Early multipotential pituitary focal hyperplasia in the α-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice

Molecular Endocrinology

Volumn 19, Issue 5, 2005, Pages 1383-1391

  Abbud, Rula A ^a   Takumi, Ichiro ^a   Barker, Erin M ^a   Ren, Song Guang ^a   Chen, Dar Yong ^a   Wawrowsky, Kolja ^a   Melmed, Shlomo ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; LUTEINIZING HORMONE; PITUITARY TUMOR TRANSFORMING GENE PROTEIN; PITUITARY TUMOR TRANSFORMING GENE PROTEIN 1; SOMATOMEDIN C; TESTOSTERONE; THYROTROPIN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CARCINOGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DEATH; GENE; GENE EXPRESSION; GROWTH HORMONE BLOOD LEVEL; HORMONE RELEASE; HYPERPLASIA; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; LUTEINIZING HORMONE BLOOD LEVEL; MICROADENOMA; MOUSE; NEPHRITIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE; PHENOTYPE; PITUITARY TUMOR TRANSFORMING GENE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; SEMINAL VESICLE DISEASE; STEM CELL; TESTOSTERONE BLOOD LEVEL; TRANSGENE; TRANSGENIC MOUSE; TUMOR MODEL; URINARY TRACT OBSTRUCTION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; FOLLICLE STIMULATING HORMONE; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HUMANS; HYPERPLASIA; MALE; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; PITUITARY DISEASES; PITUITARY GLAND; UROGENITAL SYSTEM;

ANIMALIA; MUS MUSCULUS;

EID: 17844400784     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0403     Document Type: Article

References (54)

