메뉴 건너뛰기




Volumn 7, Issue 11, 2011, Pages

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and smoothened

Author keywords

[No Author keywords available]

Indexed keywords

BBS PROTEIN; BBS3 PROTEIN; BBSOME PROTEIN; LZTFL1 PROTEIN; PROTEIN SUBUNIT; REGULATOR PROTEIN; SMOOTHENED PROTEIN; UNCLASSIFIED DRUG; BBS4 PROTEIN, MOUSE; G PROTEIN COUPLED RECEPTOR; LZTFL1 PROTEIN, HUMAN; LZTFL1PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; SMALL INTERFERING RNA; SMO PROTEIN, HUMAN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

EID: 81755177811     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002358     Document Type: Article
Times cited : (163)

References (38)
  • 1
    • 33746891890 scopus 로고    scopus 로고
    • The primary cilium as the cell's antenna: signaling at a sensory organelle
    • Singla V, Reiter JF, (2006) The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 313: 629-633.
    • (2006) Science , vol.313 , pp. 629-633
    • Singla, V.1    Reiter, J.F.2
  • 2
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: a signalling centre during vertebrate development
    • Goetz SC, Anderson KV, (2010) The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 11: 331-344.
    • (2010) Nat Rev Genet , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 3
    • 58749105340 scopus 로고    scopus 로고
    • Modeling ciliopathies: Primary cilia in development and disease
    • Quinlan RJ, Tobin JL, Beales PL, (2008) Modeling ciliopathies: Primary cilia in development and disease. Curr Top Dev Biol 84: 249-310.
    • (2008) Curr Top Dev Biol , vol.84 , pp. 249-310
    • Quinlan, R.J.1    Tobin, J.L.2    Beales, P.L.3
  • 5
    • 65649147891 scopus 로고    scopus 로고
    • Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy
    • Zaghloul NA, Katsanis N, (2009) Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy. J Clin Invest 119: 428-437.
    • (2009) J Clin Invest , vol.119 , pp. 428-437
    • Zaghloul, N.A.1    Katsanis, N.2
  • 6
    • 77956505731 scopus 로고    scopus 로고
    • Planar cell polarity acts through septins to control collective cell movement and ciliogenesis
    • Kim SK, Shindo A, Park TJ, Oh EC, Ghosh S, et al. (2010) Planar cell polarity acts through septins to control collective cell movement and ciliogenesis. Science 329: 1337-1340.
    • (2010) Science , vol.329 , pp. 1337-1340
    • Kim, S.K.1    Shindo, A.2    Park, T.J.3    Oh, E.C.4    Ghosh, S.5
  • 7
    • 77957557692 scopus 로고    scopus 로고
    • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy
    • Otto EA, Hurd TW, Airik R, Chaki M, Zhou W, et al. (2010) Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet 42: 840-850.
    • (2010) Nat Genet , vol.42 , pp. 840-850
    • Otto, E.A.1    Hurd, T.W.2    Airik, R.3    Chaki, M.4    Zhou, W.5
  • 8
    • 76549121983 scopus 로고    scopus 로고
    • BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly
    • Seo S, Baye LM, Schulz NP, Beck JS, Zhang Q, et al. (2010) BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. Proc Natl Acad Sci U S A 107: 1488-1493.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1488-1493
    • Seo, S.1    Baye, L.M.2    Schulz, N.P.3    Beck, J.S.4    Zhang, Q.5
  • 9
    • 34250012834 scopus 로고    scopus 로고
    • A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
    • Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peranen J, et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129: 1201-1213.
    • (2007) Cell , vol.129 , pp. 1201-1213
    • Nachury, M.V.1    Loktev, A.V.2    Zhang, Q.3    Westlake, C.J.4    Peranen, J.5
  • 10
    • 57049171416 scopus 로고    scopus 로고
    • A BBSome subunit links ciliogenesis, microtubule stability, and acetylation
    • Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, et al. (2008) A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Dev Cell 15: 854-865.
    • (2008) Dev Cell , vol.15 , pp. 854-865
    • Loktev, A.V.1    Zhang, Q.2    Beck, J.S.3    Searby, C.C.4    Scheetz, T.E.5
  • 11
    • 77953879123 scopus 로고    scopus 로고
    • The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia
    • Jin H, White SR, Shida T, Schulz S, Aguiar M, et al. (2010) The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell 141: 1208-1219.
    • (2010) Cell , vol.141 , pp. 1208-1219
    • Jin, H.1    White, S.R.2    Shida, T.3    Schulz, S.4    Aguiar, M.5
  • 12
    • 81755179752 scopus 로고    scopus 로고
    • Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins
    • DOI:10.1007/s00018-00010-00603-00014
