Checkpoint recovery in cells: How a molecular understanding can help in the fight against cancer

F1000 Biology Reports

Volumn 3, Issue 1, 2011, Pages

  Medema, René H ^a   Macůrek, Libor ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; CYCLIN B; CYCLIN DEPENDENT KINASE 1;

ANIMAL CELL; CANCER CELL; CANCER THERAPY; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CYTOKINESIS; DNA DAMAGE; HUMAN; HUMAN CELL; MITOSIS; MOUSE; NEOPLASM; NONHUMAN; REVIEW;

EID: 79955681281     PISSN: 17404118     EISSN: 1757594X     Source Type: Journal    
DOI: 10.3410/B3-10     Document Type: Review

References (33)

1. Jackson SP and Bartek J: The DNA-damage response in human biology and disease. Nature 2009, 461:1071-8.
2. Bartek J and Lukas J: DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 2007, 19:238-45. (Pubitemid 46386406)
3. Malumbres M and Barbacid M: Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009, 9:153-66.
4. Lindqvist A, Rodríguez-Bravo V, Medema RH: The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol 2009, 185:193-202.
5. Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, Lukas J: Regulation of G(2)/M events by Cdc25A through phosphory lation-dependent modulation of its stability. EMBO J 2002, 21:5911-20. F1000 Factor 8 Evaluated by John Petrini 04 Dec 2002
6. Goldstone S, Pavey S, Forrest A, Sinnamon J, Gabrielli B: Cdc25- dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene 2001, 20:921-32. (Pubitemid 32207109)
7. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H: Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 1997, 277:1501-5. (Pubitemid 27449237)
8. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 1997, 277:1497-501. (Pubitemid 27449236)
9. Mamely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A, Medema RH, Freire R: Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr Biol 2006, 16:1950-5. (Pubitemid 44486756)
10. Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A 2004, 101:4419-24. F1000 Factor 8 Evaluated by Jonathon Pines 28 Apr 2004
11. Mailand N, Bekker-Jensen S, Bartek J, Lukas J: Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 2006, 23:307-18. F1000 Factor 9 Evaluated by John Rouse 06 Sep 2006, Peter Jackson 09 Oct 2006
12. Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M: SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell 2006, 23:319-29. F1000 Factor 7 Evaluated by Gennaro D'Urso 06 Sep 2006, Peter Jackson 09 Oct 2006
13. Toyoshima-Morimoto F, Taniguchi E, Nishida E: Plk1 promotes nuclear translocation of human Cdc25C during prophase. EMBO Rep 2002, 3:341-8. F1000 Factor 6 Evaluated by Michael B Yaffe 08 Aug 2002
14. van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB: A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol 2010, 8:e1000287.
15. Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, Medema RH: Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol 2000, 2:672-6.
16. Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH: Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 2008, 455:119-23. F1000 Factor 7 Evaluated by Iain Hagan 13 Aug 2008, Jonathan Millar 09 Sep 2008
17. Toczyski DP, Galgoczy DJ, Hartwell LH: CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell 1997, 90:1097-106. (Pubitemid 27408523)
18. Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP: CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. PLoS Biol 2010, 8:e1000286.
19. Leroy C, Lee SE, Vaze MB, Ochsenbien F, Guerois R, Haber JE, Marsolier-Kergoat MC: PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a doublestrand break. Mol Cell 2003, 11:827-35. F1000 Factor 7 Evaluated by Orna Cohen-Fix 09 Apr 2003, Antony Carr 28 Apr 2003
20. Freeman A, Monteiro A: Phosphatases in the cellular response to DNA damage. Cell Commun Signal 2010, 8:27.
21. Lu X, Nguyen TA, Moon SH, Darlington Y, Sommer M, Donehower LA: The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. Cancer Metastasis Rev 2008, 27:123-35.
22. Lindqvist A, de Bruijn M, Macurek L, Brás A, Mensinga A, Bruinsma W, Voets O, Kranenburg O, Medema RH: Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression. EMBO J 2009, 28:3196-206.
23. Lu X, Nguyen TA, Moon SH, Darlington Y, Sommer M, Donehower LA: The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. Cancer Metastasis Rev 2008, 27:123-35.
24. Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X: Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res 2009, 69:7960-8.
25. Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ Jr., Appella E: Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 2002, 31:210-5.
26. Mochida S, Ikeo S, Gannon J, Hunt T: Regulated activity of PP2AB55[delta] is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J 2009, 28:2777-85.
27. Vigneron S, Brioudes E, Burgess A, Labbé JC, Lorca T, Castro A: Greatwall maintains mitosis through regulation of PP2A. EMBO J 2009, 28:2786-93. F1000 Factor 8 Evaluated by Angel Nebreda 30 Oct 2009
28. Burgess A, Vigneron S, Brioudes E, Labbé JC, Lorca T, Castro A: Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Proc Natl Acad Sci U S A 2010, 107:12564-9.
29. Voets E, Wolthuis RM: MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis. Cell Cycle 2010, 9:3591-601.
30. Mochida S, Maslen SL, Skehel M, Hunt T: Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science 2010, 330:1670-3. F1000 Factor 16 Evaluated by Marie-Hélène Verlhac 07 Jan 2011, Angel Nebreda 20 Jan 2011, Brian Wadzinski 21 Mar 2011, Philipp Kaldis 05 Apr 2011
31. Gharbi-Ayachi A, Labbé JC, Burgess A, Vigneron S, Strub JM, Brioudes E, Van-Dorsselaer A, Castro A, Lorca T: The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science 2010, 330:1673-7. F1000 Factor 14 Evaluated by Marie-Hélène Verlhac 07 Jan 2011, Angel Nebreda 19 Jan 2011, Philipp Kaldis 05 Apr 2011
32. Yu J, Zhao Y, Li Z, Galas S, Goldberg ML: Greatwall kinase participates in the cdc2 autoregulatory loop in Xenopus egg extracts. Mol Cell 2006, 22:83-91. F1000 Factor 7 Evaluated by Jonathon Pines 20 Apr 2006, Iain Hagan 24 Apr 2006
33. Alvarez-Fernández M, Halim VA, Krenning L, Aprelia M, Mohammed S, Heck AJ, Medema RH: Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1. EMBO Rep 2010, 11:452-8.