Expression and significance of the Wip1 proto-oncogene in colorectal cancer

Asian Pacific Journal of Cancer Prevention

Volumn 14, Issue 3, 2013, Pages 1975-1979

  Li, Zong Tao ^a   Zhang, Liu ^a,b   Gao, Xiao Zeng ^a   Jiang, Xiao Hua ^a   Sun, Li Qian ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI UNITED UNIVERSITY   (China)

Author keywords

Colorectal cancer; Immunohistochemistry; Polymerase chain reaction; Reverse transcription; Wip1

Indexed keywords

EID: 84880420467     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.3.1975     Document Type: Article

References (24)

1. Aaron JS, Suet YL, Jane J, et al (2008). Micro RNA Expression Profiles Associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA, 299, 425-36.
2. Bulavin DV, Demidov ON, Saito S, et al (2002). Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet, 31, 210-5.
3. Castellino RC, De Bortoli M, Lu X, et al (2008). Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D. J Neurooncol, 86, 245-56.
4. Ding PR, Wan DS, Pan ZZ, et al (2006). Prognostic analysis of 384 male patients with rectal cancer. Cancer, 25, 1158-61.
5. Doucette TA, Yang Y, Pedone C, et al (2012). WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma. Neurosurgery, 70, 1002-10.
6. Fiscella M, Zhang H, Fan S, et al (1997). Wip1, a novel human prote in phosphatase that is induced in response to ionizing radiation in a p53 - dependent manner. Proc Natl A cad Sci USA, 94, 6048-53.
7. Fuku T, Semba S, Yutori H, Yokozaki H (2007). Increased wildtype p53 induced phosphatase1 (Wipl or PPM1D) expression correlated with downregulation of checkpoint kinase2 in human gastric carcinoma. Pathol Int, 57, 566-71.
8. Hayashi R, Tanoue K, Durell SR, et al (2011). Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). Biochemistry, 50, 4537-49.
9. Hirasawa A, Saito-Ohara F, Inoue J, et al (2003). Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets. Clin Cancer Res, 10, 1995-2004.
10. Hu W, Feng Z, Modica I, et al (2010). Gene amplifications in well-differentiated pancreatic neuroendocrine tumors inactivate the p53 pathway. Genes Cancer, 1, 360-8.
11. Le Cuezennec X, Bulavin DV (2010). WIP1 phosphatase at the crossroads of cancer and aging. Trends Biochem Sci, 35, 109-14,.
12. Liang C, Guo E, Lu S, et al (2012). Over-expression of wildtype p53-induced phosphatase 1 confers poor prognosis of patients with gliomas. Brain Res, 1444, 65-75,.
13. Loukopoulos P, Shibata T, Katoh H, et al (2007). Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma, identification of genetic indicators that predict patient outcome. Cancer Sci, 98, 392-400.
14. Lu X, Bocangel D, Nannenga B, et al (2004). The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol Cell, 15, 621-34.
15. Lu X, Nannenga B and Donehower LA (2005). PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev, 19, 1162-74.
16. Park JY, Song JY, Kim HM, et al (2012). P53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors. Int J Biochem Cell Biol, 44, 896-904.
17. Ren WM, Zhang YY, Luo JF (2012). The PPM1D expression and significance in papillary thyroid carcinoma. Pro Bed Experim Pathol, 28, 623-6.
18. Saito OF, Imoto I, Inoue J, et al (2003). PPM1D is a potential target for 17q gain in neurob lastoma. Cancer Res, 63, 1876-83.
19. Satoh N, Maniwa Y, Bermudez VP, et al (2011). Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival. Cancer Sci, 102, 1101-6.
20. Shreeram S, Demidov ON, Hee WK, et al (2006). Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell, 23, 754-64.
21. Spinnler C, Hedstrom E, Li H, et al (2011). Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell Death Differ, 18, 1736-45.
22. Wan D (2009). Epidemiologic trend of and strategies for colorectal cancer. Chin J Cancer, 9, 897-902.
23. Wang P, Rao J, Yang H, Zhao H, Yang L (2011). Wip1 overexpression correlated with TP53/p14(ARF) pathway disruption in human astrocytomas. J Surg Oncol, 104, 679-84.
24. Yu E, Ahn YS, Jang SJ, et al (2007). Over expression of the wip1 gene abrogates the p38 MAPK/P53/Wip1 pathway and silences p16 expression in human breast cancers. Breast Cancer Res Treat, 101, 269-78.