-
1
-
-
0034096201
-
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
-
Keyse S.M. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 12 2 (2000) 186-192
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, Issue.2
, pp. 186-192
-
-
Keyse, S.M.1
-
2
-
-
0036467391
-
The p53 and Mdm2 families in cancer
-
Michael D., and Oren M. The p53 and Mdm2 families in cancer. Curr. Opin. Genet. Dev. 12 1 (2002) 53-59
-
(2002)
Curr. Opin. Genet. Dev.
, vol.12
, Issue.1
, pp. 53-59
-
-
Michael, D.1
Oren, M.2
-
3
-
-
0842324788
-
Recycling the cell cycle: cyclins revisited
-
Murray A.W. Recycling the cell cycle: cyclins revisited. Cell 116 2 (2004) 221-234
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 221-234
-
-
Murray, A.W.1
-
4
-
-
33748275681
-
The p53 tumor suppressor participates in multiple cell cycle checkpoints
-
Giono L.E., and Manfredi J.J. The p53 tumor suppressor participates in multiple cell cycle checkpoints. J. Cell. Physiol. 209 1 (2006) 13-20
-
(2006)
J. Cell. Physiol.
, vol.209
, Issue.1
, pp. 13-20
-
-
Giono, L.E.1
Manfredi, J.J.2
-
6
-
-
14044258346
-
G2 damage checkpoints: what is the turn-on?
-
O'Connell M.J., and Cimprich K.A. G2 damage checkpoints: what is the turn-on?. J. Cell Sci. 118 Pt 1 (2005) 1-6
-
(2005)
J. Cell Sci.
, vol.118
, Issue.PART 1
, pp. 1-6
-
-
O'Connell, M.J.1
Cimprich, K.A.2
-
7
-
-
34249937178
-
The ATR pathway: fine-tuning the fork
-
Paulsen R.D., and Cimprich K.A. The ATR pathway: fine-tuning the fork. DNA Repair (Amst) 6 7 (2007) 953-966
-
(2007)
DNA Repair (Amst)
, vol.6
, Issue.7
, pp. 953-966
-
-
Paulsen, R.D.1
Cimprich, K.A.2
-
8
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J., Coates J., and Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434 7033 (2005) 605-611
-
(2005)
Nature
, vol.434
, Issue.7033
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
9
-
-
30944435598
-
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
-
Smits V.A., Reaper P.M., and Jackson S.P. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr. Biol. 16 2 (2006) 150-159
-
(2006)
Curr. Biol.
, vol.16
, Issue.2
, pp. 150-159
-
-
Smits, V.A.1
Reaper, P.M.2
Jackson, S.P.3
-
10
-
-
0034125688
-
The G(2) DNA damage checkpoint targets both Wee1 and Cdc25
-
Raleigh J.M., and O'Connell M.J. The G(2) DNA damage checkpoint targets both Wee1 and Cdc25. J. Cell Sci. 113 Pt 10 (2000) 1727-1736
-
(2000)
J. Cell Sci.
, vol.113
, Issue.PART 10
, pp. 1727-1736
-
-
Raleigh, J.M.1
O'Connell, M.J.2
-
11
-
-
33750692709
-
GammaH2AX and its role in DNA double-strand break repair
-
Fillingham J., Keogh M.C., and Krogan N.J. GammaH2AX and its role in DNA double-strand break repair. Biochem. Cell Biol. 84 4 (2006) 568-577
-
(2006)
Biochem. Cell Biol.
, vol.84
, Issue.4
, pp. 568-577
-
-
Fillingham, J.1
Keogh, M.C.2
Krogan, N.J.3
-
12
-
-
10944262393
-
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
-
Unal E., et al. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol. Cell 16 6 (2004) 991-1002
-
(2004)
Mol. Cell
, vol.16
, Issue.6
, pp. 991-1002
-
-
Unal, E.1
-
13
-
-
4444298849
-
DNA damage checkpoint maintenance through sustained Chk1 activity
-
Latif C., Elzen N.R., and O'Connell M.J. DNA damage checkpoint maintenance through sustained Chk1 activity. J. Cell Sci. 117 Pt 16 (2004) 3489-3498
-
(2004)
J. Cell Sci.
, vol.117
, Issue.PART 16
, pp. 3489-3498
-
-
Latif, C.1
Elzen, N.R.2
O'Connell, M.J.3
-
14
-
-
0037081563
-
Protein phosphatase 1-targeted in many directions
-
Cohen P.T. Protein phosphatase 1-targeted in many directions. J. Cell Sci. 115 Pt 2 (2002) 241-256
-
(2002)
J. Cell Sci.
, vol.115
, Issue.PART 2
, pp. 241-256
-
-
Cohen, P.T.1
-
15
-
-
4644303544
-
Resisting arrest: recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1
-
den Elzen N., et al. Resisting arrest: recovery from checkpoint arrest through dephosphorylation of Chk1 by PP1. Cell Cycle 3 5 (2004) 529-533
-
(2004)
Cell Cycle
, vol.3
, Issue.5
, pp. 529-533
-
-
den Elzen, N.1
-
16
-
-
1842614272
-
Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
-
den Elzen N.R., and O'Connell M.J. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. EMBO J. 23 4 (2004) 908-918
-
(2004)
EMBO J.
