Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome

Cell Death and Differentiation

Volumn 14, Issue 8, 2007, Pages 1433-1442

  Semple, J I ^a   Smits, V A J ^b   Fernaud, J R ^a   Mamely, I ^a   Freire, R ^a  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CHECKPOINT KINASE 1; CLASPIN; PROTEASOME; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CASPASE 3; CASPASE 7; CASPASES; CELL CYCLE PROTEINS; DNA DAMAGE; HELA CELLS; HL-60 CELLS; HUMANS; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING;

EID: 34447651363     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402134     Document Type: Article

References (37)

1. Fischer U, Janicke RU, Schulze-Osthoff K. Many cuts to ruin: A comprehensive update of caspase substrates. Cell Death Differ 2003; 10: 76-100.
2. Smith GC, d'Adda di Fagagna F, Lakin ND, Jackson SP. Cleavage and inactivation of ATM during apoptosis. Mol Cell Biol 1999; 19 6076-6084.
3. Freire R, d'Adda Di Fagagna F, Wu L, Pedrazzi G, Stagljar I, Hickson ID et al. Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha. Nucleic Acids Res 2001; 29: 3172-3180.
4. Casciola-Rosen LA, Anhalt GJ, Rosen A. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 1995; 182: 1625-1634.
5. Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2006; 8: 37-45.
6. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300: 1542-1548.
7. Bao S, Lu T, Wang X, Zheng H, Wang LE, Wei Q et al. Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. Oncogene 2004; 23: 5586-5593.
8. Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14: 1448-1459.
9. Melo J, Toczyski D. A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol 2002; 14: 237-245.
10. Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell 2000; 6: 839-849.
11. Yoo HY, Jeong SY, Dunphy WG. Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes Dev 2006; 20: 772-783.
12. Kumagai A, Kim SM, Dunphy WG. Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Cbem 2004; 279: 49599-49608.
13. Osborn AJ, Elledge SJ. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 2003; 17: 1755-1767.
14. Lee J, Kumagai A, Dunphy WG. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol Cell 2003; 11: 329-340.
15. Lin SY, Li K, Stewart GS, Elledge SJ. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci USA 2004; 101: 6484-6489.
16. Alexandre S, Rast C, Nguyen-Ba G, Poirer GG, Vasseur P. PARP degradation in apoptotic Syrian hamster embryo (SHE) cells compared to HL60 cell line. Biochimie 2000; 82: 1115-1122.
17. Lee MW, Hirai I, Wang HG. Caspase-3-mediated cleavage of Rad6 during apoptosis. Oncogene 2003; 22: 6340-6346.
18. Clarks CA, Bennett LN, Clarke PR. Cleavage of claspin by caspase-7 during apoptosis inhibits the Chlo pathway. J Biol Chem, 2005; 280: 35337-35345.
19. Groll M, Huber R. Inhibitors of the eukaryotic 20S proteasome core particle: A structural approach. Biochim Biophys Acta 2004; 1695: 33-44.
20. Butts BD, Hudson HR, Linsemen DA, Le SS, Ryan KR, Bouchard RJ et al. Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of prosurvival and pro-apoptotic transcription factors. Mol Cell Neurosci 2005; 30: 279-289.
21. Shah GM, Shah RG, Poirier GG. Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells. Biochem Biophys Res Commun 1996; 229: 834-844.
22. Marnely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A et al. Polo-like kinase-1 controls proteasome-dependent degradation of claspin during checkpoint recovery. Curr Biol 2006; 16: 1950-1955.
23. Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE et al. SCFbeta TrCP-mediated degradation of claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 2006; 23: 319-329.
24. Mailand N, Bekker-Jensen S, Bartek J, Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 2006; 23: 307-318.
25. Chini CC, Wood J, Chen J. Chk1 is required to maintain claspin stability. Oncogene 2006; 25: 4165-4171.
26. Suh J, Lee YA, Gwag BJ. Induction and attenuation of neuronal apoptosis by proteasome inhinbitors in murine cortical cell cultures. J Neurochem 2005; 95: 684-694.
27. Demontis S, Rigo C, Piccinin S, Mizzau M, Sonego M, Fabris M et al. Twist is substrate for caspase cleavage and proteasome-mediated degradation. Cell Death Differ 2006; 13: 335-345.
28. Mollerup J, Berchtold MW. The co-chaperone p23 is degraded by caspases and the proteasome during apoptosis. FEBS Lett 2005; 579: 4187-4192.
29. Rathore N, Matta H, Chaudhary PM. An evolotionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha. J Biol Chem 2004; 279: 39350-39365.
30. Varshavsky A. The N-end rule: Functions, mysteries, uses. Proc Natl Acad Sci USA 1996; 93: 12142-12149.
31. Zhang D, Zaugg K, Mak TW, Elledge SJ. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 2006; 126: 529-542.
32. Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J. Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death. J Biol Chem 2001; 276: 12068-12075.
33. Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem 2003; 278: 30057-30062.
34. Stennicke HR, Salvesen GS. Caspases: Preparation and characterization. Methods 1999; 17: 313-319.
35. Perera D, Freire R. Human spindle checkpoint kinase Bub1 is cleaved during apoptosis. Cell Death Differ 2005; 12: 827-830.
36. Morrissey JH. Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sansitivity. Anal Biochem 1981; 117: 307-310.
37. Zhan Q, Jin S, Ng B, Plisket J, Shangary S, Rathi A et al. Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis. Oncogene 2002; 21: 5335-5345.