-
1
-
-
77649179433
-
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
-
Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 2010;10:210-215.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 210-215
-
-
Tschopp, J.1
Schroder, K.2
-
2
-
-
0032909752
-
Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1)
-
Fantuzzi G, Dinarello CA. Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J Clin Immunol 1999;19:1-11.
-
(1999)
J Clin Immunol
, vol.19
, pp. 1-11
-
-
Fantuzzi, G.1
Dinarello, C.A.2
-
3
-
-
84855594528
-
Autophagy in inflammatory diseases
-
Choi AJ, Ryter SW. Autophagy in inflammatory diseases. Int J Cell Biol 2011;2011:732798.
-
(2011)
Int J Cell Biol
, vol.2011
, pp. 732798
-
-
Choi, A.J.1
Ryter, S.W.2
-
4
-
-
84881553318
-
Autophagy and IL-1 family cytokines
-
Harris J. Autophagy and IL-1 family cytokines. Front Immunol 2013;4:83.
-
(2013)
Front Immunol
, vol.4
, pp. 83
-
-
Harris, J.1
-
5
-
-
79953176280
-
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation
-
Harris J, et al. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 2011;286:9587-9597.
-
(2011)
J Biol Chem
, vol.286
, pp. 9587-9597
-
-
Harris, J.1
-
6
-
-
78751672975
-
Autophagy in immunity and inflammation
-
Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011;469:323-335.
-
(2011)
Nature
, vol.469
, pp. 323-335
-
-
Levine, B.1
Mizushima, N.2
Virgin, H.W.3
-
7
-
-
77951237303
-
The Beclin 1 interactome
-
He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol 2010;22:140-149.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 140-149
-
-
He, C.1
Levine, B.2
-
8
-
-
0032563798
-
A protein conjugation system essential for autophagy
-
Mizushima N, et al. A protein conjugation system essential for autophagy. Nature 1998;395:395-398.
-
(1998)
Nature
, vol.395
, pp. 395-398
-
-
Mizushima, N.1
-
10
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-5728.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
-
11
-
-
43149125546
-
Organization of the pre-autophagosomal structure responsible for autophagosome formation
-
Kawamata T, Kamada Y, Kabeya Y, Sekito T, Ohsumi Y. Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol Biol Cell 2008;19:2039-2050.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 2039-2050
-
-
Kawamata, T.1
Kamada, Y.2
Kabeya, Y.3
Sekito, T.4
Ohsumi, Y.5
-
12
-
-
67650234499
-
NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets
-
Kirkin V, Lamark T, Johansen T, Dikic I. NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 2009;5:732-733.
-
(2009)
Autophagy
, vol.5
, pp. 732-733
-
-
Kirkin, V.1
Lamark, T.2
Johansen, T.3
Dikic, I.4
-
13
-
-
64049086758
-
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
-
Matsunaga K, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 2009;11:385-396.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 385-396
-
-
Matsunaga, K.1
-
14
-
-
82455210868
-
Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta
-
Dupont N, et al. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J 2011;30:4701-4711.
-
(2011)
EMBO J
, vol.30
, pp. 4701-4711
-
-
Dupont, N.1
-
15
-
-
34447643958
-
Toll-like receptor 4 is a sensor for autophagy associated with innate immunity
-
Xu Y, et al. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 2007;27:135-144.
-
(2007)
Immunity
, vol.27
, pp. 135-144
-
-
Xu, Y.1
-
16
-
-
37549043217
-
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
-
Sanjuan MA, et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 2007;450:1253-1257.
-
(2007)
Nature
, vol.450
, pp. 1253-1257
-
-
Sanjuan, M.A.1
-
17
-
-
84860153374
-
Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques
-
De Meyer I, et al. Toll-like receptor 7 stimulation by imiquimod induces macrophage autophagy and inflammation in atherosclerotic plaques. Basic Res Cardiol 2012;107:269.
-
(2012)
Basic Res Cardiol
, vol.107
, pp. 269
-
-
De Meyer, I.1
-
18
-
-
84859027576
-
Autophagy in regulation of Toll-like receptor signaling
-
Into T, Inomata M, Takayama E, Takigawa T. Autophagy in regulation of Toll-like receptor signaling. Cell Signal 2012;24:1150-1162.
-
(2012)
Cell Signal
, vol.24
, pp. 1150-1162
-
-
Into, T.1
Inomata, M.2
Takayama, E.3
Takigawa, T.4
-
19
-
-
84860705893
-
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
-
Oka T, et al. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 2012;485:251-255.
