Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 47, 2014, Pages 16901-16906

  Moparthi, Lavanya ^a   Survery, Sabeen ^a   Kreir, Mohamed ^b,c   Simonsen, Charlotte ^d   Kjellbom, Per ^a   Högestätt, Edward D ^d   Johanson, Urban ^a   Zygmunt, Peter M ^d  

^a LUND UNIVERSITY   (Sweden)

^b NANION TECHNOLOGIES GMBH   (Germany)

^c JACOBS UNIVERSITY BREMEN   (Germany)

^d LUND UNIVERSITY   (Sweden)

Author keywords

Cold sensing; Irritants; Pain; Sensory neuron; TRP channels

Indexed keywords

ANKYRIN; CALCIUM ION; CANNABINOID; ELECTROPHILE; ION CHANNEL; MENTHOL; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; OXIDIZING AGENT; THIOL; THIOL DERIVATIVE; THIOMESYLIC ACID METHYL ESTER; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; CALCIUM CHANNEL; NERVE PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARDIOVASCULAR DISEASE; CHANNEL GATING; CHEMICAL INTERACTION; CHEMOSENSITIVITY; COLD SENSITIVITY; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; LIPID BILAYER; NONHUMAN; PROTEIN DOMAIN; PURIFICATION; SECOND MESSENGER; CHEMISTRY; COLD; PATCH CLAMP TECHNIQUE; PHYSIOLOGY;

ANKYRIN REPEAT; CALCIUM CHANNELS; COLD TEMPERATURE; HUMANS; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84912567148     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412689111     Document Type: Article

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