Polyphenols-rich natural products for treatment of diabetes

Current Medicinal Chemistry

Volumn 22, Issue 1, 2015, Pages 14-22

  Dragan, S ^a   Andrica, F ^a   Serban, Maria Corina ^a   Timar, R ^a  

^a VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Natural products; Polyphenols; Type 2 diabetes mellitus

Indexed keywords

GRAPE SEED EXTRACT; NATURAL PRODUCT; POLYPHENOL; BIOLOGICAL PRODUCT;

ARONIA MELANOCARPA; ARTICHOKE; ARTICLE; CACAO; CAMELLIA SINENSIS; CARBOHYDRATE METABOLISM; CEREAL; CITRUS FRUIT; COFFEA ARABICA; CURCUMA LONGA; DIABETES MELLITUS; DYSLIPIDEMIA; GLUCOSE BLOOD LEVEL; HIPPOPHAE RHAMNOIDES; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; MORUS ALBA; NONHUMAN; OXIDATIVE STRESS; PHASEOLUS VULGARIS; POMEGRANATE; RED WINE; VACCINIUM MYRTILLUS; ANALYSIS; ANIMAL; BEVERAGE; CHEMISTRY; DIABETES MELLITUS, TYPE 2; FRUIT; METABOLISM; VEGETABLE;

ANIMALS; BEVERAGES; BIOLOGICAL PRODUCTS; CEREALS; DIABETES MELLITUS, TYPE 2; FRUIT; HUMANS; POLYPHENOLS; VEGETABLES;

EID: 84929084604     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867321666140826115422     Document Type: Article

References (101)