-
(2012)
Nature
, vol.485
, pp. 251-255
-
-
Oka, T.1
-
20
-
-
58049204465
-
Autophagy and pattern recognition receptors in innate immunity
-
Delgado M, et al. Autophagy and pattern recognition receptors in innate immunity. Immunol Rev 2009;227:189-202.
-
(2009)
Immunol Rev
, vol.227
, pp. 189-202
-
-
Delgado, M.1
-
21
-
-
73849121209
-
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
-
Travassos LH, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010;11:55-62.
-
(2010)
Nat Immunol
, vol.11
, pp. 55-62
-
-
Travassos, L.H.1
-
22
-
-
84905669136
-
Pattern recognition receptors and autophagy
-
Oh JE, Lee HK. Pattern recognition receptors and autophagy. Front Immunol 2014;5:300.
-
(2014)
Front Immunol
, vol.5
, pp. 300
-
-
Oh, J.E.1
Lee, H.K.2
-
23
-
-
78649716384
-
How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection
-
Dupont N, Temime-Smaali N, Lafont F. How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection. Biol Cell 2010;102:621-634.
-
(2010)
Biol Cell
, vol.102
, pp. 621-634
-
-
Dupont, N.1
Temime-Smaali, N.2
Lafont, F.3
-
24
-
-
84857195479
-
Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
-
Shi CS, et al. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol 2012;13:255-263.
-
(2012)
Nat Immunol
, vol.13
, pp. 255-263
-
-
Shi, C.S.1
-
25
-
-
84908053092
-
The microtubule-associated protein, EB1, links AIM2 inflammasomes with autophagy-dependent secretion
-
Wang LJ, et al. The microtubule-associated protein, EB1, links AIM2 inflammasomes with autophagy-dependent secretion. J Biol Chem 2014;289:29322-29333.
-
(2014)
J Biol Chem
, vol.289
, pp. 29322-29333
-
-
Wang, L.J.1
-
26
-
-
79251588741
-
NLRP4 negatively regulates autophagic processes through an association with beclin-1
-
Jounai N, et al. NLRP4 negatively regulates autophagic processes through an association with beclin-1. J Immunol 2011;186:1646-1655.
-
(2011)
J Immunol
, vol.186
, pp. 1646-1655
-
-
Jounai, N.1
-
27
-
-
77953601881
-
Regulation of innate immune responses by autophagy-related proteins
-
Saitoh T, Akira S. Regulation of innate immune responses by autophagy-related proteins. J Cell Biol 2010;189:925-935.
-
(2010)
J Cell Biol
, vol.189
, pp. 925-935
-
-
Saitoh, T.1
Akira, S.2
-
28
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira K, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011;12:222-230.
-
(2011)
Nat Immunol
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
-
29
-
-
79954459822
-
Inflammasome-independent modulation of cytokine response by autophagy in human cells
-
Crisan TO, et al. Inflammasome-independent modulation of cytokine response by autophagy in human cells. PLoS ONE 2011;6:e18666.
-
(2011)
PLoS ONE
, vol.6
, pp. e18666
-
-
Crisan, T.O.1
-
30
-
-
77957680501
-
Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1
-
Shi CS, Kehrl JH. Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1. Autophagy 2010;6:986-987.
-
(2010)
Autophagy
, vol.6
, pp. 986-987
-
-
Shi, C.S.1
Kehrl, J.H.2
-
31
-
-
84895819096
-
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
-
de Luca A, et al. IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci USA 2014;111:3526-3531.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 3526-3531
-
-
de Luca, A.1
-
32
-
-
78651488777
-
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly
-
Bodemann BO, et al. RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell 2011;144:253-267.
-
(2011)
Cell
, vol.144
, pp. 253-267
-
-
Bodemann, B.O.1
-
33
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
Saitoh T, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008;456:264-268.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
-
35
-
-
53549117440
-
Induction of autophagy via innate bacterial recognition
-
Yano T, Kurata S. Induction of autophagy via innate bacterial recognition. Autophagy 2008;4:958-960.
-
(2008)
Autophagy
, vol.4
, pp. 958-960
-
-
Yano, T.1
Kurata, S.2
-
36
-
-
73849151394
-
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
-
Cooney R, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010;16:90-97.
