Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: A randomized double-blind placebo-controlled clinical trial

Clinical Laboratory

Volumn 59, Issue 9-10, 2013, Pages 1071-1076

  Kianbakht, Saeed ^a   Khalighi Sigaroodi, Farahnaz ^a   Dabaghian, Fataneh Hashem ^b  

^a AVICENNA RESEARCH INSTITUTE   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Patient; Type 2 diabetes; Urtica dioica

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; GLUCOSE; HEMOGLOBIN A1C; ORAL ANTIDIABETIC AGENT; PLACEBO; URTICA DIOICA EXTRACT;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PLANT LEAF; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TREATMENT OUTCOME;

ALANINE TRANSAMINASE; ALPHA-GLUCOSIDASES; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; CREATININE; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; PLACEBOS; PLANT EXTRACTS; PLANT LEAVES; PPAR GAMMA; URTICA DIOICA;

EID: 84886444409     PISSN: 14336510     EISSN: None     Source Type: Journal    
DOI: 10.7754/Clin.Lab.2012.121019     Document Type: Article

References (20)

1. Philippe J, Raccah D. Treating type 2 diabetes: how safe are current therapeutic agents? Int J Clin Pract 2009;63:321-32.
2. Hocher B, Reichetzeder C, Alter ML. Renal and cardiac effects of DPP-4 inhibitors - from preclinical development to clinical research. Kidney Blood Press Res 2012;36:65-84.
3. Derosa G, Sibilla S. Optimizing combination treatment in the management of type 2 diabetes. Vase Health Risk Manag 2007;3:-665-71.
4. Massi-Benedetti M, Orsini-Federici M. Treatment of type 2 diabetes with combined therapy: what are the pros and cons? Diabetes Care 2008;3:131-5.
5. Tundis R, Loizzo MR, Menichini F. Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycemic potential in the treatment of diabetes: an update. Mini-Rev Med Chem 2010;10:315-31.
6. st ed. New Jersey: Medical Economics Company, 1998:1197-9.
7. Farzami B, Ahmadvand D, Vardasbi S, Majin FJ, Khaghani Sh. Induction of insulin secretion by a component of Urtica dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal and streptozocin diabetic rats. J Ethnopharmacol 2003;89:47-53. (Pubitemid 37163798)
8. Rau O, Wurglics M, Dingermann T, Abdel-Tawab M, SchubertZsilavecz M. Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor. Pharmazie 2006;61:952-6. (Pubitemid 44807270)
9. Onal S, Timur S, Okutucu B, Zihnioglu F. Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem Biotechnol 2005;35:29-36. (Pubitemid 40141502)
10. Simoes-Pires CA, Hmicha B, Marston A, Hostettmann K. A TLC bioautographic method for the detection of alpha- and beta-glucosidase inhibitors in plant extracts. Phytochem Anal 2009;20:511-5.
11. Mobasseri M, Bahrami A, Zargami N, et al. Effect of total extract of Urtica dioica on insulin and C-peptide secretion from rat (RIN5F) pancreatic β cells and glucose utilization by human muscle cells. Iran J Endocrinol Metab 2010;11:721-7.
12. Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik SA. A comprehensive review on nettle effect and efficacy profiles, Part I: herba urticae. Phytomedicine 2007;14:423-35. (Pubitemid 46818012)
13. Fodor JI, Keve T. New phytotherapical opportunity in the prevention and treatment of 2-type of diabetes mellitus. Acta Pharm Hung 2006;76:200-7. (Pubitemid 46144832)
14. Said O, Fulder S, Khalil K, Azaizeh H, Kassis E, Saad B. Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional arab herbal medicine. Evid Based Complement Alternat Med 2008;5:421-8.
15. Ozkan G, Sagdic O, Ekici L, Ozturk I, Ozcan MM. Phenolic compounds of Origanum sipyleum L. extract, and its antioxidant and antibacterial activities. J Food Lipids 2007;14:157-69. (Pubitemid 46994677)
16. Han J, Weng X, Bi K. Antioxidants from a Chinese medicinal herb - Lithospermum erythrorhizon. Food Chem 2008;106:2-10. (Pubitemid 47332078)
17. Yoo KM, Lee CH, Lee H, Moon B, Lee CY. Relative antioxidant and cytoprotective activities of common herbs. Food Chem 2008;106:929-36. (Pubitemid 47385939)
18. Kim DO, Jeong SW, Lee CY. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem 2003;81:321-6. (Pubitemid 36349460)
19. The United States Pharmacopoeial Convention. USP 28, 28th ed. Toronto: Webcom Limited 2005:2094-5.
20. Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother 2005;59:365-73. (Pubitemid 41219650)