1. Tabatabaei-Malazy, O.; Larijani, B.; Abdollahi, M. A Systematic Review of in vitro Studies Conducted on Effect of Herbal Products on Secretion of Insulin from Langerhans Islets J. Pharm. Sci., 2012, 447-466.
2. William, G.; Pickup, J. C. Handbook of Diabetes, 3rd Ed. Blackwell Publishing Ltd., 2004.
3. Cohen, R. A.; Tong, X. Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease. J. Cardiovasc. Pharm., 2010, 55(4), 308-316.
4. Cui, X. P.; Li, B. Y.; Gao, H. Q.; Wei, N.; Wang, W. L.; Lu, M. Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats. J. Nutr. Sci. Vitaminol. (Tokyo), 2008, 54, 321-328.
5. Raman, B. V.; Krishna, N. V.; Rao, N. B.; Saradhi, P. M.; Rao, B. M. V. Plants with antidiabetic activities and their medicinal values. Int. Res. J. Pharm., 2012, 3, 11-15.
6. Fröde, T. S.; M. Y. Animal models to test drugs with potential antidiabetic activity. J. Ethnopharmacol., 2008, 115(112), 173-183.
7. Münzel, T.; G. T., Bruno RM, Taddei S. Is oxidative stress a therapeutic target in cardiovascular disease? Eur. Heart J., 2010, 31(22), 2741-2748.
8. Ghosh, D.; Scheepens, A. Vascular action of polyphenols. Mol. Nutr. Food Res., 2009, 53(3), 322-331.
9. Grassi, D.; Desideri, G.; Ferri, C. Flavonoids: Antioxidants Against Atherosclerosis. Nutrients, 2010, 2, 889-902.
10. Hogan, S.; Zhang, L.; Li, J.; Sun, S.; Canning, C.; Zhou, K. Antioxidant rich grape pomace extract suppresses postprandial hyperglycemia in diabetic mice by specifically inhibiting alphaglucosidase. Nutr. Metab., 2010, 7, 71.
11. Kiyici, A.; Okudan, N.; Gokbel, H.; Belviranli, M. The effect of grape seed extracts on serum paraoxonase activities in streptozotocininduced diabetic rats. J. Med. Food, 2010, 13(3), 725-728.
12. Drel, V. R.; Sybirna, N. Protective effects of polyphenolics in red wine on diabetes associated oxidative/nitrative stress in streptozotocindiabetic rats. Cell Biol. Int., 2010, 34(12), 1147-1153.
13. Gonzalez-Rodriguez, A.; Mas Gutierrez, J. A.; Sanz-Gonzalez, S.; Ros, M.; Burks, D. J.; Valverde, A. M. Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. Diabetes, 2010, 59(3), 588-599.
14. Venturini, C. D.; Merlo, S.; Souto, A. A.; Fernandes Mda, C.; Gomez, R.; Rhoden, C. R. Resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes. Oxid. Med. Cell. Long., 2010, 3(6), 434-441.
15. Tome-Carneiro, J.; Larrosa, M.; Yanez-Gascon, M. J.; Davalos, A.; Gil-Zamorano, J.; Gonzalvez, M.; Garcia-Almagro, F. J.; Ruiz Ros, J. A.; Tomas-Barberan, F. A.; Espin, J. C.; Garcia-Conesa, M. T. One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol. Res., 2013, 72, 69-82.
16. Xu, Y. J.; Tappia, P. S.; Neki, N. S.; Dhalla, N. S. Prevention of diabetesinduced cardiovascular complications upon treatment with antioxidants. Heart Fail. Rev., 2014, 19(1), 113-121.
17. Martin, M. A.; Ramos, S.; Cordero-Herrero, I.; Bravo, L.; Goya, L. Cocoa phenolic extract protects pancreatic beta cells against oxidative stress. Nutrients, 2013, 5(8), 2955-2968.
18. Ali, F.; Ismail, A.; Kersten, S. Molecular mechanisms underlying the potential antiobesity-related diseases effect of cocoa polyphenols. Mol. Nutr. Food Res., 2014, 58(1), 33-48.
19. Katz, D. L.; Doughty, K.; Ali, A. Cocoa and chocolate in human health and disease. Antioxid. Redox Sign., 2011, 15(10), 2779-2811.
20. Latif, R. Chocolate/cocoa and human health: a review. Neth. J. Med., 2013, 71(2), 63-68.
21. Cordero-Herrera, I.; Martin, M. A.; Goya, L.; Ramos, S. Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells. Food Chem. Toxicol., 2014, 64, 10-19.
22. Mellor, D. D.; Sathyapalan, T.; Kilpatrick, E. S.; Beckett, S.; Atkin, S. L. High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients. Diabetic Med., 2010, 27(11), 1318-1321.
23. Parsaeyan, N.; Mozaffari-Khosravi, H.; Absalan, A.; Mozayan, M. R. Beneficial effects of cocoa on lipid peroxidation and inflammatory markers in type 2 diabetic patients and investigation of probable interactions of cocoa active ingredients with prostaglandin synthase-2 (PTGS-2/COX-2) using virtual analysis. J. Diabetes Metab. Disord., 2014, 13(1), 30.
