IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 9, 2014, Pages 3526-3531

  De Luca, Antonella ^a   Smeekens, Sanne P ^b   Casagrande, Andrea ^a   Iannitti, Rossana ^a   Conway, Kara L ^c   Gresnigt, Mark S ^b   Begun, Jakob ^c   Plantinga, Theo S ^a,b   Joosten, Leo A B ^b   Van Der Meer, Jos W M ^b   Chamilos, Georgios ^d   Netea, Mihai G ^b   Xavier, Ramnik J ^c,e   Dinarello, Charles A ^b,e   Romani, Luigina ^a   Van De Veerdonk, Frank L ^b,f  

^a UNIVERSITY OF PERUGIA   (Italy)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF CRETE   (Greece)

^e UNIVERSITY OF COLORADO   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Autoinflammatory disease; Crohn disease; Interleukin 1; LPS; S. aureus

Indexed keywords

INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; MICROTUBULE ASSOCIATED PROTEIN 1; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLOSIS; AUTOPHAGY; CHRONIC GRANULOMATOUS DISEASE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; TH17 CELL;

AUTOINFLAMMATORY DISEASE; CROHN DISEASE; INTERLEUKIN-1; LPS; S. AUREUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASPERGILLUS FUMIGATUS; AUTOPHAGY; COLITIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROTUBULE-ASSOCIATED PROTEINS; NADPH OXIDASE; PHAGOSOMES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN-1; STATISTICS, NONPARAMETRIC;

EID: 84895819096     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322831111     Document Type: Article

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