Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice

Diabetes

Volumn 59, Issue 3, 2010, Pages 588-599

  González Rodríguez, Águeda ^a,b   Mas Gutierrez, Jose A ^c   Sanz González, Silvia ^b,d   Ros, Manuel ^c   Burks, Deborah J ^b,d   Valverde, Ángela M ^a,b  

^a Institute of Biomedicine Alberto Sols   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSIDAD REY JUAN CARLOS   (Spain)

^d CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; RESVERATROL; TRANSCRIPTION FACTOR FKHR; ANTIOXIDANT; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; IRS2 PROTEIN, MOUSE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PTPN1 PROTEIN, MOUSE; STILBENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; INSULIN SENSITIVITY; LIVER METABOLISM; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RED WINE; RNA EXTRACTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; LIVER; LIVER CELL; METABOLISM; PANCREAS ISLET BETA CELL; PHENOTYPE; PHOSPHORYLATION; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSEPHOSPHATE DEHYDROGENASE; HEPATOCYTES; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PHENOTYPE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STILBENES;

EID: 77950366124     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0796     Document Type: Article

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