24. Kempf, K.; Herder, C.; Erlund, I.; Kolb, H.; Martin, S.; Carstensen, M.; Koenig, W.; Sundvall, J.; Bidel, S.; Kuha, S.; Tuomilehto, J. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am. J. Clin. Nutr., 2010, 91(4), 950-957.
25. Sartorelli, D. S.; Fagherazzi, G.; Balkau, B.; Touillaud, M. S.; Boutron-Ruault, M. C.; De Lauzon-Guillain, B.; Clavel-Chapelon, F. Differential effects of coffee on the risk of type 2 diabetes according to meal consumption in a French cohort of women: the E3N/EPIC cohort study. Am. J. Clin. Nutr., 2010, 91(4), 1002-1012.
26. Natella, F.; Scaccini, C. Role of coffee in modulation of diabetes risk. Nutr. Rev., 2012, 70(4), 207-217.
27. Butt, M. S.; Sultan, M. T. Coffee and its consumption: benefits and risks. Crit. Rev. Food Sci., 2011, 51(4), 363-373.
28. Ong, K. W.; Hsu, A.; Tan, B. K. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PloS One, 2012, 7(3), e32718.
29. Murase, T.; Misawa, K.; Minegishi, Y.; Aoki, M.; Ominami, H.; Suzuki, Y.; Shibuya, Y.; Hase, T. Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice. Am. J. Physiol-Endoc. M., 2011, 300(1), E122-E133.
30. Kobayashi, M.; Matsuda, Y.; Iwai, H.; Hiramitsu, M.; Inoue, T.; Katagiri, T.; Yamashita, Y.; Ashida, H.; Murai, A.; Horio, F. Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A (y) mice. J. Nutr. Sci. Vitaminol., 2012, 58(6), 408-414.
31. Lin, W. Y.; Xaiver Pi-Sunyer, F.; Chen, C. C.; Davidson, L. E.; Liu, C. S.; Li, T. C.; Wu, M. F.; Li, C. I.; Chen, W.; Lin, C. C. Coffee consumption is inversely associated with type 2 diabetes in Chinese. Eur. J. Clin. Invest., 2011, 41(6), 659-666.
32. Oboh, G.; Ogunruku, O. O.; Ogidiolu, F. O.; Ademiluyi, A. O.; Adedayo, B. C.; Ademosun, A. O. Interaction of some commercial teas with some carbohydrate metabolizing enzymes linked with type-2 diabetes: a dietary intervention in the prevention of type-2 diabetes. Adv. Prev. Med., 2014, 534082.
33. InterAct, C. Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study. PLoS One, 2012, 7(5), e36910.
34. Toolsee, N. A.; Aruoma, O. I.; Gunness, T. K.; Kowlessur, S.; Dambala, V.; Murad, F.; Googoolye, K.; Daus, D.; Indelicato, J.; Rondeau, P.; Bourdon, E.; Bahorun, T. Effectiveness of green tea in a randomized human cohort: relevance to diabetes and its complications. BioMed. Res. Int., 2013, 2013, 412379.
35. Faria, A. M.; Papadimitriou, A.; Silva, K. C.; Lopes De Faria, J. M.; Lopes De Faria, J. B. Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by reestablishing tetrahydrobiopterin levels. Diabetes, 2012, 61(7), 1838-1847.
36. Sundaram, R.; Naresh, R.; Shanthi, P.; Sachdanandam, P. Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats. Phytomedicine, 2013, 20(7), 577-584.
37. Kim, J. J.; Tan, Y.; Xiao, L.; Sun, Y. L.; Qu, X. Green tea polyphenol epigallocatechin-3-gallate enhance glycogen synthesis and inhibit lipogenesis in hepatocytes. BioMed. Res. Int., 2013, 2013, 920128.
38. Liu, C. Y.; Huang, C. J.; Huang, L. H.; Chen, I. J.; Chiu, J. P.; Hsu, C. H. Effects of green tea extract on insulin resistance and glucagonlike peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial. PloS One, 2014, 9(3), e91163.
39. Simeonov, S. B.; Botushanov, N. P.; Karahanian, E. B.; Pavlova, M. B.; Husianitis, H. K.; Troev, D. M. Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med., 2002, 44(3), 20-23.
40. Zhang, W.; Zhao, J.; Wang, J.; Pang, X.; Zhuang, X.; Zhu, X.; Qu, W. Hypoglycemic effect of aqueous extract of seabuckthorn (Hippophae rhamnoides L.) seed residues in streptozotocin-induced diabetic rats. Phytother. Res., 2010, 24(2), 228-232.
41. Socaci, S. A.; Socaciu, C.; Tofana, M.; Rati, I. V.; Pintea, A. In-tube Extraction and GC-MS Analysis of Volatile Components from Wild and Cultivated sea buckthorn (Hippophae rhamnoides L. ssp. Carpatica) Berry Varieties and Juice. Phytochem. Anal., 2013, 24(4), 319-328.
