Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 3, 2015, Pages 466-470

  De Sousa, Lorena Ramos Freitas ^a,b   Wu, Hongmei ^b   Nebo, Liliane ^a   Fernandes, João Batista ^a   Da Silva, Maria Fátima Das Graças Fernandes ^a   Kiefer, Werner ^b   Kanitz, Manuel ^c   Bodem, Jochen ^d   Diederich, Wibke E ^c   Schirmeister, Tanja ^b   Vieira, Paulo Cezar ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Biflavone; Dengue virus; Flavonol; NS2B NS3 protease

Indexed keywords

AGATHISFLAVONE; FLAVONOID; ISOQUERCITRIN; KAEMPFEROL; MYRICETIN; NS2B NS3 PROTEASE; QUERCETIN; QUERCITRIN; SERINE PROTEINASE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; NS3 PROTEASE, DENGUE VIRUS; SERINE PROTEINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; INHIBITION KINETICS; MOLECULAR DOCKING; SEROTYPE; CHEMICAL STRUCTURE; CHEMISTRY; DENGUE VIRUS; DRUG EFFECTS; ENZYMOLOGY; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION;

DENGUE VIRUS;

ANTIVIRAL AGENTS; DENGUE VIRUS; FLAVONOIDS; KINETICS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84921415788     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.12.015     Document Type: Article

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