Yang Y, Kost-Alimova M, Ingvarsson S, Qianhui Q, Kiss H, Szeles A, Kholodnyuk I, Cuthbert A, Klein G, Imreh S. 2001. Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice. Proc Natl Acad Sci USA 98:1136-1141.