42. Wang, J.; Zhang, W.; Zhu, D.; Zhu, X.; Pang, X.; Qu, W. Hypolipidaemic and hypoglycaemic effects of total flavonoids from seed residues of Hippophae rhamnoides L. in mice fed a high-fat diet. J. Sci. Food Agr., 2011, 91(8), 1446-1451.
43. Sharma, U. K.; Sharma, K.; Sharma, N.; Sharma, A.; Singh, H. P.; Sinha, A. K. Microwave-assisted efficient extraction of different parts of Hippophae rhamnoides for the comparative evaluation of antioxidant activity and quantification of its phenolic constituents by reverse-phase high-performance liquid chromatography (RPHPLC). J. Agr. Food Chem., 2008, 56(2), 374-379.
44. Bardy, G.; Virsolvy, A.; Quignard, J.; Ravier, M.; Bertrand, G.; Dalle, S.; Cros, G.; Magous, R.; Richard, S.; Oiry, C. Quercetin induces insulin secretion by direct activation of L-type calcium channels in the pancreatic beta cells. Brit. J. Pharmacol., 2013, 169(5), 1102-1113.
45. Vessal, M.; Hemmati, M.; Vasei, M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp. Biochem. Physiol. T., 2003, 135C (3), 357-364.
46. Valcheva-Kuzmanova, S. V.; Belcheva, A. Current knowledge of Aronia melanocarpa as a medicinal plant. Folia Med., 2006, 48(2), 11-17.
47. Taheri, R.; Connolly, B. A.; Brand, M. H.; Bolling, B. W. Underutilized chokeberry (Aronia melanocarpa, Aronia arbutifolia, Aronia prunifolia) accessions are rich sources of anthocyanins, flavonoids, hydroxycinnamic acids, and proanthocyanidins. J. Agr. Food Chem., 2013, 61(36), 8581-8588.
48. Rugina, D.; Sconta, Z.; Leopold, L.; Pintea, A.; Bunea, A.; Socaciu, C. Antioxidant activities of chokeberry extracts and the cytotoxic action of their anthocyanin fraction on HeLa human cervical tumor cells. J. Med. Food, 2012, 15(8), 700-706.
49. Hunyadi, A.; Herke, I.; Veres, K.; Erdei, A.; Simon, A.; Tothb, G. Volatile glycosides from the leaves of Morus alba with a potential contribution to the complex anti-diabetic activity. Nat. Prod. Commun., 2014, 9(2), 145-147.
50. Hunyadi, A.; Veres, K.; Danko, B.; Kele, Z.; Weber, E.; Hetenyi, A.; Zupko, I.; Hsieh, T. J. In vitro anti-diabetic activity and chemical characterization of an apolar fraction of Morus alba leaf water extract. Phytother. Res., 2013, 27(6), 847-851.
51. Granfeldt, Y. E.; Bjorck, I. M. A bilberry drink with fermented oatmeal decreases postprandial insulin demand in young healthy adults. Nutr. J., 2011, 10, 57.
52. McIntyre, K. L.; Harris, C. S.; Saleem, A.; Beaulieu, L. P.; Ta, C. A.; Haddad, P. S.; Arnason, J. T. Seasonal phytochemical variation of anti-glycation principles in lowbush blueberry (Vaccinium angustifolium). Planta Med., 2009, 75(3), 286-292.
53. Fan, J.; Johnson, M. H.; Lila, M. A.; Yousef, G.; De Mejia, E. G. Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management. Evid-Based Compl. Alt., 2013, 2013, 479505.
54. Takikawa, M.; Inoue, S.; Horio, F.; Tsuda, T. Dietary anthocyaninrich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J. Nutr., 2010, 140(3), 527-533.
55. Vuong, T.; Benhaddou-Andaloussi, A.; Brault, A.; Harbilas, D.; Martineau, L. C.; Vallerand, D.; Ramassamy, C.; Matar, C.; Haddad, P. S. Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKA (y) mice. Int. J. Obesity, 2009, 33(10), 1166-1173.
56. Wedick, N. M.; Pan, A.; Cassidy, A.; Rimm, E. B.; Sampson, L.; Rosner, B.; Willett, W.; Hu, F. B.; Sun, Q.; Van Dam, R. M. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am. J. Clin. Nutr., 2012, 95(4), 925-933.
57. Girones-Vilaplana, A.; Moreno, D. A.; Garcia-Viguera, C. Phytochemistry and biological activity of Spanish Citrus fruits. Food Func., 2014, 5(4), 764-772.
58. Kim, G. S.; Park, H. J.; Woo, J. H.; Kim, M. K.; Koh, P. O.; Min, W.; Ko, Y. G.; Kim, C. H.; Won, C. K.; Cho, J. H. Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. BMC Complement. Alternat. Med., 2012, 12, 31.
59. Assini, J. M.; Mulvihill, E. E.; Huff, M. W. Citrus flavonoids and lipid metabolism. Curr. Opin. Lipidol., 2013, 24(1), 34-40.
60. Constantin, R. P.; Constantin, R. P.; Bracht, A.; Yamamoto, N. S.; Ishii-Iwamoto, E. L.; Constantin, J. Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis. Fitoterapia, 2014, 92, 148-162.
