Functional analysis of two cavities in flavivirus NS5 polymerase

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14362-14372

  Zou, Gang ^a   Chen, Yen Liang ^a   Dong, Hongping ^a   Lim, Chin Chin ^a   Yap, Li Jian ^b   Yau, Yin Hoe ^b   Shochat, Susana Geifman ^b   Lescar, Julien ^b   Shi, Pei Yong ^a,c  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c 10 Biopolis Rd ^*  (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE SUBSTITUTION; ALLOSTERIC INHIBITOR; DENGUE VIRUS; DRUG DESIGN; HELICASES; METHYLTRANSFERASES; NON-ENZYMATIC; RESIDUE FUNCTIONS; REVERTANT ANALYSIS; RNA SYNTHESIS; RNA-DEPENDENT RNA POLYMERASE; SUB-DOMAINS; TWO-CAVITY; VIRAL REPLICATION;

AMINO ACIDS; FUNCTIONAL POLYMERS; POLYMERS; RNA; STRUCTURAL ANALYSIS; VIRUSES;

NUCLEIC ACIDS;

ALANINE; GENOMIC RNA; HELICASE; ISOLEUCINE; LEUCINE; LYSINE; NONSTRUCTURAL PROTEIN 5; RECOMBINANT NS5 PROTEIN; RECOMBINANT PROTEIN; RNA DIRECTED RNA POLYMERASE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENGUE VIRUS; MUTAGENESIS; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RNA SYNTHESIS; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; CRICETINAE; DNA-DIRECTED RNA POLYMERASES; DRUG DESIGN; ENZYMES; FLAVIVIRUS; LYSINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; RNA REPLICASE; SEQUENCE HOMOLOGY, AMINO ACID; TRYPTOPHAN; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

DENGUE VIRUS; FLAVIVIRUS;

EID: 79954588648     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.214189     Document Type: Article

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