A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

PLoS Pathogens

Volumn 11, Issue 3, 2015, Pages 1-27

  Zhao, Yongqian ^a,b   Soh, Tingjin Sherryl ^c,d   Zheng, Jie ^c   Chan, Kitti Wing Ki ^a   Phoo, Wint Wint ^e   Lee, Chin Chin ^a   Tay, Moon Y F ^a   Swaminathan, Kunchithapadam ^b,f   Cornvik, Tobias C ^c   Lim, Siew Pheng ^d   Shi, Pei Yong ^d   Lescar, Julien ^c,g   Vasudevan, Subhash G ^a,b   Luo, Dahai ^e  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^g PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 5; PEPSIN A; RENILLA LUCIFERIN 2 MONOOXYGENASE; S ADENOSYLHOMOCYSTEINE; VIRUS RNA; NS5 PROTEIN, DENGUE VIRUS; VIRAL PROTEIN;

ARTICLE; BHK CELL LINE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DENGUE VIRUS 3; DENGUE VIRUS 4; DEUTERIUM HYDROGEN EXCHANGE; ELECTROSTATIC PRECIPITATION; ENZYME ACTIVITY; GENE MUTATION; GENETIC TRANSFECTION; JAPANESE ENCEPHALITIS VIRUS; MASS SPECTROMETRY; MOLECULAR CLONING; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; REAL TIME POLYMERASE CHAIN REACTION; REPLICON; RNA TRANSLATION; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; VIRAL DISEASE IMMUNOFLUORESCENCE ASSAY; VIRUS REPLICATION; CHEMISTRY; DENGUE VIRUS; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

DENGUE VIRUS; FLAVIVIRUS; JAPANESE ENCEPHALITIS VIRUS;

CRYSTALLOGRAPHY, X-RAY; DENGUE VIRUS; PROTEIN STRUCTURE, TERTIARY; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84926429155     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004682     Document Type: Article

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