61. Owira, P. M.; Ojewole, J. A. The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives. Cardiovasc. J. Afr., 2010, 21(5), 280-285.
62. Basu, A.; Newman, E. D.; Bryant, A. L.; Lyons, T. J.; Betts, N. M. Pomegranate polyphenols lower lipid peroxidation in adults with type 2 diabetes but have no effects in healthy volunteers: a pilot study. J. Nutr. Metab., 2013, 2013, 708381.
63. Banihani, S.; Swedan, S.; Alguraan, Z. Pomegranate and type 2 diabetes. Nutr. Res., 2013, 33(5), 341-348.
64. Wei, Y. Y.; Yan, D.; Japar, A.; Qu, S. S.; Haji, A. A.; Parhat, K. [Effects of pomegranate flowers polyphenols on liver PON expression of diabetes combining non-alcoholic fat liver diseases rats]. Acta Pharm. Sinica, 2013, 48(1), 71-76.
65. Kam, A.; Li, K. M.; Razmovski-Naumovski, V.; Nammi, S.; Shi, J.; Chan, K.; Li, G. Q. A comparative study on the inhibitory effects of different parts and chemical constituents of pomegranate on alphaamylase and alpha-glucosidase. Phytother. Res., 2013, 27(11), 1614-1620.
66. Trojan-Rodrigues, M.; Alves, T. L.; Soares, G. L.; Ritter, M. R. Plants used as antidiabetics in popular medicine in Rio Grande do Sul, southern Brazil. J. Ethnopharmacol., 2012, 139(1), 155-163.
67. Li, H.; Xia, N.; Brausch, I.; Yao, Y.; Forstermann, U. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J. Pharmacol. Exp. Ther., 2004, 310(3), 926-932.
68. Fantini, N.; Colombo, G.; Giori, A.; Riva, A.; Morazzoni, P.; Bombardelli, E.; Carai, M. A. Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats. Phytother. Res., 2011, 25(3), 463-466.
69. Khaleeva, L. D.; Maloshtan, L. N.; Sytnik, A. G. [Comparative evaluation of the hypoglycemic activity of the vegetal complex of Phaseolus vulgaris and chlorpropamide in experimental diabetes]. Probl. Endokrin., 1987, 33(2), 69-71.
70. Venkateswaran, S.; Pari, L.; Saravanan, G. Effect of Phaseolus vulgaris on circulatory antioxidants and lipids in rats with streptozotocininduced diabetes. J. Med. Food, 2002, 5(2), 97-103.
71. Pari, L.; Venkateswaran, S. Effect of an aqueous extract of Phaseolus vulgaris on plasma insulin and hepatic key enzymes of glucose metabolism in experimental diabetes. Die Pharmazie, 2003, 58(12), 916-919.
72. Pari, L.; Venkateswaran, S. Protective role of Phaseolus vulgaris on changes in the fatty acid composition in experimental diabetes. J. Med. Food, 2004, 7(2), 204-209.
73. Fan, X.; Zhang, C.; Liu, D. B.; Yan, J.; Liang, H. P. The clinical applications of curcumin: current state and the future. Curr. Pharm. Des., 2013, 19(11), 2011-2031.
74. Zhang, D. W.; Fu, M.; Gao, S. H.; Liu, J. L. Curcumin and diabetes: a systematic review. Evid-based Compl. Alt. Med., 2013, 2013, 636053.
75. Gupta, S. C.; Patchva, S.; Aggarwal, B. B. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J., 2013, 15(1), 195-218.
76. Belobrajdic, D. P.; Bird, A. R. The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes. Nutr. J., 2013, 12, 62.
77. Fardet, A. New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? Nutr. Res. Rev., 2010, 23(1), 65-134.
78. Shatwan, I. A.; Ahmed, L. A.; Badkook, M. M. Effect of barley flour, crude cinnamon, and their combination on glycemia, dyslipidemia, and adipose tissue hormones in type 2 diabetic rats. J. Med. Food, 2013, 16(7), 656-662.
79. Han, S.; Wang, Z.; Chu, J.; Zhu, L.; Xiong, G.; Yang, Y. [Effects of flavones of buckwheat flower and leaf on insulin resistance and liver PTP1B in type 2 diabetic rats]. China J. Chinese Mater. Med., 2009, 34(23), 3114-3118.
80. Lee, C. C.; Hsu, W. H.; Shen, S. R.; Cheng, Y. H.; Wu, S. C. Fagopyrum tataricum (buckwheat) improved high-glucose-induced insulin resistance in mouse hepatocytes and diabetes in fructose-rich dietinduced mice. Exp. Diabetes Res., 2012, 375673.
81. Sakuma, M.; Yamanaka-Okumura, H.; Naniwa, Y.; Matsumoto, D.; Tsunematsu, M.; Yamamoto, H.; Taketani, Y.; Takeda, E. Dose-dependent effects of barley cooked with white rice on postprandial glucose and desacyl ghrelin levels. J. Clin. Biochem. Nutr., 2009, 44(2), 151-159.