-
(2010)
Nat Med
, vol.16
, pp. 90-97
-
-
Cooney, R.1
-
37
-
-
62449110463
-
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
-
Tal MC, et al. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci USA 2009;106:2770-2775.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2770-2775
-
-
Tal, M.C.1
-
38
-
-
84893912159
-
Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses
-
Liang Q, et al. Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses. Cell Host Microbe 2014;15:228-238.
-
(2014)
Cell Host Microbe
, vol.15
, pp. 228-238
-
-
Liang, Q.1
-
39
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011;469:221-225.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
40
-
-
64149105696
-
ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells
-
Jiang B, et al. ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells. FEBS J 2009;276:2615-2624.
-
(2009)
FEBS J
, vol.276
, pp. 2615-2624
-
-
Jiang, B.1
-
41
-
-
63349105340
-
Antioxidant properties of MitoTEMPOL and its hydroxylamine
-
Trnka J, Blaikie FH, Logan A, Smith RA, Murphy MP. Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radic Res 2009;43:4-12.
-
(2009)
Free Radic Res
, vol.43
, pp. 4-12
-
-
Trnka, J.1
Blaikie, F.H.2
Logan, A.3
Smith, R.A.4
Murphy, M.P.5
-
42
-
-
77950486855
-
Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein
-
Saxena G, Chen J, Shalev A. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem 2010;285:3997-4005.
-
(2010)
J Biol Chem
, vol.285
, pp. 3997-4005
-
-
Saxena, G.1
Chen, J.2
Shalev, A.3
-
43
-
-
0842345400
-
VDAC: the channel at the interface between mitochondria and the cytosol
-
Colombini M. VDAC: the channel at the interface between mitochondria and the cytosol. Mol Cell Biochem 2004;256-257:107-115.
-
(2004)
Mol Cell Biochem
, vol.256-257
, pp. 107-115
-
-
Colombini, M.1
-
44
-
-
16844366524
-
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
-
Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 2005;8:3-5.
-
(2005)
Rejuvenation Res
, vol.8
, pp. 3-5
-
-
Lemasters, J.J.1
-
45
-
-
84862777872
-
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
-
Shimada K, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012;36:401-414.
-
(2012)
Immunity
, vol.36
, pp. 401-414
-
-
Shimada, K.1
-
46
-
-
34247554965
-
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
-
Rioux JD, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007;39:596-604.
-
(2007)
Nat Genet
, vol.39
, pp. 596-604
-
-
Rioux, J.D.1
-
47
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
48
-
-
79953084107
-
The Nlrp3 inflammasome: contributions to intestinal homeostasis
-
Zaki MH, Lamkanfi M, Kanneganti TD. The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol 2011;32:171-179.
-
(2011)
Trends Immunol
, vol.32
, pp. 171-179
-
-
Zaki, M.H.1
Lamkanfi, M.2
Kanneganti, T.D.3
-
49
-
-
33748493563
-
Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis
-
Watanabe T, et al. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 2006;25:473-485.
-
(2006)
Immunity
, vol.25
, pp. 473-485
-
-
Watanabe, T.1
-
50
-
-
13244277880
-
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
-
Maeda S, et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 2005;307:734-738.
-
(2005)
Science
, vol.307
, pp. 734-738
-
-
Maeda, S.1
-
51
-
-
26044460479
-
NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype
-
Netea MG, et al. NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype. Neth J Med 2005;63:305-308.
-
(2005)
Neth J Med
, vol.63
, pp. 305-308
-
-
Netea, M.G.1
-
52
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe J, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007;39:207-211.
-
(2007)
Nat Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
-
53
-
-
38849140916
-
Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine: preliminary experiences
-
Tsujikawa T, et al. Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine: preliminary experiences. Endoscopy 2008;40:11-15.
-
(2008)
Endoscopy
, vol.40
, pp. 11-15
-
-
Tsujikawa, T.1
-
54
-
-
80051550866
-
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
-
Plantinga TS, et al. Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut 2011;60:1229-1235.
-
(2011)
Gut
, vol.60
, pp. 1229-1235
-
-
Plantinga, T.S.1
-
55
-
-
80052389178
-
ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation
-
Plantinga TS, Joosten LA, Netea MG. ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation. Autophagy 2011;7:1074-1075.
