The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

Antiviral Research

Volumn 118, Issue , 2015, Pages 148-158

  Luo, Dahai ^a   Vasudevan, Subhash G ^b   Lescar, Julien ^c,d  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Antiviral drug target; Crystal structures; Dengue virus; NS2BNS3 protease; Replication complex; RNA helicase; Serine protease

Indexed keywords

ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4B; NONSTRUCTURAL PROTEIN 5; NUCLEOSIDE; RNA HELICASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA; ENZYME INHIBITOR; NS2B PROTEIN, FLAVIVIRUS; NS3 PROTEIN, FLAVIVIRUS; SERINE PROTEINASE; VIRAL PROTEIN;

CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; FLAVIVIRUS; HUMAN; IMMUNE RESPONSE; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; RNA REPLICATION; VIRUS PARTICLE; ANTAGONISTS AND INHIBITORS; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; TRENDS; VIRUS REPLICATION;

DENGUE VIRUS; FLAVIVIRUS;

ANTIVIRAL AGENTS; DRUG DISCOVERY; ENZYME INHIBITORS; FLAVIVIRUS; HUMANS; RNA HELICASES; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84928471861     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.03.014     Document Type: Review

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