Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

Journal of Biological Chemistry

Volumn 272, Issue 5, 1997, Pages 2587-2590

  Gether, Ulrik ^a   Ballesteros, Juan A ^b   Seifert, Roland ^a   Sanders Bush, Elaine ^a   Weinstein, Harel ^b   Kobilka, Brian K ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DENATURATION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STABILITY; SPECTROSCOPY;

ADRENERGIC BETA-AGONISTS; ANIMALS; CELL LINE; DRUG STABILITY; GTP-BINDING PROTEINS; ISOPROTERENOL; MUTAGENESIS, SITE-DIRECTED; PROPANOLAMINES; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT PROTEINS; SPODOPTERA; THERMODYNAMICS; TRANSFECTION;

ANIMALIA;

EID: 0031018485     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.5.2587     Document Type: Article

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