메뉴 건너뛰기




Volumn 187, Issue 12, 2011, Pages 6447-6455

Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRC4 PROTEIN; UNCLASSIFIED DRUG;

EID: 83755183815     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003784     Document Type: Article
Times cited : (77)

References (56)
  • 1
    • 77950662773 scopus 로고    scopus 로고
    • Molecular pathogenesis of infections caused by Legionella pneumophila
    • Newton, H. J., D. K. Ang, I. R. van Driel, and E. L. Hartland. 2010. Molecular pathogenesis of infections caused by Legionella pneumophila. Clin. Microbiol. Rev. 23: 274-298.
    • (2010) Clin. Microbiol. Rev. , vol.23 , pp. 274-298
    • Newton, H.J.1    Ang, D.K.2    Van Driel, I.R.3    Hartland, E.L.4
  • 2
    • 0030200018 scopus 로고    scopus 로고
    • The molecular ecology of legionellae
    • DOI 10.1016/0966-842X(96)10041-X
    • Fields, B. S. 1996. The molecular ecology of legionellae. Trends Microbiol. 4: 286-290. (Pubitemid 26251783)
    • (1996) Trends in Microbiology , vol.4 , Issue.7 , pp. 286-290
    • Fields, B.S.1
  • 3
    • 0032932436 scopus 로고    scopus 로고
    • Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages
    • Segal, G., and H. A. Shuman. 1999. Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages. Infect. Immun. 67: 2117-2124. (Pubitemid 29200461)
    • (1999) Infection and Immunity , vol.67 , Issue.5 , pp. 2117-2124
    • Segal, G.1    Shuman, H.A.2
  • 4
    • 43449102176 scopus 로고    scopus 로고
    • Host cell processes that influence the intracellular survival of Legionella pneumophila
    • DOI 10.1111/j.1462-5822.2008.01145.x
    • Shin, S., and C. R. Roy. 2008. Host cell processes that influence the intracellular survival of Legionella pneumophila. Cell. Microbiol. 10: 1209-1220. (Pubitemid 351663915)
    • (2008) Cellular Microbiology , vol.10 , Issue.6 , pp. 1209-1220
    • Shin, S.1    Roy, C.R.2
  • 5
    • 59849094765 scopus 로고    scopus 로고
    • Legionella pneumophila Dot/Icm translocated substrates: A sum of parts
    • Ensminger, A. W., and R. R. Isberg. 2009. Legionella pneumophila Dot/Icm translocated substrates: a sum of parts. Curr. Opin. Microbiol. 12: 67-73.
    • (2009) Curr. Opin. Microbiol. , vol.12 , pp. 67-73
    • Ensminger, A.W.1    Isberg, R.R.2
  • 6
    • 34547217380 scopus 로고    scopus 로고
    • Effector proteins translocated by Legionella pneumophila: Strength in numbers
    • DOI 10.1016/j.tim.2007.06.006, PII S0966842X07001278
    • Ninio, S., and C. R. Roy. 2007. Effector proteins translocated by Legionella pneumophila: strength in numbers. Trends Microbiol. 15: 372-380. (Pubitemid 47126854)
    • (2007) Trends in Microbiology , vol.15 , Issue.8 , pp. 372-380
    • Ninio, S.1    Roy, C.R.2
  • 7
    • 83755222623 scopus 로고    scopus 로고
    • Innate immunity to legionella pneumophila
    • Massis, L. M., and D. S. Zamboni. 2011. Innate immunity to legionella pneumophila. Front. Microbiol. 2: 109.
