Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif

Journal of Biological Chemistry

Volumn 285, Issue 28, 2010, Pages 21636-21643

  Munter, Lisa Marie ^a   Botev, Anne ^a   Richter, Luise ^a   Hildebrand, Peter W ^b   Althoff, Veit ^a   Weise, Christoph ^a   Kaden, Daniela ^a   Multhaup, Gerd ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMINO ACID RESIDUES; AMYLOID PRECURSOR PROTEINS; DIFFERENT MECHANISMS; PRESENILINS; SECRETASES; TRANSMEMBRANE SEQUENCES; WILD TYPES;

AMINO ACIDS; GLYCOPROTEINS; ORGANIC ACIDS;

PROTEINS;

ADENOSINE; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GLYCINE; GUANOSINE; PRESENILIN 1;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROCESSING; WILD TYPE;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN PRECURSOR; CELL LINE, TUMOR; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PLASMIDS; PRESENILINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

EID: 77954359268     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.088005     Document Type: Article

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