1. Burgess R, Lunyak V, Rosenfeld M 2002 Signaling and transcriptional control of pituitary development. Curr Opin Genet Dev 12:534-539
2. Watkins-Chow DE, Camper SA 1998 How many homeobox genes does it take to make a pituitary gland? Trends Genet 14:284-290
3. Drouin J, Lamolet B, Lamonerie T, Lanctot C, Tremblay JJ 1998 The PTX family of homeodomain transcription factors during pituitary developments. Mol Cell Endocrinol 140:31-36
4. Alarid ET, Holley S, Hayakawa M, Mellon PL 1998 Discrete stages of anterior pituitary differentiation recapitulated in immortalized cell lines. Mol Cell Endocrinol 140:25-30
5. Melmed S 2003 Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112:1603-1618
6. Heaney AP, Melmed S 2004 Molecular targets in pituitary tumours. Nat Rev Cancer 4:285-295
7. Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree J, Erdos MR, Collins FS, Chandrasekharappa SC 1999 Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias. Recent Prog Horm Res 54:397-438
8. Spada A, Vallar L, Faglia G 1993 G-proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations. Front Neuroendocrinol 14:214-232
9. Stratakis CA, Matyakhina L, Courkoutsakis N, Patronas N, Voutetakis A, Stergiopoulos S, Bossis I, Carney JA 2004 Pathology and molecular genetics of the pituitary gland in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas' (Carney complex). Front Horm Res 32:253-264
10. Franklin DS, Godfrey VL, Lee H, Kovalev GI, Schoonhoven R, Chen-Kiang S, Su L, Xiong Y 1998 CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev 12:2899-2911
11. Park MS, Rosai J, Nguyen HT, Capodieci P, Cordon-Cardo C, Koff A 1999 p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. Proc Natl Acad Sci USA 96:6382-6387
12. Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T 1998 Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet 18:360-364
13. Pei L, Melmed S 1997 Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 11:433-441
14. McCabe CJ, Khaira JS, Boelaert K, Heaney AP, Tannahill LA, Hussain S, Mitchell R, Olliff J, Sheppard MC, Franklyn JA, Gittoes NJ 2003 Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour. Clin Endocrinol (Oxf) 58:141-150
15. Saez C, Pereda T, Borrero JJ, Espina A, Romero F, Tortolero M, Pintor-Toro JA, Segura DI, Japon MA 2002 Expression of hpttg proto-oncogene in lymphoid neoplasias. Oncogene 21:8173-8177
16. Shibata Y, Haruki N, Kuwabara Y, Nishiwaki T, Kato J, Shinoda N, Sato A, Kimura M, Koyama H, Toyama T, Ishiguro H, Kudo J, Terashita Y, Konishi S, Fujii Y 2002 Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer. Jpn J Clin Oncol 32:233-237
17. Saez C, Japon MA, Ramos-Morales F, Romero F, Segura DI, Tortolero M, Pintor-Toro JA 1999 hpttg Is overexpressed in pituitary adenomas and other primary epithelial neoplasias. Oncogene 18:5473-5476
18. Dominguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro JA 1998 hpttg, A human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. Oncogene 17:2187-2193
19. Yu R, Melmed S 2004 Pituitary tumor transforming gene: an update. Front Horm Res 32:175-185
20. Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S 1999 Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 5:1317-1321
21. Wang Z, Yu R, Melmed S 2001 Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol Endocrinol 15:1870-1879
22. Wang Z, Moro E, Kovacs K, Yu R, Melmed S 2003 Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic β cell proliferation and diabetes. Proc Natl Acad Sci USA 100:3428-3432
23. Orr-Weaver TL 1999 Perspectives: cell cycle. The difficulty in separating sisters. Science 285:344-345
24. Yu R, Lu W, Chen J, McCabe CJ, Melmed S 2003 Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology 144:4991-4998
25. Zou H, McGarry TJ, Bernal T, Kirschner MW 1999 Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285:418-422
26. Waizenegger I, Gimenez-Abian JF, Wernic D, Peters JM 2002 Regulation of human separase by securin binding and autocleavage. Curr Biol 12:1368-1378
27. Ramaswamy S, Ross KN, Lander ES, Golub TR 2003 A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49-54
28. Horwitz GA, Miklovsky I, Heaney AP, Ren SG, Melmed S 2003 Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression. Mol Endocrinol 17:600-609
29. Chesnokova V, Castro A-V, Kovacs K, Melmed S. Pttg is required for pituitary tumor development in Rb-deficient mice. Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA, 2004, p 127 (Abstract OR37-2)
30. Pulichino AM, Vallette-Kasic S, Couture C, Gauthier Y, Brue T, David M, Malpuech G, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, Drouin J 2003 Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency. Genes Dev 17:711-716
31. Bakke M, Zhao L, Parker KL 2001 Approaches to define the role of SF-1 at different levels of the hypothalamic-pituitary-steroidogenic organ axis. Mol Cell Endocrinol 179:33-37
32. Kendall SK, Gordon DF, Birkmeier TS, Petrey D, Sarapura VD, O'Shea KS, Wood WM, Lloyd RV, Ridgway EC, Camper SA 1994 Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone α-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland. Mol Endocrinol 8:1420-1433
33. Wenig B, Heffess C, Adair C 1997 Atlas of endocrine pathology. 1st ed. Philadelphia: W.B. Saunders Co.
34. Asa SL 1998 Atlas of tumor pathology: tumors of the pituitary. 3rd series ed. Washington, DC: Armed Forces Institute of Pathology
35. Matzuk MM, DeMayo FJ, Hadsell LA, Kumar TR 2003 Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice. Biol Reprod 69:338-346
36. Rulli SB, Ahtiainen P, Makela S, Toppari J, Poutanen M, Huhtaniemi I 2003 Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin. Endocrinology 144:4980-4990
37. Cushman LJ, Burrows HL, Seasholtz AF, Lewandoski M, Muzyczka N, Camper SA 2000 Cre-mediated recombination in the pituitary gland. Genesis 28:167-174
38. Seuntjens E, Hauspie A, Vankelecom H, Denef C 2002 Ontogeny of plurihormonal cells in the anterior pituitary of the mouse, as studied by means of hormone mRNA detection in single cells. J Neuroendocrinol 14:611-619
39. White MC, Newland P, Daniels M, Turner SJ, Mathias D, Teasdale G, Kendall-Taylor P 1986 Growth hormone secreting pituitary adenomas are heterogeneous in cell culture and commonly secrete glycoprotein hormone α-subunit. Clin Endocrinol (Oxf) 25:173-179
40. Oppenheim DS, Kana AR, Sangha JS, Klibanski A 1990 Prevalence of α-subunit hypersecretion in patients with pituitary tumors: clinically nonfunctioning and somatotroph adenomas. J Clin Endocrinol Metab 70:859-864
41. Shimon I, Nass D, Gross DJ 2001 Pituitary macroadenoma secreting thyrotropin and growth hormone: remission of bihormonal hypersecretion in response to lanreotide therapy. Pituitary 4:265-269
42. Mohammad HP, Abbud RA, Parlow AF, Lewin JS, Nilson JH 2003 Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage. Endocrinology 144:4626-4636
43. Abbud RA, Ameduri RK, Rao JS, Nett TM, Nilson JH 1999 Chronic hypersecretion of luteinizing hormone in transgenic mice selectively alters responsiveness of the α-subunit gene to gonadotropin-releasing hormone and estrogens. Mol Endocrinol 13:1449-1459
44. Santos AF, Huang H, Tindall DJ 2004 The androgen receptor: a potential target for therapy of prostate cancer. Steroids 69:79-85
45. Oliver SE, Barrass B, Gunnell DJ, Donovan JL, Peters TJ, Persad RA, Gillatt D, Neal DE, Hamdy FC, Holly JM 2004 Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancer. Cancer Epidemiol Biomarkers Prev 13:163-165
46. Konno-Takahashi N, Takeuchi T, Shimizu T, Nishimatsu H, Fukuhara H, Kamijo T, Moriyama N, Tejima S, Kitamura T 2003 Engineered IGF-I expression induces glandular enlargement in the murine prostate. J Endocrinol 177:389-398
47. Cohen P, Clemmons DR, Rosenfeld RG 2000 Does the GH-IGF axis play a role in cancer pathogenesis? Growth Horm IGF Res 10:297-305
48. DiGiovanni J, Kiguchi K, Frijhoff A, Wilker E, Bol DK, Beltran L, Moats S, Ramirez A, Jorcano J, Conti C 2000 Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice. Proc Natl Acad Sci USA 97:3455-3460
49. Ruan W, Powell-Braxton L, Kopchick JJ, Kleinberg DL 1999 Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development. Endocrinology 140:1984-1989
50. Romero F, Gil-Bernabe AM, Saez C, Japon MA, Pintor-Toro JA, Tortolero M 2004 Securin is a target of the UV response pathway in mammalian cells. Mol Cell Biol 24:2720-2733
51. Hamid T, Kakar SS 2004 PTTG/securin activates expression of p53 and modulates its function. Mol Cancer 3:18
52. Bernal JA, Luna R, Espina A, Lazaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA 2002 Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. Nat Genet 32:306-311
53. Wang Z, Melmed S 2000 Pituitary tumor transforming gene (PTTG) transforming and transactivation activity. J Biol Chem 275:7459-7461
54. Ren SG, Kim S, Taylor J, Dong J, Moreau JP, Culler MD, Melmed S 2003 Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand. J Clin Endocrinol Metab 88:5414-5421