Effect of barley flour, crude cinnamon, and their combination on glycemia, dyslipidemia, and adipose tissue hormones in type 2 diabetic rats

Journal of Medicinal Food

Volumn 16, Issue 7, 2013, Pages 656-662

  Shatwan, Israa Ali ^a,b   Ahmed, Lamiaa Ali ^b   Badkook, Maha Mohamed ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b University of Helwan   (Egypt)

Author keywords

adiponectin; barley; cinnamon; diabetes mellitus; glucose; insulin; leptin; lipid profile; pancreas histology; rats

Indexed keywords

ADIPONECTIN; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARLEY; CHOLESTEROL BLOOD LEVEL; CINNAMON; CONTROLLED STUDY; DYSLIPIDEMIA; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HORMONE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ADIPOKINES; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; CINNAMOMUM ZEYLANICUM; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; FLOUR; GLYCEMIC INDEX; HORDEUM; HUMANS; INSULIN; LIPIDS; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 84880813164     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.0083     Document Type: Article

References (54)

1. Bhattacharya S, Dey D, Roy SS: Molecular mechanism of insulin resistance. J Biosci 2007;32:405-413
2. Al-Maatouq M, Al-Arouj M, Assaad SH, Assaad SN, Azar ST, Hassoun AA, Jarrah N, Zatari S, Alberti, KG: Optimising the medical management of hyperglycaemia in type 2 diabetes in the Middle East: Pivotal role of metformin. Inter J Clin Pract 2010;64:149-159
3. Wang HJ, Jin YX, Shen W, Neng J, Wu T, Li YJ, Fu ZW: Low dose streptozotocin (STZ) combined with high energy intake can effectively induce type 2 diabetes through altering the related gene expression. Asia Pac J Clin Nutr 2007;116: 412-417
4. Margoni A, Perrea DN, Vlachos I, Prokopaki G, Pantopoulou A, Fotis L, Kostaki M, Papavassiliou AG: Serum leptin, adiponectin and tumor necrosis factor-A in hyperlipidemic rats with/without concomitant diabetes mellitus. Mol Med 2011; 17:36-40
5. Hong H, Jai WM: Effects of malted barley extract and banana extract on blood glucose levels in genetically diabetic mice. J Med Food 2004;7:487-490
6. Hinata M, Ono M, Midorikawa S, Nakanishi K: Metabolic improvement of male prisoners with type 2 diabetes in Fukushima Prison, Japan. Diabetes Res Clin Prac 2007;77:327-332
7. Izydorczyk MS, Dexter JE: Barley b-glucans and arabinoxylans: Molecular structure, physicochemical properties and uses in food products-A review. Food Res Int 2008;41:850-868
8. Kim H, Stote KS, Behall KM, Spears K, Vinyard B, Conway JM: Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: A dose response study in obese women with increased risk for insulin resistance. Eur J Nutr 2009;48:170-175
9. Kim SH, Hyun SH, Choung SY: Anti-Diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 2006;104:119-123
10. Broadhurst CL, Polansky MM, Anderson RA: Insulin-Like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 2000;48:849-852
11. Harlan Laboratories, Inc.: Teklad lab animal diets. www.harlan .com/products-and-services/research-models-and-services/laboratory-animal-diets (accessed January 28, 2011
12. Zhang M, Lv XY, Li J, Xu ZG, Chen L: The characterization of high-fat diet and multiple low-Dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res 2008;2008:1-9
13. Flanagan AM, Brown JL, Santiago CA, Aad PY, Spicer LJ, Spicer MT: High-fat diets promote insulin resistance through cytokine gene expression in growing female rats. J Nutr Biochem 2008;19:505-513
14. Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P: Combination of high-fat diet-fed and low-Dose streptozotocintreated rat: A model for type 2 diabetes and pharmacological screening. Pharmacol Res 2005;52:313-320
15. Sahin K, Onderci M, Tuzcu M, Ustundag B, Cikim G, Ozercan IH, Sriramoju V, Juturu V, Komorowski JR: Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: The fat-fed, streptozotocin-Treated rat. Metabolism 2007;56:1233-1240
16. Tonyushkina K, Nichols JH: Glucose meters: A review of technical challenges to obtaining accurate results. J Diabetes Sci Technol 2009;3:971-980
17. Schettler G, Nussel E: Enzymatic calorimetric determination of high density lipoprotein cholesterol by CHOD-PAP method. Arb Med Soz Med Prov Med 1975;10:25
18. Okada M, Matsui H, Ito Y: Low-Density lipoprotein cholesterol can be chemically measured: A new superior method. J Lab Clin Med 1998;132:195-201
19. Izawa S, Okada M, Matsui H, Horita YA: New direct method for measuring HDL cholesterol which does not produce any biased values. J Med Pharm Sci 1997;137:1385-1388
20. Furuta M, Carroll R, Martin S, Swift HH, Ravazzola M, Orci L, Steiner DF: Incomplete processing of pro-insulin to insulin accompanied by elevation of des-31,32 proinsulin intermediates in islets of mice lacking active PC2 J Biol Chem 1998;273:3431-3437
21. Kimura E, Matsumoto K, Samori T, Kato S, Kawahara T: Onestep enzyme-Linked immunosorbent assay (ELISA) for measurement of serum free leptin. Clin Chim Acta 2000;296:45-57
22. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF: A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995;270:26746-26749
23. Borges GR, Oliveira M, Salgado HC, Fazan R: Myocardial performance in conscious streptozotocin diabetic rats. Cardiovasc Diabetol 2006;5:26
