Dengue protease activity: The structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target

Bioscience Reports

Volumn 31, Issue 5, 2011, Pages 399-409

  Phong, Wai Y ^a   Moreland, Nicole J ^b   Lim, Siew P ^a   Wen, Daying ^a,c   Paradkar, Prasad N ^b   Vasudevan, Subhash G ^b  

^a NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Allosteric inhibitor; Dengue; Flavivirus; NS2B; NS3; Protease

Indexed keywords

AMINO ACID; GLUTATHIONE TRANSFERASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3F10; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; PROTEINASE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; IMMUNOGLOBULIN F(AB) FRAGMENT; PEPTIDE FRAGMENT; PROTEIN BINDING; SERINE PROTEINASE; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; DRUG TARGETING; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NONHUMAN; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS; TRANSACTIVATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION; WEST NILE FLAVIVIRUS; AMINO ACID SEQUENCE; CHEMISTRY; DENGUE VIRUS; ENZYME ACTIVE SITE; ENZYME STABILITY; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; KINETICS; MOLECULAR GENETICS; PROTEIN DEGRADATION;

DENGUE VIRUS; FLAVIVIRUS; WEST NILE VIRUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; CATALYTIC DOMAIN; DENGUE VIRUS; ENZYME ACTIVATION; ENZYME STABILITY; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEOLYSIS; SERINE PROTEASES; VIRAL PROTEINS;

EID: 80052828348     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20100142     Document Type: Article

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