TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

Free Radical Biology and Medicine

Volumn 72, Issue , 2014, Pages 200-209

  Trevisan, Gabriela ^a,b   Hoffmeister, Carin ^a   Rossato, Mateus Fortes ^a   Oliveira, Sara Marchesan ^a   Silva, Mariane Arnoldi ^a   Silva, Cássia Regina ^a   Fusi, Camilla ^c   Tonello, Raquel ^a   Minocci, Daiana ^c   Guerra, Gustavo Petri ^d   Materazzi, Serena ^c   Nassini, Romina ^c   Geppetti, Pierangelo ^c   Ferreira, Juliano ^a,e  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSIDADE TECNOLÓGICA FEDERAL DO PARANÁ   (Brazil)

^e FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

CGRP; Free radicals; Gout; Hydrogen peroxide; IL 1 ; Nociception

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAMPHOR; CATALASE; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; URATE; ANTIOXIDANT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EDEMA; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DELETION; GOUT; HYPERALGESIA; INFLAMMATION; MALE; MOUSE; NEUTROPHIL; NONHUMAN; OUTCOME ASSESSMENT; PARAMETERS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNOVIUM; ANIMAL; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GOUT; HYDROGEN PEROXIDE; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICE; MICE, KNOCKOUT; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; TRPC CATION CHANNELS;

EID: 84900867509     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.04.021     Document Type: Article

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