24. Yamac M, Zeytinoglu M, Kanbak G, Bayramoglu G, Senturk H: Hypoglycemic effect of crude exopolysaccharides produced by Cerrena unicolor, Coprinus comatus, and Lenzites betulina isolates in streptozotocin-induced diabetic rats. Pharm Biol 2009; 47:168-174
25. Lee JS, Son HS, Maeng YS, Chang YK, Ju JS: Effect of buckwheat on organ weight, glucose and lipid metabolism in streptozotocininduced diabetic rats. Korean J Nutr 1994;27:819-827
26. Roussel AM, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA: Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr 2009;28:16-21
27. Akilen R, Tsiami A, Devendra D, Robinson N: Glycated haemoglobin and blood pressure-Lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: A randomized, placebo-controlled, double-blind clinical trial. Diabet Med 2010;27:1159-1167
28. Hlebowicz J, Darwiche G, Bjorgell O, Almer LO: Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr 2007;85:1552-1556
29. Ping H, Zhang G, Ren G: Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice. Food Chem Toxicol 2010;48:2344-2349
30. Haghighian HK, Naimi AF, Gargari BP, Asgharzadeh AA, Nemati A: Effect of cinnamon supplementation on blood glucose and lipid levels in type 2 diabetic patients. J Paramed Sci 2011; 2:ISSN 2008-4978
31. Kim SH, Choung SY: Antihyperglycemic and antihyperlipidemic action of Cinnamomi cassiae (Cinnamon bark) extract in C57BL/ Ks db/db mice. Arch Pharm Res 2010;33:325-333
32. Chen J, Raymond K: Beta-glucans in the treatment of diabetes and associated cardiovascular risks. Vasc Health Risk Manag 2008;4:1265-1272
33. Sakuma M, Yamanaka-Okumura H, Naniwa Y, Matsumoto D, Tsunematsu M, Yamamoto H, Taketani Y, Takeda E: Dosedependent effects of barley cooked with white rice on postprandial glucose and desacyl ghrelin levels. J Clin Biochem Nutri 2009;44:151-159
34. Nilsson AC, Ostman EM, Holst JJ, Björck IM: Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast. J Nutr 2008;138:732-739
35. Bridges SR, Anderson JW, Deakins DA, Wood CA: Oat bran increases serum acetate of hypercholesterolemic men. Am J Clin Nutr 1992;56:455-459
36. Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN: Insulin sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr 2005;82:559-567
37. Kim SP, Catalano KJ, Hsu IR, Chiu JD, Richey JM, Bergman RN: Nocturnal free fatty acids are uniquely elevated in the longitudinal development of dietinduced insulin resistance and hyperinsulinemia. Am J Physiol Endocrinol Metab 2007;292: E1590-E1598
38. Yousef MI, Haroun M, El-Masry MH, Ateia RE: Biochemical and immunological study on the effects of barley and it components as hypoglycemic agents in diabetic rats. Am Biochem Biotech 2006;2:1-8
39. Vincent JB: Elucidating a biological role for chromium at a molecular level. Acc Chem Res 2000;33:503-510
40. Casiraghi MC, Garsetti M, Testolin G, Brighenti F: Post-prandial responses to cereal products enriched with barley beta-glucan. J Am Coll Nutr 2006;25:313-320
41. Modi KP, Vishwakarma SL, Goyal RK, Bhatt PA: Beneficial effects of coenzyme Q10 in streptozotocin-induced type I diabetic rats. Iran J Pharmacol Ther 2006;5:61-65
42. Mooradian AD: Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 2009;5:150-159
43. Reddy JK, Hashimoto T: Peroxisomal beta-oxidation and peroxisome proliferator-Activated receptor alpha: An adaptive metabolic system. Annu Rev Nutr 2001;21:193-230
44. Keogh GF, Cooper GJ, Mulvey TB, McArdle BH, Coles GD, Monro JA, Poppitt SD: Randomized controlled crossover study of the effect of highly beta-glucan enriched barley on cardiovascular disease risk factors in mildly hypercholesterolemic men. Am J Clin Nutr 2003;78:711-718
45. Queenan KM, Stewart ML, Smith KN, Thomas W, Fulcher RG, Slavin JL: Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. Nutr J 2007;6:1-8
46. Andersson M, Ellegård L, Andersson H: Oat bran stimulates bile acid synthesis within 8 h as measured by 7alpha-hydroxy-4-cholesten-3-one. Am J Clin Nutr 2002;76:1111-1116
47. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006;116: 1784-1792
48. Duncan BB, Schmidt MI, Pankow JS, Bang H, Couper D, Ballantyne CM, Hoogeveen RC, Heiss G: Adiponectin and the development of type 2 diabetes: The Atherosclerosis Risk in Communities Study. Diabetes 2004;53:2473-2478
49. Hardie DG: The AMP-Activated protein kinase cascade: The key sensor of cellular energy status. Endocrinology 2003;144:5179-5183
50. Shimabukuro M, Higa N, Asahi T, Oshiro Y, Takasu N, Tagawa T, Ueda S, Shimomura I, Funahashi T, Matsuzawa Y: Hypoadiponectinemia is closely linked to endothelial dysfunction in man. J Clin Endocrinol Metab 2003;88:3236-3240
51. Miyazaki Y, Mahankli A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA: Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care 2001;24: 710-719
52. Delporte ML, El Mkadem SA, Quisquater M, Brichard SM: Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. Am Physiol Endocrinol Metab 2004;287:E446-E453
53. Belobrajdic DP, Lam YY, Mano M, Wittert GA, Bird AR: Cereal based diets modulate some markers of oxidative stress and inflammation in lean and obese Zucker rats. Nutr Metab 2011;8:27
54. Szkudelski T: The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas. Physiol Res 2001;50:537-546