    • Domire JS, Green JA, Lee KG, Johnson AD, Askwith CC, et al. (2010) Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins. Cell Mol Life Sci DOI:10.1007/s00018-00010-00603-00014.
    • (2010) Cell Mol Life Sci
    • Domire, J.S.1    Green, J.A.2    Lee, K.G.3    Johnson, A.D.4    Askwith, C.C.5
  • 13
    • 41949116864 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
    • Berbari NF, Lewis JS, Bishop GA, Askwith CC, Mykytyn K, (2008) Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc Natl Acad Sci U S A 105: 4242-4246.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 4242-4246
    • Berbari, N.F.1    Lewis, J.S.2    Bishop, G.A.3    Askwith, C.C.4    Mykytyn, K.5
  • 14
    • 76149101303 scopus 로고    scopus 로고
    • The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
    • Lechtreck KF, Johnson EC, Sakai T, Cochran D, Ballif BA, et al. (2009) The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella. J Cell Biol 187: 1117-1132.
    • (2009) J Cell Biol , vol.187 , pp. 1117-1132
    • Lechtreck, K.F.1    Johnson, E.C.2    Sakai, T.3    Cochran, D.4    Ballif, B.A.5
  • 16
    • 0035307372 scopus 로고    scopus 로고
    • The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3
    • Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, et al. (2001) The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. Genomics 73: 10-19.
    • (2001) Genomics , vol.73 , pp. 10-19
    • Kiss, H.1    Kedra, D.2    Kiss, C.3    Kost-Alimova, M.4    Yang, Y.5
  • 17
    • 77950794746 scopus 로고    scopus 로고
    • Tumor-suppressive functions of leucine zipper transcription factor-like 1
    • Wei Q, Zhou W, Wang W, Gao B, Wang L, et al. (2010) Tumor-suppressive functions of leucine zipper transcription factor-like 1. Cancer Res 70: 2942-2950.
    • (2010) Cancer Res , vol.70 , pp. 2942-2950
    • Wei, Q.1    Zhou, W.2    Wang, W.3    Gao, B.4    Wang, L.5
  • 18
    • 3543096759 scopus 로고    scopus 로고
    • Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
    • Sutton RB, Fasshauer D, Jahn R, Brunger AT, (1998) Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature 395: 347-353.
    • (1998) Nature , vol.395 , pp. 347-353
    • Sutton, R.B.1    Fasshauer, D.2    Jahn, R.3    Brunger, A.T.4
  • 19
    • 0035918229 scopus 로고    scopus 로고
    • Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly
    • Misura KM, Scheller RH, Weis WI, (2001) Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly. J Biol Chem 276: 13273-13282.
    • (2001) J Biol Chem , vol.276 , pp. 13273-13282
    • Misura, K.M.1    Scheller, R.H.2    Weis, W.I.3
  • 20
    • 33751252292 scopus 로고    scopus 로고
    • Direct observation of individual endogenous protein complexes in situ by proximity ligation
    • Soderberg O, Gullberg M, Jarvius M, Ridderstrale K, Leuchowius KJ, et al. (2006) Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 3: 995-1000.
    • (2006) Nat Methods , vol.3 , pp. 995-1000
    • Soderberg, O.1    Gullberg, M.2    Jarvius, M.3    Ridderstrale, K.4    Leuchowius, K.J.5
  • 21
    • 34248214629 scopus 로고    scopus 로고
    • Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles
    • Ou G, Koga M, Blacque OE, Murayama T, Ohshima Y, et al. (2007) Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell 18: 1554-1569.
    • (2007) Mol Biol Cell , vol.18 , pp. 1554-1569
    • Ou, G.1    Koga, M.2    Blacque, O.E.3    Murayama, T.4    Ohshima, Y.5
  • 22
    • 49449086772 scopus 로고    scopus 로고
    • Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts
    • Ocbina PJ, Anderson KV, (2008) Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev Dyn 237: 2030-2038.
    • (2008) Dev Dyn , vol.237 , pp. 2030-2038
    • Ocbina, P.J.1    Anderson, K.V.2
  • 23
    • 76049114315 scopus 로고    scopus 로고
    • Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
    • Kim J, Kato M, Beachy PA, (2009) Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A 106: 21666-21671.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21666-21671
    • Kim, J.1    Kato, M.2    Beachy, P.A.3
  • 24
    • 62549159642 scopus 로고    scopus 로고
    • Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
    • Rohatgi R, Milenkovic L, Corcoran RB, Scott MP, (2009) Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A 106: 3196-3201.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3196-3201
    • Rohatgi, R.1    Milenkovic, L.2    Corcoran, R.B.3    Scott, M.P.4
  • 25
    • 9344261783 scopus 로고    scopus 로고
    • Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin
    • Nishimura DY, Fath M, Mullins RF, Searby C, Andrews M, et al. (2004) Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proc Natl Acad Sci U S A 101: 16588-16593.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16588-16593
