TRPA1 as a drug target - Promise and challenges

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 388, Issue 4, 2015, Pages 451-463

  Chen, Jun ^a   Hackos, David H ^a  

^a GENENTECH INC   (United States)

Author keywords

Challenges; Drug target; Promise; TRPA1

Indexed keywords

ANKYRIN; CALCIUM; DIVALENT CATION; G PROTEIN COUPLED RECEPTOR; MONOCLONAL ANTIBODY; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; PROTON; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1 ANTAGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; UNCLASSIFIED DRUG; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

AGONIST; CALCIUM CELL LEVEL; COLD SENSITIVITY; COUGHING; DRUG RESEARCH; DRUG TARGETING; HUMAN; HYPERACTIVITY; LUNG EDEMA; MODULATION; NOCICEPTION; NONHUMAN; PAIN; PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; PRURITUS; RESPIRATION DEPRESSION; RESPIRATORY TRACT DISEASE; REVIEW; SNEEZING; SPECIES DIFFERENCE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; METABOLISM;

ANIMALS; HUMANS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84925507483     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1088-3     Document Type: Review

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