    • (2011) Front. Microbiol. , vol.2 , pp. 109
    • Massis, L.M.1    Zamboni, D.S.2
  • 8
    • 0037228017 scopus 로고    scopus 로고
    • Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila
    • DOI 10.1038/ng1065
    • Diez, E., S. H. Lee, S. Gauthier, Z. Yaraghi, M. Tremblay, S. Vidal, and P. Gros. 2003. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nat. Genet. 33: 55-60. (Pubitemid 36068682)
    • (2003) Nature Genetics , vol.33 , Issue.1 , pp. 55-60
    • Diez, E.1    Lee, S.-H.2    Gauthier, S.3    Yaraghi, Z.4    Tremblay, M.5    Vidal, S.6    Gros, P.7
  • 9
    • 0023873444 scopus 로고
    • Growth of Legionella pneumophila in Thioglycolate-elicited peritoneal macrophages from A/J mice
    • Yamamoto, Y., T. W. Klein, C. A. Newton, R. Widen, and H. Friedman. 1988. Growth of Legionella pneumophila in thioglycolate-elicited peritoneal macrophages from A/J mice. Infect. Immun. 56: 370-375. (Pubitemid 18040499)
    • (1988) Infection and Immunity , vol.56 , Issue.2 , pp. 370-375
    • Yamamoto, Y.1    Klein, T.W.2    Newton, C.A.3    Widen, R.4    Friedman, H.5
  • 11
    • 58049200723 scopus 로고    scopus 로고
    • Function of Nod-like receptors in microbial recognition and host defense
    • Franchi, L., N. Warner, K. Viani, and G. Nuñez. 2009. Function of Nod-like receptors in microbial recognition and host defense. Immunol. Rev. 227: 106-128.
    • (2009) Immunol. Rev. , vol.227 , pp. 106-128
    • Franchi, L.1    Warner, N.2    Viani, K.3    Nuñez, G.4
  • 12
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder, K., and J. Tschopp. 2010. The inflammasomes. Cell 140: 821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 16
    • 77952706524 scopus 로고    scopus 로고
    • Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila
    • Archer, K. A., F. Ader, K. S. Kobayashi, R. A. Flavell, and C. R. Roy. 2010. Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infect. Immun. 78: 2477-2487.
    • (2010) Infect. Immun. , vol.78 , pp. 2477-2487
    • Archer, K.A.1    Ader, F.2    Kobayashi, K.S.3    Flavell, R.A.4    Roy, C.R.5
  • 19
    • 57149112520 scopus 로고    scopus 로고
    • Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila
    • Shin, S., C. L. Case, K. A. Archer, C. V. Nogueira, K. S. Kobayashi, R. A. Flavell, C. R. Roy, and D. S. Zamboni. 2008. Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog. 4: e1000220.
    • (2008) PLoS Pathog. , vol.4
    • Shin, S.1    Case, C.L.2    Archer, K.A.3    Nogueira, C.V.4    Kobayashi, K.S.5    Flavell, R.A.6    Roy, C.R.7    Zamboni, D.S.8
  • 21
    • 65449134828 scopus 로고    scopus 로고
    • Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    • Case, C. L., S. Shin, and C. R. Roy. 2009. Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Infect. Immun. 77: 1981-1991.
    • (2009) Infect. Immun. , vol.77 , pp. 1981-1991
    • Case, C.L.1    Shin, S.2    Roy, C.R.3
  • 22
  • 25
    • 77349118460 scopus 로고    scopus 로고
    • Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis
    • Silveira, T. N., and D. S. Zamboni. 2010. Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis. Infect. Immun. 78: 1403-1413.
    • (2010) Infect. Immun. , vol.78 , pp. 1403-1413
    • Silveira, T.N.1    Zamboni, D.S.2
  • 28
    • 33744493091 scopus 로고    scopus 로고
    • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    • DOI 10.1038/ni1344, PII N1344
    • Miao, E. A., C. M. Alpuche-Aranda, M. Dors, A. E. Clark, M. W. Bader, S. I. Miller, and A. Aderem. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7: 569-575. (Pubitemid 43797337)
    • (2006) Nature Immunology , vol.7 , Issue.6 , pp. 569-575
    • Miao, E.A.1    Alpuche-Aranda, C.M.2    Dors, M.3    Clark, A.E.4    Bader, M.W.5    Miller, S.I.6    Aderem, A.7
  • 29
    • 37549041954 scopus 로고    scopus 로고
    • Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
    • Sutterwala, F. S., L. A. Mijares, L. Li, Y. Ogura, B. I. Kazmierczak, and R. A. Flavell. 2007. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J. Exp. Med. 204: 3235-3245.
