Structure-guided discovery of a novel non-peptide inhibitor of dengue virus NS2B-NS3 protease

Chemical Biology and Drug Design

Volumn 86, Issue 3, 2015, Pages 255-264

  Li, Linfeng ^a,b   Basavannacharya, Chandrakala ^c   Chan, Kitti Wing Ki ^c   Shang, Luqing ^a,b   Vasudevan, Subhash G ^c   Yin, Zheng ^a,b  

^a NANKAI UNIVERSITY   (China)

^b Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin   (China)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

dengue virus; dengue virus bioassay; pharmacophore; protease inhibitor; virtual screening

Indexed keywords

ANTIVIRUS AGENT; NS2B NS3 PROTEASE; NS2B NS3 PROTEASE INHIBITOR; PROTEINASE; UNCLASSIFIED DRUG; NS2B PROTEIN, FLAVIVIRUS; NS3 PROTEIN, FLAVIVIRUS; PROTEIN BINDING; PROTEINASE INHIBITOR; RNA HELICASE; SERINE PROTEINASE; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENGUE; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPUTER SIMULATION; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; HAMSTER; MOLECULAR DOCKING; PROCEDURES; TUMOR CELL LINE; VIROLOGY; X RAY CRYSTALLOGRAPHY;

DENGUE VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; COMPUTER SIMULATION; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DENGUE; DENGUE VIRUS; DRUG DISCOVERY; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEASE INHIBITORS; PROTEIN BINDING; RNA HELICASES; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84939253143     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12500     Document Type: Review

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