Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 30, 2011, Pages 12419-12424

  Sauer, John Demian ^a   Pereyre, Sabine ^a,c   Archer, Kristina A ^a   Burke, Thomas P ^a   Hanson, Bill ^b   Lauer, Peter ^b   Portnoy, Daniel A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Aduro BioTech Inc   (United States)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

CD8 + T cells; Cell mediated immunity; Innate immunity; Pathogenesis; Vaccine

Indexed keywords

BACTERIAL VACCINE; FLAGELLIN; INFLAMMASOME; INFLAMMASOME NLRC4; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LISTERIA MONOCYTOGENES VACCINE; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BONE MARROW CELL; CD8+ T LYMPHOCYTE; CELL DEATH; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENETIC ENGINEERING; HOST CELL; IMMUNITY; IMMUNIZATION; INNATE IMMUNITY; LEGIONELLA PNEUMOPHILA; LISTERIA MONOCYTOGENES; LISTERIOSIS; LOW DRUG DOSE; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTECTION; PROTEIN SECRETION; T LYMPHOCYTE; WILD TYPE;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CYTOSKELETAL PROTEINS; FEMALE; FLAGELLIN; GENETIC ENGINEERING; HOST-PATHOGEN INTERACTIONS; IMMUNITY, CELLULAR; IMMUNITY, INNATE; IMMUNIZATION; INFLAMMASOMES; LEGIONELLA PNEUMOPHILA; LISTERIA MONOCYTOGENES; LISTERIOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; T-LYMPHOCYTES; VIRULENCE;

LEGIONELLA PNEUMOPHILA; LISTERIA MONOCYTOGENES;

EID: 79961065571     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1019041108     Document Type: Article

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