    • (2007) J. Exp. Med. , vol.204 , pp. 3235-3245
    • Sutterwala, F.S.1    Mijares, L.A.2    Li, L.3    Ogura, Y.4    Kazmierczak, B.I.5    Flavell, R.A.6
  • 32
    • 0027443142 scopus 로고
    • Identification of Legionella pneumophila genes required for growth within and killing of human macrophages
    • Sadosky, A. B., L. A.Wiater, and H. A. Shuman. 1993. Identification of Legionella pneumophila genes required for growth within and killing of human macrophages. Infect. Immun. 61: 5361-5373. (Pubitemid 23353920)
    • (1993) Infection and Immunity , vol.61 , Issue.12 , pp. 5361-5373
    • Sadosky, A.B.1    Wiater, L.A.2    Shuman, H.A.3
  • 33
    • 0037311180 scopus 로고    scopus 로고
    • Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia
    • DOI 10.1128/AAC.47.2.533-540.2003
    • Edelstein, P. H., W. J. Weiss, and M. A. Edelstein. 2003. Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia. Antimicrob. Agents Chemother. 47: 533-540. (Pubitemid 36158078)
    • (2003) Antimicrobial Agents and Chemotherapy , vol.47 , Issue.2 , pp. 533-540
    • Edelstein, P.H.1    Weiss, W.J.2    Edelstein, M.A.C.3
  • 34
    • 0018687457 scopus 로고
    • Charcoal-yeast extract agar: Primary isolation medium for Legionella pneumophila
    • Feeley, J. C., R. J. Gibson, G. W. Gorman, N. C. Langford, J. K. Rasheed, D. C. Mackel, and W. B. Baine. 1979. Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophila. J. Clin. Microbiol. 10: 437-441. (Pubitemid 10250171)
    • (1979) Journal of Clinical Microbiology , vol.10 , Issue.4 , pp. 437-441
    • Feeley, J.C.1    Gibson, R.J.2    Gorman, G.W.3
  • 35
    • 0033019702 scopus 로고    scopus 로고
    • Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth
    • DOI 10.1046/j.1365-2958.1999.01410.x
    • Zuckman, D. M., J. B. Hung, and C. R. Roy. 1999. Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth. Mol. Microbiol. 32: 990-1001. (Pubitemid 29255765)
    • (1999) Molecular Microbiology , vol.32 , Issue.5 , pp. 990-1001
    • Zuckman, D.M.1    Hung, J.B.2    Roy, C.R.3
  • 36
    • 33645791082 scopus 로고    scopus 로고
    • Flagellin-deficient Legionella mutants evade caspase-1- And Naip5-mediated macrophage immunity
    • Ren, T., D. S. Zamboni, C. R. Roy, W. F. Dietrich, and R. E. Vance. 2006. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog. 2: e18.
    • (2006) PLoS Pathog. , vol.2
    • Ren, T.1    Zamboni, D.S.2    Roy, C.R.3    Dietrich, W.F.4    Vance, R.E.5
  • 37
    • 78650718978 scopus 로고    scopus 로고
    • A method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells
    • Marim, F. M., T. N. Silveira, D. S. Lima, Jr., and D. S. Zamboni. 2010. A method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells. PLoS ONE 5: e15263.
    • (2010) PLoS ONE , vol.5
    • Marim, F.M.1    Silveira, T.N.2    Lima Jr., D.S.3    Zamboni, D.S.4
  • 38
    • 0041563931 scopus 로고    scopus 로고
    • Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system
    • DOI 10.1046/j.1365-2958.2003.03626.x
    • Zamboni, D. S., S. McGrath, M. Rabinovitch, and C. R. Roy. 2003. Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system. Mol. Microbiol. 49: 965-976. (Pubitemid 36981342)
    • (2003) Molecular Microbiology , vol.49 , Issue.4 , pp. 965-976
    • Zamboni, D.S.1    McGrath, S.2    Rabinovitch, M.3    Roy, C.R.4
  • 39
    • 0028920863 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
    • Kuida, K., J. A. Lippke, G. Ku, M. W. Harding, D. J. Livingston, M. S. Su, and R. A. Flavell. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267: 2000-2003.
