Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus ns2b-ns3 protease: Fold analysis by pseudocontact shifts

Journal of the American Chemical Society

Volumn 133, Issue 47, 2011, Pages 19205-19215

  De La Cruz, Laura ^a   Nguyen, Thi Hoang Duong ^a,c   Ozawa, Kiyoshi ^a   Shin, James ^b   Graham, Bim ^b   Huber, Thomas ^a   Otting, Gottfried ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOUND INHIBITORS; C-TERMINAL SEGMENTS; COFACTORS; CONFORMATIONAL CHANGE; CONFORMATIONAL EXCHANGE; DENGUE VIRUS; DRUG DESIGN; DRUG TARGETS; INHIBITOR DESIGN; ISOTOPE LABELING; LOW-MOLECULAR WEIGHT; NMR SPECTRUM; OPEN CONFORMATION; PARAMAGNETIC RELAXATION ENHANCEMENTS; POSITIVELY CHARGED; SELECTIVE MUTATION; SPECTRAL OVERLAP; STRUCTURAL CHANGE; STRUCTURAL MODELS; TECHNIQUES USED; TWO-COMPONENT; WEST NILE VIRUS;

CRYSTAL STRUCTURE; GADOLINIUM; ISOTOPES; MODEL STRUCTURES; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAMAGNETIC MATERIALS; PARAMAGNETISM; VIRUSES;

STRUCTURAL DESIGN;

GADOLINIUM; LANTHANIDE; PROTEINASE;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DENGUE VIRUS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; ISOTOPE LABELING; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; VIRUS INHIBITION; WEST NILE FLAVIVIRUS;

BINDING SITES; DENGUE VIRUS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; PROTEASE INHIBITORS; PROTEIN FOLDING; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 81855172065     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208435s     Document Type: Article

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