, vol.23
, Issue.4
, pp. 908-918
-
-
den Elzen, N.R.1
O'Connell, M.J.2
-
17
-
-
0029664616
-
rad-Dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint
-
Walworth N.C., and Bernards R. rad-Dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271 (1996) 353-356
-
(1996)
Science
, vol.271
, pp. 353-356
-
-
Walworth, N.C.1
Bernards, R.2
-
18
-
-
25444527426
-
Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D
-
Lu X., Nguyen T.A., and Donehower L.A. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D. Cell Cycle 4 8 (2005) 1060-1064
-
(2005)
Cell Cycle
, vol.4
, Issue.8
, pp. 1060-1064
-
-
Lu, X.1
Nguyen, T.A.2
Donehower, L.A.3
-
19
-
-
33749830382
-
Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint
-
Macip S., et al. Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint. Oncogene 25 45 (2006) 6037-6047
-
(2006)
Oncogene
, vol.25
, Issue.45
, pp. 6037-6047
-
-
Macip, S.1
-
20
-
-
33749626550
-
Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit
-
Leung-Pineda V., Ryan C.E., and Piwnica-Worms H. Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol. Cell. Biol. 26 20 (2006) 7529-7538
-
(2006)
Mol. Cell. Biol.
, vol.26
, Issue.20
, pp. 7529-7538
-
-
Leung-Pineda, V.1
Ryan, C.E.2
Piwnica-Worms, H.3
-
21
-
-
0032412774
-
Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast
-
Verkade H.M., and O'Connell M.J. Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast. Mol. Gen. Genet. 260 5 (1998) 426-433
-
(1998)
Mol. Gen. Genet.
, vol.260
, Issue.5
, pp. 426-433
-
-
Verkade, H.M.1
O'Connell, M.J.2
-
22
-
-
0029827367
-
The Schizosaccharomyces pombe rad3 checkpoint gene
-
Bentley N.J., et al. The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 15 23 (1996) 6641-6651
-
(1996)
EMBO J.
, vol.15
, Issue.23
, pp. 6641-6651
-
-
Bentley, N.J.1
-
23
-
-
31444445458
-
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery
-
Keogh M.C., et al. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439 7075 (2006) 497-501
-
(2006)
Nature
, vol.439
, Issue.7075
, pp. 497-501
-
-
Keogh, M.C.1
-
24
-
-
3042793923
-
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast
-
Nakamura T.M., et al. Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol. Cell. Biol. 24 14 (2004) 6215-6230
-
(2004)
Mol. Cell. Biol.
, vol.24
, Issue.14
, pp. 6215-6230
-
-
Nakamura, T.M.1
-
25
-
-
0042991379
-
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors
-
Bassing C.H., et al. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114 3 (2003) 359-370
-
(2003)
Cell
, vol.114
, Issue.3
, pp. 359-370
-
-
Bassing, C.H.1
-
26
-
-
0030593033
-
Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
-
Sanchez Y., et al. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271 (1996) 357-360
-
(1996)
Science
, vol.271
, pp. 357-360
-
-
Sanchez, Y.1
-
27
-
-
0031460633
-
The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway
-
Cohen-Fix O., and Koshland D. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. Proc. Natl. Acad. Sci. USA 94 26 (1997) 14361-14366
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, Issue.26
, pp. 14361-14366
-
-
Cohen-Fix, O.1
Koshland, D.2
-
28
-
-
0035105240
-
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest
-
Pellicioli A., et al. Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol. Cell 7 2 (2001) 293-300
-
(2001)
Mol. Cell
, vol.7
, Issue.2
, pp. 293-300
-
-
Pellicioli, A.1
-
29
-
-
34547196917
-
Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage
-
O'Neill B.M., et al. Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc. Natl. Acad. Sci. USA 104 22 (2007) 9290-9295
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, Issue.22
, pp. 9290-9295
-
-
O'Neill, B.M.1
-
30
-
-
0344643062
-
PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break
-
Leroy C., et al. PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol. Cell 11 3 (2003) 827-835
-
(2003)
Mol. Cell
, vol.11
, Issue.3
, pp. 827-835
-
-
Leroy, C.1
-
31
-
-
18344386695
-
SCF-mediated protein degradation and cell cycle control
-
Ang X.L., and Wade Harper J. SCF-mediated protein degradation and cell cycle control. Oncogene 24 17 (2005) 2860-2870
-
(2005)
Oncogene
, vol.24
, Issue.17
, pp. 2860-2870
-
-
Ang, X.L.1
Wade Harper, J.2
-
32
-
-
24044476837
-
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway
-
Zhang Y.W., et al. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol. Cell 19 5 (2005) 607-618
-
(2005)
Mol. Cell
, vol.19
, Issue.5
, pp. 607-618
-
-
Zhang, Y.W.1
-
33
-
-
0033634679
-
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
-
Kumagai A., and Dunphy W.G. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 6 4 (2000) 839-849
-
(2000)
Mol. Cell
, vol.6
, Issue.4
, pp. 839-849
-
-
Kumagai, A.1
Dunphy, W.G.2
-
34
-
-
2542459341
-
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
-
Yoo H.Y., et al. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117 5 (2004) 575-588
-
(2004)
Cell
, vol.117
, Issue.5
, pp. 575-588
-
-
Yoo, H.Y.1
-
35
-
-
33749246225
-
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
-
Mamely I., et al. Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr. Biol. 16 19 (2006) 1950-1955
-
(2006)
Curr. Biol.