    • (1995) Science , vol.267 , pp. 2000-2003
    • Kuida, K.1    Lippke, J.A.2    Ku, G.3    Harding, M.W.4    Livingston, D.J.5    Su, M.S.6    Flavell, R.A.7
  • 41
    • 23944485009 scopus 로고    scopus 로고
    • Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death
    • DOI 10.1128/IAI.73.9.5720-5734.2005
    • Molofsky, A. B., L. M. Shetron-Rama, and M. S. Swanson. 2005. Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infect. Immun. 73: 5720-5734. (Pubitemid 41193007)
    • (2005) Infection and Immunity , vol.73 , Issue.9 , pp. 5720-5734
    • Molofsky, A.B.1    Shetron-Rama, L.M.2    Swanson, M.S.3
  • 42
    • 7044233334 scopus 로고    scopus 로고
    • Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila
    • DOI 10.1128/IAI.72.11.6221-6229.2004
    • Derré, I., and R. R. Isberg. 2004. Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila. Infect. Immun. 72: 6221-6229. (Pubitemid 39425398)
    • (2004) Infection and Immunity , vol.72 , Issue.11 , pp. 6221-6229
    • Derre, I.1    Isberg, R.R.2
  • 43
    • 0030994460 scopus 로고    scopus 로고
    • Analysis of the Legionella pneumophila fliI gene: Intracellular growth of a defined mutant defective for flagellum biosynthesis
    • Merriam, J. J., R. Mathur, R. Maxfield-Boumil, and R. R. Isberg. 1997. Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis. Infect. Immun. 65: 2497-2501. (Pubitemid 27237346)
    • (1997) Infection and Immunity , vol.65 , Issue.6 , pp. 2497-2501
    • Merriam, J.J.1    Mathur, R.2    Maxfield-Boumil, R.3    Isberg, R.R.4
  • 46
    • 83755222619 scopus 로고    scopus 로고
    • The Nlrc4 inflammasome contributes to restriction of pulmonary infection by flagellated Legionella spp. that trigger pyroptosis
    • Pereira, M. S. F., G. G. Marques, J. E. Dellama, and D. S. Zamboni. 2011. The Nlrc4 inflammasome contributes to restriction of pulmonary infection by flagellated Legionella spp. that trigger pyroptosis. Front. Microbiol. 2: 33.
    • (2011) Front. Microbiol. , vol.2 , pp. 33
    • Pereira, M.S.F.1    Marques, G.G.2    Dellama, J.E.3    Zamboni, D.S.4
  • 50
    • 73449114288 scopus 로고    scopus 로고
    • Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis
    • Whitfield, N. N., B. G. Byrne, and M. S. Swanson. 2009. Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis. Infect. Immun. 78: 423-432.
    • (2009) Infect. Immun. , vol.78 , pp. 423-432
    • Whitfield, N.N.1    Byrne, B.G.2    Swanson, M.S.3
  • 51
    • 75749083323 scopus 로고    scopus 로고
    • Virulence factors encoded by Legionella longbeachae identified on the basis of the genome sequence analysis of clinical isolate D-4968
    • Kozak, N. A., M. Buss, C. E. Lucas, M. Frace, D. Govil, T. Travis, M. Olsen-Rasmussen, R. F. Benson, and B. S. Fields. 2010. Virulence factors encoded by Legionella longbeachae identified on the basis of the genome sequence analysis of clinical isolate D-4968. J. Bacteriol. 192: 1030-1044.
    • (2010) J. Bacteriol. , vol.192 , pp. 1030-1044
    • Kozak, N.A.1    Buss, M.2    Lucas, C.E.3    Frace, M.4    Govil, D.5    Travis, T.6    Olsen-Rasmussen, M.7    Benson, R.F.8    Fields, B.S.9
  • 52
    • 33947126020 scopus 로고    scopus 로고
    • Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila
    • DOI 10.1111/j.1462-5822.2006.00839.x
    • Fortier, A., C. de Chastellier, S. Balor, and P. Gros. 2007. Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila. Cell. Microbiol. 9: 910-923. (Pubitemid 46394902)
    • (2007) Cellular Microbiology , vol.9 , Issue.4 , pp. 910-923
    • Fortier, A.1    De Chastellier, C.2    Balor, S.3    Gros, P.4
  • 53
    • 70350454786 scopus 로고    scopus 로고
    • Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4
    • Fortier, A., K. Doiron, M. Saleh, S. Grinstein, and P. Gros. 2009. Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4. Infect. Immun. 77: 4794-4805.
    • (2009) Infect. Immun. , vol.77 , pp. 4794-4805
    • Fortier, A.1    Doiron, K.2    Saleh, M.3    Grinstein, S.4    Gros, P.5
  • 56
    • 66449093432 scopus 로고    scopus 로고
    • Experimental Legionella longbeachae infection in intratracheally inoculated mice
    • Gobin, I., M. Susa, G. Begic, E. L. Hartland, and M. Doric. 2009. Experimental Legionella longbeachae infection in intratracheally inoculated mice. J. Med. Microbiol. 58: 723-730.
    • (2009) J. Med. Microbiol. , vol.58 , pp. 723-730
    • Gobin, I.1    Susa, M.2    Begic, G.3    Hartland, E.L.4    Doric, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.