The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 32, 2010, Pages 14188-14193

  Li, Min ^a   Fang, Xiao ^a   Baker, Darren J ^b   Guo, Linjie ^a   Gao, Xue ^a   Wei, Zhubo ^a   Han, Shuhua ^a   Van Deursen, Jan M ^b   Zhang, Pumin ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE; DNA DAMAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINDLE ASSEMBLY CHECKPOINT; ANIMAL; METABOLISM; NEOPLASM; TRANSGENIC MOUSE;

ANEUPLOIDY; ANIMALS; CELL CYCLE PROTEINS; DNA DAMAGE; DNA-BINDING PROTEINS; MICE; MICE, TRANSGENIC; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; MUS;

EID: 77956271440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1005960107     Document Type: Article

References (31)

1. Lew DJ, Burke DJ (2003) The spindle assembly and spindle position checkpoints. Annu Rev Genet 37:251-282.
2. Pinsky BA, Biggins S (2005) The spindle checkpoint: Tension versus attachment. Trends Cell Biol 15:486-493.
3. King RW, et al. (1995) A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81:279-288.
4. Yu H, King RW, Peters JM, Kirschner MW (1996) Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Curr Biol 6:455-466. (Pubitemid 126656293)
5. King RW, Deshaies RJ, Peters JM, Kirschner MW (1996) How proteolysis drives the cell cycle. Science 274:1652-1659. (Pubitemid 26414887)
6. Zou H, McGarry TJ, Bernal T, Kirschner MW (1999) Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285:418-422.
7. Baker DJ, Dawlaty MM, Galardy P, van Deursen JM (2007) Mitotic regulation of the anaphase-promoting complex. Cell Mol Life Sci 64:589-600.
8. Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Natl Rev 8:379-393.
9. Li R, Murray AW (1991) Feedback control of mitosis in budding yeast. Cell 66:519-531. (Pubitemid 121001388)
10. Yamamoto A, Guacci V, Koshland D (1996) Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J Cell Biol 133:99-110.
11. Babu JR, et al. (2003) Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol 160:341-353.
12. Baker DJ, et al. (2004) BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 36:744-749.
13. Baker DJ, et al. (2006) Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol 172:529-540.
14. Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM (2007) Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol 179:255-267.
15. Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW (2007) Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11:25-36. (Pubitemid 46070223)
16. Dai W, et al. (2004) Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res 64:440-445.
17. Iwanaga Y, et al. (2007) Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res 67:160-166.
18. Michel LS, et al. (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409:355-359.
19. Li M, Fang X, Wei Z, York JP, Zhang P (2009) Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol 185:983-994.
20. Hanks S, et al. (2004) Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 36:1159-1161.
21. Mertens F, Johansson B, Mitelman F (1994) Isochromosomes in neoplasia. Genes Chromosomes Cancer 10:221-230.
22. Boveri T (2008) Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci 121 (Suppl 1):1-84.
23. Holland AJ, Cleveland DW (2009) Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis. Natl Rev 10:478-487.
24. Williams BR, et al. (2008) Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 322:703-709.
25. Torres EM, et al. (2007) Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science 317:916-924.
26. Weaver BA, ClevelandDW(2007) Aneuploidy: Instigator and inhibitor of tumorigenesis. Cancer Res 67:10103-10105.
27. Lengauer C, Kinzler KW, Vogelstein B (1997) Genetic instability in colorectal cancers. Nature 386:623-627.
28. Alexander A, et al. (2010) ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci USA 107:4153-4158.
29. Thompson SL, Compton DA (2010) Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol 188:369-381.
30. Barlow C, et al. (1996) Atm-deficient mice: A paradigm of ataxia telangiectasia. Cell 86:159-171. (Pubitemid 26259926)
31. Harborth J, Elbashir SM, Bechert K, Tuschl T, Weber K (2001) Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 114:4557-4565.