TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis

Journal of Neuroscience

Volumn 33, Issue 13, 2013, Pages 5603-5611

  Schwartz, Erica S ^a   La, Jun Ho ^a   Scheff, Nicole N ^a   Davis, Brian M ^a   Albers, Kathryn M ^a   Gebhart, G F ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CERULETIDE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; RAP PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR 1 ANTAGONIST;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; BEHAVIOR; CHRONIC INFLAMMATION; CHRONIC PAIN; CHRONIC PANCREATITIS; CONTROLLED STUDY; FIBROSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; MONOCYTE; MOUSE; NECROSIS; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMIDINES; ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, DIFFERENTIATION; CAERULEIN; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EXPLORATORY BEHAVIOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; MORPHINE; NEUTROPHIL INFILTRATION; NODOSE GANGLION; OXIMES; PAIN; PAIN MEASUREMENT; PANCREAS; PANCREATITIS, CHRONIC; PEROXIDASE; PYRIDINES; RNA, MESSENGER; SENSORY RECEPTOR CELLS; TIME FACTORS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 84875422211     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1806-12.2013     Document Type: Article

References (32)

1. Aley KO, Martin A, McMahon T, Mok J, Levine JD, Messing RO (2001) Nociceptor sensitization by extracellular signal-regulated kinases. J Neurosci 21:6933-6939. Medline
2. Anaparthy R, Pasricha PJ (2008) Pain and chronic pancreatitis: is it the plumbing or the wiring? Curr Gastroenterol Rep 10:101-106. CrossRef Medline
3. Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV (2001) Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Mol Cell Neurosci 18:183-196. CrossRef Medline
4. Berridge MJ, Lipp P, Bootman MD (2000) The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1:11-21. CrossRef Medline
5. Bron R, Klesse LJ, Shah K, Parada LF, Winter J (2003) Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol Cell Neurosci 22:118-132. CrossRef Medline
6. Dai Y, Fukuoka T, Wang H, Yamanaka H, Obata K, Tokunaga A, Noguchi K (2004) Contribution of sensitized P2X receptors in inflamed tissue to the mechanical hypersensitivity revealed by phosphorylated ERK in DRG neurons. Pain 108:258-266. CrossRef Medline
7. Demir IE, Tieftrunk E, Maak M, Friess H, Ceyhan GO (2010) Pain mechanisms in chronic pancreatitis: of a master and his fire. Langenbecks Arch Surg 396:151-160. CrossRef Medline
8. Detlefsen S, Sipos B, Zhao J, Drewes AM, Klöppel G (2008) Autoimmune pancreatitis: expression and cellular source of profibrotic cytokines and their receptors. Am J Surg Pathol 32:986-995. CrossRef Medline
9. Dimcevski G, Staahl C, Andersen SD, Thorsgaard N, Funch-Jensen P, Arendt-Nielsen L, Drewes AM (2007) Assessment of experimental pain from skin, muscle, and esophagus in patients with chronic pancreatitis. Pancreas 35:22-29. CrossRef Medline
10. Firner M, Greffrath W, Treede RD (2006) Phosphorylation of extracellular signal-related protein kinase is required for rapid facilitation of heatinduced currents in rat dorsal root ganglion neurons. Neuroscience 143: 253-263. CrossRef Medline
11. 2 indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450. Medline
12. Kao CH, Wang SJ, Chen CY, Yeh SH (1994) Detection of esophageal carcinoma using Tc-99m MIBI SPECT imaging. Clin Nucl Med 19:1069-1074. CrossRef Medline
13. Liddle RA (2007) The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis. Biochim Biophys Acta 1772:869-878. CrossRef Medline
14. Liddle RA, Nathan JD (2004) Neurogenic inflammation and pancreatitis. Pancreatology 4:551-559, discussion 559-560. Medline
15. Lieb JG 2nd, Forsmark CE (2009) Review article: pain and chronic pancreatitis. Aliment Pharmacol Ther 29:706-719. CrossRef Medline
16. Lindsay TH, Halvorson KG, Peters CM, Ghilardi JR, Kuskowski MA, Wong GY, Mantyh PW (2006) A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas. Neuroscience 137:1417-1426. CrossRef Medline
17. Lu SG, Gold MS (2008) Inflammation-Induced Increase in Evoked Calcium Transients in Subpopulations of Rat Dorsal Root Ganglion Neurons. Neuroscience 153:279-288. CrossRef Medline
18. Lu SG, Zhang X, Gold MS (2006) Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons. J Physiol 577:169-190. CrossRef Medline
19. Lu SG, Zhang XL, Luo ZD, Gold MS (2010) Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons. Pain 151:633-643. CrossRef Medline
20. Ma W, Bisby MA (2000) Calcitonin gene-related peptide, substance P and protein gene product 9.5 immunoreactive axonal fibers in the rat footpad skin following partial sciatic nerve injuries. J Neurocytol 29:249-262. CrossRef Medline
21. Ma W, Zheng WH, Powell K, Jhamandas K, Quirion R (2001) Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study. Eur J Neurosci 14:1091-1104. CrossRef Medline
22. Nathan JD, Patel AA, McVey DC, Thomas JE, Prpic V, Vigna SR, Liddle RA (2001) Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol 281: G1322-1328. Medline
23. Obata K, Noguchi K (2004) MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci 74:2643-2653. CrossRef Medline
24. Obata K, Yamanaka H, Dai Y, Tachibana T, Fukuoka T, Tokunaga A, Yoshikawa H, Noguchi K (2003) Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci 23:4117-4126. Medline
25. Puylaert M, Kapural L, Van Zundert J, Peek D, Lataster A, Mekhail N, van Kleef M, Keulemans YC (2011) Pain in chronic pancreatitis. Pain Pract 11:492-505. CrossRef Medline
26. 2 transients in rat DRG neurons. Soc Neurosci Abstr 37:380.29.
27. Schwartz ES, Christianson JA, Chen X, La JH, Davis BM, Albers KM, Gebhart GF (2011) Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology 140:1283-1291.e1-2. CrossRef Medline
28. Xu GY, Winston JH, Shenoy M, Yin H, Pendyala S, Pasricha PJ (2007) Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis. Gastroenterology 133:1282-1292. CrossRef Medline
29. Zhuang ZY, Xu H, Clapham DE, Ji RR (2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci 24:8300-8309. CrossRef Medline
30. Zhuang ZY, Gerner P, Woolf CJ, Ji RR (2005) ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114: 149-159. CrossRef Medline
31. Zhu W, Oxford GS (2011) Differential gene expression of neonatal and adult DRG neurons correlates with the differential sensitization of TRPV1 responses to nerve growth factor. Neurosci Lett 500:192-196. CrossRef Medline
32. Zhu WJ, Roper SN (2001) Brain-derived neurotrophic factor enhances fast excitatory synaptic transmission in human epileptic dentate gyrus. Ann Neurol 50:188-194. CrossRef Medline