Regulation of rad17 protein turnover unveils an impact of rad17-APC cascade in breast carcinogenesis and treatment

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18134-18145

  Zhou, Zhuan ^a   Jing, Chao ^b   Zhang, Liyong ^a   Takeo, Fujita ^a,c   Kim, Hyun ^a   Huang, Yi ^d   Liu, Zhihua ^b   Wan, Yong ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b CANCER HOSPITAL   (China)

^c NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMO SENSITIZATIONS; GENOME INSTABILITY; GENOME STABILITY; PROTEIN TURNOVERS; TUMORIGENESIS;

GENES;

PATHOLOGY;

APC PROTEIN; CISPLATIN; DOXORUBICIN; NUCLEIC ACID BINDING PROTEIN; PROTEIN RAD17; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; CANCER CHEMOTHERAPY; CELL TRANSFORMATION; CHEMOSENSITIZATION; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; EPITHELIUM CELL; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; REGULATORY MECHANISM;

APC; CARCINOGENESIS; CHROMOSOMES/NON-HISTONE CHROMOSOMAL PROTEINS; DNA BINDING PROTEIN; GENOME INSTABILITY; PROTEIN DYNAMICS; PROTEIN STABILITY; PROTEIN TURNOVER; RAD17;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CADHERINS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DNA DAMAGE; FEMALE; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; MCF-7 CELLS; MODELS, GENETIC; PROTEIN BINDING; PROTEOLYSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 84880079013     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.456962     Document Type: Article

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