Impact of amyloid precursor protein hydrophilic transmembrane residues on amyloid-beta generation

Biochemistry

Volumn 54, Issue 17, 2015, Pages 2777-2784

  Oestereich, Felix ^a,b   Bittner, Heiko J ^c   Weise, Christoph ^b   Grohmann, Lisa ^b   Janke, Lisa Kristin ^b   Hildebrand, Peter W ^c   Multhaup, Gerhard ^a,b   Munter, Lisa Marie ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GLYCOPROTEINS; HYDROPHILICITY; NEURODEGENERATIVE DISEASES; PEPTIDES;

ALZHEIMER'S DISEASE; AMINO ACID RESIDUES; AMYLOID PRECURSOR PROTEINS; HYDROPHILIC RESIDUES; MUTATIONAL ANALYSIS; PROTEOLYTIC FRAGMENTS; SEQUENTIAL PROCESSING; TRANSMEMBRANE SEQUENCES;

PROTEINS;

AMINO ACID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; GAMMA SECRETASE; THREONINE; VALINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROPHILICITY; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POINT MUTATION; PRIORITY JOURNAL; WESTERN BLOTTING; AMINO ACID SEQUENCE; BIOSYNTHESIS; CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; BLOTTING, WESTERN; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR SEQUENCE DATA;

EID: 84928949393     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00217     Document Type: Article

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