-
(2011)
Autophagy
, vol.7
, pp. 1074-1075
-
-
Plantinga, T.S.1
Joosten, L.A.2
Netea, M.G.3
-
56
-
-
45949086355
-
Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability
-
Al-Sadi R, Ye D, Dokladny K, Ma TY. Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. J Immunol 2008;180:5653-5661.
-
(2008)
J Immunol
, vol.180
, pp. 5653-5661
-
-
Al-Sadi, R.1
Ye, D.2
Dokladny, K.3
Ma, T.Y.4
-
57
-
-
79955790354
-
Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease
-
Henckaerts L, et al. Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease. Inflamm Bowel Dis 2011;17:1392-1397.
-
(2011)
Inflamm Bowel Dis
, vol.17
, pp. 1392-1397
-
-
Henckaerts, L.1
-
58
-
-
84881025556
-
Impaired autophagy and APP processing in Alzheimer's disease: the potential role of Beclin 1 interactome
-
Salminen A, et al. Impaired autophagy and APP processing in Alzheimer's disease: the potential role of Beclin 1 interactome. Prog Neurobiol 2013;106-107:33-54.
-
(2013)
Prog Neurobiol
, vol.106-107
, pp. 33-54
-
-
Salminen, A.1
-
59
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
Pickford F, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008;118:2190-2199.
-
(2008)
J Clin Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
-
60
-
-
77952272127
-
Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors
-
Li Z, et al. Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors. BMC Cancer 2010;10:98.
-
(2010)
BMC Cancer
, vol.10
, pp. 98
-
-
Li, Z.1
-
61
-
-
84863011747
-
MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy
-
Zou Z, et al. MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. J Biol Chem 2012;287:4148-4156.
-
(2012)
J Biol Chem
, vol.287
, pp. 4148-4156
-
-
Zou, Z.1
-
62
-
-
85046981182
-
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
-
Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 2012;8:165-176.
-
(2012)
Autophagy
, vol.8
, pp. 165-176
-
-
Korkmaz, G.1
le Sage, C.2
Tekirdag, K.A.3
Agami, R.4
Gozuacik, D.5
-
63
-
-
4544248870
-
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
-
Horowitz PM, et al. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci 2004;24:7895-7902.
-
(2004)
J Neurosci
, vol.24
, pp. 7895-7902
-
-
Horowitz, P.M.1
-
64
-
-
30844468003
-
Caspase-1 activation of caspase-6 in human apoptotic neurons
-
Guo H, et al. Caspase-1 activation of caspase-6 in human apoptotic neurons. Cell Death Differ 2006;13:285-292.
-
(2006)
Cell Death Differ
, vol.13
, pp. 285-292
-
-
Guo, H.1
-
65
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
-
Halle A, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 2008;9:857-865.
-
(2008)
Nat Immunol
, vol.9
, pp. 857-865
-
-
Halle, A.1
-
66
-
-
57849144282
-
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
-
Ojala J, et al. Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiol Aging 2009;30:198-209.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 198-209
-
-
Ojala, J.1
-
67
-
-
74549169836
-
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
-
Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation 2009;6:41.
-
(2009)
J Neuroinflammation
, vol.6
, pp. 41
-
-
Salminen, A.1
Kauppinen, A.2
Suuronen, T.3
Kaarniranta, K.4
Ojala, J.5
-
68
-
-
84859448447
-
Autophagy links inflammasomes to atherosclerotic progression
-
Razani B, et al. Autophagy links inflammasomes to atherosclerotic progression. Cell Metab 2012;15:534-544.
-
(2012)
Cell Metab
, vol.15
, pp. 534-544
-
-
Razani, B.1
-
69
-
-
0025241696
-
The relation between genotype and phenotype in cystic fibrosis-analysis of the most common mutation (delta F508)
-
Kerem E, et al. The relation between genotype and phenotype in cystic fibrosis-analysis of the most common mutation (delta F508). N Engl J Med 1990;323:1517-1522.
-
(1990)
N Engl J Med
, vol.323
, pp. 1517-1522
-
-
Kerem, E.1
-
70
-
-
78650812864
-
Cystic fibrosis: a disorder with defective autophagy
-
Luciani A, et al. Cystic fibrosis: a disorder with defective autophagy. Autophagy 2011;7:104-106.
-
(2011)
Autophagy
, vol.7
, pp. 104-106
-
-
Luciani, A.1
-
71
-
-
84872742749
-
Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr DeltaF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery
-
Abdulrahman BA, et al. Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr DeltaF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery. J Biol Chem 2013;288:2049-2058.