82. Gil, A.; Ortega, R. M.; Maldonado, J. Wholegrain cereals and bread: a duet of the Mediterranean diet for the prevention of chronic diseases. Public Health Nutr., 2011, 14 (12A), 2316-2322.
83. Rosen, L. A.; Ostman, E. M.; Bjorck, I. M. Effects of cereal breakfasts on postprandial glucose, appetite regulation and voluntary energy intake at a subsequent standardized lunch; focusing on rye products. Nutr. J., 2011, 10, 7.
84. Grace, M. H.; Esposito, D.; Dunlap, K. L.; Lila, M. A. Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries. J. Agric. Food Chem., 2013. [Epub ahead of Print].
85. Gupta, A.; Upadhyay, N. K.; Sawhney, R. C.; Kumar, R. A polyherbal formulation accelerates normal and impaired diabetic wound healing. Wound Repair Regen., 2008, 16(6), 784-790.
86. Lehtonen, H. M.; Jarvinen, R.; Linderborg, K.; Viitanen, M.; Venojarvi, M.; Alanko, H.; Kallio, H. Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophae rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites. Eur. J. Clin. Nutr., 2010, 64(12), 1465-1471.
87. Orhan, D. D.; Aslan, M.; Sendogdu, N.; Ergun, F.; Yesilada, E. Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum album subspecies (European mistletoe) in streptozotocindiabetic rats. J. Ethnopharmacol., 2005, 98(1-2), 95-102.
88. Islam, M. S. Effects of the aqueous extract of white tea (Camellia sinensis) in a streptozotocin-induced diabetes model of rats. Phytomedicine, 2011, 19(1), 25-31.
89. Mustata, G. T.; Rosca, M.; Biemel, K. M.; Reihl, O.; Smith, M. A.; Viswanathan, A.; Strauch, C.; Du, Y.; Tang, J.; Kern, T. S.; Lederer, M. O.; Brownlee, M.; Weiss, M. F.; Monnier, V. M. Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking. Diabetes, 2005, 54(2), 517-526.
90. Eddouks, M.; Maghrani, M. Phlorizin-like effect of Fraxinus excelsior in normal and diabetic rats. J. Ethnopharmacol., 2004, 94(1), 149-154.
91. Visen, P.; Saraswat, B.; Visen, A.; Roller, M.; Bily, A.; Mermet, C.; He, K.; Bai, N.; Lemaire, B.; Lafay, S.; Ibarra, A. Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers. J. Ethnopharmacol., 2009, 126(2), 226-232.
92. Maghrani, M.; Zeggwagh, N. A.; Lemhadri, A.; El Amraoui, M.; Michel, J. B.; Eddouks, M. Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus. J. Ethnopharmacol., 2004, 91(2-3), 309-316.
93. Dar, S. A.; Ganai, F. A.; Yousuf, A. R.; Balkhi, M. U.; Bhat, T. M.; Sharma, P. Pharmacological and toxicological evaluation of Urtica dioica. Pharm. Biol., 2013, 51(2), 170-180.
94. Ghorbani, A.; Shafiee-Nick, R.; Rakhshandeh, H.; Borji, A. Antihyperlipidemic effect of a polyherbal mixture in streptozotocininduced diabetic rats. J. Lipids, 2013, 675759.
95. Kianbakht, S.; Khalighi-Sigaroodi, F.; Dabaghian, F. H. Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: a randomized double-blind placebocontrolled clinical trial. Clin. Lab., 2013, 59(9-10), 1071-1076.
96. Namazi, N.; Tarighat, A.; Bahrami, A. The effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: a randomized double-blind clinical trial. Pak. K. Biol. Sci., 2012, 15(2), 98-102.
97. Sarikaphuti, A.; Nararatwanchai, T.; Hashiguchi, T.; Ito, T.; Thaworanunta, S.; Kikuchi, K.; Oyama, Y.; Maruyama, I.; Tancharoen, S. Preventive effects of anthocyanins on diabetes in Zucker diabetic fatty rats. Exp. Ther. Med., 2013, 6(3), 689-695.
98. Wang, H. J.; Chiang, B. H. Anti-diabetic effect of a traditional Chinese medicine formula. Food Func., 2012, 3(11), 1161-1169.
99. Wang, Y.; Xiang, L.; Wang, C.; Tang, C.; He, X. Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract. PloS One, 2013, 8(7), e71144.
100. Helmstadter, A. Beans and diabetes: Phaseolus vulgaris preparations as antihyperglycemic agents. J. Med. Food, 2010, 13, (2), 251-254.
101. Longo-Mbenza, B.; Muaka, M. The protective effect of phaseolus vulgaris on cataract in type 2 diabetes: a profitable hypothesis. Med. Hypothesis, 2013, 2(4), 105-108.