Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

Molecular Neurodegeneration

Volumn 9, Issue 1, 2014, Pages

  Ohki, Yu ^a   Shimada, Naoaki ^a   Tominaga, Aya ^a   Osawa, Satoko ^a   Higo, Takuya ^a   Yokoshima, Satoshi ^a,b   Fukuyama, Tohru ^a,b   Tomita, Taisuke ^a,c   Iwatsubo, Takeshi ^a,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Secretase modulator; Alzheimer disease; Intramembrane proteolysis; Presenilin; Secretases

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; FENOFIBRATE; GAMMA SECRETASE; PRESENILIN 1;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; POINT MUTATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

AMYLOID BETA-PEPTIDES; ANIMALS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN STRUCTURE, QUATERNARY; TRANSFECTION;

EID: 84892395099     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-9-7     Document Type: Article

References (47)

1. Alzheimer's disease: the challenge of the second century. Holtzman DM, Morris JC, Goate AM, Sci Transl Med 2011 3 77sr71
2. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y, Neuron 1994 13 45 53
3. Novel research horizons for presenilins and gamma-secretases in cell biology and disease. De Strooper B, Annaert W, Annu Rev Cell Dev Biol 2010 26 235 260
4. The role of presenilin cofactors in the gamma-secretase complex. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T, Nature 2003 422 438 441
5. Structural biology of presenilins and signal peptide peptidases. Tomita T, Iwatsubo T, J Biol Chem 2013 288 14673 14680
6. gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y, J Neurosci 2009 29 13042 13052
7. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. Sato C, Morohashi Y, Tomita T, Iwatsubo T, J Neurosci 2006 26 12081 12088
8. Protein trafficking and maturation regulate intramembrane proteolysis. Morohashi Y, Tomita T, Biochimica et biophysica acta 1828 2013 2855 2861
9. Secretase inhibitors and modulators for Alzheimer's disease treatment. Tomita T, Expert Rev Neurother 2009 9 661 679
10. Phenylpiperidine-type gamma-secretase modulators target the transmembrane domain 1 of presenilin 1. Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T, Embo J 2011 30 4815 4824
11. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the gamma-secretase. Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T, J Neurosci 2010 30 15943 15950
12. Substrate-targeting gamma-secretase modulators. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, et al. Nature 2008 453 925 929
13. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, et al. Nat Med 2005 11 545 550
14. Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Beel AJ, Barrett P, Schnier PD, Hitchcock SA, Bagal D, Sanders CR, Jordan JB, Biochemistry 2009 48 11837 11839
15. NSAID-based gamma-secretase modulators do not bind to the amyloid-beta polypeptide. Barrett PJ, Sanders CR, Kaufman SA, Michelsen K, Jordan JB, Biochemistry 2011 50 10328 10342
16. Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B, Nat Cell Biol 2000 2 461 462
17. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. Watanabe N, Image I II, Takagi S, Tominaga A, Image Image I, Tomita T, Iwatsubo T, J Biol Chem 2010 285 19738 19746
18. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B, Science 2002 296 2215 2218
19. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B, J Biol Chem 2004 279 50790 50798
20. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H, Proc Natl Acad Sci U S A 2002 99 8025 8030
21. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B, Neuron 2001 32 579 589
22. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM, J Neurochem 2005 94 1315 1328
23. gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. Zhao G, Cui MZ, Mao G, Dong Y, Tan J, Sun L, Xu X, J Biol Chem 2005 280 37689 37697
24. DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S, Ihara Y, Biochemistry 2006 45 3952 3960
25. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T, Embo J 2002 21 1524 1534
26. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y, J Neurosci 2005 25 436 445
27. gamma-secretase modulators and presenilin 1 mutants act differently on presenilin/gamma-secretase function to cleave abeta42 and abeta43. Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M, Cell Rep 2013 3 42 51
28. Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis. Urban S, Biochem J 2010 425 501 512
29. The crystal structure of GXGD membrane protease FlaK. Hu J, Xue Y, Lee S, Ha Y, Nature 2011 475 528 531
30. Structure of a presenilin family intramembrane aspartate protease. Li X, Dang S, Yan C, Gong X, Wang J, Shi Y, Nature 2013 493 56 61
31. Relationship of sidechain hydrophobicity and alpha-helical propensity on the stability of the single-stranded amphipathic alpha-helix. Monera OD, Sereda TJ, Zhou NE, Kay CM, Hodges RS, J Pept Sci 1995 1 319 329
32. Inhibition of gamma-secretase activity by helical beta-peptide foldamers. Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T, J Am Chem Soc 2009 131 7353 7359
33. Designed helical peptides inhibit an intramembrane protease. Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS, J Am Chem Soc 2003 125 11794 11795
34. Inhibition of gamma-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T, Biochemistry 2013 52 61 69
35. Long amyloid beta-protein secreted from wild-type human neuroblastoma IMR-32 cells. Asami-Odaka A, Ishibashi Y, Kikuchi T, Kitada C, Suzuki N, Biochemistry 1995 34 10272 10278
36. Parallel synthesis of DAPT derivatives and their gamma-secretase- inhibitory activity. Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T, Bioorg Med Chem Lett 2004 14 1983 1985
37. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, et al. Nature 2000 405 689 694
38. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T, J Biol Chem 2007 282 12388 12396
39. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin. Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T, J Neurosci 1999 19 10627 10634
40. The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. Sato C, Takagi S, Tomita T, Iwatsubo T, J Neurosci 2008 28 6264 6271
41. Stable association of presenilin derivatives and absence of presenilin interactions with APP. Thinakaran G, Regard JB, Bouton CM, Harris CL, Price DL, Borchelt DR, Sisodia SS, Neurobiol Dis 1998 4 438 453
42. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE, J Biol Chem 2004 279 15153 15160
43. Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Kitamura T, Koshino Y, Shibata F, Oki T, Nakajima H, Nosaka T, Kumagai H, Exp Hematol 2003 31 1007 1014
44. The presenilin 2 mutation (N141I) linked to familial alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grunberg J, Haass C, et al. Proc Natl Acad Sci U S A 1997 94 2025 2030
45. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T, J Biol Chem 2005 280 41967 41975
46. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L- alanyl]-S-phenylglycine t-butyl ester). Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T, J Biol Chem 2006 281 14670 14676
47. An approach to the targeted attachment of peptides and proteins to solid supports. Hofmann K, Kiso Y, Proc Natl Acad Sci U S A 1976 73 3516 3518