Towards the design of flavivirus helicase/NTPase inhibitors: Crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain

Novartis Foundation Symposium

Volumn 277, Issue , 2006, Pages 87-97

  Xu, Ting ^a   Sampath, Aruna ^b   Chao, Alex ^b   Wen, Daying ^b   Nanao, Max ^d   Luo, Dahai ^a   Chene, Patrick ^c   Vasudevan, Subhash G ^b   Lescar, Julien ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^c NOVARTIS PHARMA AG   (Switzerland)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; HELICASE; NS3 PROTEIN, FLAVIVIRUS; NUCLEOSIDE TRIPHOSPHATASE; RNA HELICASE; SERINE PROTEINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; DENGUE VIRUS; DIMERIZATION; DRUG ANTAGONISM; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLIZATION; DENGUE VIRUS; DIMERIZATION; DNA HELICASES; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEOSIDE-TRIPHOSPHATASE; RNA HELICASES; SERINE ENDOPEPTIDASES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 33947500211     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (19)

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