-
(2013)
J Biol Chem
, vol.288
, pp. 2049-2058
-
-
Abdulrahman, B.A.1
-
72
-
-
77956396747
-
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
-
Luciani A, et al. Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol 2010;12:863-875.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 863-875
-
-
Luciani, A.1
-
73
-
-
80655134731
-
Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
-
Abdulrahman BA, et al. Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy 2011;7:1359-1370.
-
(2011)
Autophagy
, vol.7
, pp. 1359-1370
-
-
Abdulrahman, B.A.1
-
74
-
-
84900457679
-
IFN-gamma stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages
-
Assani K, Tazi MF, Amer AO, Kopp BT. IFN-gamma stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. PLoS ONE 2014;9:e96681.
-
(2014)
PLoS ONE
, vol.9
, pp. e96681
-
-
Assani, K.1
Tazi, M.F.2
Amer, A.O.3
Kopp, B.T.4
-
75
-
-
84864299407
-
Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients
-
Kopp BT, et al. Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients. Biochem Biophys Res Commun 2012;424:221-227.
-
(2012)
Biochem Biophys Res Commun
, vol.424
, pp. 221-227
-
-
Kopp, B.T.1
-
76
-
-
0034072264
-
Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations
-
Balk RA. Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations. Crit Care Clin 2000;16:179-192.
-
(2000)
Crit Care Clin
, vol.16
, pp. 179-192
-
-
Balk, R.A.1
-
77
-
-
65649151403
-
Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study
-
Watanabe E, et al. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest 2009;89:549-561.
-
(2009)
Lab Invest
, vol.89
, pp. 549-561
-
-
Watanabe, E.1
-
78
-
-
84862888230
-
Autophagy: an emerging immunological paradigm
-
Deretic V. Autophagy: an emerging immunological paradigm. J Immunol 2012;189:15-20.
-
(2012)
J Immunol
, vol.189
, pp. 15-20
-
-
Deretic, V.1
-
79
-
-
10944253145
-
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
-
Gutierrez MG, et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004;119:753-766.
-
(2004)
Cell
, vol.119
, pp. 753-766
-
-
Gutierrez, M.G.1
-
80
-
-
77949997805
-
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties
-
Ponpuak M, et al. Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity 2010;32:329-341.
-
(2010)
Immunity
, vol.32
, pp. 329-341
-
-
Ponpuak, M.1
-
82
-
-
0142240338
-
Immune control of tuberculosis by IFN-gamma-inducible LRG-47
-
MacMicking JD, Taylor GA, McKinney JD. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 2003;302:654-659.
-
(2003)
Science
, vol.302
, pp. 654-659
-
-
MacMicking, J.D.1
Taylor, G.A.2
McKinney, J.D.3
-
83
-
-
33748506089
-
Human IRGM induces autophagy to eliminate intracellular mycobacteria
-
Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006;313:1438-1441.
-
(2006)
Science
, vol.313
, pp. 1438-1441
-
-
Singh, S.B.1
Davis, A.S.2
Taylor, G.A.3
Deretic, V.4
-
84
-
-
78649833818
-
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
-
Singh SB, et al. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol 2010;12:1154-1165.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1154-1165
-
-
Singh, S.B.1
-
85
-
-
68149126054
-
Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide
-
Coulombe F, et al. Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med 2009;206:1709-1716.
-
(2009)
J Exp Med
, vol.206
, pp. 1709-1716
-
-
Coulombe, F.1
-
86
-
-
77957119308
-
Innate immunity to mycobacteria: vitamin D and autophagy
-
Jo EK. Innate immunity to mycobacteria: vitamin D and autophagy. Cell Microbiol 2010;12:1026-1035.
-
(2010)
Cell Microbiol
, vol.12
, pp. 1026-1035
-
-
Jo, E.K.1
-
87
-
-
84873812985
-
Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country
-
Cheallaigh CN, et al. Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country. PLoS ONE 2013;8:e53330.
-
(2013)
PLoS ONE
, vol.8
, pp. e53330
-
-
Cheallaigh, C.N.1
-
88
-
-
78650310661
-
HIV-1 trans-activator protein dysregulates IFN-gamma signaling and contributes to the suppression of autophagy induction
-
Li JC, et al. HIV-1 trans-activator protein dysregulates IFN-gamma signaling and contributes to the suppression of autophagy induction. AIDS 2011;25:15-25.
