Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 22, 2014, Pages 6344-6352

  Liu, Hailong ^a,b   Wu, Ruoming ^c   Sun, Yanyan ^c   Ye, Yan ^a   Chen, Jing ^a   Luo, Xiaomin ^a   Shen, Xu ^a   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Dengue virus; NS2B NS3; Thiadiazo

Indexed keywords

3 (1 BENZYL 1H INDOL 3 YL) 2 CYANO N [5 (TRIFLUOROMETHYL)1,3,4 THIADIAZOL 2 YL]ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) 2 CYANO N [5 [(NAPHTHALEN 1YLMETHYL)SULFANYL] 1,3,4 THIADIAZOL 2 YL]PROP 2 ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) 2 CYANO N [5 [[(4 FLUOROPHENYL)METHYL]SULFANYL] 1,3,4 THIADIAZOL 2 YL]PROP 2 ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) 2 CYANO N [5 [[(4 METHOXYPHENYL)METHYL]SULFANYL] 1,3,4 THIADIAZOL 2 YL]PROP 2 ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) N [5 (BENZYLSULFANYL)1,3,4 THIADIAZOL 2 YL] 2 CYANOPROP 2 ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) N [5 [[(2 CHLOROPHENYL)METHYL]SULFANYL] 1,3,4 THIADIAZOL 2 YL]2 CYANOPROP 2 ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) N [5 [[(2 METHYLPHENYL)METHYL]SULFANYL] 1,3,4 THIADIAZOL 2 YL]PROP 2 ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) N [5 [[(4 BROMOPHENYL)METHYL]SULFANYL] 1,3,4 THIADIAZOL 2 YL]2 CYANOPROP 2 ENAMIDE; 3 (1 BENZYL 1H INDOL 3 YL) N [5 [[(4 CHLOROPHENYL)METHYL]SULFANYL] 1,3,4 THIADIAZOL 2 YL]2 CYANOPROP 2 ENAMIDE; ACRYLAMIDE DERIVATIVE; N [5 (BENZYLSULFANYL) 1,3,4 THIADIAZOL 2 YL] 2 CYANO 3 [1 [(2 CYANOPHENYL)METHYL] 1H INDOL 3 YL]PROP 2 ENAMIDE; N [5 (BENZYLSULFANYL) 1,3,4 THIADIAZOL 2 YL] 2 CYANO 3 [1 [(2 FLUOROPHENYL)METHYL] 1H INDOL 3 YL]PROP 2 ENAMIDE; N [5 (BENZYLSULFANYL) 1,3,4 THIADIAZOL 2 YL] 2 CYANO 3 [1 [(4 FLUOROPHENYL)METHYL] 1H INDOL 3 YL]PROP 2 ENAMIDE; N [5 (BENZYLSULFANYL) 1,3,4 THIADIAZOL 2 YL] 2 CYANO 3 [1 [[4 (TRIFLUOROMETHYL)PHENYL]METHYL] 1H INDOL 3 YL]PROP 2 ENAMIDE; N [5 (BENZYLSULFANYL) 1,3,4 THIADIAZOL 2 YL] 3 [1[[2,4 BIS(TRIFLUOROMETHYL)PHENYL]METHYL] 1H INDOL 3 YL] 2 CYANOPROP 2 ENAMIDE; NS2B NS3 PROTEASE; PROTEINASE; PROTEINASE INHIBITOR; THIADIAZOLOACRYLAMIDE DERIVATIVE; UNCLASSIFIED DRUG; ACRYLAMIDE; NS2A PROTEIN, DENGUE VIRUS TYPE 2; NS3 PROTEASE, DENGUE VIRUS; PROTEIN BINDING; SERINE PROTEINASE; THIADIAZOLE DERIVATIVE; VIRUS PROTEIN;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DENGUE VIRUS 2; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IC50; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; PLASMID; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DENGUE VIRUS; ENZYMOLOGY; KINETICS; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

ACRYLAMIDE; BINDING SITES; DENGUE VIRUS; KINETICS; MOLECULAR DOCKING SIMULATION; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84908377381     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.09.057     Document Type: Article

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