, vol.16
, Issue.19
, pp. 1950-1955
-
-
Mamely, I.1
-
36
-
-
33746413746
-
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
-
Peschiaroli A., et al. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23 3 (2006) 319-329
-
(2006)
Mol. Cell
, vol.23
, Issue.3
, pp. 319-329
-
-
Peschiaroli, A.1
-
37
-
-
33746429958
-
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
-
Mailand N., et al. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 23 3 (2006) 307-318
-
(2006)
Mol. Cell
, vol.23
, Issue.3
, pp. 307-318
-
-
Mailand, N.1
-
38
-
-
0242389822
-
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation
-
Margolis S.S., et al. PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. EMBO J. 22 21 (2003) 5734-5745
-
(2003)
EMBO J.
, vol.22
, Issue.21
, pp. 5734-5745
-
-
Margolis, S.S.1
-
39
-
-
0027514175
-
Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer
-
Coleman T.R., Tang Z., and Dunphy W.G. Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer. Cell 72 (1993) 919-929
-
(1993)
Cell
, vol.72
, pp. 919-929
-
-
Coleman, T.R.1
Tang, Z.2
Dunphy, W.G.3
-
40
-
-
0031792832
-
The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast
-
Kanoh J., and Russell P. The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast. Mol. Biol. Cell 9 12 (1998) 3321-3334
-
(1998)
Mol. Biol. Cell
, vol.9
, Issue.12
, pp. 3321-3334
-
-
Kanoh, J.1
Russell, P.2
-
41
-
-
0027267674
-
Phosphorylation and inactivation of the mitotic inhibitor wee1 by the nim1/cdr1 kinase
-
Parker L.L., et al. Phosphorylation and inactivation of the mitotic inhibitor wee1 by the nim1/cdr1 kinase. Nature 363 (1993) 736-738
-
(1993)
Nature
, vol.363
, pp. 736-738
-
-
Parker, L.L.1
-
42
-
-
0027201553
-
Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase
-
Wu L., and Russell P. Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase. Nature 363 6431 (1993) 738-741
-
(1993)
Nature
, vol.363
, Issue.6431
, pp. 738-741
-
-
Wu, L.1
Russell, P.2
-
43
-
-
0031741184
-
The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe
-
Breeding C.S., et al. The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe. Mol. Biol. Cell 9 12 (1998) 3399-3415
-
(1998)
Mol. Biol. Cell
, vol.9
, Issue.12
, pp. 3399-3415
-
-
Breeding, C.S.1
-
44
-
-
33748900571
-
Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1
-
Calonge T.M., and O'Connell M.J. Antagonism of Chk1 signaling in the G2 DNA damage checkpoint by dominant alleles of Cdr1. Genetics 174 1 (2006) 113-123
-
(2006)
Genetics
, vol.174
, Issue.1
, pp. 113-123
-
-
Calonge, T.M.1
O'Connell, M.J.2
-
45
-
-
10344236495
-
DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7
-
Yamada A., et al. DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7. J. Cell Biol. 167 5 (2004) 841-849
-
(2004)
J. Cell Biol.
, vol.167
, Issue.5
, pp. 841-849
-
-
Yamada, A.1
-
46
-
-
21844458914
-
Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast
-
Asano S., et al. Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast. EMBO J. 24 12 (2005) 2194-2204
-
(2005)
EMBO J.
, vol.24
, Issue.12
, pp. 2194-2204
-
-
Asano, S.1
-
47
-
-
23244443806
-
New checkpoint blockers begin human trials
-
Garber K. New checkpoint blockers begin human trials. J. Natl. Cancer Inst. 97 14 (2005) 1026-1028
-
(2005)
J. Natl. Cancer Inst.
, vol.97
, Issue.14
, pp. 1026-1028
-
-
Garber, K.1
-
48
-
-
34447646297
-
Inhibitors of checkpoint kinases: from discovery to the clinic
-
Janetka J.W., et al. Inhibitors of checkpoint kinases: from discovery to the clinic. Curr. Opin. Drug Discov. Dev. 10 4 (2007) 473-486
-
(2007)
Curr. Opin. Drug Discov. Dev.
, vol.10
, Issue.4
, pp. 473-486
-
-
Janetka, J.W.1
|