-
(2011)
AIDS
, vol.25
, pp. 15-25
-
-
Li, J.C.1
-
89
-
-
84869217908
-
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
-
Castillo EF, et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci USA 2012;109:E3168-E3176.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E3168-E3176
-
-
Castillo, E.F.1
-
90
-
-
80053625777
-
Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response
-
Kleinnijenhuis J, et al. Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response. Immunology 2011;134:341-348.
-
(2011)
Immunology
, vol.134
, pp. 341-348
-
-
Kleinnijenhuis, J.1
-
91
-
-
34548434775
-
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
-
Suzuki T, et al. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog 2007;3:e111.
-
(2007)
PLoS Pathog
, vol.3
, pp. e111
-
-
Suzuki, T.1
-
92
-
-
83755183815
-
Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo
-
Pereira MS, et al. Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo. J Immunol 2011;187:6447-6455.
-
(2011)
J Immunol
, vol.187
, pp. 6447-6455
-
-
Pereira, M.S.1
-
93
-
-
79961065571
-
Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity
-
Sauer JD, et al. Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity. Proc Natl Acad Sci USA 2011;108:12419-12424.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 12419-12424
-
-
Sauer, J.D.1
-
94
-
-
37549041954
-
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
-
Sutterwala FS, et al. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med 2007;204:3235-3245.
-
(2007)
J Exp Med
, vol.204
, pp. 3235-3245
-
-
Sutterwala, F.S.1
-
96
-
-
68349143052
-
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy
-
Dupont N, et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 2009;6:137-149.
-
(2009)
Cell Host Microbe
, vol.6
, pp. 137-149
-
-
Dupont, N.1
-
97
-
-
31944448737
-
Intracellular survival of Shigella
-
Ogawa M, Sasakawa C. Intracellular survival of Shigella. Cell Microbiol 2006;8:177-184.
-
(2006)
Cell Microbiol
, vol.8
, pp. 177-184
-
-
Ogawa, M.1
Sasakawa, C.2
-
98
-
-
38049086105
-
A role for Nod-like receptors in autophagy induced by Shigella infection
-
Suzuki T, Nunez G. A role for Nod-like receptors in autophagy induced by Shigella infection. Autophagy 2008;4:73-75.
-
(2008)
Autophagy
, vol.4
, pp. 73-75
-
-
Suzuki, T.1
Nunez, G.2
-
99
-
-
84855176661
-
Replication of legionella pneumophila in human cells: why are we susceptible?
-
Khweek AA, Amer A. Replication of legionella pneumophila in human cells: why are we susceptible? Front Microbiol 2010;1:133.
-
(2010)
Front Microbiol
, vol.1
, pp. 133
-
-
Khweek, A.A.1
Amer, A.2
-
100
-
-
33846024748
-
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
-
Amer A, et al. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 2006;281:35217-35223.
-
(2006)
J Biol Chem
, vol.281
, pp. 35217-35223
-
-
Amer, A.1
-
101
-
-
79952798601
-
Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes
-
Abdelaziz DH, et al. Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes. J Biol Chem 2011;286:3203-3208.
-
(2011)
J Biol Chem
, vol.286
, pp. 3203-3208
-
-
Abdelaziz, D.H.1
-
102
-
-
84876850002
-
A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy
-
Khweek AA, et al. A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy. Eur J Immunol 2013;43:1333-1344.
-
(2013)
Eur J Immunol
, vol.43
, pp. 1333-1344
-
-
Khweek, A.A.1
-
103
-
-
33744464740
-
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
-
Franchi L, et al. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol 2006;7:576-582.
-
(2006)
Nat Immunol
, vol.7
, pp. 576-582
-
-
Franchi, L.1
-
104
-
-
77649202817
-
Modulation of caspases and their non-apoptotic functions by Legionella pneumophila
-
Amer AO. Modulation of caspases and their non-apoptotic functions by Legionella pneumophila. Cell Microbiol 2010;12:140-147.
-
(2010)
Cell Microbiol
, vol.12
, pp. 140-147
-
-
Amer, A.O.1
-
105
-
-
84881627553
-
The expanding role of NLRs in antiviral immunity
-
Lupfer C, Kanneganti TD. The expanding role of NLRs in antiviral immunity. Immunol Rev 2013;255:13-24.
-
(2013)
Immunol Rev
, vol.255
, pp. 13-24
-
-
Lupfer, C.1
Kanneganti, T.D.2
|