    • Nishimura, D.Y.1    Fath, M.2    Mullins, R.F.3    Searby, C.4    Andrews, M.5
  • 26
    • 2942625562 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly
    • Mykytyn K, Mullins RF, Andrews M, Chiang AP, Swiderski RE, et al. (2004) Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly. Proc Natl Acad Sci U S A 101: 8664-8669.0.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8664-8669
    • Mykytyn, K.1    Mullins, R.F.2    Andrews, M.3    Chiang, A.P.4    Swiderski, R.E.5
  • 27
    • 44449141342 scopus 로고    scopus 로고
    • Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways
    • Kishimoto N, Cao Y, Park A, Sun Z, (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Developmental cell 14: 954-961.
    • (2008) Developmental Cell , vol.14 , pp. 954-961
    • Kishimoto, N.1    Cao, Y.2    Park, A.3    Sun, Z.4
  • 28
    • 20244381625 scopus 로고    scopus 로고
    • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
    • Kim JC, Badano JL, Sibold S, Esmail MA, Hill J, et al. (2004) The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. Nat Genet 36: 462-470.
    • (2004) Nat Genet , vol.36 , pp. 462-470
    • Kim, J.C.1    Badano, J.L.2    Sibold, S.3    Esmail, M.A.4    Hill, J.5
  • 29
    • 33846978104 scopus 로고    scopus 로고
    • Intraflagellar transport is essential for endochondral bone formation
    • Haycraft CJ, Zhang Q, Song B, Jackson WS, Detloff PJ, et al. (2007) Intraflagellar transport is essential for endochondral bone formation. Development 134: 307-316.
    • (2007) Development , vol.134 , pp. 307-316
    • Haycraft, C.J.1    Zhang, Q.2    Song, B.3    Jackson, W.S.4    Detloff, P.J.5
  • 30
    • 41349107244 scopus 로고    scopus 로고
    • THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    • Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, et al. (2008) THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet 40: 403-410.
    • (2008) Nat Genet , vol.40 , pp. 403-410
    • Tran, P.V.1    Haycraft, C.J.2    Besschetnova, T.Y.3    Turbe-Doan, A.4    Stottmann, R.W.5
  • 31
    • 44349147745 scopus 로고    scopus 로고
    • Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome
    • Tobin JL, Di Franco M, Eichers E, May-Simera H, Garcia M, et al. (2008) Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A 105: 6714-6719.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6714-6719
    • Tobin, J.L.1    Di Franco, M.2    Eichers, E.3    May-Simera, H.4    Garcia, M.5
  • 33
    • 79955808192 scopus 로고    scopus 로고
    • Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways
    • Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, et al. (2011) Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell 145: 513-528.
    • (2011) Cell , vol.145 , pp. 513-528
    • Sang, L.1    Miller, J.J.2    Corbit, K.C.3    Giles, R.H.4    Brauer, M.J.5
  • 34
    • 79955513961 scopus 로고    scopus 로고
    • MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
    • Williams CL, Li C, Kida K, Inglis PN, Mohan S, et al. (2011) MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis. The Journal of cell biology 192: 1023-1041.
    • (2011) The Journal of Cell Biology , vol.192 , pp. 1023-1041
    • Williams, C.L.1    Li, C.2    Kida, K.3    Inglis, P.N.4    Mohan, S.5
  • 35
    • 77956388187 scopus 로고    scopus 로고
    • CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content
    • Craige B, Tsao CC, Diener DR, Hou Y, Lechtreck KF, et al. (2010) CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content. J Cell Biol 190: 927-940.
    • (2010) J Cell Biol , vol.190 , pp. 927-940
    • Craige, B.1    Tsao, C.C.2    Diener, D.R.3    Hou, Y.4    Lechtreck, K.F.5
  • 36
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 37
    • 32144432437 scopus 로고    scopus 로고
    • The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
    • Arnold K, Bordoli L, Kopp J, Schwede T, (2006) The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics 22: 195-201.
    • (2006) Bioinformatics , vol.22 , pp. 195-201
    • Arnold, K.1    Bordoli, L.2    Kopp, J.3    Schwede, T.4
  • 38
    • 0034800374 scopus 로고    scopus 로고
    • InterProScan-an integration platform for the signature-recognition methods in InterPro
    • Zdobnov EM, Apweiler R, (2001) InterProScan-an integration platform for the signature-recognition methods in InterPro. Bioinformatics 17: 847-848.
    • (2001) Bioinformatics , vol.17 , pp. 847-848
    • Zdobnov, E.M.1    Apweiler, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.