Effects of flavones of buckwheat flower and leaf on insulin resistance and liver PTP1B in type 2 diabetic rats

Zhongguo Zhongyao Zazhi

Volumn 34, Issue 23, 2009, Pages 3114-3118

  Han, Shuying ^a   Wang, Zhilu ^a   Chu, Jinxiu ^a   Zhu, Lisha ^a   Xiong, Guoshun ^a   Yang, Yunxia ^a  

^a NORTH CHINA COAL MEDICAL COLLEGE   (China)

Author keywords

Flavones of buckwheat flower and leaf; Insulin resistance; PTP1B; Type 2 diabetes mellitus

Indexed keywords

BUCKWHEAT FLAVONE; FLAVONE; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BUCKWHEAT; CONTROLLED STUDY; DRUG EFFECT; FLOWER; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; LIVER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT LEAF; PROTEIN EXPRESSION; RAT;

ANIMALS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FAGOPYRUM; FLAVONES; FLOWERS; GENE EXPRESSION; HUMANS; INSULIN RESISTANCE; LIVER; MALE; PLANT EXTRACTS; PLANT LEAVES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 77249104164     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Chinese source
2. Chinese source
3. Chinese source
4. Lee M K, Miles P D G, Khoursheed M, et al. Metabolie effects of troglitazone on fructose-induced insulin resistance in the rat [J]. Diabetes, 1994, 43:1435.
5. Haj FG, Verveer P J, Squire A, et al. Imaging sites of receptor dephosphorylation by ptp 1B on the surface of the endoplasmic reticulum[J]. Science, 2002, 295(5560):1708.
6. Kasibhatla B, Wos J, Peters K G. Targeting protein tyrosine phosphatase to enhance insulin action for the potential treatment of diabetes[J]. Curr Opin Investig Drugs, 2007, 8(10):805.
7. Egawa K, Maegawa H, Shimizu S, et al. Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in L6 myocytes and Fao hepatoma cells[J]. Biol Chem, 2002, 276:10207.
8. Chinese source
9. Yeh S L, Wang W Y, Huang C H, et al. Pro-oxidative effect of β-carotene and the interaction with flavonoids on UVA-induced DNA strand breaks in mouse fibroblast C3H10T1/2 cell[J]. J Nutr Biochem, 2005, 16(12):729.
10. Chinese source
11. Hooft van Huijsduijnen R, Sauer W H, Bombrun A, et al. Prospects for inhibitors of protein tyrosine phosphatase 1B as antidiabetic drugs[J]. J Med Chem, 2004, 47( 17):4142.
12. Dixit M, Tripathi B K, Tamrakar A K, et al. Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors[J]. Bioorg Med Chem, 2007, 15(2):727.
13. Hansen S K, Erlanson Andersen M T, Shiau T P, et al. Alloxteric inhibion of PTPl B activi by selective modification of a non-active site cysteine residue[J]. Biochemistry, 2005, 44(21):7704.